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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
111 Results for "
uncoupled
" in MedChemExpress (MCE) Product Catalog:
Products (111)
111 Results for "uncoupled" in MCE Product Catalog:
Cat. No.: HY-168639
Target:
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AP39 prodrug 1 (Compound M1) is a mitochondria-targeted H2S prodrug. AP39 prodrug 1 induces ROS-dependent mild mitochondrial uncoupling, activating mitochondria-associated AMPK to suppress Palmitic acid (PA) (HY-N0830)-induced lipid deposition in hepatocytes .
Cat. No.: HY-153812
CAS No.: 675197-89-4
Synonyms: AST070
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AST 7062601 (AST070) is a Ucp1 inducer that strongly induces endogenous Ucp1 expression in primary mouse brown adipocytes. Ucp1 refers to uncoupling protein, found in brown and beige fat cells. In mammals, UCP1 oxidizes fatty acids and uncouples ATP production in mitochondria to promote energy dissipation as heat. AST 7062601 can be used to study thermogenic, uncoupled respiration .
Cat. No.: HY-169926
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AK-4 is a glucose-lowering agent, acting function as a mitochondrial uncoupler .
Cat. No.: HY-106472
CAS No.: 40198-53-6
Synonyms: EMD 26644
Tioxaprofen is a new anti-mycotic drug against Trichophyton mentagrophytes and T. rubrum, and is a potent uncoupling agent of mitochondrial respiration .
Cat. No.: HY-121292
CAS No.: 34148-01-1
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Clidanac is a potent anti-inflammatory agent. Clidanac can uncouple the oxidative phosphorylation and can be used for the research of rheumatoid arthritis .
Cat. No.: HY-137922
CAS No.: 2379550-82-8
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SHS4121705 is an orally effective mitochondrial uncoupling agent with an IC50 of 4.3 μM in L6 myoblasts. SHS4121705 can be used in the study of non-alcoholic steatohepatitis (NASH) .
Cat. No.: HY-139994
CAS No.: 2820169-36-4
Synonyms: XP
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XN methyl pyrazole (XP) is an orally active, blood-brain barrier permeable uncoupler/proton carrier. XN methyl pyrazole uncouples oxidative phosphorylation, depolarizes mitochondrial transmembrane potential, increases energy expenditure, spontaneous activity levels, and cortical inosine monophosphate levels. XN methyl pyrazole reduces plasma purine and energy metabolite levels, improves glucose tolerance, and decreases weight gain, while avoiding potential estrogenic side effects. XN methyl pyrazole can be used in studies related to diet-induced obesity and insulin resistance .
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Cat. No.: HY-113371R
CAS No.: 6061-96-7
Synonyms: Methylcitric acid (Standard)
Cat. No.: HY-P5315
CAS No.: 2769088-82-4
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Cat. No.: HY-159881
Target:
Research Areas:
SHS206 (compound 6n) is an orally active mitochondrial uncoupler that reduces hepatic triglyceride levels. SHS206 exhibits in vivo efficacy in the GAN mouse model and shows inhibitory effects on metabolic dysfunction-associated steatohepatitis (MASH) .
Cat. No.: HY-B1729S
CAS No.: 21273-38-1
Cat. No.: HY-B1729S1
CAS No.: 1219804-65-5
Cat. No.: HY-W032022S2
CAS No.: 52598-04-6
Cat. No.: HY-W032022S3
CAS No.: 64118-18-9
Cat. No.: HY-W032022S4
CAS No.: 1335436-46-8
Cat. No.: HY-157933
Target:
Research Areas:
SF-C5-TPP is an potent mitochondria-targeted protonophoric uncoupler. SF-C5-TPP has significant proton transfer activity on model planar bilayer lipid membranes. SF-C5-TPP inhibits the growth of Bacillus subtilis with a MIC of 2 μM >[1].
Cat. No.: HY-14881S2
Cat. No.: HY-174787
Human ACKR3 mRNA encodes the human atypical chemokine receptor 3 (ACKR3) protein, a member of the G-protein coupled receptor family. ACKR3 is a typical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis.
Cat. No.: HY-N6687R
CAS No.: 52665-69-7
Synonyms: A-23187 (Standard); Antibiotic A-23187 (Standard)
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
