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Results for "

2B1

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Adenosine Receptor (1) Adrenergic Receptor (2) Amyloid-β (2) Anaplastic lymphoma kinase (ALK) (1) Apoptosis (1) ATP-binding cassette (ABC) transporters (2) Bacterial (1) Bradykinin Receptor (1) Calcium Channel (2) Caspase (1) CGRP Receptor (1) Cholinesterase (ChE) (3) COX (1) Cytochrome P450 (6) Drug Metabolite (1) Endogenous Metabolite (2) ERK (3) Fluorescent Dye (1) G-quadruplex (1) GABA Receptor (1) HIF/HIF Prolyl-Hydroxylase (1) iGluR (23) Influenza Virus (4) Interleukin Related (1) JNK (1) MEK (1) MMP (2) Nuclear Hormone Receptor 4A/NR4A (1) OAT (5) Potassium Channel (4) PROTACs (1) Raf (1) Reactive Oxygen Species (ROS) (2) Reference Standards (4) Ser/Thr Kinase (1) Sigma Receptor (1) Small Interfering RNA (siRNA) (14) SOD (1) TNF Receptor (1)
By Research Areas:	Cancer (8) Cardiovascular Disease (4) Infection (5) Inflammation/Immunology (7) Metabolic Disease (2) Neurological Disease (21)
Click Chemistry:	Alkynes (2)
Oligonucleotides:	Rat Pre-designed siRNA Sets (3) Mouse Pre-designed siRNA Sets (3) Human Pre-designed siRNA Sets (8) siRNAs (14)

Inhibitors & Agonists

Fluorescent Dye

Biochemical Assay Reagents

Peptides

Natural
Products

Recombinant Proteins

Isotope-Labeled Compounds

Antibodies

Click Chemistry

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-N3513

Mulberrin 5+ Cited Publications Kuwanon C	OAT	Cardiovascular Disease
Mulberrin is a strong inhibitor of organic anion-transporting polypeptide 2B1 (OATP2B1)-mediated estrone-3-sulfate (E3S) uptake with an IC₅₀ value being 1.8?±1.5 μM.

HY-12882A

Ifenprodil tartrate 5+ Cited Publications NP-120 tartrate; RC-61-91 tartrate	iGluR Adrenergic Receptor Potassium Channel Calcium Channel Influenza Virus	Infection Neurological Disease
Ifenprodil (NP-120) tartrate, a cerebral vasodilator, is a noncompetitive NMDA receptor antagonist. Ifenprodil tartrate exerts high affinity at NR1A/NR2B receptors (IC₅₀=0.34 μM) over 400-fold than at NR1A/NR2A receptors (IC₅₀=146 μM) . Ifenprodil tartrate is an α1 adrenergic receptor antagonist. Ifenprodil tartrate inhibits GIRK (Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil tartrate has reliable inhibitory effects against A/H1N1 strains (EC₅₀ of 6.6 µM). Ifenprodil tartrate has neuroprotective, anticonvulsant and antinociceptive effects. Ifenprodil tartrate can be used for the study of cerebrovascular diseases and peripheral arterial obliterative disease .

HY-13457

TCN 201 1 Publications Verification	iGluR	Neurological Disease
TCN 201 is a potent, selective and non-competitive antagonist of GluN1/GluN2A NMDA receptor, with a pIC₅₀ of 6.8. TCN 201 is selective for GluN1/GluN2A NMDA receptor over GluN1/GluN2B NMDA receptor (pIC₅₀<4.3) .

HY-12882

Ifenprodil Maximum Cited Publications 10 Publications Verification NP-120; RC-61-91	iGluR Adrenergic Receptor Potassium Channel Calcium Channel Influenza Virus	Infection Neurological Disease
Ifenprodil (NP-120), a cerebral vasodilator, is a noncompetitive NMDA receptor antagonist. Ifenprodil exerts high affinity at NR1A/NR2B receptors (IC₅₀=0.34 μM) over 400-fold than at NR1A/NR2A receptors (IC₅₀=146 μM) . Ifenprodil is an α1 adrenergic receptor antagonist. Ifenprodil inhibits GIRK (Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil has reliable inhibitory effects against A/H1N1 strains (EC₅₀ of 6.6 µM). Ifenprodil has neuroprotective, anticonvulsant and antinociceptive effects. Ifenprodil can be used for the study of cerebrovascular diseases and peripheral arterial obliterative disease .

HY-B1042

Oxolamine citrate SKF-9976 citrate; AF-438 citrate	Cytochrome P450	Inflammation/Immunology
Oxolamine citrate (SKF-9976 citrate) is an orally active antitussive. Oxolamine citrate can inhibit *CYP2B1/2*. Oxolamine citrate has anti-inflammatory effects on the respiratory organs of guinea pigs. Oxolamine citrate increases the AUC of Warfarin (HY-B0687) and prolongs its terminal half-life. Oxolamine citrate can be used in respiratory disease research .

HY-N7755

Estradiol 3-glucuronide sodium	Endogenous Metabolite ATP-binding cassette (ABC) transporters OAT	Others
Estradiol 3-glucuronide sodium is an estrogen metabolite, which is a glucuronide conjugate formed by the catalysis of uridine diphosphate glucuronosyltransferase in tissues such as the liver from Estradiol (HY-B0141). Estradiol 3-glucuronide sodium is a potent substrate of Mrp2, with an S₅₀ of 55.7 μM. Estradiol 3-glucuronide sodium achieves hepatobiliary transport in hepatocytes through basolateral uptake via OATP1B1, OATP1B3 and *OATP2B1, as well as apical efflux via MRP2* and BCRP .

