23210-56-2
Chemical Structure
Ifenprodil
Synonym(s): NP-120; RC-61-91
- CAS No.: 23210-56-2
- Formula:C21H27NO2
- Molecular Weight:325.44
IUPAC Name: 4-(2-(4-benzylpiperidin-1-yl)-1-hydroxypropyl)phenol
InChIKey: UYNVMODNBIQBMV-UHFFFAOYSA-N
SMILES: OC(C1=CC=C(O)C=C1)C(C)N(CC2)CCC2CC3=CC=CC=C3
Biological Activity: Ifenprodil (NP-120), a cerebral vasodilator, is a noncompetitive NMDA receptor antagonist. Ifenprodil exerts high affinity at NR1A/NR2B receptors (IC50=0.34 μM) over 400-fold than at NR1A/NR2A receptors (IC50=146 μM)[1]. Ifenprodil is an α1 adrenergic receptor antagonist. Ifenprodil inhibits GIRK (Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil has reliable inhibitory effects against A/H1N1 strains (EC50 of 6.6 µM). Ifenprodil has neuroprotective, anticonvulsant and antinociceptive effects. Ifenprodil can be used for the study of cerebrovascular diseases and peripheral arterial obliterative disease[2][4].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Ifenprodil | 99.94% | Ifenprodil (NP-120), a cerebral vasodilator, is a noncompetitive NMDA receptor antagonist. Ifenprodil exerts high affinity at NR1A/NR2B receptors (IC50=0.34 μM) over 400-fold than at NR1A/NR2A receptors (IC50=146 μM). Ifenprodil is an α1 adrenergic receptor antagonist. Ifenprodil inhibits GIRK (Kir3), reduces inward currents through the basal GIRK activity. Ifenprodil has reliable inhibitory effects against A/H1N1 strains (EC50 of 6.6 µM). Ifenprodil has neuroprotective, anticonvulsant and antinociceptive effects. Ifenprodil can be used for the study of cerebrovascular diseases and peripheral arterial obliterative disease. | ||||||||||||||||||||
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Similarity Score 0.80
HY-13993Ro 25-6981 -
Similarity Score 0.79
HY-13993BRo 25-6981 hydrochloride -
Similarity Score 0.78
HY-W018061C(R,R)-Traxoprodil -
Similarity Score 0.78
HY-W018061RTraxoprodil (Standard) -
Similarity Score 0.73
HY-122425Nylidrin -
Similarity Score 0.72
HY-B1404RNylidrin hydrochloride (Standard) -
Similarity Score 0.70
HY-12881Eliprodil -
Similarity Score 0.70
HY-13993ARo 25-6981 Maleate -
Similarity Score 0.69
HY-149803AS1R agonist 1 hydrochloride -
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References
- [1]. Williams K, et al. Ifenprodil discriminates subtypes of the N-methyl-D-aspartate receptor: selectivity and mechanisms at recombinant heteromeric receptors. Mol Pharmacol. 1993 Oct;44(4):851-9. [Content Brief]
- [2]. Kobayashi T, et al. Inhibition of G protein-activated inwardly rectifying K+ channels by ifenprodil. Neuropsychopharmacology. 2006 Mar;31(3):516-24. [Content Brief]
- [4]. Jang Y, et al. In Vitro and In Vivo Antiviral Activity of Nylidrin by Targeting the Hemagglutinin 2-Mediated Membrane Fusion of Influenza A Virus. Viruses. 2020 May 25;12(5):581. [Content Brief]
