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Results for "

ACAT Inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (86) Apoptosis (6) Calcium Channel (1) Caspase (1) Drug Derivative (2) Endogenous Metabolite (3) Environmental Pollutants (1) ERK (6) Fatty Acid Synthase (FASN) (1) Fungal (1) Interleukin Related (1) Isotope-Labeled Compounds (4) Keap1-Nrf2 (1) NF-κB (3) Parasite (1) Phosphatase (1) Phytohormone (1) PPAR (1) Reference Standards (8)
By Research Areas:	Cancer (13) Cardiovascular Disease (24) Endocrinology (2) Infection (16) Inflammation/Immunology (16) Metabolic Disease (33) Neurological Disease (2)

Inhibitors & Agonists

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13215

Avasimibe Maximum Cited Publications 17 Publications Verification CI-1011; PD-148515	Acyltransferase	Cancer
Avasimibe (CI-1011; PD-148515) is an orally active acyl coenzyme A-cholesterol acyltransferase (ACAT; also called SOAT)) inhibitor with IC₅₀s of 24 and 9.2 µM for *ACAT1* and *ACAT2*, respectively . Avasimibe can be used for the research of prostate cancer .

HY-100400A

K-604 dihydrochloride 5+ Cited Publications	Acyltransferase	Cardiovascular Disease
K-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT-1) inhibitor with an IC₅₀ of 0.45±0.06 μM.

HY-N4193

Glabrol 3 Publications Verification	Acyltransferase	Cardiovascular Disease
Glabrol (Compound 1), One isoprenyl flavonoid was isolated from ethanol extract of licorice roots, is a potent and non-competitive Acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor with an IC₅₀ value of 24.6 μM for rat liver microsomal ACAT activity .

HY-111880

γ-Sanshool	Acyltransferase	Cardiovascular Disease
γ-Sanshool can be isolated from Zanthoxylum piperitum. γ-Sanshool inhibits human *ACAT-1* and *ACAT-2* activities with IC₅₀s of 12.0 and 82.6 μM .

HY-100399

Nevanimibe 3 Publications Verification PD-132301; ATR-101	Acyltransferase Apoptosis	Cancer
Nevanimibe (PD-132301) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC₅₀ of 9 nM. Nevanimibe inhibits ACAT2 with an EC₅₀ of 368 nM. Nevanimibe induces cell apoptosis and has the potential for adrenocortical cancer .

HY-100399A

Nevanimibe hydrochloride 3 Publications Verification PD-132301 hydrochloride; ATR101 hydrochloride	Acyltransferase Apoptosis	Cancer
Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC₅₀ of 9 nM. Nevanimibe hydrochloride inhibits ACAT2 with an EC₅₀ of 368 nM. Nevanimibe hydrochloride induces cell apoptosis and has the potential for adrenocortical cancer .

HY-112487

Sandoz 58-035	Acyltransferase	Endocrinology
Sandoz 58-035 is a competitive inhibitor of cholesterol acyltransferase (ACAT). Sandoz 58-035 effectively inhibits (>98%) hormonally stimulated cholesterol esterification in cells .

HY-117832

Pyripyropene A 1 Publications Verification	Acyltransferase	Infection Cardiovascular Disease Inflammation/Immunology
Pyripyropene A is an orally active, potent and selective sterol O-acyltransferase 2 (SOAT2)/acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) inhibitor, with an IC₅₀ of 0.07 µM. Pyripyropene A attenuates hypercholesterolemia and atherosclerosis in vivo .

HY-107572

PD 128042 CI 976	Acyltransferase	Metabolic Disease
PD 128042 (CI 976) is a potent, orally active, and selective inhibitor of *ACAT* (acyl coenzyme A:cholesterol acyltransferase) with an IC₅₀s of 73 nM. PD 128042 is also a potent LPAT (lysophospholipid acyltransferase) inhibitor. PD 128042 inhibits Golgi-associated LPAT activity (IC₅₀=15 μM). PD 128042 inhibits multiple membrane trafficking steps, including ones found in the endocytic and secretory pathway .

HY-105445

CP-113818 2 Publications Verification	Acyltransferase	Neurological Disease
CP-113818 is a potent cholesterol acyltransferase (ACAT) inhibitor. CP-113818 can be used for the research of Alzheimer's disease .