HY-126848

Diclofenac acyl glucuronide D-1-O-G	Drug Metabolite SOD COX Reactive Oxygen Species (ROS) OAT	Inflammation/Immunology
Diclofenac acyl glucuronide (D-1-O-G) is an orally active glucuronide metabolite of Diclofenac (HY-15036). Diclofenac acyl glucuronide exhibits SOD inhibitory activity, COX-1 inhibitory activity (IC₅₀ = 0.620 μM), and COX-2 inhibitory activity (IC₅₀ = 2.91 μM). Diclofenac acyl glucuronide induces reactive oxygen species (ROS) production and acts as a substrate of *OATP2B1*. Diclofenac acyl glucuronide induces small intestinal ulcers . Diclofenac acyl glucuronide can be used in research related to intestinal diseases and small intestinal ulcers .

HY-131452

1-Ethynylpyrene	Cytochrome P450	Cancer
1-Ethynylpyrene is an aryl acetylenic inhibitor of cytochromes P450 1A1, 1A2, and *2B1* with IC₅₀s of 0.18, 0.32, and 0.04 μM, respectively . 1-Ethynylpyrene is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-101043

4-PPBP maleate	Sigma Receptor iGluR	Neurological Disease
4-PPBP maleate is a potent σ 1 receptor ligand and agonist. 4-PPBP maleate is a non-competitive, selective NR1a/2B NMDA receptors (expressed in Xenopus oocytes) antagonist. 4-PPBP maleate provides neuroprotection .

HY-B1404

Nylidrin hydrochloride Buphenine hydrochloride	iGluR Influenza Virus	Infection Cardiovascular Disease Inflammation/Immunology
Nylidrin hydrochloride (Buphenine hydrochloride) is an orally active β-adrenergic agonist. Nylidrin hydrochloride antagonizes NR1_A/2B NMDA receptors (IC₅₀ = 0.18 μM in Xenopus oocytes). Nylidrin hydrochloride reduces the levels of NP, HA, and M1. Nylidrin hydrochloride has antiviral activity against multiple H1N1 subtype influenza A viruses. Nylidrin hydrochloride improves hemorrhagic shock and anti-allergic effects .

HY-W585842

Estradiol 3-glucuronide	Endogenous Metabolite ATP-binding cassette (ABC) transporters OAT	Others
Estradiol 3-glucuronide is an estrogen metabolite, which is a glucuronide conjugate formed from Estradiol (HY-B0141) via catalysis by uridine diphosphate glucuronosyltransferases in tissues such as the liver. Estradiol 3-glucuronide is a potent substrate of Mrp2, with an S₅₀ value of 55.7 μM. Estradiol 3-glucuronide achieves hepatobiliary transport in hepatocytes through basolateral uptake via OATP1B1, OATP1B3 and *OATP2B1, as well as apical efflux via MRP2* and BCRP .

HY-W008038

NMDAR antagonist 3	iGluR	Others
NMDAR antagonist 3 (Compound 2) is an antagonist of the NMDA receptor. NMDAR antagonist 3 has a certain but weak inhibitory activity against the *NR1A/2B* subtype of the NMDA receptor .

HY-107707

TCS 46b	iGluR	Neurological Disease
TCS 46b (Compound 46b) is a potent, selective and orally active NMDA NR1A/2B receptor antagonist with an IC₅₀ of 5.3 nM . TCS 46b is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

HY-N13009

MO-2097	Raf HIF/HIF Prolyl-Hydroxylase ERK MEK Reactive Oxygen Species (ROS) Apoptosis Caspase	Cancer
MO-2097 is a RAF-1/HIF-1α inhibitor. MO-2097 induces RAF-1 destabilization, leading to a reduction in EMT-associated transcription factors and mesenchymal markers. MO-2097 inhibits HIF-1a protein expression mediated by hnRNPA2B1 under hypoxic and mimetic hypoxia. MO-2097 induces mitochondrial ROS, which leads to apoptosis in cells. MO-2097 effectively suppresses colorectal cancer metastasis by inhibiting the RAF/MEK/ERK signaling pathway. MO-2097 attenuates tumor growth in a xenograft HCT116 cell mouse model. MO-2097 can be used for the study of colorectal cancer .

HY-122735

Inh2-B1	Ser/Thr Kinase Bacterial	Infection
Inh2-B1 is a Ser/Thr protein kinase (STK1) inhibitor. Inh2-B1 specifically inhibits STK1 activity by directly binding to its ATP-binding catalytic domain. Inh2-B1 down-regulates cell wall hydrolase genes and disrupts the biofilm formation of Methicillin-resistant Staphylococcus aureus (MRSA) clearly .

HY-177127

Satoprodil	iGluR	Neurological Disease
Satoprodil (example 2) is a potent N-methyl-D-aspartate (NMDA) receptor negative allosteric modulator with an IC₅₀ value of 123 nM for NR2B .

HY-112095

EVT-101 free base ENS-101 free base	iGluR	Neurological Disease
EVT-101 free base is a GluN₂B antagonist. EVT-101 free base binds at the same GluN₁/GluN₂B dimer interface as Ifenprodil (HY-12882). EVT-101 free base inhibits calcium influx in chicken-derived cells, with an EC₅₀ of 22 nM. EVT-101 can be used in the research of brain disorders .

