6665-83-4
Chemical Structure
6-Hydroxyflavone
- CAS No.: 6665-83-4
- Formula:C15H10O3
- Molecular Weight:238.24
IUPAC Name: 6-hydroxy-2-phenyl-4H-chromen-4-one
InChIKey: GPZYYYGYCRFPBU-UHFFFAOYSA-N
SMILES: O=C1C=C(C2=CC=CC=C2)OC3=CC=C(O)C=C13
Biological Activity: 6-Hydroxyflavone is an orally effective flavonoid compound. 6-Hydroxyflavone can inhibit LPS (HY-D1056) -induced NO production and has anti-inflammatory effects. 6-Hydroxyflavone promotes osteoblast differentiation by activating AKT, ERK 1/2 and JNK signaling pathways. 6-Hydroxyflavone has an inhibitory effect on bovine hemoglobin (BHb) glycosylation. 6-Hydroxyflavone has a kidney protective effect. In addition, 6-Hydroxyflavone enhances GABA-induced current through the Benzodiazepine sites of γ-aminobutyric acid (GABAA) receptors. 6-Hydroxyflavone shows a clear preference for α2 - and α3 - subtypes, which play an anti-anxiety role[1][2][3][4][5][6].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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6-Hydroxyflavone | 99.92% | 6-Hydroxyflavone is an orally effective flavonoid compound. 6-Hydroxyflavone can inhibit LPS (HY-D1056) -induced NO production and has anti-inflammatory effects. 6-Hydroxyflavone promotes osteoblast differentiation by activating AKT, ERK 1/2 and JNK signaling pathways. 6-Hydroxyflavone has an inhibitory effect on bovine hemoglobin (BHb) glycosylation. 6-Hydroxyflavone has a kidney protective effect. In addition, 6-Hydroxyflavone enhances GABA-induced current through the Benzodiazepine sites of γ-aminobutyric acid (GABAA) receptors. 6-Hydroxyflavone shows a clear preference for α2 - and α3 - subtypes, which play an anti-anxiety role. | ||||||||||||||||||||
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References
- [1]. Das S, et al. Characterization of non-covalent binding of 6-hydroxyflavone and 5,7-dihydroxyflavone with bovine hemoglobin: Multi-spectroscopic and molecular docking analyses. J Photochem Photobiol B. 2018 Jan;178:40-52. [Content Brief]
- [2]. Lai CH, et al. Effects of 6-Hydroxyflavone on Osteoblast Differentiation in MC3T3-E1 Cells. Evid Based Complement Alternat Med. 2014;2014:924560. [Content Brief]
- [3]. Wang X, et al. 6-Hydroxyflavone and derivatives exhibit potent anti-inflammatory activity among mono-, di- and polyhydroxylated flavones in kidney mesangial cells. PLoS One. 2015 Mar 19;10(3):e0116409. [Content Brief]
- [4]. Ren L, et al. GABA(A) receptor subtype selectivity underlying anxiolytic effect of 6-hydroxyflavone. Biochem Pharmacol. 2010 May 1;79(9):1337-44. [Content Brief]
- [5]. Din ZU, et al. The flavonoid 6-hydroxyflavone prevention of cisplatin-induced nephrotoxicity. Histol Histopathol. 2020 Oct;35(10):1197-1209. [Content Brief]
