2 Results for "

(3S)Lenalidomide-5-Pip-Boc

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "(3S)Lenalidomide-5-Pip-Boc" in MCE Product Catalog:

Art. -Nr.: HY-W998234
CAS. Nr.: 3026842-89-4
Forschungsgebiete:  

Cancer

(3S) Lenalidomide-5-Pip-Boc is an E3 ligase ligand-linker conjugate that is applicable to research related to PROTAC synthesis. (3S) Lenalidomide-5-Pip-Boc serves as the E3 ligase ligand-linker conjugate for PROTAC ERα Degrader-10 (HY-170336) and PROTAC ER Degrader-14 (HY-170340) .
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1
1 Cited Publications
Art. -Nr.: HY-P10899
Target:  

PROTACs TGF-beta/Smad

Forschungsgebiete:  

Endocrinology

ETTAC-2 is a LRG1 PROTAC degrader, degrading LRG1 via the ubiquitin-proteasome pathway with a DC50 value of 8.38 μM. ETTAC-2 penetrates damaged renal cells to reduce the extracellular secretion of LRG1. ETTAC-2 effectively inhibits the TGF-β-Smad3 signaling pathway and diminishes the secretion of fibrosis-associated extracellular matrix proteins. ETTAC-2 degrades LRG1 within fibrotic kidneys and the efficacy in inhibiting the TGF-β-Smad3 pathway both in vitro and vivo. ETTAC-2 can be used for renal fibrosis research .
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