TrkB Protein, Human (HEK293, Fc)
TrkB Protein, Human (HEK293, Fc) is the recombinant human-derived TrkB protein, expressed by HEK293, with C-hFc tag.
- Species: Human
- Source: HEK293
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Storage:Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
Description
TrkB Protein, Human (HEK293, Fc) is the recombinant human-derived TrkB protein, expressed by HEK293, with C-hFc tag.
Background
TrkB protein, also known as tropomyosin receptor kinase B, is composed of a non-catalytic isoform. Unlike its catalytic isoform, the non-catalytic isoform of TrkB lacks intrinsic kinase activity. The catalytic isoform of TrkB is responsible for initiating signaling cascades upon activation by its ligands, such as brain-derived neurotrophic factor (BDNF). However, the non-catalytic isoform of TrkB is believed to modulate the activity of the catalytic isoform and regulate its signaling pathways. While the precise role of the non-catalytic isoform of TrkB is still being investigated, it is thought to play a regulatory role in various cellular processes, particularly in neuronal development and synaptic plasticity. Further research is needed to fully elucidate the functional significance of the non-catalytic isoform of TrkB and its contribution to neuronal function.
Technical Parameters
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Species Human
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Source HEK293
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Tag C-hFc
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Accession
AAH31835 (C32-H430)
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Gene ID4915
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Molecular Construction
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N-term
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TrkB (C32-H430)
Accession # AAH31835 -
hFc
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C-term
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Protein Length
Extracellular Domain
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Synonyms
NTRK2; Neurotrophic Tyrosine Kinase, Receptor, Type 2, Isoform CRA_a; Neurotrophic Receptor Tyrosine Kinase 2; Neurotrophic Tyrosine Kinase, Receptor, Type 2; TRKB; Neurotrophin Receptor Tyrosine Kinase Type 2; BDNF/NT-3 Growth Factors Receptor; BDNF-Tropomyosine Receptor Kinase B; Neurotrophic Tyrosine Kinase Receptor Type 2; Tyrosine-Protein Kinase Receptor; Tropomyosin-Related Kinase B; Tyrosine Kinase Receptor B; GP145-TrkB; TrkB Tyrosine Kinase; Trk-B; EIEE58; CDNA FLJ76753, Highly Similar To Homo Sapiens Neurotrophic Tyrosine Kinase, Receptor, Type 2 (NTRK2), Transcript Variant B, MRNA; DEE58; Neurotrophin Receptor Tyrosine Kinase Type 2 Truncated Isoform; OBHD
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AA Sequence
CPTSCKCSASRIWCSDPSPGIVAFPRLEPNSVDPENITEIFIANQKRLEIINEDDVEAYVGLRNLTIVDSGLKFVAHKAFLKNSNLQHINFTRNKLTSLSRKHFRHLDLSELILVGNPFTCSCDIMWIKTLQEAKSSPDTQDLYCLNESSKNIPLANLQIPNCGLPSANLAAPNLTVEEGKSITLSCSVAGDPVPNMYWDVGNLVSKHMNETSHTQGSLRITNISSDDSGKQISCVAENLVGEDQDSVNLTVHFAPTITFLESPTSDHHWCIPFTVKGNPKPALQWFYNGAILNESKYICTKIHVTNHTEYHGCLQLDNPTHMNNGDYTLIAKNEYGKDEKQISAHFMGWPGIDDGANPNYPDVIYEDYGTAANDIGDTTNRSNEIPSTDVTDKTGREH
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Predicted Molecular Mass
70.4 kDa
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Molecular Weight
Approximately 86-116 kDa, based on SDS-PAGE under reducing conditions, due to the glycosylation.
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Glycosylation
Yes
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Purity
≥ 98%, as determined by reducing SDS-PAGE.
Product Properties
Lyophilized powder.
<1 EU/μg, determined by LAL method.
It is not recommended to reconstitute to a concentration less than 100 μg/mL in ddH2O. For long term storage it is recommended to add a carrier protein (0.1% BSA, 5% HSA, 10% FBS or 5% Trehalose).
Stored at -20°C for 2 years from date of receipt. After reconstitution, it is stable at 4°C for 1 week or -20°C for longer (with carrier protein). It is recommended to freeze aliquots at -20°C or -80°C for extended storage.
Room temperature in continental US; may vary elsewhere.
Documentation
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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