HY-100401

Pactimibe CS-505 free base	Acyltransferase	Cardiovascular Disease
Pactimibe (CS-505 free base) is a dual *ACAT1/2* inhibitor with IC₅₀s of 4.9 μM and 3.0 μM, respectively. Pactimibe (CS-505 free base) inhibits *ACAT* with IC₅₀s of 2.0 μM, 2.7 μM, 4.7 μM in the liver, macrophages and THP-1 cells, respectively . Pactimibe (CS-505 free base) noncompetitively inhibits oleoyl-CoA with a K_i value of 5.6 μM. Moreover, Pactimibe (CS-505 free base) obviously inhibits cholesteryl ester formation with an IC₅₀ of 6.7 μM. Pactimibe (CS-505 free base) possesses anti-atherosclerotic potential with lowering plasma cholesterol activity .

HY-N3807

Enniatin B1 1 Publications Verification	Acyltransferase ERK NF-κB	Infection Cardiovascular Disease Cancer
Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ of 73 μM in an enzyme assay using rat liver microsomes . Enniatin B1 crosss the blood-brain barrier . Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation .

HY-107396

YM-750	Acyltransferase	Cardiovascular Disease
YM-750 is a potent acyl-CoA:cholesterol acyltransferase *(ACAT)* inhibitor (IC₅₀=0.18 μM). ACAT catalyzes the formation of cholesteryl esters from cholesterol and long-chain fatty-acyl-coenzyme A .

HY-16437

RP-64477	Acyltransferase	Cardiovascular Disease
RP-64477 is a potent inhibitor of the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT).

HY-100401A

Pactimibe sulfate CS-505	Acyltransferase	Cardiovascular Disease
Pactimibe sulfate (CS-505) is a dual *ACAT1/2* inhibitor with IC₅₀s of 4.9 μM and 3.0 μM, respectively. Pactimibe sulfate (CS-505) inhibits *ACAT* with IC₅₀s of 2.0 μM, 2.7 μM, 4.7 μM in the liver, macrophages and THP-1 cells, respectively . Pactimibe sulfate (CS-505) noncompetitively inhibits oleoyl-CoA with a K_i value of 5.6 μM. Moreover, Pactimibe sulfate (CS-505) obviously inhibits cholesteryl ester formation with an IC₅₀ of 6.7 μM. Pactimibe sulfate (CS-505) possesses anti-atherosclerotic potential with lowering plasma cholesterol activity .

HY-121254

GERI-BP002-A	Environmental Pollutants Acyltransferase	Cancer
GERI-BP002-A is an inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT) produced by Aspergillus fumigatus F93, which can be used in cancer research .

HY-N10788

Pomonic acid	Acyltransferase	Inflammation/Immunology
Pomonic acid is an acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor. Pomonic acid reduces the esterification of free cholesterol to cholesteryl esters and the accumulation of intracellular cholesteryl esters. Pomonic acid can be used in the research of atherosclerosis .

HY-N3806

Enniatin B	Acyltransferase ERK	Infection Cardiovascular Disease Cancer
Enniatin B is a Fusarium mycotoxin. Enniatin B inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ of 113 μM in an enzyme assay using rat liver microsomes . Enniatins B decreases the activation of ERK (p44/p42) .

HY-19286

Eflucimibe F 12511	Acyltransferase	Cancer
Eflucimibe (F 12511) is a new acyl-coenzyme A cholesterol O-acyltransferase (ACAT) inhibitor. Eflucimibe can be used in the research of atherosclerosis .

HY-169813

Yakuchinone B	Acyltransferase	Cardiovascular Disease
Yakuchinone B is an Acyl-CoA: cholesterol O-acyltransferase (ACAT) inhibitor with hypocholesterolemic activity, which is found in the seeds of Zingiberaceae. Yakuchinone B inhibits rat hepatic *ACAT* with an IC₅₀ value of 20.6 μM. Yakuchinone B is promising for research of hypercholesterolemia and atherosclerosis .