HY-N3513R

Mulberrin (Standard) Kuwanon C (Standard)	Reference Standards Others	Cardiovascular Disease
Mulberrin (Standard) is the analytical standard of Mulberrin. This product is intended for research and analytical applications. Mulberrin is a strong inhibitor of organic anion-transporting polypeptide 2B1 (OATP2B1)-mediated estrone-3-sulfate (E3S) uptake with an IC₅₀ value being 1.8 ±1.5 μM.

HY-179108

NMDAR modulator 1	iGluR	Neurological Disease
NMDAR modulator 1 (Compound 12) is a positive, allosteric *GluN1/GluN2B* receptor modulator. NMDAR modulator 1 enhances NMDAR current. NMDAR modulator 1 can be used in the research of psychiatric disorders .

HY-169951

Lu AF90103	iGluR	Neurological Disease
Lu AF90103 (Compound 42e) is a methyl ester prodrug of compound 42d capable of penetrating the blood-brain barrier. Compound 42d acts as a partial agonist of the *GluN1/GluN2B* complex, exhibiting 24% efficacy, and has an EC₅₀ value of 78 nM. Lu AF90103 plays an important role in neuropsychiatric diseases research .

HY-B0822S1

Fipronil-13C6	GABA Receptor Cytochrome P450	Inflammation/Immunology
Fipronil- ¹³C₆ is the ¹³C-labeled Fipronil. Fipronil is an insecticide that acts as a selective antagonist of insect GABA receptors (IC50s = 30 nM and 1,600 nM for cockroach and rat receptors, respectively). Fipronil also inhibits desensitizing and non-desensitizing glutamate-induced chloride currents in cockroach neurons (IC50s = 800 nM and 10 nM, respectively). Fipronil induces activity of the cytochrome P450 (CYP) isoforms CYP1A1/2, CYP2B1/2, and CYP3A1/2 in isolated rat liver microsomes.

HY-179248

Adenosine receptor antagonist 7	Adenosine Receptor ERK JNK MMP	Cancer
Adenosine receptor antagonist 7 is an orally active triple *A1/A2A/A2B* adenosine receptor antagonist with K_i values of 1.5, 0.6 and 21 nM. Adenosine receptor antagonist 7 shows potent inhibitory activity (IC₅₀ = 0.8 nM) of cAMP production in A2AR-HEK293 cells. Adenosine receptor antagonist 7 can enhance infiltration of effector T cells and increase the CD8+/Treg ratio companied with Avelumab (HY-108730). Adenosine receptor antagonist 7can be used for the research of cancer, such as colon cancer .

HY-RS01194

ATP2B1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
ATP2B1 Human Pre-designed siRNA Set A contains three designed siRNAs for ATP2B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

ATP2B1 Human Pre-designed siRNA Set A ATP2B1 Human Pre-designed siRNA Set A

HY-RS04248

EIF2B1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
EIF2B1 Human Pre-designed siRNA Set A contains three designed siRNAs for EIF2B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

EIF2B1 Human Pre-designed siRNA Set A EIF2B1 Human Pre-designed siRNA Set A

HY-RS00786

AP2B1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
AP2B1 Human Pre-designed siRNA Set A contains three designed siRNAs for AP2B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

AP2B1 Human Pre-designed siRNA Set A AP2B1 Human Pre-designed siRNA Set A

HY-RS19554

Sult2b1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sult2b1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Sult2b1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sult2b1 Mouse Pre-designed siRNA Set A Sult2b1 Mouse Pre-designed siRNA Set A

HY-RS14021

SULT2B1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SULT2B1 Human Pre-designed siRNA Set A contains three designed siRNAs for SULT2B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SULT2B1 Human Pre-designed siRNA Set A SULT2B1 Human Pre-designed siRNA Set A

HY-RS12818

SH2B1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SH2B1 Human Pre-designed siRNA Set A contains three designed siRNAs for SH2B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SH2B1 Human Pre-designed siRNA Set A SH2B1 Human Pre-designed siRNA Set A

HY-RS06262

HNRNPA2B1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
HNRNPA2B1 Human Pre-designed siRNA Set A contains three designed siRNAs for HNRNPA2B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HNRNPA2B1 Human Pre-designed siRNA Set A HNRNPA2B1 Human Pre-designed siRNA Set A

HY-RS13356

SLCO2B1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
SLCO2B1 Human Pre-designed siRNA Set A contains three designed siRNAs for SLCO2B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

SLCO2B1 Human Pre-designed siRNA Set A SLCO2B1 Human Pre-designed siRNA Set A

HY-RS08010

MAN2B1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
MAN2B1 Human Pre-designed siRNA Set A contains three designed siRNAs for MAN2B1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

MAN2B1 Human Pre-designed siRNA Set A MAN2B1 Human Pre-designed siRNA Set A

HY-162852

OAF89	G-quadruplex	Cancer
OAF89 is a small molecule that interacts with G-Quadruplexes (G4s) and dsDNA with an IC₅₀ of 1.07 μM in normal lung epithelial cells BEAS-2B .

HY-126123

NR2B-selective NMDA receptor antagonist 1	iGluR Potassium Channel	Neurological Disease
NR2B-selective NMDA receptor antagonist 1 (compound 29) is a potent antagonist of NR1/NR2B receptors, with IC₅₀s of 0.05 μM, 0.73 μM, 2.4 μM to NR1/NR2B NMDA receptor, hERG, α1-AdR, respectivity. NR2B-selective NMDA receptor antagonist 1 exhibites efficient permeability across the blood–brain barrier .

