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Results for "

α3

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (1) AAK1 (1) Akt (1) Amino Acid Derivatives (1) Amyloid-β (1) Apoptosis (9) Autophagy (7) Biochemical Assay Reagents (3) CDK (7) CFTR (1) Cholinesterase (ChE) (3) Collagen (1) Cuproptosis (2) Cytochrome P450 (2) DNA-PK (2) DNA/RNA Synthesis (1) Drug Derivative (3) Drug Isomer (1) Drug Metabolite (2) DYRK (1) Endogenous Metabolite (2) Environmental Pollutants (1) ERK (2) Fungal (1) GABA Receptor (36) GDNF Receptor (1) Glycine Receptor (GlyR) (1) Glycosidase (1) GSK-3 (24) iGluR (2) Integrin (2) Isotope-Labeled Compounds (9) JNK (2) MHC (1) Microtubule/Tubulin (6) MMP (1) Molecular Glues (1) Na+/K+ ATPase (2) nAChR (39) NF-κB (2) NOD-like Receptor (NLR) (5) p38 MAPK (2) Parasite (4) Pim (1) PKA (1) PKC (2) Prostaglandin Receptor (1) Reactive Oxygen Species (ROS) (2) Reference Standards (13) STAT (1) Tau Protein (3) TGF-β Receptor (2) Wnt (1) β-catenin (2)
By Research Areas:	Cancer (32) Cardiovascular Disease (1) Endocrinology (2) Infection (10) Inflammation/Immunology (17) Metabolic Disease (9) Neurological Disease (85)
Click Chemistry:	Alkynes (2)

146

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Peptides

Inhibitory Antibodies

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

GMP Molecules

Elesclomol Maximum Cited Publications 115 Publications Verification STA-4783	Reactive Oxygen Species (ROS) Apoptosis Cuproptosis	Cancer
Elesclomol (STA-4783) is a potent copper ionophore and promotes copper-dependent cell death (cuproptosis). Elesclomol specifically binds ferredoxin 1 (FDX1) α2/α3 helices and β5 strand. Elesclomol inhibits FDX1-mediated Fe-S cluster biosynthesis. Elesclomol is an oxidative stress inducer that induces cancer cell apoptosis. Elesclomol is a reactive oxygen species (ROS) inducer. Elesclomol can be used for Menkes and associated disorders of hereditary copper deficiency research ^[3] .

Colchicine Maximum Cited Publications 62 Publications Verification	Environmental Pollutants Apoptosis Autophagy Microtubule/Tubulin NOD-like Receptor (NLR)	Cancer
Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC₅₀ of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the *NLRP3* inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research ^[3] .

Bufalin 5+ Cited Publications	Na+/K+ ATPase	Cancer
Bufalin is an active component isolated from Chan Su, acts as a potent Na ⁺/K ⁺-ATPase inhibitor, binds to the subunit α1, α2 and α3, with K_d of 42.5, 45 and 40 nM, respectively . Anti-cancer activity .

LY2090314 15+ Cited Publications	GSK-3	Cancer
LY2090314 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with IC₅₀ values of 1.5 nM and 0.9 nM for GSK-3α and GSK-3β, respectively.

SB 216763 40+ Cited Publications	GSK-3 Autophagy	Neurological Disease Cancer
SB 216763 is potent, selective and ATP-competitive *GSK-3* inhibitor with IC₅₀s of 34.3 nM for both GSK-3α and GSK-3β.

E7820 5 Publications Verification ER68203-00	Molecular Glues Integrin	Infection Metabolic Disease Cancer
E7820 (ER68203-00), an orally active aromatic sulfonamide derivative, is a molecular glue that induces the targeted degradation of splicing factor RBM39 by recruiting the E3 ubiquitin ligase CUL4-RBX1-DDB1-DCAF15 (CRL4 ^DCAF15). E7820 is an angiogenesis inhibitor suppressing an expression of integrin alpha2 subunit on endothelium. E7820 inhibits rat aorta angiogenesis with an IC₅₀ of 0.11 μg/ml. E7820 modulates α-1, α-2, α-3, and α-5 integrin mRNA expression. E7820 can be used for the study of acute myeloid leukemia (AML) ^[3].

α-Bungarotoxin 5+ Cited Publications	nAChR	Neurological Disease
α-Bungarotoxin is a competitive antagonist at nicotinic acetylcholine receptors (nAChRs). α-Bungarotoxin, a selective α7 receptor blocker, blocks α7 currents with an IC₅₀ of 1.6 nM and has no effects on α3β4 currents at concentrations up to 3 μM .

AZD7325	GABA Receptor Cytochrome P450	Neurological Disease Inflammation/Immunology
AZD7325 is a potent and orally active partial selective PAM of GABAAα2 and Aα3 receptor (K_i=0.3 and 1.3 nM, respectively), and has less antagonistic efficacy at the Aα1 and Aα5 receptor subtypes . AZD7325 is a moderate CYP1A2 and a potent CYP3A4* inducer* in vitro . AZD7325 has the potential for the investigation of anxiety and dravet syndrome ^[3]. PAM: positive allosteric modulator.

Levamisole 10+ Cited Publications (-)-Tetramisole	nAChR Parasite	Infection Inflammation/Immunology Cancer
Levamisole ((-)-Levamisole), an anthelmintic agent with immunomodulatory properties. Levamisole acts as a positive allosteric modulator (PAM) for the *α3β2* (EC₅₀=300 μM) and *α3β4* (EC₅₀=100 μM) subtype of nAChRs. Orally active .

AZD2858 5+ Cited Publications	GSK-3	Neurological Disease
AZD2858 is a potent, orally active *GSK-3* inhibitor, with IC₅₀s of 0.9 and 5 nM for *GSK-3α* and *GSK-3β*, respectively, used in the research of fracture healing.

PSMα3	NF-κB p38 MAPK	Infection Inflammation/Immunology
PSMα3 is an inhibitor of NF-κB p65 and p38 MAPK. PSMα3 forms membrane pores and binds to residues of human insulin B chain to inhibit insulin aggregation. PSMα3 forms α-type amyloid-like fibrils to exert cytotoxic effects, and acts as a functional amyloid virulence determinant of Staphylococcus aureus. PSMα3 is applicable to research related to spondyloarthritis, rheumatoid arthritis, insulin-derived amyloidosis, and Staphylococcus aureus infection ^[3].

CHIR-98014 5+ Cited Publications	GSK-3	Metabolic Disease
CHIR-98014 is a potent, cell-permeable *GSK-3* inhibitor with IC₅₀s of 0.65 and 0.58 nM for *GSK-3α* and *GSK-3β*, respectively; it shows less potent activities against cdc2 and erk2.

6-Hydroxyflavone 2 Publications Verification	Akt ERK JNK GABA Receptor	Neurological Disease Metabolic Disease Inflammation/Immunology
6-Hydroxyflavone is an orally effective flavonoid compound. 6-Hydroxyflavone can inhibit LPS (HY-D1056) -induced NO production and has anti-inflammatory effects. 6-Hydroxyflavone promotes osteoblast differentiation by activating AKT, ERK 1/2 and JNK signaling pathways. 6-Hydroxyflavone has an inhibitory effect on bovine hemoglobin (BHb) glycosylation. 6-Hydroxyflavone has a kidney protective effect. In addition, 6-Hydroxyflavone enhances GABA-induced current through the Benzodiazepine sites of γ-aminobutyric acid (GABA_A) receptors. 6-Hydroxyflavone shows a clear preference for α2 - and α3 - subtypes, which play an anti-anxiety role ^[3] .

Darigabat PF-06372865; CVL-865	GABA Receptor	Neurological Disease
Darigabat (PF-06372865) is an orally active, α2/α3/α5 subtype-selective GABA_A positive allosteric modulator (PAM). Darigabat is a high affinity ligand at GABA_A receptors containing α1/α2/α3/α5 subunits (K_is of 2.9 nM, 21 nM, 134 nM for α2, α1 PAM, α2 PAM, respectively), with low affinity for α4/α6 subunits. Darigabat can across the blood-brain barrier (BBB). Darigabat has anxiolytic activity and has the potential for epilepsy .

PTBP1-RNA-binding inhibitor P6 TFA PTBP1 α3-helix derived peptide P6 TFA	DNA/RNA Synthesis	Others
PTBP1-RNA-binding inhibitor P6 (PTBP1 α3-helix derived peptide P6) TFA is a stapled peptide inhibitor of the splicing factor PTBP1, which inhibits alternative splicing events regulated by PTBP1. PTBP1 binds RNA through its RNA recognition motif .