HY-124064

TMP-153	Acyltransferase	Metabolic Disease
TMP-153 is an orally active inhibitor of *ACAT* with an IC₅₀ value of approximately 5-10 nM against hepatic and intestinal *ACAT* in varicose animals. TMP-153 exhibits cholesterol-lowering effects and can be utilized in the research of atherosclerosis .

HY-N10224

Terpendole C	Acyltransferase	Metabolic Disease
Terpendole C, produced by Albophoma yamanashiensis, shows potent inhibitory activity against acyl-CoA: cholesterol acyltransferase (ACAT) .

HY-N8331

Terpendole I	Endogenous Metabolite Acyltransferase	Metabolic Disease
Terpendole I is a fungal indole diterpenoid and an *ACAT* inhibitor (IC₅₀ = 145 µM). Terpendole I can be used in studies related to lipid metabolism .

HY-129344

CL 277082	Acyltransferase	Metabolic Disease
CL 277082 is a potent and selective acyl CoA:cholesterol acyltransferase (ACAT) inhibitor in microsomes. CL 277082 inhibits ACAT with IC₅₀ values of 0.14 μM for intestinal mucosal microsomes, 0.74 μM for liver, and 1.18 μM for rat adrenal. CL 277082 is a ACAT-catalyzed cholesterol esterification and cholesterol absorption inhibitor .

HY-101576

RP 70676	Acyltransferase	Metabolic Disease
RP 70676 is a potent inhibitor of *ACAT, with IC₅₀* of 25 and 44 nM for rat and rabbit ACAT.

HY-100288

RP 73163 Racemate	Acyltransferase	Metabolic Disease
RP 73163 Racemate is the racemate of RP 73163. RP 73163 is a potent *ACAT* inhibitor, with cholesterol lowering activity.

HY-N6702

Enniatin A	Acyltransferase	Infection Cardiovascular Disease
Enniatin A is a Fusarium mycotoxin. Enniatin A inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ of 22 μM in an enzyme assay using rat liver microsomes .

HY-101627

YM17E	Acyltransferase	Metabolic Disease
YM17E is an inhibitor of acyl CoA:cholesterol acyltransferase (ACAT), with IC₅₀ of 44 nM in rabbit liver microsomes in vitro.

HY-16281

Lecimibide DuP 128	Acyltransferase	Metabolic Disease
Lecimibide (DuP 128) is a potent and specific acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor for antihyperlipidemia research .

HY-120082

FR-182980	Acyltransferase	Metabolic Disease
FR-182980 is an orally active *ACAT1* inhibitor (IC₅₀: 30 nM). FR-182980 has hypocholesterolemic activity and can be used for research of atherosclerosis .

HY-123040

ACAT Inhibitor 1	Drug Derivative	Others
ACAT Inhibitor 1 is an active compound.

HY-19251

CL-283796	Acyltransferase	Cardiovascular Disease Metabolic Disease
CL-283796 is a potent and orally active acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor. CL-283796 reduces low-density lipoprotein (LDL) cholesterol without affecting cholesterol absorption in African green monkeys. CL-283796 can be used for hypercholesterolemia research .

HY-N10234

Phenylpyropene A	Acyltransferase	Infection
Phenylpyropene A, a fungal metabolite, is a potent acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor with an IC₅₀ of 0.8 μM .

HY-121407

Lateritin	Acyltransferase	Infection Cancer
Lateritin is a potent inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT), isolated from the mycelial cake of Gibberella lateritium IFO 7188 . Lateritin also inhibits the growth of a mini-panel of human cancer cell lines, gram-positive bacteria, and Candida albicans .

HY-129340

AS-183	Acyltransferase	Cardiovascular Disease
AS-183 is an inhibitor of cholesterol acyltransferase (ACAT) (IC₅₀=0.94 µM). AS-183 also inhibits the formation of cholesterol esters in HepG2, CaCo2 and THP-1 cells with IC₅₀ values of 18.1, 25.5 and 34.5 µM, respectively. AS-183 can be used in the study of atherosclerosis and hypercholesterolemia .

HY-139020

ACAT-IN-3	Acyltransferase	Inflammation/Immunology
ACAT-IN-3 is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor. ACAT-IN-3 inhibits NF-κB mediated transcription .

HY-139024

ACAT-IN-7	Acyltransferase	Inflammation/Immunology
ACAT-IN-7 is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor. ACAT-IN-7 inhibits NF-κB mediated transcription .