HY-115824

7ETMC	Cytochrome P450	Others
7ETMC is a cytochrome P450 inhibitor with selective inhibition of human cytochrome P450s 1A1 and 1A2. 7ETMC has inhibitory effects on P450s 1A1 and 1A2 with IC?? values of 0.46μM and 0.50μM, respectively, within the first six minutes, and has no inhibitory activity against P450s 2A6 and 2B1. Except for 7-ethynyl-3-methyl-4-phenylcoumarin, the remaining inhibitors show mechanism-based inhibition of P450s 1A1 and 1A2.

HY-169950

NMDA agonist 1	iGluR	Neurological Disease
NMDA agonist 1 (compound 42d) is a potent NMDA agonist with a K_i value of 96 nM. NMDA agonist 1 acts as a partial agonist of the GluN1/GluN2B complex with an EC₅₀ value of 78 nM .

HY-161821

Antitumor agent-173	Interleukin Related TNF Receptor MMP	Cancer
Antitumor agent-173 (Compound 4b) is a prodrug of Cycloicaritin (HY-N1940). Antitumor agent-173 is a substrate for OATP2B1. Antitumor agent-173 selectively inhibits the growth of tumor Antitumor agent-173 significantly increases the oral bioavailability of Cycloicaritin and exerts good antitumor activity and safety .

HY-120523

UBP646	iGluR	Neurological Disease
UBP646 is a potent GluN1/GluN2D receptors potentiator, and also potentiates the other three subtypes, GluN1/GluN2A, GluN1/GluN2B, and GluN1/GluN2C receptors .

HY-161750

PROTAC ALK degrader-2	PROTACs Anaplastic lymphoma kinase (ALK)	Cancer
PROTAC ALK degrader-2 (B1-PEG) is an ALK degrader based on PROTACs, with the DC₅₀ of 45 nM in H3122 EML4-ALK DC50 (GSH+). PROTAC ALK degrader-2, through PEGylation, is engineered to self-organize into micelles in water and releases its active form in response to the tumor-specific high GSH environment .

HY-B1717

Oxolamine	Cytochrome P450	Inflammation/Immunology
Oxolamine (SKF-9976) is an orally active antitussive. Oxolamine can inhibit *CYP2B1/2*. Oxolamine has anti-inflammatory effects on the respiratory organs of guinea pigs. Oxolamine increases the AUC of Warfarin (HY-B0687) and prolongs its terminal half-life. Oxolamine can be used in respiratory disease research .

HY-172884

MDAR-IN-1	Cholinesterase (ChE) iGluR	Neurological Disease
MDAR IN-1 (Compound 5m) is a brain-penetrant inhibitor of acetylcholinesterase (AChE) and antagonist of the GluN1/GluN2B subtype of NMDAR receptor. MDAR IN-1 effectively inhibits AChE activity, enhances cholinergic neurotransmission, and blocks NMDAR, reducing excitatory neurotoxicity. MDAR IN-1 is promising for research of Alzheimer's disease .

HY-169907

Anticancer agent 258	Nuclear Hormone Receptor 4A/NR4A	Neurological Disease Metabolic Disease Cancer
Anticancer agent 258 is an imidazo [1,2-B][1,2,4] triazol derivative. Anticancer agent 258 regulates the activity of nuclear receptors. Anticancer agent 258 has an EC₅₀ of 63 nM against Nurr in N2A cells. Anticancer agent 258 has IC₅₀ of 0.1 pM for Nur77 in HEK293 cells. Anticancer agent 258 can be used in the study of cancer, metabolic diseases and neurological disorders .

HY-155735

AChE/Aβ-IN-2	iGluR Cholinesterase (ChE) Amyloid-β	Neurological Disease
AChE/Aβ-IN-2 (compound 33) is a potent and orally active inhibitor of acetylcholinesterase (AChE) with IC₅₀ of 135 nM, as well as an antagonist of NMDA receptor (GluN1-1b/GluN2B subunit combination) with IC₅₀ of 5.054 μM. AChE/Aβ-IN-2 also inhibits Aβ aggregation and shows good blood-brain barrier permeability. AChE/Aβ-IN-2 improves cognitive and spatial memory impairment in rats model .

HY-155733

AChE/Aβ-IN-1	iGluR Cholinesterase (ChE) Amyloid-β	Neurological Disease
AChE/Aβ-IN-1 (compound 32) is a potent and orally active inhibitor of acetylcholinesterase (AChE) with an IC₅₀ of 86 nM, as well as an antagonist of NMDA receptor (GluN1-1b/GluN2B subunit combination) with IC₅₀ of 3.876 μM. AChE/Aβ-IN-1 also inhibits Aβ aggregation and shows good blood-brain barrier permeability and neuroprotection. AChE/Aβ-IN-1 improves cognitive and spatial memory impairment in rats model .

HY-172213

(3S,6R)-NML	iGluR	Neurological Disease
(3S,6R)-NML is a NMDA receptor antagonist, with pIC50s of 4.8 (GluN1-GluN2A), 4.6 (GluN1-GluN2B), 5.0 (GluN1-GluN2C), 5.0 (GluN1-GluN2D) respectively. (3S,6R)-NML can be used for depression research .

HY-B1404R

Nylidrin hydrochloride (Standard) Buphenine hydrochloride (Standard)	Reference Standards iGluR Influenza Virus	Infection Cardiovascular Disease Inflammation/Immunology
Nylidrin (hydrochloride) (Standard) is the analytical standard of Nylidrin hydrochloride (HY-B1404). This product is intended for research and analytical applications. Nylidrin hydrochloride (Buphenine hydrochloride) is an orally active β-adrenergic agonist. Nylidrin hydrochloride antagonizes NR1_A/2B NMDA receptors (IC₅₀ = 0.18 μM in Xenopus oocytes). Nylidrin hydrochloride reduces the levels of NP, HA, and M1. Nylidrin hydrochloride has antiviral activity against multiple H1N1 subtype influenza A viruses. Nylidrin hydrochloride improves hemorrhagic shock and anti-allergic effects .