Adiphenine hydrochloride 3 Publications Verification	nAChR	Neurological Disease
Adiphenine hydrochloride is a non-competitive inhibitor of nicotinic acetylcholine receptor (nAChR), with an IC₅₀s of 1.9, 1.8, 3.7, and 6.3 μM for α1, *α3β4, α4β2, and α4β4*, respectively. Adiphenine hydrochloride has anticonvulsant effects ^[3].

TPA-023B	GABA Receptor	Neurological Disease
TPA-023B is a high-affinity and orally active GABA_A receptor *α2/α3* subtype (K_is of 0.73 nM/2 nM) partial agonist and a α1 subtype (K_i of 1.8 nM) antagonist. TPA-023B has non-sedating anxiolytic-like properties .

TPA 023	GABA Receptor	Neurological Disease
TPA 023 is a GABAA α2/α3 subtype-selective agonist, with K_i of 0.19-0.41 nM.

SB 415286 5+ Cited Publications	GSK-3 Apoptosis	Metabolic Disease
SB 415286 is a potent and selective cell permeable inhibitor of *GSK-3α, with an IC₅₀* of 77.5 nM, and a K_i of 30.75 nM; SB 415286 is equally effective at inhibiting human *GSK-3α* and *GSK-3β*.

DMCM hydrochloride	GABA Receptor	Neurological Disease
DMCM hydrochloride is a nonselective full inverse agonist of benzodiazepine. DMCM shows bnding afinity at human recombinant GABAA αxβ3γ2 receptor subtypes with K_is of 10 nM, 13 nM, 7.5 nM, 2.2 nM for α1, α2, α3, and α5 receptors, respectively .

L-838417-d9	Isotope-Labeled Compounds GABA Receptor	Neurological Disease
L-838417-d₉ is the deuterium labeled L-838417 (HY-W009009). L-838417 is a selective partial agonist at the α2, α3 and α5 subtypes of the GABA_A receptor and an antagonist at the α1, with binding K_i values of 0.79 nM, 0.67 nM, 1.67 nM, 267 nM, 2.25 nM and 2183 nM for α1β3γ2, α2β3γ2, α3β3γ2, α4β3γ2, α5β3γ2 and α6β3γ2. L-838417 has anti-anxiety activity .

SL651498	GABA Receptor	Neurological Disease
SL651498 is a full agonist of α2 and α3 GABAA receptors, and a partial agonist of α1 and α5 GABAA receptors. SL651498 shows anxiolytic and anticonvulsant activities .

AT 1001 1 Publications Verification	nAChR	Neurological Disease Metabolic Disease Inflammation/Immunology
AT 1001 is an orally effective α3β4 nicotinic acetylcholine receptor (α3β4 nAChR) antagonist with a K_i value of 2.64 nM. AT 1001 reversibly blocks Epibatidine (HY-101078)-induced inward currents in HEK cells transfected with α3β4 nAChR. AT 1001 dose-dependently blocks nicotine self-administration behavior in rats, alleviates gluten-induced gastrointestinal symptoms, blocks tight junction toxin-induced immune responses, and reduces the incidence of type 1 diabetes in rats. AT 1001 can be used in the research of nicotine addiction and celiac disease ^[3].

Epiallopregnanolone 5α,3β-THDOC	GABA Receptor iGluR	Neurological Disease
Epiallopregnanolone (5α,3β-THDOC), a 3β-hydroxy neurosteroid, an antagonist at GABAA receptors and a NMDA receptor enhancer .

NS3861 1 Publications Verification	nAChR	Neurological Disease
NS3861 is an agonist of nicotinic acetylcholine receptors (nAChRs) and binds with high affinity to heteromeric α3β4 nAChR. The binding K_i values of 0.62, 25, 7.8, 55 nM for α3β4, α3β2, α4β4, α4β2, respectively .

Colchicine (Standard)	Reference Standards Microtubule/Tubulin NOD-like Receptor (NLR) Autophagy Apoptosis	Cancer
Colchicine (Standard) is the analytical standard of Colchicine. This product is intended for research and analytical applications. Colchicine, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC50 of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine has extensive anti-inflammatory, immunosuppressive and strong anti-fibrosis effects and has the potential for gouty arthritis research ^[3] .

14-3-3-IN-2	MMP	Others
14-3-3-IN-2 is a 14-3-3 protein inhibitor with an IC₅₀ of 15 nM. 14-3-3-IN-2 can disrupt the interaction of 14-3-3α with aminopeptidase N and down-regulate 14-3-3α increased MMP-1 mRNA levels .

NS11394 3 Publications Verification	GABA Receptor	Neurological Disease
NS11394 is an orally active and unique subtype-selective GABA_A positive allosteric receptor (PAM), with a K_i of ~0.5 nM. NS11394 shows a selectivity profile in the order of GABA_A-5 > α3 > α2 > α1-containing receptors. NS11394 has anxiolytic and anti-inflammatory properties ^[3].

AN317	nAChR	Neurological Disease
AN317 is a selective agonist for α6β2-containing nicotinic acetylcholine receptor (nAChR) with K_i of 6.2 nM and 4.1 nM, for α6/α3β2β3 receptor and α4β2 receptor, respectively. AN317 induces dopamine release in the synaptosomes of the rat striatum, enhances dopaminergic neuronal activity in substantia nigra, and exhibits protective efficacy to rat neurons against dopamine neurotoxin MPP ⁺. AN317 exhibits good pharmacokinetic characteristics in rats. AN317 penetrates the blood-brain barrier (BB) .

Colchicine,suitable for plant cell culture	Biochemical Assay Reagents Microtubule/Tubulin	Inflammation/Immunology Cancer
Colchicine,suitable for plant cell culture, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC₅₀ of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine,suitable for plant cell culture can be used for plant cell culture ^[3] .

L-838417	GABA Receptor	Neurological Disease
L-838417 is a selective partial agonist at the α2, α3 and α5 subtypes of the GABA_A receptor and an antagonist at the α1, with binding K_i values of 0.79 nM, 0.67 nM, 1.67 nM, 267 nM, 2.25 nM and 2183 nM for α1β3γ2, α2β3γ2, α3β3γ2, α4β3γ2, α5β3γ2 and α6β3γ2. L-838417 has anti-anxiety activity .

N-Acetylgalactosaminyltransferase 1 GALNT1	Endogenous Metabolite β-catenin Wnt	Cancer
N-Acetylgalactosaminyltransferase 1 (GALNT1) is a glycosyltransferase that initiates mucin-type O-glycosylation by transferring α-GalNAc from UDP-GalNAc to serine (Ser) or threonine (Thr) residues in proteins. Overexpression of N-Acetylgalactosaminyltransferase 1 in gastric cancer can promote abnormal O-glycosylation of CD44, thereby activating the Wnt/β-catenin signaling pathway and regulating the malignant behavior of gastric cancer cells. Additionally, N-Acetylgalactosaminyltransferase 1 plays a crucial role in cancer growth and metastasis by modifying the O-glycosylation of various glycoproteins, such as mucin (MUC1), osteopontin (OPN), matrix metalloproteinase-14 (MMP14), and integrin α3 .

MRK-898	GABA Receptor	Neurological Disease
MRK-898 is an orally active GABA(A) receptor modulator. MRK-898 binds to α1, α2, α3 or α5 subunit of GABA(A) receptor with K_i values of 1.2 nM, 1.0 nM, 0.73 nM, and 0.50 nM, respectively. However, α1-containing GABA(A) receptors are identified as the "sedative" and α2- and/or α3-containing receptors as the "anxiolytic" subtype(s) .

BIP-135	GSK-3	Neurological Disease
BIP-135 is a potent and selective ATP-competitive *GSK-3* inhibitor, with IC₅₀s of 16 nM and 21 nM for GSK-3α and GSK-3β, respectively. BIP 135 exhibits neuroprotective effect .

CVN417	nAChR	Neurological Disease
CVN417 is an orally active α6 subunit-containing nAChR antagonist, modulating phasic dopaminergic neurotransmission in an impulse-dependent manner. CVN417 inhibits Ca(2+) effluents mediated by nAChR subunits with IC₅₀s of 0.086 μM (α6), 2.56 μM (α3) and 0.657 μM (α4), respectively. CVN417 attenuates resting tremor in Rodent models, displays the potential to improve movement dysfunction, in conditions such as Parkinson's disease .

