1. Flavonoids
  2. Mulberrin

Mulberrin (Synonyms: Kuwanon C)

Cat. No.: HY-N3513 Purity: 99.53%
Handling Instructions

Mulberrin is a strong inhibitor of organic anion-transporting polypeptide 2B1 (OATP2B1)-mediated estrone-3-sulfate (E3S) uptake with an IC50 value being 1.8 ±1.5 μM.

For research use only. We do not sell to patients.

Mulberrin Chemical Structure

Mulberrin Chemical Structure

CAS No. : 62949-79-5

Size Price Stock Quantity
5 mg USD 190 In-stock
Estimated Time of Arrival: December 31
10 mg USD 310 In-stock
Estimated Time of Arrival: December 31
25 mg USD 660 In-stock
Estimated Time of Arrival: December 31
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Based on 1 publication(s) in Google Scholar

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Description

Mulberrin is a strong inhibitor of organic anion-transporting polypeptide 2B1 (OATP2B1)-mediated estrone-3-sulfate (E3S) uptake with an IC50 value being 1.8 ±1.5 μM.

In Vitro

Mulberrin is a flavone with two isopentenyl groups at positions 3 and 8. Mulberrin is a strong inhibitor of OATP2B1 with more than 80% inhibition.Mulberrin also inhibits organic anion-transporting polypeptide (OATP)-mediated uptake of Atorvastatin, Fluvastatin, and Rosuvastatin[1].

Molecular Weight

422.47

Formula

C₂₅H₂₆O₆

CAS No.

62949-79-5

SMILES

C/C(C)=C\CC1=C2C(C(C(C/C=C(C)\C)=C(C3=C(C=C(O)C=C3)O)O2)=O)=C(O)C=C1O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
  4°C 2 years
In solvent -80°C 6 months
  -20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (236.70 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3670 mL 11.8352 mL 23.6703 mL
5 mM 0.4734 mL 2.3670 mL 4.7341 mL
10 mM 0.2367 mL 1.1835 mL 2.3670 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: ≥ 1.67 mg/mL (3.95 mM); Clear solution

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: ≥ 1.67 mg/mL (3.95 mM); Clear solution

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 1.67 mg/mL (3.95 mM); Clear solution

*All of the co-solvents are provided by MCE.
References
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Keywords:

MulberrinKuwanon COthersInhibitorinhibitorinhibit

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Mulberrin
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HY-N3513
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