HY-12882AR

Ifenprodil tartrate (Standard) NP-120 tartrate (Standard); RC-61-91 tartrate (Standard)	iGluR Potassium Channel Reference Standards	Neurological Disease
Ifenprodil (tartrate) (Standard) is the analytical standard of Ifenprodil (tartrate). This product is intended for research and analytical applications. Ifenprodil tartrate is a typical noncompetitive NMDA receptor antagonist. Ifenprodil tartrate exerts high affinity at NR1A/NR2B receptors (IC50=0.34 μM) over 400-fold than at NR1A/NR2A receptors (IC50=146 μM) . Ifenprodil tartrate inhibits GIRK (Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil tartrate has the potential to be a cerebral vasodilator .

HY-105353

CEB-1604	iGluR	Neurological Disease
CEB-1604 is an NMDA receptor antagonist. CEB-1604 inhibits NMDA-induced currents in oocytes transfected with NMDA receptor isoforms (NR1/NR2A, NR1/NR2B, NR1/NR2C, NR1/NR2D) with IC₅₀ values ranging from 5 to 12 μM. CEB-1604 abolishes NMDA-dependent epileptiform discharges in rat cortical wedge preparations and reduces the depolarizing effects of NMDA. CEB-1604 can be used in the research field of neurological damage diseases .

HY-RS20524

Atp2b1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Atp2b1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Atp2b1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Atp2b1 Mouse Pre-designed siRNA Set A Atp2b1 Mouse Pre-designed siRNA Set A

HY-RS26050

Sult2b1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Sult2b1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Sult2b1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Sult2b1 Rat Pre-designed siRNA Set A Sult2b1 Rat Pre-designed siRNA Set A

HY-RS27033

Atp2b1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Atp2b1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Atp2b1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Atp2b1 Rat Pre-designed siRNA Set A Atp2b1 Rat Pre-designed siRNA Set A

Cat. No.	Product Name	Target	Research Area

HY-182539

DD04107	CGRP Receptor	Others Neurological Disease
DD04107 is a neuronal exocytosis inhibitor with a rat *Syt1-C2B* domain binding K_a of 2.4 μM. DD04107 interferes with synaptobrevin-syntaxin-SNAP-25 complex formation and Syt1-SNARE complex interaction to block α-calcitonin gene-related peptide (α-CGRP) exocytotic release from primary sensory neurons. DD04107 blocks inflammatory ion channel recruitment to nociceptor plasma membranes. DD04107 can be used for the research of chronic inflammatory pain, neuropathic pain, osteosarcoma pain, chemotherapy-induced peripheral neuropathy, diabetic neuropathy, inflammatory pain .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N3513

Mulberrin 5+ Cited Publications Kuwanon C	Cardiovascular Disease Flavonoids other families Classification of Application Fields Flavones Phenols Polyphenols Plants Disease Research Fields Source Classification	OAT
Mulberrin is a strong inhibitor of organic anion-transporting polypeptide 2B1 (OATP2B1)-mediated estrone-3-sulfate (E3S) uptake with an IC₅₀ value being 1.8?±1.5 μM.

HY-12882A

Ifenprodil tartrate 5+ Cited Publications NP-120 tartrate; RC-61-91 tartrate	Alkaloids Piperidine Alkaloids Neurological Disease Classification of Application Fields Crassulaceae Sedum sarmentosum Bunge Plants Disease Research Fields Source Classification	iGluR Adrenergic Receptor Potassium Channel Calcium Channel Influenza Virus
Ifenprodil (NP-120) tartrate, a cerebral vasodilator, is a noncompetitive NMDA receptor antagonist. Ifenprodil tartrate exerts high affinity at NR1A/NR2B receptors (IC₅₀=0.34 μM) over 400-fold than at NR1A/NR2A receptors (IC₅₀=146 μM) . Ifenprodil tartrate is an α1 adrenergic receptor antagonist. Ifenprodil tartrate inhibits GIRK (Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil tartrate has reliable inhibitory effects against A/H1N1 strains (EC₅₀ of 6.6 µM). Ifenprodil tartrate has neuroprotective, anticonvulsant and antinociceptive effects. Ifenprodil tartrate can be used for the study of cerebrovascular diseases and peripheral arterial obliterative disease .

HY-126848

Diclofenac acyl glucuronide D-1-O-G	Structural Classification Alkaloids Classification of Application Fields Other Alkaloids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Drug Metabolite SOD COX Reactive Oxygen Species (ROS) OAT
Diclofenac acyl glucuronide (D-1-O-G) is an orally active glucuronide metabolite of Diclofenac (HY-15036). Diclofenac acyl glucuronide exhibits SOD inhibitory activity, COX-1 inhibitory activity (IC₅₀ = 0.620 μM), and COX-2 inhibitory activity (IC₅₀ = 2.91 μM). Diclofenac acyl glucuronide induces reactive oxygen species (ROS) production and acts as a substrate of *OATP2B1*. Diclofenac acyl glucuronide induces small intestinal ulcers . Diclofenac acyl glucuronide can be used in research related to intestinal diseases and small intestinal ulcers .