(5α)-3,6-Dioxocholan-24-oic acid	Endogenous Metabolite	Endocrinology
(5α)-3,6-Dioxocholan-24-oic acid is a secondary bile acid .

NS-2710	GABA Receptor	Neurological Disease
NS-2710 is a high-efficacy GABAAα3 agonist with a K_i of 9.2 nM. NS-2710 can be used for anxiety research .

MRK-623	GABA Receptor	Neurological Disease
MRK-623 (Compound 14k) is an orally active, high-affinity GABA_A receptor agonist, with the K_i values of 0.85 nM, 3.7 nM, 4.0 nM, and 0.53 nM for α1, α2, α3, and α5, respectively. MRK-623 shows anxiolytic effect .

AM-1488	Others	Neurological Disease
AM-1488 is a potent, orally active glycine receptor (GlyR) potentiator (hGlyRα3 EC₅₀=0.45 μM) .

Colchicine-d6	Isotope-Labeled Compounds Microtubule/Tubulin NOD-like Receptor (NLR) Autophagy Apoptosis	Cancer
Colchicine-d₆ is the deuterium labeled Colchicine. Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC₅₀ of 3 nM ^[3]. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs) .

Colchicine-d3	Isotope-Labeled Compounds Microtubule/Tubulin NOD-like Receptor (NLR) Autophagy Apoptosis	Cancer
Colchicine-d₃ is the deuterium labeled Colchicine. Colchicine is a tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC₅₀ of 3 nM ^[3]. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs) .

NS3861 fumarate 1 Publications Verification	nAChR	Neurological Disease
NS3861 fumarate is an agonist of nicotinic acetylcholine receptors (nAChRs) and binds with high affinity to heteromeric α3β4 nAChR. The binding K_i values of 0.62, 25, 7.8, 55 nM for α3β4, α3β2, α4β4, α4β2, respectively .

HZ166	GABA Receptor	Neurological Disease
HZ166 is a GABAA receptor subtype-selective benzodiazepine site agonist with preferential activity at α2- and α3-GABAA receptors. HZ166 shows anti-hyperalgesic effects . HZ166 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

F4-Trp 4,5,6,7-Tetrafluoro-L-tryptophan	nAChR	Neurological Disease
F4-Trp (4,5,6,7-Tetrafluoro-L-tryptophan) is a ligand targeting the α3β4 nicotinic acetylcholine receptor (α3β4 nAChR). F4-Trp is promising for research of neurotransmission, addiction, and related diseases, such as neurological diseases .

Pygenic acid B 2α,3α,24-Trihydroxyurs-12-en-28-oic acid	Fungal	Infection
Pygenic acid B is a triterpenoid that can be isolated from the leaves of Glochidion obliquum. Pygenic acid B shows antifungal activity against C. musae. Pygenic acid B shows ONOO- scavenging activity ^[3].

(Rac)-CP-601927 hydrochloride	nAChR	Neurological Disease
(Rac)-CP-601927 hydrochloride is the racemate of CP-601927. CP-601927 is a nAChR agonist with Ki values 1.2 nM and 102 nM for α4β2 and α3β4 nAChR, respectively .

Cat. No.	Product Name	Type

HY-16294G

LY2090314	Fluorescent Dyes
LY2090314 (GMP) is LY2090314 (HY-16294) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. LY2090314 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with IC₅₀ values of 1.5 nM and 0.9 nM for GSK-3α and GSK-3β, respectively.

Cat. No.	Product Name	Type

HY-16569B

Colchicine,suitable for plant cell culture

Biochemical Assay Reagents

Colchicine,suitable for plant cell culture, an orally active alkaloid, is a potent tubulin inhibitor and a microtubule disrupting agent. Colchicine inhibits microtubule polymerization with an IC₅₀ of 3 nM. Colchicine is also a competitive antagonist of the α3 glycine receptors (GlyRs). Colchicine prevents non-steroidal anti-inflammatory drug (NSAID)-induced small intestinal injury by inhibiting activation of the NLRP3 inflammasome. Colchicine,suitable for plant cell culture can be used for plant cell culture ^[3] .

HY-W698353

Fuc1-α-3GlcNAc1-β-Ome

Biochemical Assay Reagents

Fuc1-α-3GlcNAc1-β-Ome is a class of biochemical reagents used in glycobiology research. Glycobiology studies the structure, synthesis, biology, and evolution of sugars. It involves carbohydrate chemistry, enzymology of glycan formation and degradation, protein-glycan recognition, and the role of glycans in biological systems. This field is closely related to basic research, biomedicine, and biotechnology .

HY-W127431

Methyl (3α,5α)-3-(acetyloxy)-6-oxocholan-24-oate 5α-Cholanic acid-3α-ol-6-one 3-acetate methyl ester	Biochemical Assay Reagents
Methyl (3α,5α)-3-(acetyloxy)-6-oxocholan-24-oate is a biochemical reagent that can be used as a biological material or organic compound for life science related research.

HY-16294G

LY2090314	Biochemical Assay Reagents
LY2090314 (GMP) is LY2090314 (HY-16294) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. LY2090314 is a potent inhibitor of glycogen synthase kinase-3 (GSK-3) with IC₅₀ values of 1.5 nM and 0.9 nM for GSK-3α and GSK-3β, respectively.

Cat. No.	Product Name	Target	Research Area

HY-P1264

α-Bungarotoxin 5+ Cited Publications	nAChR	Neurological Disease
α-Bungarotoxin is a competitive antagonist at nicotinic acetylcholine receptors (nAChRs). α-Bungarotoxin, a selective α7 receptor blocker, blocks α7 currents with an IC₅₀ of 1.6 nM and has no effects on α3β4 currents at concentrations up to 3 μM .

HY-P2358

PSMα3	NF-κB p38 MAPK	Infection Inflammation/Immunology
PSMα3 is an inhibitor of NF-κB p65 and p38 MAPK. PSMα3 forms membrane pores and binds to residues of human insulin B chain to inhibit insulin aggregation. PSMα3 forms α-type amyloid-like fibrils to exert cytotoxic effects, and acts as a functional amyloid virulence determinant of Staphylococcus aureus. PSMα3 is applicable to research related to spondyloarthritis, rheumatoid arthritis, insulin-derived amyloidosis, and Staphylococcus aureus infection ^[3].

HY-P5960

PTBP1-RNA-binding inhibitor P6 TFA PTBP1 α3-helix derived peptide P6 TFA	DNA/RNA Synthesis	Others
PTBP1-RNA-binding inhibitor P6 (PTBP1 α3-helix derived peptide P6) TFA is a stapled peptide inhibitor of the splicing factor PTBP1, which inhibits alternative splicing events regulated by PTBP1. PTBP1 binds RNA through its RNA recognition motif .

HY-P10934

LXY3 LXY2	Integrin	Cancer
LXY3 (LXY2) is a *VLA-3*-blocking peptide that inhibits the interaction between integrin α3β1 (VLA-3) on neutrophil surfaces and laminin in the basement membrane, thereby preventing neutrophil migration across the tumor vascular basement membrane barrier. LXY3 is used to block neutrophil-mediated nanoparticle release from perivascular pools into the tumor interstitium. LXY3 is commonly employed for targeted imaging of breast cancer .

HY-P5959

PTBP1 α3-helix derived peptide P1 TFA	Peptides	Others
PTBP1α3-helix derived peptide P1 is a polypeptide that inhibits RNA binding .

HY-171746

F4-Trp 4,5,6,7-Tetrafluoro-L-tryptophan	nAChR	Neurological Disease
F4-Trp (4,5,6,7-Tetrafluoro-L-tryptophan) is a ligand targeting the α3β4 nicotinic acetylcholine receptor (α3β4 nAChR). F4-Trp is promising for research of neurotransmission, addiction, and related diseases, such as neurological diseases .

HY-P5081

Endotrophin (Mus musculus)	TGF-β Receptor Collagen	Inflammation/Immunology
Endotrophin (Mus musculus) is an adipokine, a cleavage fragment derived from Collagen VI, whose levels are elevated in adipose tissue and breast tumors of obese mice. Endotrophin (Mus musculus) activates the TGF-β signaling pathway and reduces the expression of hormone-sensitive lipase. Endotrophin (Mus musculus) induces adipogenesis, lipid accumulation, fibrosis, inflammation, angiogenesis, adipose tissue expansion, epithelial-mesenchymal transition, and insulin resistance; it also induces Cisplatin (HY-17394) resistance in cancer cells. Endotrophin (Mus musculus) can be used in research related to metabolic diseases such as obesity and type 2 diabetes, as well as cancers such as breast cancer ^[3].

