4 Results for "

2-oxoglutarate dehydrogenase complex

" in MedChemExpress (MCE) Product Catalog:
Products (4)

4 Results for "2-oxoglutarate dehydrogenase complex" in MCE Product Catalog:

Succinyl phosphonate
Succinyl phosphonate
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Cat. No.: HY-12688
CAS No.: 26647-82-5
Category:  

Neurological Disease Ketones, Aldehydes, Acids Endogenous metabolite Disease Research Fields

Target:  

Mitochondrial Metabolism Reactive Oxygen Species (ROS) Amyloid-β

Succinyl phosphonate is a α-Ketoglutarate Dehydrogenase Complex (KGDHC) modulator with neuroprotective activity. Succinyl phosphonate protects this complex, reduces cellular succinyl-CoA concentration, downregulates protein succinylation levels, and inhibits the activity of the α-ketoglutarate dehydrogenase complex. Succinyl phosphonate corrects hypoxic or ethanol-induced behavioral impairments, modulates exploratory behavior and emotional stress responses, and improves hypoxia tolerance. Succinyl phosphonate reduces glutamate excitotoxicity, restores the activity of the α-ketoglutarate dehydrogenase complex, reverses the changes in glutamate dehydrogenase and glutamine synthetase activities induced by β-amyloid (Amyloid-β), modulates cognitive function, and prevents β-amyloid-induced neuronal damage. Succinyl phosphonate improves microglial senescence, alleviates neuroinflammation, reactive oxygen species (ROS) production, lipid peroxidation, and the expression of proinflammatory cytokines. Succinyl phosphonate can be used in the research of Alzheimer's disease, aging-related neuroinflammation, and Parkinson's disease .
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OGDC-E Protein, Mouse (His-SUMO)
OGDC-E Protein, Mouse (His-SUMO)
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Cat. No.: HY-P71567
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: OGDH; Alpha-Ketoglutarate dehydrogenase; oxoglutarate dehydrogenase; Alpha-KGDH-E1; OGDC-E1; OGDH-E1; Thiamine Diphosphate (ThDP)-Dependent 2-oxoglutarate dehydrogenase; HsOGDH; 2-oxoglutarate dehydrogenase complex Component E1; E1o; 2-oxoglutarate Dehydr
Species:  
Mouse
Source:  
E. coli
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DLST Antibody
DLST Antibody
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Cat. No.: HY-P81071
Synonyms: 2-oxoglutarate dehydrogenase complex component E2; Dihydrolipoamide S succinyltransferase (E2 component of 2 oxo glutarate complex); Dihydrolipoamide S succinyltransferase; Dihydrolipoamide succinyltransferase component of 2 oxoglutarate dehydrogenase complex; Dihydrolipoamide succinyltransferase component of 2-oxoglutarate dehydrogenase complex; Dihydrolipoyllysine residue succinyltransferase component of 2 oxoglutarate dehydrogenase complex; Dihydrolipoyllysine residue succinyltransferase component of 2 oxoglutarate dehydrogenase complex mitochondrial; Dihydrolipoyllysine-residue succinyltransferase component of 2-oxoglutarate dehydrogenase complex; Dlst; DLTS; E2; E2K; mitochondrial; ODO2_HUMAN; OGDC-E2.

Host:  

Rabbit

Application:  

WB, ELISA, IHC-P, IHC-F, ICC/IF

Reactivity:  

Human, Mouse

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DLST Protein, Human (sf9, His)
DLST Protein, Human (sf9, His)
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Cat. No.: HY-P75709
Purity:  ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: DLST; Dihydrolipoamide Succinyltransferase Component Of 2-oxoglutarate dehydrogenase complex; Prev. DLTS; CDNA, FLJ79362, Moderately Similar To Dihydrolipoyllysine-Residue Succinyltransferase Component Of 2- oxoglutarate dehydrogenase complex, Mitochondri
Species:  
Human
Source:  
Sf9 insect cells
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