HY-N13009

MO-2097	Phenols Polyphenols Morus alba L. Plants Moraceae Source Classification	Raf HIF/HIF Prolyl-Hydroxylase ERK MEK Reactive Oxygen Species (ROS) Apoptosis Caspase
MO-2097 is a RAF-1/HIF-1α inhibitor. MO-2097 induces RAF-1 destabilization, leading to a reduction in EMT-associated transcription factors and mesenchymal markers. MO-2097 inhibits HIF-1a protein expression mediated by hnRNPA2B1 under hypoxic and mimetic hypoxia. MO-2097 induces mitochondrial ROS, which leads to apoptosis in cells. MO-2097 effectively suppresses colorectal cancer metastasis by inhibiting the RAF/MEK/ERK signaling pathway. MO-2097 attenuates tumor growth in a xenograft HCT116 cell mouse model. MO-2097 can be used for the study of colorectal cancer .

HY-N3513R

Mulberrin (Standard) Kuwanon C (Standard)	Structural Classification Flavonoids other families Flavones Phenols Polyphenols Plants Source Classification	Reference Standards Others
Mulberrin (Standard) is the analytical standard of Mulberrin. This product is intended for research and analytical applications. Mulberrin is a strong inhibitor of organic anion-transporting polypeptide 2B1 (OATP2B1)-mediated estrone-3-sulfate (E3S) uptake with an IC₅₀ value being 1.8 ±1.5 μM.

HY-12882AR

Ifenprodil tartrate (Standard) NP-120 tartrate (Standard); RC-61-91 tartrate (Standard)	Alkaloids Piperidine Alkaloids Crassulaceae Sedum sarmentosum Bunge Plants Source Classification	iGluR Potassium Channel Reference Standards
Ifenprodil (tartrate) (Standard) is the analytical standard of Ifenprodil (tartrate). This product is intended for research and analytical applications. Ifenprodil tartrate is a typical noncompetitive NMDA receptor antagonist. Ifenprodil tartrate exerts high affinity at NR1A/NR2B receptors (IC50=0.34 μM) over 400-fold than at NR1A/NR2A receptors (IC50=146 μM) . Ifenprodil tartrate inhibits GIRK (Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil tartrate has the potential to be a cerebral vasodilator .

Species:	Human (5) Mouse (1) Xenopus laevis (1)
Tag:	SUMO (1) His (5) Tag Free (1) Myc (1) GST (1) B2M (1)
Source:	E. coli (7)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P76666

	SULT2B1 Protein, Human (His) 1 Publications Verification ST2B1; Sulfotransferase 2B1; Alcohol Sulfotransferase; HSST2	Human	E. coli
	The SULT2B1 protein uses PAPS to catalyze sulfate conjugation, mainly sulfating cholesterol, and shows significant activity on steroids such as pregnenolone and DHEA. It plays a crucial role in epidermal cholesterol metabolism, regulating epidermal proliferation and differentiation. SULT2B1 Protein, Human (His) is the recombinant human-derived SULT2B1 protein, expressed by E. coli , with N-His labeled tag.

HY-P71011A

	SULT2B1 Protein, Human (311a.a, C-His) Sulfotransferase Family Cytosolic 2B Member 1; ST2B1; Sulfotransferase 2B1; Alcohol Sulfotransferase; Hydroxysteroid Sulfotransferase 2; SULT2B1; HSST2	Human	E. coli
	The SULT2B1 protein uses PAPS to catalyze sulfate conjugation, mainly sulfating cholesterol, and shows significant activity on steroids such as pregnenolone and DHEA.It plays a crucial role in epidermal cholesterol metabolism, regulating epidermal proliferation and differentiation.SULT2B1 Protein, Human (C-His) is the recombinant human-derived SULT2B1 protein, expressed by E.coli , with C-6*His labeled tag.

HY-P72231

	HNRNPA2B1 Protein, Human (GST) Hnrnpa2B1; Hnrpa2B1; Heterogeneous nuclear ribonucleoproteins A2/B1; hnRNP A2/B1	Human	E. coli
	Heterogeneous nuclear ribonucleoproteins A2/B1 is an important RNA-binding protein that affects the RNA processing, splicing, transport and stability of many genes. Heterogeneous nuclear ribonucleoproteins A2/B1 is expressed during proliferation and metastasis of various cancer types and promotes such processes. HNRNPA2B1 Protein, Human (GST) is the recombinant human-derived HNRNPA2B1 protein, expressed by E. coli , with N-GST labeled tag.

HY-P705534

	HNRNPA2B1 Protein, Human (His) Hnrnpa2B1; Hnrpa2B1; Heterogeneous nuclear ribonucleoproteins A2/B1; hnRNP A2/B1	Human	E. coli
	Heterogeneous nuclear ribonucleoproteins A2/B1 is an important RNA-binding protein that affects the RNA processing, splicing, transport and stability of many genes. Heterogeneous nuclear ribonucleoproteins A2/B1 is expressed during proliferation and metastasis of various cancer types and promotes such processes. HNRNPA2B1 Protein, Human (His) is the recombinant human-derived HNRNPA2B1 protein, expressed by E. coli , with N-10*His labeled tag.