HY-P2358A

PSMα3 TFA	NF-κB p38 MAPK	Infection Inflammation/Immunology
PSMα3 TFA is an inhibitor of NF-κB p65 and p38 MAPK. PSMα3 TFA forms membrane pores and binds to residues of human insulin B chain to inhibit insulin aggregation. PSMα3 TFA forms α-type amyloid-like fibrils to exert cytotoxic effects, and acts as a functional amyloid virulence determinant of Staphylococcus aureus. PSMα3 TFA is applicable to research related to spondyloarthritis, rheumatoid arthritis, insulin-derived amyloidosis, and Staphylococcus aureus infection ^[3].

HY-W017255

(S)-3-Thienylglycine L-R-(3-Thieyl)glycie; L-α-3-Thieylglycie	Amino Acid Derivatives	Others
(S)-3-Thienylglycine (L-R-(3-Thieyl)glycie; L-α-3-Thieylglycie) is aamino acids and their derivatives.

HY-P5833

κ-Bungarotoxin κ-Bgt	nAChR	Neurological Disease
κ-Bungarotoxin (κ-Bgt) is a potent, selective, and slowly reversible antagonist of α3β2 neuronal nicotinic acetylcholine receptors with an IC₅₀ of 2.30 nM .

Cat. No.	Product Name	Target	Research Area	Image

HY-P99748

Nadecnemab	TGF-β Receptor	Inflammation/Immunology
Nadecnemab is an IgG4κ antibody targeting to *GFRA3, glial cell derived neurotrophic factor family receptor alpha 3*. Nadecnemab can be used for research of osteoarthritis of the knee/pain .

HY-P991751

Anti-Mouse MHC Class I (H-2Db) Antibody (28-14-8S)	MHC	Inflammation/Immunology
Anti-Mouse MHC Class I (H-2Db) Antibody (28-14-8S) reacts with the α3 domains of H-2Db of the MHC class I alloantigen expressed on nucleated cells from mice of the H-2Db haplotype. Recommend Isotype Controls: Mouse IgG2a kappa, Isotype Control (HY-P99978) .

HY-P992360

GT-002	GABA Receptor	Neurological Disease Cancer
GT-002 is a partial positive allosteric modulator targeting the α3 subtype of GABAA receptors, as well as a specific binder of tumor-associated TF-glycosylated *LYPD3*. GT-002 mildly enhances GABA-induced chloride currents by binding to the benzodiazepine site of GABAA receptors, thereby alleviating prefrontal hypofunction and improving cognitive, memory and social interaction abilities. GT-002 can be used in research related to schizophrenia spectrum disorders, various squamous cell carcinomas, colorectal cancer, non-small cell lung cancer, and aromatic L-amino acid decarboxylase deficiency ^[3] .

Species:	Human (37) Rat (1) Mouse (3)
Tag:	SUMO (3) His (26) Strep (3) Tag Free (4) Avi (11) GST (3) Fc (9)
Source:	HEK293 (26) sf9 insect cells (1) Sf9 insect cells (6) E. coli (7)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P705291

	*Chimeric HLA-A02:01&H-2Kb&B2M&GP100(YLEPGPVTA) Monomer Protein, Human&Mouse (Biotinylated, HEK293, His-Avi)** Chimeric HLA-A*0201 (H-2Kb α3) with B2M with GP100(YLEPGPVTA)	Human;Mouse	HEK293

HY-P72148

	COL4A3 Protein, Human (His) Alpha 3 type IV collagen; Alpha3 type IV collagen; CO4A3_HUMAN; COL4A 3; Col4a3; Collagen alpha 3IV; chain; Collagen IV alpha 3 polypeptide; Collagen type IV alpha 3 Goodpasture antigen; ; Collagen type IV alpha 3; Collagen type IV alpha 3 chain; Goodpasture antigen; OTTHUMP00000195044; Tumstatin	Human	E. coli
	The COL4A3 protein is an important type IV collagen component that, together with laminin, proteoglycans, and nestin/nesidin, plays a role in forming the "chicken wire" network structure in the glomerular basement membrane (GBM). Key role. Its cleavage product tumstatin is derived from the NC1 domain of collagen α 3(IV) and has dual anti-angiogenic and anti-tumor cell activities. COL4A3 Protein, Human (His) is the recombinant human-derived COL4A3 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P76951

	*GFRA3/GDNFR-alpha-3* Protein, Mouse (HEK293, Fc)** GDNF family receptor alpha-3; GFR-alpha-3	Mouse	HEK293
	GFRA3/GDNFR-alpha-3 Protein, a receptor for glial cell line-derived neurotrophic factor (artemin), facilitates artemin-induced autophosphorylation and RET receptor tyrosine kinase activation. Interacting with SORL1, it hints at potential involvement in signaling cascades linked to neurotrophic responses. GFRA3/GDNFR-alpha-3 Protein, Mouse (HEK293, Fc) is the recombinant mouse-derived GFRA3/GDNFR-alpha-3 protein, expressed by HEK293 , with C-hFc labeled tag.

HY-P76952

	*GFRA3/GDNFR-alpha-3* Protein, Mouse (HEK293, His)** GDNF family receptor alpha-3; GFR-alpha-3	Mouse	HEK293
	GFRA3/GDNFR-alpha-3 Protein, a receptor for glial cell line-derived neurotrophic factor (artemin), facilitates artemin-induced autophosphorylation and RET receptor tyrosine kinase activation. Interacting with SORL1, it hints at potential involvement in signaling cascades linked to neurotrophic responses. GFRA3/GDNFR-alpha-3 Protein, Mouse (HEK293, His) is the recombinant mouse-derived GFRA3/GDNFR-alpha-3 protein, expressed by HEK293 , with C-His labeled tag.

HY-P77373

	*GFRA3/GDNFR-alpha-3* Protein, Human (HEK293, His)** GDNF family receptor alpha-3; GFR-alpha-3; GFRA3	Human	HEK293
	GFRA3/GDNFR-alpha-3 Protein, as the receptor for glial cell line-derived neurotrophic factor ARTN, is crucial for mediating RET receptor tyrosine kinase autophosphorylation and activation upon artemin stimulation. Its interaction with SORL1 suggests involvement in diverse cellular signaling pathways. GFRA3/GDNFR-alpha-3 Protein, Human (HEK293, His) is the recombinant human-derived GFRA3/GDNFR-alpha-3 protein, expressed by HEK293 , with C-His labeled tag.

HY-P77372

	*GFRA3/GDNFR-alpha-3* Protein, Human (HEK293, His-Fc)** GDNF family receptor alpha-3; GFR-alpha-3; GFRA3	Human	HEK293
	GFRA3/GDNFR-alpha-3 Protein, as the receptor for glial cell line-derived neurotrophic factor ARTN, is crucial for mediating RET receptor tyrosine kinase autophosphorylation and activation upon artemin stimulation. Its interaction with SORL1 suggests involvement in diverse cellular signaling pathways. GFRA3/GDNFR-alpha-3 Protein, Human (HEK293, His-Fc) is the recombinant human-derived GFRA3/GDNFR-alpha-3 protein, expressed by HEK293 , with C-hFc, C-His labeled tag.

HY-P700790

	MICA Protein, Human (HEK293, mFc) MICA; MIC-A; MICA alpha 3	Human	HEK293
	MICA is the gene for major histocompatibility complex class I chain-associated protein A, encoding a highly polymorphic cell surface protein. Unlike traditional class I molecules, it lacks beta-2-microglobulin association. MICA Protein, Human (HEK293, mFc) is the recombinant human-derived MICA protein, expressed by HEK293 , with N-mFc labeled tag.

HY-P72144

	CHRNA3 Protein, Human (His-SUMO) ACHA3_HUMAN; AChR; Cholinergic receptor neuronal nicotinic alpha polypeptide 3; Cholinergic receptor nicotinic alpha 3; Cholinergic receptor nicotinic alpha polypeptide 3; CHRNA 3; CHRNA3; LNCR2; MGC104879; NACHRA 3; NACHRA3; Neuronal acetylcholine receptor protein alpha 3 chain precursor; Neuronal acetylcholine receptor subunit alpha 3; Neuronal acetylcholine receptor subunit alpha-3; Neuronal nicotinic acetylcholine receptor alpha 3 subunit; PAOD2	Human	E. coli
	CHRNA3 Protein, a critical contributor to collagen fibrillogenesis, regulates the rate of fibril formation and influences the assembly and organization of collagen fibrils. Binding to both type I and type II collagen, CHRNA3 plays a pivotal role in shaping the structural integrity of the extracellular matrix. CHRNA3 Protein, Human (His-SUMO) is the recombinant human-derived CHRNA3 protein, expressed by E. coli , with N-10*His, N-SUMO labeled tag.

