3 Results for "

(S)-Pomalidomide

" in MedChemExpress (MCE) Product Catalog:
Products (3)

3 Results for "(S)-Pomalidomide" in MCE Product Catalog:

Cat. No.: HY-10984A
CAS No.: 202271-89-4
Synonyms: (S)-CC-4047
Target:  

Endogenous Metabolite

Research Areas:  

Cancer

(S)-Pomalidomide ((S)-CC-4047) is an angiogenesis-inhibiting drug with growth-inhibitory activity against B-cell tumors. (S)-Pomalidomide can induce complete tumor regression in BurKitt lymphoma cells. (S)-Pomalidomide serves as an immunomodulator with potential applications in inhibiting hematological malignancies .
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Cat. No.: HY-169232
Target:  

PROTACs PD-1/PD-L1

Research Areas:  

Cancer

PCC16 chloride is a dual PROTAC degrader targeting DHHC3 and PD-L1, with a DC50 of 0.103 μM for PD-L1 degradation. PCC16 chloride induces DHHC3 degradation via the ubiquitin-proteasome pathway by recruiting the CRBN E3 ubiquitin ligase (E3 ubiquitin ligase). By targeting DHHC3-which is essential for PD-L1 palmitoylation and membrane stability-PCC16 chloride reduces PD-L1 levels, decreases PD-L1 membrane retention time, and impairs its immunosuppressive function. PCC16 chloride enhances anti-tumor immunity by disrupting PD-L1-mediated immunosuppression. PCC16 chloride can be used in the research of immune checkpoint blockade-resistant cancers .
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Cat. No.: HY-182337
Research Areas:  

Others

(S)-Thalidomide 4-fluoride is an E3 ligase linker conjugate that can be used for the synthesis of DeDPP4 (HY-182336) .
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