3 Results for "

(S)-Nornicotine

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "(S)-Nornicotine" in MCE Product Catalog:

(S)-Nornicotine
(S)-Nornicotine
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Cat. No.: HY-W040430
CAS No.: 494-97-3
Category:  

Alkaloids Other Diseases Pyridine Alkaloids Endogenous metabolite Disease Research Fields

Target:  

Drug Metabolite Cytochrome P450 nAChR

(S)-Nornicotine is a nicotine metabolite that crosses the blood-brain barrier. (S)-Nornicotine weakly inhibits human CYP2A6 with a Ki >300 μM. (S)-Nornicotine promotes dopamine release in rat striatal and nucleus accumbens slices and increases endogenous DOPAC overflow through a calcium-dependent nAChR pathway that is sensitive to Mecamylamine (HY-B1395A). (S)-Nornicotine reduces behavioral responses maintained by nicotine or sucrose, exerts analgesic effects in persistent inflammatory pain and neuropathic pain models, and enhances the analgesic effect of morphine. (S)-Nornicotine is useful for research on tobacco dependence and pain .
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(S)-Nornicotine hydrochloride
(S)-Nornicotine hydrochloride
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Cat. No.: HY-W040430A
CAS No.: 101832-65-9
Category:  

Alkaloids Pyrrole Alkaloids Other Diseases Pyridine Alkaloids Endogenous metabolite Disease Research Fields

Target:  

Drug Metabolite Cytochrome P450 nAChR

(S)-Nornicotine hydrochloride is a nicotine metabolite that crosses the blood-brain barrier. (S)-Nornicotine hydrochloride weakly inhibits human CYP2A6 with a Ki >300 μM. (S)-Nornicotine hydrochloride promotes dopamine release in rat striatal and nucleus accumbens slices and increases endogenous DOPAC overflow through a calcium-dependent nAChR pathway that is sensitive to Mecamylamine (HY-B1395A). (S)-Nornicotine hydrochloride reduces behavioral responses maintained by nicotine or sucrose, exerts analgesic effects in persistent inflammatory pain and neuropathic pain models, and enhances the analgesic effect of morphine. (S)-Nornicotine hydrochloride is useful for research on tobacco dependence and pain .
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(S)-Nornicotine (Standard)
(S)-Nornicotine (Standard)
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Cat. No.: HY-W040430R
CAS No.: 494-97-3
Category:  

Alkaloids Pyridine Alkaloids Endogenous metabolite

Target:  

Reference Standards Drug Metabolite Cytochrome P450 nAChR

(S)-Nornicotine (Standard) is the analytical standard of (S)-Nornicotine (HY-W040430). This product is intended for research and analytical applications. (S)-Nornicotine is a nicotine metabolite that crosses the blood-brain barrier. (S)-Nornicotine weakly inhibits human CYP2A6 with a Ki >300 μM. (S)-Nornicotine promotes dopamine release in rat striatal and nucleus accumbens slices and increases endogenous DOPAC overflow through a calcium-dependent nAChR pathway that is sensitive to Mecamylamine (HY-B1395A). (S)-Nornicotine reduces behavioral responses maintained by nicotine or sucrose, exerts analgesic effects in persistent inflammatory pain and neuropathic pain models, and enhances the analgesic effect of morphine. (S)-Nornicotine is useful for research on tobacco dependence and pain .
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