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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
41 Results for "
2-oxoglutarate
" in MedChemExpress (MCE) Product Catalog:
Products (41)
41 Results for "2-oxoglutarate" in MCE Product Catalog:
7
7 Cited Publications
Target:
Research Areas:
IOX4 is a selective HIF prolyl-hydroxylase 2 (PHD2) inhibitor with an IC50 value of 1.6 nM, induces HIFα in cells and in wildtype mice with marked induction in the brain tissue. IOX4 competes with and displaces 2-oxoglutarate (2OG) at the active site of PHD2 .
6
6 Cited Publications
Cat. No.: HY-W013636B
CAS No.: 71686-01-6
Target:
3
1
Research Areas:
N-Oxalylglycine (N-Oxaloglycine) is a Jumonji C-domain-containing histone lysine demethylase inhibitor. N-Oxalylglycine inhibits JMJD2A, JMJD2C and JMJD2D. N-Oxalylglycine also inhibits HIF prolylhydroxylase domain-1 (PHD-1) and PHD-2, with an IC50 of 2.1 μM and 5.6 μM, respectively [2].
1
1 Cited Publications
Cat. No.: HY-P71917
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: P4HB; Protein Disulfide Isomerase Family A, Member 1; Prev. ERBA2L; Cellular Thyroid Hormone-Binding Protein; Prev. PO4DB; Prolyl 4-Hydroxylase, Beta Polypeptide; PDIA1; Collagen Prolyl 4-Hydroxylase Beta; PDI; Procollagen-Proline, 2-oxoglutarate 4-Dioxyg
Species:
Human
Source:
E. coli
Target:
Research Areas:
L-Ornithine 2-oxoglutarate (Ornithine alpha-ketoglutarate) is a nutritional compound that is a salt of amino acids with antioxidant and anti-inflammatory effects. L-Ornithine 2-oxoglutarate stimulates the production of insulin and growth hormone, and promotes intracellular amino acid transport and protein synthesis [2].
Cat. No.: HY-44134R
CAS No.: 13192-04-6
Synonyms: Dimethyl α-ketoglutarate (Standard)
Category:
Cat. No.: HY-12688
CAS No.: 26647-82-5
Cat. No.: HY-147064A
CAS No.: 1187-99-1
Target:
Research Areas:
CPI-4203 is a potent KDM5A inhibitor with an IC50 of 250 nM. CPI-4203 is competitive with 2-oxoglutarate (2-OG). CPI-4203 is structurally related to CPI-455 (HY-100421) but is less potent .
Cat. No.: HY-E71609
Target:
Research Areas:
2-Oxoglutarate reductase (EC 1.1.1.399) is an oxidoreductase that catalyzes the reversible interconversion between 2-hydroxyglutarate (2-HG) and 2-oxoglutarate (also known as α-ketoglutarate, α-KG).
Cat. No.: HY-147064
Research Areas:
DL-4-Hydroxy-2-ketoglutarate lithium is one of the metabolites that is characteristically elevated in the urine of patients with type 3 primary hyperoxaluria (PH3), and it is produced by the accumulation of substrates of mitochondrial 4-hydroxy-2-oxoglutarate aldolase (HOGA). DL-4-Hydroxy-2-ketoglutarate lithium can be used in studies related to PH3 .
Cat. No.: HY-W013636BR
CAS No.: 71686-01-6
Cat. No.: HY-E71608
Target:
Research Areas:
2-Oxoglutarate decarboxylase (EC 4.1.1.71) requires thiamine diphosphate.
Cat. No.: HY-E71607
Target:
Research Areas:
2-Oxoglutarate carboxylase (EC 6.4.1.7) is a biotin-containing enzyme that requires Mg2+ for its activity.
Cat. No.: HY-E71099
Target:
Research Areas:
(R)-Dichlorprop dioxygenase (2-oxoglutarate) (EC 1.14.11.44) is a Fe2+-dependent enzyme. (R)-Dichlorprop dioxygenase (2-oxoglutarate) (EC 1.14.11.44) is involved in the degradation of the (R)-enantiomer of the phenoxyalkanoic acid herbicides mecoprop and dichlorprop.
Cat. No.: HY-E71610
Target:
Research Areas:
2-Oxoglutarate synthase (EC 1.2.7.3) contains thiamine diphosphate and two [4Fe-4S] clusters.
Cat. No.: HY-179266
Research Areas:
FTO-IN-15 (Compound 8a) is a potent and selective dual-competitive FTO inhibitor with an IC50 of 43.7 nM, showing high selectivity over ALKBH3 and ALKBH5. FTO-IN-15 substantially inhibits FTO demethylation by simultaneously occupying the substrate and 2-oxoglutarate (2-OG) pockets. FTO-IN-15 can be used for the research of acute myeloid leukemia (AML) .
Cat. No.: HY-E71805
Target:
Research Areas:
4-Aminobutyrate-2-oxoglutarate transaminase (EC 2.6.1.19) is a transferase that can convert 4-aminobutanoate and 2-oxoglutarate into succinate semialdehyde and L-glutamate.
Research Areas:
N-Oxalylglycine (Standard) is the analytical standard of N-Oxalylglycine. This product is intended for research and analytical applications. N-Oxalylglycine (N-Oxaloglycine) is a Jumonji C-domain-containing histone lysine demethylase inhibitor. N-Oxalylglycine inhibits JMJD2A, JMJD2C and JMJD2D. N-Oxalylglycine also inhibits HIF prolylhydroxylase domain-1 (PHD-1) and PHD-2, with an IC50 of 2.1 μM and 5.6 μM, respectively [2].
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
