252935-94-7
252935-94-7
Chemical Structure
CHIR-98014
- CAS No.: 252935-94-7
- Formula:C20H17Cl2N9O2
- Molecular Weight:486.31
IUPAC Name: N2-(2-((4-(2,4-dichlorophenyl)-5-(1H-imidazol-1-yl)pyrimidin-2-yl)amino)ethyl)-5-nitropyridine-2,6-diamine
InChIKey: MDZCSIDIPDZWKL-UHFFFAOYSA-N
SMILES: ClC1=CC(Cl)=CC=C1C2=NC(NCCNC3=CC=C([N+]([O-])=O)C(N)=N3)=NC=C2N4C=CN=C4
Biological Activity: CHIR-98014 is a potent, cell-permeable GSK-3 inhibitor with IC50s of 0.65 and 0.58 nM for GSK-3α and GSK-3β, respectively; it shows less potent activities against cdc2 and erk2.
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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CHIR-98014 | 98.44% | CHIR-98014 is a potent, cell-permeable GSK-3 inhibitor with IC50s of 0.65 and 0.58 nM for GSK-3α and GSK-3β, respectively; it shows less potent activities against cdc2 and erk2. | ||||||||||||||||||||
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Keywords
