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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
43 Results for "
ZIP
" in MedChemExpress (MCE) Product Catalog:
Products (43)
43 Results for "ZIP" in MCE Product Catalog:
Cat. No.: HY-P83574A
Synonyms: DAPK3; ZIPK; Death-associated protein kinase 3; DAP kinase 3; DAP-like kinase; Dlk; MYPT1 kinase; ZIPper-interacting protein kinase; ZIP-kinase
Cat. No.: HY-189126
CAS No.: 1240580-64-6
Research Areas:
YL064 is a multi-target STAT3-c-MYC inhibitor that directly binds to ATXN3 and inhibits its deubiquitinating activity, thereby promoting the ubiquitination and proteasomal degradation of oncogenic substrates of ATXN3. YL064 inhibits the phosphorylation of STAT3-Tyr705 without altering the total protein level of STAT3; meanwhile, it directly binds to the SH2 domain of STAT3 to block the dimerization, nuclear translocation, and DNA-binding activity of STAT3. YL064 directly targets the C-terminal HLH-Zip domain of c-Myc, upregulates the phosphorylation of c-Myc at the Thr58 site, and induces the ubiquitination and proteasome-dependent degradation of c-Myc. YL064 suppresses tumor cell proliferation, induces G2/M cell cycle arrest, reduces cell migration and invasion capacities, and triggers cancer cell apoptosis. YL064 can be used in related research on breast cancer, prostate cancer, diffuse large B-cell lymphoma, and multiple myeloma .
Cat. No.: HY-P704189
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: SLC39A1; Solute Carrier Family 39 (Zinc Transporter), Member 3; Prev. ZIRTL; Zinc-Iron-Regulated Transporter-Like; ZIP1; Alternative Protein SLC39A1; Solute Carrier Family 39 (Zinc Transporter), Member 1; SLC39A1 Protein; Zrt- And Irt-Like Protein 1; HZIP
Species:
Human
Source:
E. coli
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