HY-139025

ACAT-IN-8	Acyltransferase	Inflammation/Immunology
ACAT-IN-8 (example 206) is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor. ACAT-IN-8 inhibits NF-κB mediated transcription .

HY-139021

ACAT-IN-4	Acyltransferase	Inflammation/Immunology
ACAT-IN-4 (Example 208) is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor. ACAT-IN-4 inhibits NF-κB mediated transcription .

HY-139021A

ACAT-IN-4 hydrochloride	Acyltransferase	Inflammation/Immunology
ACAT-IN-4 hydrochloride (Example 208) is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor. ACAT-IN-4 hydrochloride inhibits NF-κB mediated transcription .

HY-139022

ACAT-IN-5	Acyltransferase	Inflammation/Immunology
ACAT-IN-5 (example 19) is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor. ACAT-IN-5 inhibits NF-κB mediated transcription .

HY-101648

ACAT-IN-1 cis isomer	Acyltransferase	Metabolic Disease
ACAT-IN-1 cis isomer is a potent *ACAT* inhibitor with an IC₅₀ of 100 nM.

HY-139026

ACAT-IN-9	Acyltransferase	Inflammation/Immunology
ACAT-IN-9 is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor extracted from patent EP1236468A1, example 207. ACAT-IN-9 inhibits NF-κB mediated transcription .

HY-139019

ACAT-IN-2	Acyltransferase	Inflammation/Immunology
ACAT-IN-2 is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor extracted from patent EP1236468A1, example 187. ACAT-IN-2 inhibits NF-κB mediated transcription .

HY-139023

ACAT-IN-6	Acyltransferase	Inflammation/Immunology
ACAT-IN-6 is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor extracted from patent EP1236468A1, example 200. ACAT-IN-6 potently inhibits NF-κB mediated transcription .

HY-139027A

ACAT-IN-10 dihydrochloride	Acyltransferase	Inflammation/Immunology
ACAT-IN-10 dihydrochloride is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor extracted from patent EP1236468A1, example 197. ACAT-IN-10 dihydrochloride weakly inhibits NF-κB mediated transcription .

HY-139027

ACAT-IN-10	Acyltransferase	Inflammation/Immunology
ACAT-IN-10 is an acyl-Coenzyme A:cholesterol acyltransferase (ACAT) inhibitor extracted from patent EP1236468A1, example 197. ACAT-IN-10 weakly inhibits NF-κB mediated transcription .

HY-U00369

FCE 28654	Acyltransferase	Cardiovascular Disease
FCE 28654 is an inhibitor of acylCoA: cholesterol acyltransferase (ACAT), weakly inhibiting *ACAT* in microsomes from rabbit aorta and intestine, and monkey liver, with IC₅₀s of 2.55, 1.08 and 5.69 μM, respcetively.

HY-N14649

Purpactin C	Acyltransferase	Metabolic Disease
Purpactin C is a cholesterol acyltransferase (ACAT) inhibitor .

HY-N14648

Purpactin B	Acyltransferase	Metabolic Disease
Purpactin B is a cholesterol acyltransferase (ACAT) inhibitor .

Cat. No.	Product Name	Target	Research Area

HY-P11865

Ac-ATS010-KE	Caspase Apoptosis	Cancer
Ac-ATS010-KE is a selective polypeptide inhibitor of caspase-3. Ac-ATS010-KE protects cells from FasL-induced apoptosis. The unmethylated form of Ac-ATS010-KE exhibits better cell viability than the fully methylated form. Ac-ATS010-KE can be used in research on cancers such as colorectal cancer and the development of caspase-3-targeted molecular probes .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N4193

Glabrol 3 Publications Verification	Cardiovascular Disease Flavonoids Classification of Application Fields Leguminosae Flavonones Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Source Classification	Acyltransferase
Glabrol (Compound 1), One isoprenyl flavonoid was isolated from ethanol extract of licorice roots, is a potent and non-competitive Acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor with an IC₅₀ value of 24.6 μM for rat liver microsomal ACAT activity .