HY-P76870

	*DEFA3/Defensin alpha 3* Protein, Human (HEK293, Fc)** Neutrophil defensin 3; HNP-3; Neutrophil defensin 2; HNP-2; DEF3	Human	HEK293
	The DEFA3/defensin alpha 3 protein is a potent effector in innate immunity against a variety of infectious agents, including bacteria, fungi, and viruses. It neutralizes bacterial toxins, such as Bacillus anthracis lethal factor and Staphylococcus aureus leukocidin, and plays a key role in blocking herpes simplex virus infection by preventing viral attachment. DEFA3/Defensin alpha 3 Protein, Human (HEK293, Fc) is the recombinant human-derived DEFA3/Defensin alpha 3 protein, expressed by HEK293 , with N-hFc labeled tag.

HY-P75684

	COL6A3 Protein, Human (HEK293) Collagen alpha-3(VI) chain; COL6A3	Human	HEK293
	COL6A3 protein is an important component of type VI collagen and has the function of a cell-binding protein. Collagen VI trimers are composed of three distinct chains: alpha-1(VI), alpha-2(VI), and alpha-3(VI), alpha-5(VI), or alpha-6(VI). COL6A3 Protein, Human (HEK293) is the recombinant human-derived COL6A3 protein, expressed by HEK293 , with tag free.

HY-P75685

	COL6A3 Protein, Human (HEK293, His) Collagen alpha-3(VI) chain; COL6A3	Human	HEK293
	COL6A3 protein is an important component of type VI collagen and has the function of a cell-binding protein. Collagen VI trimers are composed of three distinct chains: alpha-1(VI), alpha-2(VI), and alpha-3(VI), alpha-5(VI), or alpha-6(VI). COL6A3 Protein, Human (HEK293, His) is the recombinant human-derived COL6A3 protein, expressed by HEK293 , with N-His labeled tag.

HY-P71083

	TPM3 Protein, Human Tropomyosin Alpha-3 Chain; Gamma-Tropomyosin; Tropomyosin-3; Tropomyosin-5; hTM5; TPM3	Human	E. coli
	TPM3 is a member of the tropomyosin family that binds actin filaments in muscle and nonmuscle cells. In striated muscle, it regulates calcium-dependent contraction together with the troponin complex. TPM3 Protein, Human is the recombinant human-derived TPM3 protein, expressed by E. coli , with tag free.

HY-P75683

	COL4A3 Protein, Rat (HEK293, Fc) Collagen alpha-3(IV) chain; Goodpasture antigen; Tumstatin; COL4A3	Rat	HEK293
	The COL4A3 protein is a key type IV collagen component that forms the major structural element of the glomerular basement membrane (GBM). It collaborates with laminin, proteoglycans, and nestin/nesidin to create a "chicken wire" network that is critical for maintaining the structural integrity of the GBM. COL4A3 Protein, Rat (HEK293, Fc) is the recombinant rat-derived COL4A3 protein, expressed by HEK293 , with N-hFc labeled tag.

HY-P77242

	TMED4 Protein, Human (HEK293, His) Transmembrane emp24 domain-containing protein 4; ERS25; GMP25iso; p24alpha3	Human	HEK293
	The TMED4 protein is complexly involved in vesicular protein trafficking in the early secretory pathway, which is critical for targeting and maintenance of the Golgi apparatus. Its involvement extends to the biosynthesis of secretions, emphasizing its role in processing. TMED4 Protein, Human (HEK293, His) is the recombinant human-derived TMED4 protein, expressed by HEK293 , with C-His labeled tag.

HY-P77243

	TMED4 Protein, Human (HEK293, Fc) Transmembrane emp24 domain-containing protein 4; ERS25; GMP25iso; p24alpha3	Human	HEK293
	The TMED4 protein is complexly involved in vesicular protein trafficking in the early secretory pathway, which is critical for targeting and maintenance of the Golgi apparatus. Its involvement extends to the biosynthesis of secretions, emphasizing its role in processing. TMED4 Protein, Human (HEK293, Fc) is the recombinant human-derived TMED4 protein, expressed by HEK293 , with C-mFc labeled tag.

HY-P703235

	GLRA3 Protein, Human (sf9, Strep) Glycine receptor subunit alpha-3; GLRA3; Homo sapiens; Human; Chloride channel; Ion channel; Ligand-gated ion channel; Receptor	Human	Sf9 insect cells
	GLRA3 Protein, Human (sf9, Strep) is the recombinant human-derived GLRA3, expressed by sf9 insect cells , with Strep labeled tag. ,

HY-P701773

	RSK2 Protein, Human RPS6KA3; Ribosomal protein S6 kinase alpha-3; S6K-alpha-3; 90 kDa ribosomal protein S6 kinase 3; p90-RSK 3; p90RSK3; Insulin-stimulated protein kinase 1; ISPK-1; MAP kinase-activated protein kinase 1b; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK-1b; Ribosomal S6 kinase 2; RSK-2; pp90RSK2	Human	E. coli
	RSK2 is a kinase downstream of ERK signaling and plays a critical role in mediating mitosis and stress responses. It activates transcription factors (CREB1, ETV1, NR4A1), affecting proliferation, survival and differentiation. RSK2 Protein, Human is the recombinant human-derived RSK2 protein, expressed by E. coli , with tag free.

HY-P701774

	RSK2 Protein, Human (His) RPS6KA3; Ribosomal protein S6 kinase alpha-3; S6K-alpha-3; 90 kDa ribosomal protein S6 kinase 3; p90-RSK 3; p90RSK3; Insulin-stimulated protein kinase 1; ISPK-1; MAP kinase-activated protein kinase 1b; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK-1b; Ribosomal S6 kinase 2; RSK-2; pp90RSK2	Human	E. coli
	RSK2 is a kinase downstream of ERK signaling and plays a critical role in mediating mitosis and stress responses. It activates transcription factors (CREB1, ETV1, NR4A1), affecting proliferation, survival and differentiation. RSK2 Protein, Human (His) is the recombinant human-derived RSK2 protein, expressed by E. coli , with N-6*His labeled tag.

HY-P74327A

	CD1D Protein, Human (His-SUMO) Antigen-presenting glycoprotein CD1d; CD1.1; CD1A; CD1d; CD1D antigen; CD1D antigen d polypeptide; CD1d molecule; CD1D_HUMAN; Cd1d1 ; differentiation antigen CD1 alpha 3 ; HMC class I antigen like glycoprotein CD1D ; Ly 38; MGC34622; R3; R3G1; T cell surface glycoprotein CD1d ; Thymocyte antigen CD1D	Human	E. coli
	The CD1D protein, a key antigen-presenting molecule, binds self and non-self glycolipids, presenting them to T-cell receptors on natural killer T-cells. Partnering with B2M, it centrally orchestrates immune responses, and its interactions with MHC II emphasize its significance in the intricate network of immune system regulation. CD1D Protein, Human (His-SUMO) is the recombinant human-derived CD1D, expressed by E. coli, with N-6His, N-SUMO labeled tag. The total length of CD1D Protein, Human (His-SUMO) is 282 a.a.*.

HY-P705881

	RSK2 Protein, Human (sf9) RPS6KA3; Ribosomal protein S6 kinase alpha-3; S6K-alpha-3; 90 kDa ribosomal protein S6 kinase 3; p90-RSK 3; p90RSK3; Insulin-stimulated protein kinase 1; ISPK-1; MAP kinase-activated protein kinase 1b; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK-1b; Ribosomal S6 kinase 2; RSK-2; pp90RSK2	Human	sf9 insect cells

HY-P72412

	SIRP alpha/CD172a Protein, Human (Biotinylated, HEK293, His-Avi) HP Substrate 1; SHPS-1; Bit; Sirp-Alpha-1; Sirp-Alpha-2; Sirp-Alpha-3; p84; CD172a; BIT; MFR; MYD1; PTPNS1; SHPS1; SIRP	Human	HEK293
	The SIRP α V4/CD172a protein is an immunoglobulin-like cell surface receptor for CD47 that acts as a docking protein to facilitate the translocation of PTPN6, PTPN11, and other partners to the plasma membrane. It supports the adhesion of cerebellar neurons, promotes neurite growth, and promotes glial cell attachment. SIRP alpha/CD172a Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived SIRP alpha/CD172a protein, expressed by HEK293 , with C-Avi, C-6*His labeled tag.