HY-P72232

	HNRNPA2B1 Protein, Mouse (His-SUMO, Myc) Hnrnpa2B1; Hnrpa2B1; Heterogeneous nuclear ribonucleoproteins A2/B1; hnRNP A2/B1	Mouse	E. coli
	The HNRNPA2B1 protein is an important heterogeneous nuclear ribonucleoprotein (hnRNP) that plays a key role in RNA processing and transport. It forms hnRNP particles that compact and stabilize transcripts to influence various cellular functions, including transcription, mRNA processing, nuclear export, localization, translation, and mRNA stability. HNRNPA2B1 Protein, Mouse (His-SUMO) is the recombinant mouse-derived HNRNPA2B1 protein, expressed by E. coli , with N-10*His, N-SUMO, C-Myc labeled tag.

HY-P72230

	HNRNPA2B1 Protein, Human (His-B2M) Hnrnpa2B1; Hnrpa2B1; Heterogeneous nuclear ribonucleoproteins A2/B1; hnRNP A2/B1	Human	E. coli
	Heterogeneous nuclear ribonucleoproteins A2/B1 is an important RNA-binding protein that affects the RNA processing, splicing, transport and stability of many genes. Heterogeneous nuclear ribonucleoproteins A2/B1 is expressed during proliferation and metastasis of various cancer types and promotes such processes. HNRNPA2B1 Protein, Human (His-B2M) is the recombinant human-derived HNRNPA2B1 protein, expressed by E. coli , with N-6*His, B2M labeled tag.

HY-P72331

	Histone H2B 1.1 Protein, Xenopus laevis H2B1.1	Xenopus laevis	E. coli
	Histone H2B 1.1 protein is a key nucleosome component that compacts DNA into chromatin, thereby restricting access to cellular processes. Histone H2B 1.1 Protein, Xenopus laevis is the recombinant Xenopus laevis-derived Histone H2B 1.1 protein, expressed by E. coli , with tag free.

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Cat. No.	Product Name	Chemical Structure

HY-B0822S1

Fipronil-13C6

Fipronil- ¹³C₆ is the ¹³C-labeled Fipronil. Fipronil is an insecticide that acts as a selective antagonist of insect GABA receptors (IC50s = 30 nM and 1,600 nM for cockroach and rat receptors, respectively). Fipronil also inhibits desensitizing and non-desensitizing glutamate-induced chloride currents in cockroach neurons (IC50s = 800 nM and 10 nM, respectively). Fipronil induces activity of the cytochrome P450 (CYP) isoforms CYP1A1/2, CYP2B1/2, and CYP3A1/2 in isolated rat liver microsomes.

Host:	Mouse (12) Rabbit (5)
Reactivity:	Human (17) Rat (16) Mouse (14)
Application:	IHC-P (13) ICC/IF (6) IF-Tissue (1) IP (1) WB (13) ChIP (1) FC (4) ELISA (4)
Isotype:	IgG1, k (1) IgG (5) IgG1 (10)
Conjugation:	Non-conjugated (17)
Clonality:	Monoclonal (8) Monoclonal Antibody (2) Recombinant (4)
Modification:	Unmodified (10)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P87473

	SULT2B1 Antibody (YA7160)	WB	Human
	SULT2B1 Antibody (YA7160) is a Mouse-derived and non-conjugated IgG1, Kappa monoclonal antibody, targeting to SULT2B1.

HY-P81931

	PMCA1 Antibody (YA1676) ATP2B1; PMCA1	WB, IHC-P	Human, Mouse, Rat
	PMCA1 Antibody (YA1676) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PMCA1.

HY-P81931A

	PMCA1 Antibody (YA1676)(PBS only) ATP2B1; PMCA1	WB, IHC-P	Human, Mouse, Rat
	PMCA1 Antibody (YA1676) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to PMCA1.

HY-P87162

	hnRNP A2B1 Antibody (YA6855) Heterogeneous nuclear ribonucleoprotein A2 antibody; Heterogeneous nuclear ribonucleoprotein A2/B1 antibody; Heterogeneous nuclear ribonucleoprotein B1 antibody; Heterogeneous nuclear ribonucleoproteins A2/B1 antibody; hnRNP A2 / hnRNP B1 antibody; hnRNP A2 antibody; hnRNP A2/B1 antibody; hnRNP B1 antibody; hnRNP-A2 antibody; hnRNP-B1 antibody; Heterogeneous nuclear ribonucleoprotein A2 antibody; Heterogeneous nuclear ribonucleoprotein A2/B1 antibody; Heterogeneous nuclear ribonucleoprotein B1 antibody; Heterogeneous nuclear ribonucleoproteins A2/B1 antibody; hnRNP A2 / hnRNP B1 antibody; hnRNP A2 antibody; hnRNP A2/B1 antibody; hnRNP B1 antibody; hnRNP-A2 antibody; hnRNP-B1 antibody; hnRNPA2 antibody; Hnrnpa2B1 antibody; hnRNPB1 antibody; HNRPA2 antibody; HNRPA2B1 antibody; HNRPB1 antibody; Nuclear ribonucleoprotein particle A2 protein antibody; RNP A2 antibody; RNP B1 antibody; RNP-A2 antibody; RNP-B1 antibody; RNPA2 antibody; RNPB1 antibody; ROA2_HUMAN antibody; SNRPB1 antibody;	WB, IHC-P, ICC/IF, FC, IF-Tissue	Human, Mouse, Rat
	hnRNP A2B1 Antibody (YA6855) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to hnRNP A2B1.

HY-P84077

	BMP-4 Antibody (YA3774) ZYME; BMP2B; OFC11; BMP2B1; MCOPS6	WB, ICC/IF, FC, ELISA	Human, Rat
	BMP-4 Antibody (YA3774) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to BMP-4.

