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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
28 Results for "
IDE
" in MedChemExpress (MCE) Product Catalog:
Products (28)
28 Results for "IDE" in MCE Product Catalog:
Cat. No.: HY-182280
Target:
Research Areas:
BDM71230 is an orally active inducer of insulin-degrading enzyme (IDE), with an EC50 of 1.9 μM against human IDE. BDM71230 binds to the interface of IDE dimers and enhances the catalytic activity of IDE via steric effects. BDM71230 can potentiate the hydrolytic effect of IDE on insulin and slightly attenuate the hypoglycemic effect of insulin. BDM71230 serves as a pharmacological tool for investigating IDE function and is applicable to studies related to glucose intolerance .
Cat. No.: HY-P70291
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: IDE; Insulin Protease; Insulin Degrading Enzyme; Abeta-Degrading Protease; Insulin-Degrading Enzyme; Insulinase; Insulysin; CDNA FLJ35968 Fis, Clone TESTI2013053, Highly Similar To INSULIN-DEGRADING ENZYME
Species:
Human
Source:
HEK293
Cat. No.: HY-W038421
CAS No.: 141556-42-5
Synonyms: 1,3-Dimesityl-1H-imidazol-3-ium-2-IDE
1,3-Bis(2,4,6-trimethylphenyl)-1,3-dihydro-2H-imidazol-2-ylidene (1,3-Dimesityl-1H-imidazol-3-ium-2-ide) is a metal-organic framework (MOF).
Cat. No.: HY-110197A
Target:
Research Areas:
6bK formate is a selective insulin-degrading enzyme (IDE) inhibitor with an IC50 of 50 nM. 6bK formate binds to the distal pocket of IDE, thereby blocking substrate binding, peptide unfolding and cleavage processes, and reducing the degradation of insulin, glucagon and amylin. 6bK formate improves oral glucose tolerance but impairs intraperitoneal glucose tolerance. 6bK formate can be used in research related to type 2 diabetes .
Cat. No.: HY-110197R
CAS No.: 1774353-12-6
Target:
Research Areas:
6bK TFA (Standard) is the analytical standard of 6bK (TFA) (HY-110197). This product is intended for research and analytical applications. 6bK TFA is a potent and selective insulin degrading enzyme (IDE) inhibitor with an IC50 value of 50 nM. 6bK TFA increases circulating insulin in high-fat-fed mice. Acute administration of 6bK TFA enhances glucose tolerance to oral glucose, notably to a greater extent in high-fat-fed mice. 6bK TFA can be used for type 2 diabetes research .
Cat. No.: HY-P992056
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