HY-P706084

	p85α/p110α Protein, Human (Active, sf9, His-GST) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; PtdIns-3-kinase subunit p110-alpha; p110alpha; Phosphoinositide 3-kinase alpha; Phosphoinositide-3-kinase catalytic alpha polypeptide; Serine/threonine protein kinase PIK3CA; 2.7.11.1; Phosphatidylinositol 3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alpha; GRB1	Human	Sf9 insect cells

HY-P706085

	p85α/p110α Protein, Human (Active, H1047R, sf9, GST) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; PtdIns-3-kinase subunit p110-alpha; p110alpha; Phosphoinositide 3-kinase alpha; Phosphoinositide-3-kinase catalytic alpha polypeptide; Serine/threonine protein kinase PIK3CA; 2.7.11.1; Phosphatidylinositol 3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alpha; GRB1	Human	Sf9 insect cells

HY-P77836

	SIRP alpha V2/CD172a Protein, Human (HEK293, His) CD172a; BIT; MFR; MYD1; MYD-1; P84; PTPNS1; SHP substrate 1; SHPS1; SHPS-1; SHPS1CD172A; SIRP alpha; SIRPA; Sirp-alpha-1; SIRPalpha2; Sirp-alpha-2; Sirp-alpha-3	Human	HEK293
	SIRP alpha V2/CD172a Protein, Human (HEK293, His) is the recombinant human-derived SIRP alpha V2/CD172a protein, expressed by HEK293, with C-His labeled tag.

HY-P77837

	SIRP alpha V2/CD172a Protein, Human (HEK293, Fc) CD172a; BIT; MFR; MYD1; MYD-1; P84; PTPNS1; SHP substrate 1; SHPS1; SHPS-1; SHPS1CD172A; SIRP alpha; SIRPA; Sirp-alpha-1; SIRPalpha2; Sirp-alpha-2; Sirp-alpha-3	Human	HEK293
	SIRP alpha V2/CD172a Protein, Human (HEK293, Fc) is the recombinant human-derived SIRP alpha V2/CD172a protein, expressed by HEK293, with C-hFc labeled tag.

HY-P78211

	SIRP alpha/CD172a Protein, Human (Biotinylated, HEK293, Fc-Avi) CD172a; BIT; MFR; MYD1; MYD-1; P84; PTPNS1; SHP substrate 1; SHPS1; SHPS-1; SHPS1CD172A; SIRP alpha; SIRPA; Sirp-alpha-1; SIRPalpha2; Sirp-alpha-2; Sirp-alpha-3	Human	HEK293
	The SIRP α V4/CD172a protein is an immunoglobulin-like cell surface receptor for CD47 that acts as a docking protein to facilitate the translocation of PTPN6, PTPN11, and other partners to the plasma membrane. It supports the adhesion of cerebellar neurons, promotes neurite growth, and promotes glial cell attachment. SIRP alpha/CD172a Protein, Human (Biotinylated, HEK293, Fc-Avi) is the recombinant human-derived SIRP alpha/CD172a protein, expressed by HEK293 , with C-Avi, C-hFc labeled tag.

HY-P77843

	SIRP alpha V4/CD172a Protein, Human (HEK293, His-Avi) CD172a; BIT; MFR; MYD1; MYD-1; P84; PTPNS1; SHP substrate 1; SHPS1; SHPS-1; SHPS1CD172A; SIRP alpha; SIRPA; Sirp-alpha-1; SIRPalpha2; Sirp-alpha-2; Sirp-alpha-3	Human	HEK293
	The SIRP α V4/CD172a protein is an immunoglobulin-like cell surface receptor for CD47 that acts as a docking protein to facilitate the translocation of PTPN6, PTPN11, and other partners to the plasma membrane. It supports the adhesion of cerebellar neurons, promotes neurite growth, and promotes glial cell attachment. SIRP alpha V4/CD172a Protein, Human (HEK293, His-Avi) is the recombinant human-derived SIRP alpha V4/CD172a protein, expressed by HEK293 , with C-Avi, C-His labeled tag and E33G, L44S, T50S, T52I, R54H mutation.

HY-P77844

	SIRP alpha V4/CD172a Protein, Human (Biotinylated, HEK293, His-Avi) CD172a; BIT; MFR; MYD1; MYD-1; P84; PTPNS1; SHP substrate 1; SHPS1; SHPS-1; SHPS1CD172A; SIRP alpha; SIRPA; Sirp-alpha-1; SIRPalpha2; Sirp-alpha-2; Sirp-alpha-3	Human	HEK293
	The SIRP α V4/CD172a protein is an immunoglobulin-like cell surface receptor for CD47 that acts as a docking protein to facilitate the translocation of PTPN6, PTPN11, and other partners to the plasma membrane. It supports the adhesion of cerebellar neurons, promotes neurite growth, and promotes glial cell attachment. SIRP alpha V4/CD172a Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived SIRP alpha V4/CD172a protein, expressed by HEK293 , with C-Avi, C-His labeled tag and E33G, L44S, T50S, T52I, R54H mutation.

HY-P77846

	SIRP alpha V6/CD172a Protein, Human (Biotinylated, HEK293, His-Avi) CD172a; BIT; MFR; MYD1; MYD-1; P84; PTPNS1; SHP substrate 1; SHPS1; SHPS-1; SHPS1CD172A; SIRP alpha; SIRPA; Sirp-alpha-1; SIRPalpha2; Sirp-alpha-2; Sirp-alpha-3	Human	HEK293
	The SIRP α V4/CD172a protein is an immunoglobulin-like cell surface receptor for CD47 that acts as a docking protein to facilitate the translocation of PTPN6, PTPN11, and other partners to the plasma membrane. It supports the adhesion of cerebellar neurons, promotes neurite growth, and promotes glial cell attachment. SIRP alpha V6/CD172a Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived SIRP alpha V6/CD172a protein, expressed by HEK293 , with C-Avi, C-His labeled tag and S105P, , , , mutation.

HY-P77840

	SIRP alpha V2/CD172a Protein, Human (Biotinylated, HEK293, His-Avi) CD172a; BIT; MFR; MYD1; MYD-1; P84; PTPNS1; SHP substrate 1; SHPS1; SHPS-1; SHPS1CD172A; SIRP alpha; SIRPA; Sirp-alpha-1; SIRPalpha2; Sirp-alpha-2; Sirp-alpha-3	Human	HEK293
	SIRP alpha V2/CD172a Protein, Human (Biotinylated, HEK293, His-Avi) is the recombinant human-derived SIRP alpha V2/CD172a protein, expressed by HEK293, with C-Avi, C-His labeled tag.

HY-P77841

	SIRP alpha V3 Protein, Human (H54L, HEK293, His-Avi) CD172a; BIT; MFR; MYD1; MYD-1; P84; PTPNS1; SHP substrate 1; SHPS1; SHPS-1; SHPS1CD172A; SIRP alpha; SIRPA; Sirp-alpha-1; SIRPalpha2; Sirp-alpha-2; Sirp-alpha-3	Human	HEK293
	SIRP alpha V3 Protein, Human (H54L, HEK293, His-Avi) is the recombinant human-derived SIRP alpha V3 protein, expressed by HEK293, with C-Avi, C-His labeled tag.

HY-P77842

	SIRP alpha V3 Protein, Human (Biotinylated, H54L, HEK293, His-Avi) CD172a; BIT; MFR; MYD1; MYD-1; P84; PTPNS1; SHP substrate 1; SHPS1; SHPS-1; SHPS1CD172A; SIRP alpha; SIRPA; Sirp-alpha-1; SIRPalpha2; Sirp-alpha-2; Sirp-alpha-3	Human	HEK293
	SIRP alpha V3 Protein, Human (Biotinylated, H54L, HEK293, His-Avi) is the recombinant human-derived SIRP alpha V3 protein, expressed by HEK293, with C-Avi, C-His labeled tag.

