2. GPCR/G Protein MAPK/ERK Pathway
  3. Ras SOS1
  4. (S)-BAY-293

(S)-BAY-293 is a negative control of BAY 293. BAY 293 is a potent KRAS-SOS1 interaction inhibitor.

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(S)-BAY-293

(S)-BAY-293 Estructura química

No. CAS : 2244904-69-4

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Other Forms of (S)-BAY-293:

(S)-BAY-293 Related Antibodies

Top Publications Citing Use of Products

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Ver todas las isoformas
K-Ras H-Ras N-Ras Ras

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Descripciòn

(S)-BAY-293 is a negative control of BAY 293. BAY 293 is a potent KRAS-SOS1 interaction inhibitor[1].

Cellular Effect
Cell Line Type Value Description References
Calu-1 IC50
1840 nM
Compound: Compound 24
Antiproliferative activity against human Calu-1 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay
Antiproliferative activity against human Calu-1 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay
[PMID: 30683722]
K562 IC50
7500 nM
Compound: Compound 24
Antiproliferative activity against human K562 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay
Antiproliferative activity against human K562 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay
[PMID: 30683722]
MOLM-13 IC50
7570 nM
Compound: Compound 24
Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay
Antiproliferative activity against human MOLM-13 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay
[PMID: 30683722]
NCI-H358 IC50
3390 nM
Compound: Compound 24
Antiproliferative activity against human NCI-H358 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay
Antiproliferative activity against human NCI-H358 cells assessed as inhibition of cell viability incubated for 72 hrs by Cell Titer Glo assay
[PMID: 30683722]
Peso molecular

448.58

Fòrmula

C25H28N4O2S
No. CAS
Appearance

Solid

Color

White to off-white

SMILES

COC1=C(OC)C=C(N=C(C)N=C2N[C@@H](C)C3=CC(C4=C(CNC)C=CC=C4)=CS3)C2=C1
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Pureza y Documentación
Referencias
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(S)-BAY-293 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

(S)-BAY-2932244904-69-4RasSOS1Ras/Rac guanine nucleotide exchange factor 1Inhibitorinhibitorinhibit

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Nombre del producto:
(S)-BAY-293
Cat. No.:
HY-114398A
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