HY-111880

γ-Sanshool	Zanthoxylum bungeanum Maxim. Structural Classification Alkaloids Other Alkaloids Rutaceae Plants Source Classification	Acyltransferase
γ-Sanshool can be isolated from Zanthoxylum piperitum. γ-Sanshool inhibits human *ACAT-1* and *ACAT-2* activities with IC₅₀s of 12.0 and 82.6 μM .

HY-117832

Pyripyropene A 1 Publications Verification	Cardiovascular Disease Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Inflammation/Immunology Disease Research Fields Source Classification	Acyltransferase
Pyripyropene A is an orally active, potent and selective sterol O-acyltransferase 2 (SOAT2)/acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2) inhibitor, with an IC₅₀ of 0.07 µM. Pyripyropene A attenuates hypercholesterolemia and atherosclerosis in vivo .

HY-N3807

Enniatin B1 1 Publications Verification	Infection Cardiovascular Disease Alkaloids Microorganisms Classification of Application Fields Other Alkaloids Disease Research Fields Source Classification	Acyltransferase ERK NF-κB
Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ of 73 μM in an enzyme assay using rat liver microsomes . Enniatin B1 crosss the blood-brain barrier . Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation .

HY-121254

GERI-BP002-A	Structural Classification Natural Products Microorganisms Source Classification	Environmental Pollutants Acyltransferase
GERI-BP002-A is an inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT) produced by Aspergillus fumigatus F93, which can be used in cancer research .

HY-N10788

Pomonic acid	Triterpenes Structural Classification Terpenoids Verbenaceae Plants Lantana camaraLinn. Source Classification	Acyltransferase
Pomonic acid is an acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor. Pomonic acid reduces the esterification of free cholesterol to cholesteryl esters and the accumulation of intracellular cholesteryl esters. Pomonic acid can be used in the research of atherosclerosis .

HY-N3806

Enniatin B	Infection Cardiovascular Disease Alkaloids Microorganisms Classification of Application Fields Disease Research Fields Source Classification	Acyltransferase ERK
Enniatin B is a Fusarium mycotoxin. Enniatin B inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ of 113 μM in an enzyme assay using rat liver microsomes . Enniatins B decreases the activation of ERK (p44/p42) .

HY-169813

Yakuchinone B	Monophenols Phenols Plants Alpinia oxyphylla Miq. Source Classification Zingiberaceae	Acyltransferase
Yakuchinone B is an Acyl-CoA: cholesterol O-acyltransferase (ACAT) inhibitor with hypocholesterolemic activity, which is found in the seeds of Zingiberaceae. Yakuchinone B inhibits rat hepatic *ACAT* with an IC₅₀ value of 20.6 μM. Yakuchinone B is promising for research of hypercholesterolemia and atherosclerosis .

HY-N10224

Terpendole C	Alkaloids Microorganisms Classification of Application Fields Metabolic Disease Disease Research Fields Indole Alkaloids Source Classification	Acyltransferase
Terpendole C, produced by Albophoma yamanashiensis, shows potent inhibitory activity against acyl-CoA: cholesterol acyltransferase (ACAT) .

HY-N8331

Terpendole I	Alkaloids Structural Classification Microorganisms Classification of Application Fields Terpenoids Diterpenoids Disease Research Fields Indole Alkaloids Source Classification Cancer	Endogenous Metabolite Acyltransferase
Terpendole I is a fungal indole diterpenoid and an *ACAT* inhibitor (IC₅₀ = 145 µM). Terpendole I can be used in studies related to lipid metabolism .

HY-N6702

Enniatin A	Cardiovascular Disease Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Source Classification	Acyltransferase
Enniatin A is a Fusarium mycotoxin. Enniatin A inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ of 22 μM in an enzyme assay using rat liver microsomes .

HY-N10234

Phenylpyropene A	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Acyltransferase
Phenylpyropene A, a fungal metabolite, is a potent acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor with an IC₅₀ of 0.8 μM .

HY-129340

AS-183	Natural Products Microorganisms Source Classification	Acyltransferase
AS-183 is an inhibitor of cholesterol acyltransferase (ACAT) (IC₅₀=0.94 µM). AS-183 also inhibits the formation of cholesterol esters in HepG2, CaCo2 and THP-1 cells with IC₅₀ values of 18.1, 25.5 and 34.5 µM, respectively. AS-183 can be used in the study of atherosclerosis and hypercholesterolemia .