HY-P77845

	SIRP alpha V6/CD172a Protein, Human (HEK293, His-Avi) CD172a; BIT; MFR; MYD1; MYD-1; P84; PTPNS1; SHP substrate 1; SHPS1; SHPS-1; SHPS1CD172A; SIRP alpha; SIRPA; Sirp-alpha-1; SIRPalpha2; Sirp-alpha-2; Sirp-alpha-3	Human	HEK293
	The SIRP α V4/CD172a protein is an immunoglobulin-like cell surface receptor for CD47 that acts as a docking protein to facilitate the translocation of PTPN6, PTPN11, and other partners to the plasma membrane. It supports the adhesion of cerebellar neurons, promotes neurite growth, and promotes glial cell attachment. SIRP alpha V6/CD172a Protein, Human (HEK293, His-Avi) is the recombinant human-derived SIRP alpha V6/CD172a protein, expressed by HEK293 , with C-Avi, C-His labeled tag and S105P, , , , mutation.

HY-P704886

	SIRP alpha V8/CD172a Protein, Human (118a.a, HEK293, Llama Fc) CD172a; BIT; MFR; MYD1; MYD-1; P84; PTPNS1; SHP substrate 1; SHPS1; SHPS-1; SHPS1CD172A; SIRP alpha; SIRPA; Sirp-alpha-1; SIRPalpha2; Sirp-alpha-2; Sirp-alpha-3	Human	HEK293

HY-P77847

	SIRP alpha V8/CD172a Protein, Human (S44L, S50T, I52T, H54R, V57A, HEK293, His-Avi) CD172a; BIT; MFR; MYD1; MYD-1; P84; PTPNS1; SHP substrate 1; SHPS1; SHPS-1; SHPS1CD172A; SIRP alpha; SIRPA; Sirp-alpha-1; SIRPalpha2; Sirp-alpha-2; Sirp-alpha-3	Human	HEK293
	SIRP alpha V8/CD172a Protein, Human (S44L, S50T, I52T, H54R, V57A, HEK293, His-Avi) is the recombinant human-derived SIRP alpha V8/CD172a protein, expressed by HEK293, with C-Avi, C-His labeled tag.

HY-P704884

	SIRP alpha V8/CD172a Protein, Human (S44L, S50T, I52T, H54R, V57A, HEK293, His) CD172a; BIT; MFR; MYD1; MYD-1; P84; PTPNS1; SHP substrate 1; SHPS1; SHPS-1; SHPS1CD172A; SIRP alpha; SIRPA; Sirp-alpha-1; SIRPalpha2; Sirp-alpha-2; Sirp-alpha-3	Human	HEK293

HY-P705719

	PIK3CA Protein, Human (sf9, His, StrepⅡ) Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; PtdIns-3-kinase subunit p110-alpha; p110alpha; Phosphoinositide 3-kinase alpha; Phosphoinositide-3-kinase catalytic alpha polypeptide; Serine/threonine protein kinase PIK3CA; 2.7.11.1; PIK3CA; Homo sapiens; Human; PI3-kinase subunit alpha; Kinase; Serine/threonine-protein kinase; Transferase; 2.7.1.137	Human	Sf9 insect cells
	PIK3CA Protein, Human (sf9, His, StrepⅡ) is the recombinant human-derived PIK3CA, expressed by sf9 insect cells , with Strep, His labeled tag.

HY-P703580

	PIK3CA Protein, Human (Active, H1047R, sf9, His, StrepⅡ) 1 Publications Verification Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform; Phosphatidylinositol 4,5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; PtdIns-3-kinase subunit p110-alpha; p110alpha; Phosphoinositide 3-kinase alpha; Phosphoinositide-3-kinase catalytic alpha polypeptide; Serine/threonine protein kinase PIK3CA; 2.7.11.1; PIK3CA; Homo sapiens; Human; PI3-kinase subunit alpha; Kinase; Serine/threonine-protein kinase; Transferase; 2.7.1.137	Human	Sf9 insect cells
	PIK3CA Protein, Human (Active, H1047R, sf9, His, StrepⅡ) is the recombinant human-derived PIK3CA, expressed by sf9 insect cells , with Strep, His labeled tag.

HY-P706099

	RSK2 Protein, Human (Active, sf9, His-GST) Ribosomal protein S6 kinase alpha-3; 90 kDa ribosomal protein S6 kinase 3; p90-RSK 3; p90RSK3; Insulin-stimulated protein kinase 1; ISPK-1; MAP kinase-activated protein kinase 1b; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK-1b; Ribosomal S6 kinase 2; RSK-2; pp90RSK2; ISPK1; MAPKAPK1B; RSK2	Human	Sf9 insect cells

HY-P71529

	ST3GAL3 Protein, Human (His-SUMO) 3 sialyltransferase; 3(4) GlcNAc alpha-2; 3-sialyltransferase 3; 3-sialyltransferase; 3-ST 3; 4-galactoside alpha-2; 4GlcNAc alpha 2 3 sialyltransferase; Alpha 2 3 sialyltransferase II; Alpha 2 3 sialyltransferase III; Alpha 2 3 ST 3; Alpha 2; Beta galactoside alpha 3 sialyltransferase 3; Beta-galactoside alpha-2; CMP N acetylneuraminate beta 1 4 galactoside alpha 2 3 sialyltransferase; CMP-N-acetylneuraminate-beta-1; EC 2.4.99.6; Gal beta 1 3; Gal beta 1 3(4) GlcNAc alpha 2 3 sialyltransferase; Gal beta 1 3(4)GlcNAc alpha 2 3 sialyltransferase; Gal beta-1; N acetyllactosaminide alpha 2 3 sialyltransferase; N-acetyllactosaminide alpha-2; OTTHUMP00000008820; OTTHUMP00000008821; OTTHUMP00000008822; OTTHUMP00000008823; Sialyltransferase 6 (N acetyllacosaminide alpha 2 3 sialyltransferase); Sialyltransferase 6; SIAT6; SIAT6_HUMAN; ST3 beta galactoside alpha 2 3 sialyltransferase 3; ST3 beta galactoside alpha 2,3 sialyltransferase 3; ST3Gal III; St3gal3; ST3GALII; ST3GalIII; ST3N	Human	E. coli
	ST3GAL3 protein plays a central role in cellular processes by catalyzing the formation of NeuAc-alpha-2,3-Gal-beta-1,4-GlcNAc-, NeuAc-alpha-2,3-Gal-beta-1,3-GlcNAc- and NeuAc-α-2,3-Gal-beta-1,3-GalNAc- sequences are present in the terminal carbohydrate groups of glycoproteins and glycolipids. ST3GAL3 Protein, Human (His-SUMO) is the recombinant human-derived ST3GAL3 protein, expressed by E. coli , with N-His, N-SUMO labeled tag.

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Host:	Mouse (6) Rabbit (12)
Reactivity:	Human (16) mouse (1) Rat (14) Mouse (14) rat (1) human (1)
Application:	IHC-P (10) ICC/IF (11) IF-Tissue (3) IP (7) IHC-F (2) WB (16) FC (3) ELISA (7)
Isotype:	IgG (10) IgG1 (3) IgG/Kappa (2) IgG2a (2)
Conjugation:	Non-conjugated (18) Biotin (7)
Clonality:	Polyclonal (1) Monoclonal (14) Recombinant (7)
Modification:	Phosphorylated (3) Unmodified (13)

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HY-P89936

	karyopherin α3 Antibody (YA9280)	WB, ICC/IF, IF-Tissue, IP, ELISA	human, mouse, rat
	karyopherin α3 Antibody (YA9280) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to karyopherin α3.

HY-P81803

	*Laminin alpha 3* Antibody (YA1548)** LAMA3; Laminin 5 alpha3; E170; LAMNA; LOCS; laminin alpha 3; Laminin A3	WB, ICC/IF	Human
	Laminin alpha 3 Antibody (YA1548) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Laminin alpha 3.

HY-P88815

	*TUBA3E (Tubulin alpha 3e) Antibody (YA8499)* alpha 3e; tubulin	ICC/IF, FC	Human, Mouse, Rat
	TUBA3E (Tubulin alpha 3e) Antibody (YA8499) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to TUBA3E (Tubulin alpha 3e).

HY-P88815A

	*TUBA3E (Tubulin alpha 3e) Antibody (YA8499)(PBS only)* alpha 3e; tubulin	ICC/IF, FC	Human, Mouse, Rat
	TUBA3E (Tubulin alpha 3e) Antibody (YA8499) is a Mouse-derived and non-conjugated IgG2a monoclonal antibody, targeting to TUBA3E (Tubulin alpha 3e).

HY-P83256

	CTNNA3 Antibody (YA3001) Alpha T catenin; Cadherin associated protein; Catenin alpha 3; Catna3; CTNNA3; VR22	WB, IHC-P, IP	Human, Mouse, Rat
	CTNNA3 Antibody (YA3001) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to CTNNA3.