HY-P84077A

	BMP-4 Antibody (YA3774)(PBS only) ZYME; BMP2B; OFC11; BMP2B1; MCOPS6	WB, ICC/IF, FC, ELISA	Human, Rat
	BMP-4 Antibody (YA3774) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to BMP-4.

HY-P810678

	Acetyl-Histone H2B (Lys20) Antibody (YA9936) GL105; H2B GL105; H2B histone family member O; H2B histone family member S; H2B.1; H2B.1 B; H2B.b; H2B.c; H2B.d; H2B.e	WB, IHC-P, ICC/IF, ChIP	Human, Mouse, Rat
	Acetyl-Histone H2B (Lys20) Antibody (YA9936) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Acetyl-Histone H2B (Lys20).

HY-P88454

	HIST1H2BA Antibody (YA8138) bA317E16.3; H2BFU; STBP; TH2B; TSH2B; TSH2B.1	IHC-P	Human, Mouse, Rat
	HIST1H2BA Antibody (YA8138) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HIST1H2BA.

HY-P88454A

	HIST1H2BA Antibody (YA8138)(PBS only) bA317E16.3; H2BFU; STBP; TH2B; TSH2B; TSH2B.1	IHC-P	Human, Mouse, Rat
	HIST1H2BA Antibody (YA8138) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to HIST1H2BA.

HY-P83922

	Lamin A Antibody (YA3619) FPL; IDC; LFP; CDDC; EMD2; FPLD; HGPS; LDP1; LMN1; LMNC; PRO1; CDCD1; CMD1A; FPLD2; LMNL1; CMT2B1	WB, IHC-P, ELISA	Human, Mouse, Rat
	Lamin A Antibody (YA3619) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Lamin A.

HY-P83922A

	Lamin A Antibody (YA3619)(PBS only) FPL; IDC; LFP; CDDC; EMD2; FPLD; HGPS; LDP1; LMN1; LMNC; PRO1; CDCD1; CMD1A; FPLD2; LMNL1; CMT2B1	WB, IHC-P, ELISA	Human, Mouse, Rat
	Lamin A Antibody (YA3619) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Lamin A.

HY-P85684

	Histone H2B Antibody (YA5376) HIST1H2BB; H2BFF; Histone H2B type 1-B; Histone H2B.1; Histone H2B.f; H2B/f	WB, ICC/IF	Human, Mouse, Rat
	Histone H2B Antibody (YA5376) is a Mouse-derived and non-conjugated monoclonal antibody, targeting to Histone H2B.

HY-P88306

	GABPB1 Antibody (YA7990) BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4TF1B; GABPB; GABPB-1; GABPB2; NRF2B1; NRF2B2	IHC-P	Human, Mouse, Rat
	GABPB1 Antibody (YA7990) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GABPB1.

HY-P810665

	Phospho-Lamin A + Lamin C (Ser22) Antibody (YA9925) FPL; IDC; LFP; CDDC; EMD2; FPLD; HGPS; LDP1; LMN1; LMNC; PRO1; CDCD1; CMD1A; FPLD2; LMNL1; CMT2B1	WB, IHC-P	Human, Mouse, Rat
	Phospho-Lamin A + Lamin C (Ser22) Antibody (YA9925) is a Rabbit-derived and non-conjugated IgG Recombinant, Monoclonal antibody, targeting to Phospho-Lamin A + Lamin C (Ser22).

HY-P88306A

	GABPB1 Antibody (YA7990)(PBS only) BABPB2; E4TF1; E4TF1-47; E4TF1-53; E4TF1B; GABPB; GABPB-1; GABPB2; NRF2B1; NRF2B2	IHC-P	Human, Mouse, Rat
	GABPB1 Antibody (YA7990) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to GABPB1.

HY-P80706

	Histone H2B Antibody (YA737) H2BK5ac; H2B 1A; H2B; H2B histone family; H2B2f; H2Ba; H2Bf; HIST2H2BF; histone H2B; histone H2B type 1; Histone H2B type 2-F	WB, IHC-P	Human, Mouse, Rat
	Histone H2B Antibody (YA737) is a Mouse-derived and non-conjugated IgG1 monoclonal antibody, targeting to Histone H2B.

HY-P80163

	Histone H2B Antibody (YA378) H2B GL105 antibody; H2B histone family member O antibody; H2B histone family member S antibody; H2B.1 antibody; H2B.1 B antibody; H2B.b antibody; H2B.c antibody; H2B.d antibody; H2B.e antibody; H2B.f antibody; H2B.j antibody; H2B.q antibody; H2B/b antibody; H2B/c antibody; H2B/d antibody; H2B/e antibody; H2B/f antibody; H2B/j antibody; H2B/o antibody; H2B/q antibody; H2BFB antibody; H2BFC antibody; H2BFD antibody; H2BFE antibody; H2BFF antibody; H2BFJ antibody; H2BFO antibody; H2BFQ antibody; H2BFS antibody; HIRIP2 antibody; HIST1H2BB antibody; HIST1H2BD antibody; HIST1H2BH antibody; HIST1H2BL antibody; HIST1H2BM antibody; HIST1H2BN antibody; HIST2H2BE antibody; Histone H2B antibody; Histone H2B type 1 B antibody; Histone H2B type 1 D antibody; Histone H2B type 1 H antibody; Histone H2B type 1 L antibody; Histone H2B type 1 M antibody; Histone H2B type 1 N antibody; Histone H2B type 2 E antibody; histone protein antibody	WB, ICC/IF, IHC-P, IP, FC	Human, Mouse, Rat
	Histone H2B Antibody (YA378) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to Histone H2B.