HY-N14649

Purpactin C	Natural Products Microorganisms Source Classification	Acyltransferase
Purpactin C is a cholesterol acyltransferase (ACAT) inhibitor .

HY-N14648

Purpactin B	Microorganisms Ketones, Aldehydes, Acids Source Classification	Acyltransferase
Purpactin B is a cholesterol acyltransferase (ACAT) inhibitor .

HY-N14573

Glisoprenin B	Natural Products Microorganisms Source Classification	Acyltransferase
Glisoprenin B is a cholesterol acyltransferase (ACAT) inhibitor .

HY-N14525

Glisoprenin A	Natural Products Microorganisms Source Classification	Acyltransferase
Glisoprenin A is a cholesterol acyltransferase (ACAT) inhibitor, and it can inhibit the formation of Appressorium on the hydrophobic surface of Magnaporthegrisea .

HY-N14715

Gypsetin	Natural Products Microorganisms Source Classification	Acyltransferase
Gypsetin can inhibit acylcoenzyme A, cholesterol acyltransferase (ACAT) activity, inhibit rat liver microbody ACAT with an IC₅₀ of 18 μM, and its action is competitive with oleoyl-COA substrate, K_i value is 5.5 μM. Gypsetin also inhibits Oleic acid from forming cholesterol esters with an IC₅₀ of 0.65 μM .

HY-N14688

Phenylpyropene B	Natural Products Microorganisms Source Classification	Acyltransferase
Phenylpyropene B can inhibit ACAT activity with IC₅₀ of 12.8 μM .

HY-N14574

Glisoprenin C	Structural Classification Natural Products Microorganisms Source Classification	Acyltransferase
Glisoprenin C is a cholesterol acyltransferase (ACAT) inhibitor, and it can inhibit the formation of Appressorium on the hydrophobic surface of Magnaporthegrisea .

HY-N14816

Glisoprenin E	Natural Products Microorganisms Source Classification	Acyltransferase
Glisoprenin E is a cholesterol acyltransferase (ACAT) inhibitor, and it can inhibit the formation of Appressorium on the hydrophobic surface of Magnaporthegrisea .

HY-N14813

Glisoprenin D	Natural Products Microorganisms Source Classification	Acyltransferase
Glisoprenin D is a cholesterol acyltransferase (ACAT) inhibitor, and it can inhibit the formation of Appressorium on the hydrophobic surface of Magnaporthegrisea .

HY-N9552

Purpactin A	Natural Products Microorganisms Source Classification	Acyltransferase
Purpactin A is a cholesterol acyltransferase (ACAT) inhibitor found in Pen. Purpurogenum FO-6 .

HY-N14968

Enniatin F	Natural Products Microorganisms Source Classification	Parasite Fungal
Enniatin F has insecticidal and antifungal activity. Enniatin F also can inhibit acyl-CoA, cholesterol acyltransferase (ACAT) .

HY-N9524

Ilexoside XLVIII	Aquifoliaceae Triterpenes Classification of Application Fields Ochrosia balansae (Guillaumin) Baill. ex Guillaumin Terpenoids Metabolic Disease Plants Disease Research Fields Source Classification	Acyltransferase
Ilexoside XLVIII is an acyl CoA cholesteryl acyl transferase (ACAT) inhibitor. Ilexoside XLVIII is a triterpene saponin isolated from an aqueous extract of the leaves of Ilex kudincha .

HY-N14614

Pyripyropene B	Natural Products Microorganisms Ketones, Aldehydes, Acids Source Classification	Acyltransferase
Pyripyropene B is a powerful acyl-CoA: cholesterol acyltransferase 2 (ACAT2) inhibitor found in the fungus Aspergillus fumigatus FO 1289. Pyripyropene B inhibits acyl-CoA: cholesterol acyltransferase with an IC₅₀ of 117 nM .

HY-N15411

Helminthosporol	Terpenoids Sesquiterpenes Millettia erythrocalyx Gagnep. Plants Compositae Source Classification	Acyltransferase Phytohormone
Helminthosporol is a natural plant growth-regulator that can promote the growth of rice and lettuce seedlings. Helminthosporol can also inhibit the activity of acyl-CoA: cholesterol acyltransferase (ACAT) in rat liver microsomes and the synthesis of cholesterol esters in macrophages .

