5262-39-5
5262-39-5
Chemical Structure
N-Oxalylglycine
Synonym(s): N-Oxaloglycine
- CAS No.: 5262-39-5
- Formula:C4H5NO5
- Molecular Weight:147.09
IUPAC Name: 2-((carboxymethyl)amino)-2-oxoacetic acid
InChIKey: BIMZLRFONYSTPT-UHFFFAOYSA-N
SMILES: O=C(O)CNC(C(O)=O)=O
Biological Activity: N-Oxalylglycine (N-Oxaloglycine) is a Jumonji C-domain-containing histone lysine demethylase inhibitor. N-Oxalylglycine inhibits JMJD2A, JMJD2C and JMJD2D. N-Oxalylglycine also inhibits HIF prolylhydroxylase domain-1 (PHD-1) and PHD-2, with an IC50 of 2.1 μM and 5.6 μM, respectively[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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N-Oxalylglycine | 99.18% | N-Oxalylglycine (N-Oxaloglycine) is a Jumonji C-domain-containing histone lysine demethylase inhibitor. N-Oxalylglycine inhibits JMJD2A, JMJD2C and JMJD2D. N-Oxalylglycine also inhibits HIF prolylhydroxylase domain-1 (PHD-1) and PHD-2, with an IC50 of 2.1 μM and 5.6 μM, respectively. | ||||||||||||||||||||
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N-Oxalylglycine (Standard) | ≥98% | N-Oxalylglycine (Standard) is the analytical standard of N-Oxalylglycine. This product is intended for research and analytical applications. N-Oxalylglycine (N-Oxaloglycine) is a Jumonji C-domain-containing histone lysine demethylase inhibitor. N-Oxalylglycine inhibits JMJD2A, JMJD2C and JMJD2D. N-Oxalylglycine also inhibits HIF prolylhydroxylase domain-1 (PHD-1) and PHD-2, with an IC50 of 2.1 μM and 5.6 μM, respectively. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.84
HY-N1477Dencichine -
Similarity Score 0.84
HY-N6030(Rac)-Dencichine -
Similarity Score 0.83
HY-W141933N-Succinylglycine -
Similarity Score 0.82
HY-W686479N-Oxalyl-L-alanine -
Similarity Score 0.81
HY-138094N-(2-Hydroxyethyl)oxamic acid -
Similarity Score 0.81
HY-W141926N-Glutarylglycine -
Similarity Score 0.80
HY-W129833H-Asp-Gly-OH -
Similarity Score 0.79
HY-W012683Iminodiacetic acid -
Similarity Score 0.79
HY-W1013112-(2-Acetamidoacetamido)acetic acid -
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References
- [1]. Hamada S, et al. Synthesis and activity of N-oxalylglycine and its derivatives as Jumonji C-domain-containing histone lysine demethylase inhibitors. Bioorg Med Chem Lett. 2009 May 15;19(10):2852-5. [Content Brief]
- [2]. Hamada S, et al. Design, synthesis, enzyme-inhibitory activity, and effect on human cancer cells of a novel series of jumonji domain-containing protein 2 histone demethylase inhibitors. J Med Chem. 2010 Aug 12;53(15):5629-38. [Content Brief]
