(S)-ACE-OH

Cat. No.: HY-169325 Pureza: 99.17%: Ficha de datos
COA

SDS
Instrucciones de manejo
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(S)-ACE-OH is a molecular glue with anticancer activity. (S)-ACE-OH promotes nucleoporin degradation and disruption of nucleocytoplasmic trafficking by inducing the interaction between E3 ubiquitin ligase TRIM21 and nucleoporin NUP98.

Para uso exclusivo en investigación. No vendemos a pacientes.

(S)-ACE-OH Estructura química

Tamaño	Stock	Cantidad
Oil + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO ready for reconstitution	En stock	Estimated Time of Arrival: December 31
Solution
10 mM * 1 mL in DMSO	En stock	Estimated Time of Arrival: December 31
Oil
5 mg	En stock	Estimated Time of Arrival: December 31
10 mg	En stock	Estimated Time of Arrival: December 31
25 mg	En stock	Estimated Time of Arrival: December 31
50 mg	En stock	Estimated Time of Arrival: December 31
100 mg	En stock	Estimated Time of Arrival: December 31
200 mg	Obtener un presupuesto
500 mg	Obtener un presupuesto

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This product is a controlled substance and not for sale in your territory.

Revisión del cliente

Based on 1 publication(s) in Google Scholar

Other Forms of (S)-ACE-OH:

(R)-ACE-OH Obtener un presupuesto

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

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Referencias
Revisión del cliente

Descripciòn

Peso molecular

328.47

Fòrmula

C₁₉H₂₄N₂OS

Appearance

Oil

Color

Off-white to light yellow

SMILES

C[C@@H](C1=CC2=C(SC3=C(N2CCCN(C)C)C=CC=C3)C=C1)O

Envío

Room temperature in continental US; may vary elsewhere.

Almacenamiento

4°C, protect from light, stored under nitrogen

*In solvent : -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen)

Solvente y solubilidad

In Vitro:

DMSO : 100 mg/mL (304.44 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions

Concentration Solvent Mass	1 mg	5 mg	10 mg

1 mM	3.0444 mL	15.2221 mL	30.4442 mL
5 mM	0.6089 mL	3.0444 mL	6.0888 mL
10 mM	0.3044 mL	1.5222 mL	3.0444 mL

View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Calculadora de molaridad
Calculadora de dilución

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

Concentration _(start)

Volume _(start)

Concentration _(final)

Volume _(final)

In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Pureza y Documentación

Purity: 99.17%

Select Batch:

Ficha de datos (271 KB) SDS (251 KB)

COA (252 KB) HNMR (247 KB) RP-HPLC (259 KB) LCMS (235 KB)

Instrucciones de manejo (2659 KB)

Referencias

[1]. Lu P, et al. Selective degradation of multimeric proteins by TRIM21-based molecular glue and PROTAC degraders[J]. Cell, 2024. [Content Brief]

Complete Stock Solution Preparation Table

Optional Solvent	Concentration Solvent Mass	1 mg	5 mg	10 mg	25 mg

DMSO	1 mM	3.0444 mL	15.2221 mL	30.4442 mL	76.1105 mL
	5 mM	0.6089 mL	3.0444 mL	6.0888 mL	15.2221 mL
	10 mM	0.3044 mL	1.5222 mL	3.0444 mL	7.6110 mL
	15 mM	0.2030 mL	1.0148 mL	2.0296 mL	5.0740 mL
	20 mM	0.1522 mL	0.7611 mL	1.5222 mL	3.8055 mL
	25 mM	0.1218 mL	0.6089 mL	1.2178 mL	3.0444 mL
	30 mM	0.1015 mL	0.5074 mL	1.0148 mL	2.5370 mL
	40 mM	0.0761 mL	0.3806 mL	0.7611 mL	1.9028 mL
	50 mM	0.0609 mL	0.3044 mL	0.6089 mL	1.5222 mL
	60 mM	0.0507 mL	0.2537 mL	0.5074 mL	1.2685 mL
	80 mM	0.0381 mL	0.1903 mL	0.3806 mL	0.9514 mL
	100 mM	0.0304 mL	0.1522 mL	0.3044 mL	0.7611 mL

(S)-ACE-OH Related Classifications

Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-ACE-OHMolecular GluesAnticancermolecular glueE3 ubiquitin ligasenuclear porinInhibitorinhibitorinhibit

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(S)-ACE-OH

Revisión del cliente

Other Forms of (S)-ACE-OH:

(S)-ACE-OH Related Antibodies

Recomendaciones destacadas

•Related Screening Libraries:

•Related Small Molecules:

•Related Proteins:

Actividad biológica

Pureza y Documentación

Referencias

Revisión del cliente

Calculadora de molaridad

Calculadora de dilución

Complete Stock Solution Preparation Table

(S)-ACE-OH Related Classifications

Keywords:

Productos vistos recientemente:

Revisión del cliente

Request for HNMR Report

SAFETY DATA SHEET (SDS)

Request for HNMR Report