2. GPCR/G Protein Neuronal Signaling
  3. 5-HT Receptor
  4. SB-203186

SB-203186 is a highly selective 5-HT4 receptor antagonist. SB-203186 exhibits a potent competitive antagonistic effect, with its pKB value being 8.3 in the isolated right atrium model of piglets. SB-203186 can dose-dependently shift the 5-HT-induced tachycardia curve to the right, and does not inhibit the maximum response. SB-203186 is an efficient 5-HT₄ antagonist in pig and human atria, but has no significant inhibitory effect in rat atria. SB-203186 can be used for the study of diseases such as arrhythmias and abnormal myocardial contraction.

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SB-203186

SB-203186 Estructura química

No. CAS : 135938-17-9

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SB-203186 Related Antibodies

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5-HT Receptor 5-HT1 Receptor 5-HT2 Receptor 5-HT3 Receptor 5-HT4 Receptor 5-HT5 Receptor 5-HT6 Receptor 5-HT7 Receptor

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Descripciòn

SB-203186 is a highly selective 5-HT4 receptor antagonist. SB-203186 exhibits a potent competitive antagonistic effect, with its pKB value being 8.3 in the isolated right atrium model of piglets. SB-203186 can dose-dependently shift the 5-HT-induced tachycardia curve to the right, and does not inhibit the maximum response. SB-203186 is an efficient 5-HT₄ antagonist in pig and human atria, but has no significant inhibitory effect in rat atria. SB-203186 can be used for the study of diseases such as arrhythmias and abnormal myocardial contraction[1][2].

IC50 & Target[1]

5-HT4 Receptor

8.3 (pkB)

Peso molecular

272.34

Fòrmula

C16H20N2O2
No. CAS
SMILES

O=C(C1=CNC2=C1C=CC=C2)OCCN3CCCCC3
Envío

Room temperature in continental US; may vary elsewhere.
Almacenamiento

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SB-203186 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SB-203186135938-17-9SB203186SB 2031865-HT ReceptorSerotonin Receptor5-hydroxytryptamine Receptor5-HT4 receptor antagonistcompetitive antagonismpKB valuespecies differenceInhibitorinhibitorinhibit

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Nombre del producto:
SB-203186
Cat. No.:
HY-135439
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