UBE2J1 Protein, Human (Active)
Based on 1 Customer Validation
UBE2J1 Protein, Human (Active) is the recombinant human-derived UBE2J1, expressed by E. coli , with tag Free labeled tag. ,
- Species: Human
- Source: E. coli
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Storage:Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
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Biological Activity
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Technical Parameters
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Product Properties
- Documentation
- Help & FAQs
Biological Activity
UBE2J1 Protein, Human (Active) is the recombinant human-derived UBE2J1, expressed by E. coli , with tag Free labeled tag. ,
UBE2J1 is a ubiquitin-conjugating enzyme that catalyzes the covalent attachment of ubiquitin to other proteins. It functions in the selective degradation of misfolded membrane proteins via the endoplasmic reticulum-associated degradation (ERAD) pathway and is essential for cellular recovery from ER stress. Additionally, UBE2J1 plays a role in the MAPKAPK2-dependent translational control of TNF-alpha synthesis. It also acts as a platform for perinuclear positioning of the endosomal system by mediating ubiquitination of SQSTM1 through interaction with the E3 ubiquitin-protein ligase RNF26. In male fecundity, UBE2J1 interacts with the E3 ubiquitin-protein ligase RNF133 to exert its function.
Active
Technical Parameters
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Species Human
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Source E. coli
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Tag Tag Free
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Accession
Q9Y385 (M1-T282)
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Gene ID51465
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Protein Length
Partial
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Synonyms
UBE2J1; Ubiquitin Conjugating Enzyme E2 J1; NCUBE1; HSPC153; CGI‑76; UBC6; Ubiquitin‑Conjugating Enzyme E2, J1 (UBC6 Homolog,Yeast); Yeast Ubiquitin‑Conjugating Enzyme UBC6 Homolog E; Non‑Canonical Ubiquitin‑Conjugating Enzyme 1; Ubiquitin‑Conjugating Enz
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AA Sequence
METRYNLKSPAVKRLMKEAAELKDPTDHYHAQPLEDNLFEWHFTVRGPPDSDFDGGVYHGRIVLPPEYPMKPPSIILLTANGRFEVGKKICLSISGHHPETWQPSWSIRTALLAIIGFMPTKGEGAIGSLDYTPEERRALAKKSQDFCCEGCGSAMKDVLLPLKSGSDSSQADQEAKELARQISFKAEVNSSGKTISESDLNHSFSLTDLQDDIPTTFQGATASTSYGLQNSSAASFHQPTQPVAKNTSMSPRQRRAQQQSQRRLSTSPDVIQGHQPRDNHT
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Predicted Molecular Mass
31.3 kDa
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Purity
≥ 95%, as determined by reducing SDS-PAGE.
Product Properties
Solution
1.Supplied as a 0.22 μm filtered solution of 50 mM Tris-HCl, pH 7.5, 200 mM NaCl, 20% glycerol, 1 mM DTT.
2.Supplied as a 0.22 μm filtered solution of 50 mM HEPES, pH 7.5, 200 mM NaCl, 20% glycerol, 1 mM DTT.
Note: For SPR assay, please replace the buffer. Primary amine components (e.g., Tris, imidazole) can affect protein-coupled chips.
Please refer to the lot-specific COA for specific buffer information.
<1 EU/μg, determined by LAL method.
Please use rapid thawing with running water to thaw the protein.
Stored at -80°C for 1 year from date of receipt. It is stable at -20°C for 3 months after opening. It is recommended to freeze aliquots at -80°C for extended storage. Avoid repeated freeze-thaw cycles.
Shipping with dry ice.
Documentation
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Data Sheet (237 KB)
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SDS (251 KB)
- English - EN (251 KB)
- Français - FR (251 KB)
- Deutsch - DE (251 KB)
- Norwegian - NO (251 KB)
- Español - ES (251 KB)
- Swedish - SV (251 KB)
- Italian - IT (251 KB)
- Korean - KR (251 KB)
- Portuguese - PT (251 KB)
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Handling Instructions (2659 KB)
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
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