HY-N6704

Enniatin A1	Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Antibacterial Disease Research Anticancer Disease Research Fields Cancer Source Classification	ERK Apoptosis
Enniatin A1 isolated from Fusarium mycotoxins is a cyclic hexadepsipeptide consisting of alternating D-α-hydroxyisovaleric acids and N-methyl-L-amino acids. Enniatin A1 possesses anticarcinogenic properties by induction of apoptosis and disruption of ERK signalling pathway. Enniatin A1 inhibits *ACAT* with an IC₅₀ of 49 μM in rat liver microsomes .

HY-N18066

Esculeogenin A	Structural Classification Solanum lycopersicum L. Solanaceae Plants Steroids Source Classification	Drug Derivative Acyltransferase NF-κB PPAR Fatty Acid Synthase (FASN) Keap1-Nrf2
Esculeogenin A is the sapogenol of tomato saponin Esculeoside A (HY-N18067). Esculeogenin A is an orally active hepatoprotective, hypolipidemic, and antioxidant agent. Esculeogenin A regulates molecular targets like PPARα, SREBP1, Nrf2, NF-κB, *ACAT1/ACAT2* to promote hepatic fatty acid oxidation, suppress de novo lipogenesis, enhance antioxidant defense, and inhibit inflammation. Esculeogenin A improves liver function, alleviates hyperlipidemia, and inhibits hepatic steatosis and foam cell formation, preventing nonalcoholic fatty liver disease in high-fat-diet-fed rats and reducing atherosclerotic lesions in apoE-deficient mice. Esculeogenin A can be used for the research of nonalcoholic fatty liver disease, atherosclerosis, and hyperlipidemia .

HY-N17326

Ilekudinol B	Weigela subsessilis (Nakai) L.H.Bailey Structural Classification Caprifoliaceae Terpenoids Plants Pentacyclic Triterpenoids Source Classification	Acyltransferase Phosphatase Interleukin Related
Ilekudinol B is an inhibitor of *ACAT* and PTP1B, with an IC₅₀ of 5.3 μM and a K_i of 11.6 μM against human PTP1B. Ilekudinol B inhibits the classical pathway of the complement system, with an IC₅₀ of 51 μM. Ilekudinol B inhibits TNF-α-induced cellular IL-8 secretion, promotes glucose uptake in skeletal muscle myotubes, and acts as an insulin mimetic and insulin sensitizer. Ilekudinol B can be used in research related to type 2 diabetes, obesity, and inflammatory diseases .

Cat. No.	Product Name	Chemical Structure

HY-N6702S

Enniatin A-13C36
Enniatin A- ¹³C₃₆ is the ¹³C-labeled Enniatin A (HY-N6702). Enniatin A is a Fusarium mycotoxin. Enniatin A inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ of 22 μM in an enzyme assay using rat liver microsomes .

HY-N3806S

Enniatin B-13C33
Enniatin B- ¹³C₃₃ is the ¹³C-labeled Enniatin B (HY-N3806). Enniatin B is a Fusarium mycotoxin. Enniatin B inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 113 μM in an enzyme assay using rat liver microsomes . Enniatins B decreases the activation of ERK (p44/p42) .

HY-N6704S

Enniatin A1-13C35

Enniatin A1- ¹³C₃₅ is the ¹³C-labeled Enniatin A1 (HY-N6704). Enniatin A1 isolated from Fusarium mycotoxins is a cyclic hexadepsipeptide consisting of alternating D-α-hydroxyisovaleric acids and N-methyl-L-amino acids. Enniatin A1 possesses anticarcinogenic properties by induction of apoptosis and disruption of ERK signalling pathway. Enniatin A1 inhibits ACAT with an IC50 of 49 μM in rat liver microsomes .

HY-N3807S

Enniatin B1-13C34

Enniatin B1- ¹³C₃₄ is the ¹³C-labeled Enniatin B1 (HY-N3807). Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ of 73 μM in an enzyme assay using rat liver microsomes . Enniatin B1 crosss the blood-brain barrier . Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation .

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