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HGPRT inhibitor

" in MedChemExpress (MCE) Product Catalog:
Art. -Nr. Produktname Target Forschungsgebiete Chemical Structure
  • HY-W070294
    8-Azahypoxanthine

    		DNA/RNA Synthesis Cancer
    8-Azahypoxanthine is a purine analog and an inhibitor of hypoxanthine-guanine phosphoribosyltransferase (HGPRT). 8-Azahypoxanthine exhibits antitumor activity and can be used in the research of tumors such as adenocarcinoma .
    8-Azahypoxanthine
  • HY-W013111
    2′-Deoxy-GDP trisodium

    dGDP trisodium; 2'-Deoxyguanosine-5'-diphosphate trisodium

    		 Nucleoside Antimetabolite/Analog Parasite Infection
    2′-Deoxy-GDP (dGDP) trisodium, a guanosine monophosphate (GMP) analogue, is a hypoxanthine phosphoribosyltransferase (HGPRT) inhibitor with an IC50 of 12.5 μM. HGPRT is a central enzyme in the purine recycling pathway of all protozoan parasites .
    2′-Deoxy-GDP trisodium
  • HY-158323
    HGPRT/TBrHGPRT1-IN-1

    		Parasite Infection Cancer
    HGPRT/TBrHGPRT1-IN-1 (Compound 5) is a selective inhibitor targeting human hypoxanthine-guanine phosphoribosyltransferase (HGPRT) and Trypanosoma bruce HGPRT1 (TBrHGPRT1) (both Ki=3 nM). HGPRT/TBrHGPRT1-IN-1 ultimately results in decreased cell growth. HGPRT/TBrHGPRT1-IN-1 is primarily used in the research of infectious diseases and cancer .
    HGPRT/TBrHGPRT1-IN-1

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