HY-P85356

	RSK2 Antibody (YA5048) RPS6KA3; ISPK1; MAPKAPK1B; RSK2; Ribosomal protein S6 kinase alpha-3; S6K-alpha-3; 90 kDa ribosomal protein S6 kinase 3; p90-RSK 3; p90RSK3; Insulin-stimulated protein kinase 1; ISPK-1; MAP kinase-activated protein kinase 1b; MAPK-activated	WB, IHC-P, IHC-F, FC, IF-Tissue	Human, Mouse, Rat
	RSK2 Antibody (YA5048) is a Rabbit-derived and non-conjugated monoclonal antibody, targeting to RSK2.

HY-P80850

	Phospho-RSK2 (Ser227) Antibody (YA156) RPS6KA3; ISPK1; MAPKAPK1B; RSK2; Ribosomal protein S6 kinase alpha-3; S6K-alpha-3; 90 kDa ribosomal protein S6 kinase 3; p90-RSK 3; p90RSK3; Insulin-stimulated protein kinase 1; ISPK-1; MAP kinase-activated protein kinase 1b; MAPK-activated	WB, IP	Human, Mouse, Rat
	Phospho-RSK2 (Ser227) Antibody (YA156) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Phospho-RSK2 (Ser227).

HY-P86159

	RSK2 Antibody (YA5851) Ribosomal protein S6 kinase alpha-3; S6K-alpha-3; 90 kDa ribosomal protein S6 kinase 3; p90-RSK 3; p90RSK3; Insulin-stimulated protein kinase 1; ISPK-1; MAP kinase-activated protein kinase 1b; MAPK-activated protein kinase 1b; MAPKAP kinase 1b; MAPKAPK-1b; Ribosomal S6 kinase 2; RSK-2; pp90RSK2;	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	RSK2 Antibody (YA5851) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to RSK2.

HY-P83192

	Guanylyl Cyclase alpha 1 Antibody (YA2937) GUCY1A3; GC-S-alpha-1; GUC1A3; GUCA3; GCS-alpha-3; GUCY1A1; GC-SA3; GCS-alpha-1; GUCSA3	WB	Human
	Guanylyl Cyclase alpha 1 Antibody (YA2937) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Guanylyl Cyclase alpha 1.

HY-P82892

	Collagen VI A1+A2+A3 Antibody (YA2637) Alpha 1 (VI) chain (61 AA); COL6A1; COL6A2; COL6A3; Collagen alpha 2(VI) chain; Collagen alpha 3(VI) chain; OPLL; PP3610	WB, IHC-P, ICC/IF	Human, Mouse, Rat
	Collagen VI A1+A2+A3 Antibody (YA2637) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Collagen VI A1+A2+A3.

HY-P80867

	PI3 Kinase p85 alpha Antibody (YA689) 3 Publications Verification PIK3R1; GRB1; Phosphatidylinositol 3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase s	WB, IHC-P	Human, Mouse, Rat
	PI3 Kinase p85 alpha Antibody (YA689) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PI3 Kinase p85 alpha.

HY-P80846

	Phospho-PI3 Kinase p85/p55 (Tyr467/Tyr199) Antibody 5+ Cited Publications PIK3R1; GRB1; Phosphatidylinositol 3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase s	WB, IHC-F, IHC-P, ICC/IF, ELISA	Human, Mouse, Rat
	Phospho-PI3 Kinase p85/p55 (Tyr467/Tyr199) Antibody is a Rabbit-derived and non-conjugated IgG polyclonal antibody, targeting to Phospho-PI3 Kinase p85/p55 (Tyr467/Tyr199).

HY-P810696

	Phospho-PI3 Kinase p85/p55 (Tyr458/Tyr199) Antibody (YA9946) PIK3R1; GRB1; Phosphatidylinositol 3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase s	WB, ELISA, IF-Tissue	Human, Mouse, Rat
	Phospho-PI3 Kinase p85/p55 (Tyr458/Tyr199) Antibody (YA9946) is a Rabbit-derived and non-conjugated IgG Recombinant monoclonal antibody, targeting to Phospho-PI3 Kinase p85/p55 (Tyr458/Tyr199).

HY-P80867A

	PI3 Kinase p85 alpha Antibody (YA689)(PBS only) PIK3R1; GRB1; Phosphatidylinositol 3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase s	WB, IHC-P	Human, Mouse, Rat
	PI3 Kinase p85 alpha Antibody (YA689) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to PI3 Kinase p85 alpha.

HY-P86639

	Collagen IV Antibody (YA6331) Arresten; BSVD; CO4A1_HUMAN; COL4A1; COL4A1 NC1 domain; COL4A2; COL4A3; COL4A4; COL4A5; collagen alpha-1; IV; chain; Collagen IV Alpha 1 Polypeptide; Collagen IV Alpha 2 Polypeptide; Collagen Of Basement Membrane Alpha 1 Chain; Collagen Of Basement Membrane Alpha 2 Chain; Collagen Type IV Alpha 1; collagen type IV alpha 1 chain; Collagen Type IV Alpha 2; Collagen Type IV Alpha 3; Collagen Type IV Alpha 4; Collagen Type IV Alpha 5; RatOR	WB, IHC-P, ICC/IF, IP, ELISA	Human
	Collagen IV Antibody (YA6331) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Collagen IV.

HY-P85740

	PI3 Kinase p85 alpha Antibody (YA5432) PIK3R1; GRB1; Phosphatidylinositol 3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alpha	WB, IHC-P, ICC/IF	Rat, Mouse
	PI3 Kinase p85 alpha Antibody (YA5432) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to PI3 Kinase p85 alpha.

HY-P86645

	PI3 Kinase p85 alpha Antibody (YA6337) PIK3R1; GRB1; Phosphatidylinositol 3-kinase regulatory subunit alpha; PI3-kinase regulatory subunit alpha; PI3K regulatory subunit alpha; PtdIns-3-kinase regulatory subunit alpha; Phosphatidylinositol 3-kinase 85 kDa regulatory subunit alpha; PI3-kinase subunit p85-alpha; PtdIns-3-kinase regulatory subunit p85-alpha	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	PI3 Kinase p85 alpha Antibody (YA6337) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PI3 Kinase p85 alpha.

HY-P86078

	PI3 Kinase p110 alpha/PIK3CA Antibody (YA5770) 5-bisphosphate 3-kinase 110 kDa catalytic subunit alpha; 5-bisphosphate 3-kinase catalytic subunit alpha isoform; caPI3K; CLOVE; CWS5; MCAP; MCM; MCMTC; MGC142161; MGC142163; p110 alpha; p110alpha; Phosphatidylinositol 3 kinase catalytic alpha polypeptide; Phosphatidylinositol 3 kinase catalytic 110 KD alpha; Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha; Phosphatidylinositol 4 5 bisphosphate 3 kinase catalytic subunit alpha isoform; Phosphatidylinositol 4,5 bisphosphate 3 kinase 110 kDa catalytic subunit alpha; Phosphatidylinositol-4; Phosphoinositide 3 kinase catalytic alpha polypeptide; PI 3 Kinase catalytic subunit alpha; PI3 kinase p110 subunit alpha; PI3-kinase subunit alpha; PI3K; PI3K-alpha; PI3KC A; PIK3C A; Pik3ca; PK3CA; PK3CA_HUMAN; PtdIns 3 kinase p110; PtdIns-3-kinase subunit alpha; PtdIns-3-kinase subunit p110-alpha; Serine/threonine protein kinase PIK3CA	WB, ICC/IF, IP, ELISA	Human, Mouse, Rat
	PI3 Kinase p110 alpha/PIK3CA Antibody (YA5770) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PI3 Kinase p110 alpha/PIK3CA.

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Cat. No.	Product Name		Classification

HY-123249

HZ166		Alkynes
HZ166 is a GABAA receptor subtype-selective benzodiazepine site agonist with preferential activity at α2- and α3-GABAA receptors. HZ166 shows anti-hyperalgesic effects . HZ166 is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-14318

Altinicline SIB-1508Y free base		Alkynes
Altinicline (SIB-1508Y free base) is a selective α4β2 nicotinic acetylcholine receptor (nAChR) agonist, with no activity against α7 or α1β1γδ nAChRs and only extremely low activity against *α3β4* nAChRs. Altinicline reverses escape deficits and increases avoidance responses. Altinicline is applicable to research related to depression .

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