γ-Sanshool
Based on 1 Customer Validation
γ-Sanshool can be isolated from Zanthoxylum piperitum. γ-Sanshool inhibits human ACAT-1 and ACAT-2 activities with IC50s of 12.0 and 82.6 μM.
For research use only. We do not sell to patients.
- Purity: 98.53%
- CAS No.: 78886-65-4
- Formula: C18H27NO
- Molecular Weight:273.41
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Storage:
-80°C, protect from light, stored under nitrogen
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Biological Activity
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Chemical Information
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Solvent & Solubility
- Purity & Documentation
- References
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Help & FAQs
Biological Activity
12.0 and 82.6 μM (human ACAT-1 and ACAT-2)[1]
Chemical Information
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CAS No. 78886-65-4
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Appearance Solid
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Molecular Weight 273.41
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Formula C18H27NO
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Color White to off-white
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SMILES
C/C=C/C=C/C=C\CC/C=C/C=C/C(NCC(C)C)=O
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Structure Classification
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Initial Source
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Shipping
Shipping with dry ice.
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Storage
-80°C, protect from light, stored under nitrogen
Solvent & Solubility
DMSO : 50 mg/mL (182.88 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
Select the appropriate dissolution method based on your experimental animal and administration route.
- For the following dissolution methods, please ensure to first prepare a clear stock solution using an In Vitro approach and then sequentially add co-solvents:
- To ensure reliable experimental results, the clarified stock solution can be appropriately stored based on storage conditions. As for the working solution for In Vivo experiments, it is recommended to prepare freshly and use it on the same day.
- The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.
Please enter the basic information of animal experiments:
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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Please enter your animal formula composition:
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%DMSO +
Recommended: Keep the proportion of DMSO in working solution below 2% if your animal is weak.
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%+
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+%Tween-80 + +
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%Saline +
The co-solvents required include: DMSO, . All of co-solvents are available by MedChemExpress (MCE). , Tween 80. All of co-solvents are available by MedChemExpress (MCE).
Working solution concentration: 0.22 mg/mL
Method for preparing stock solution: mg drug dissolved in μL DMSO. Stock solution concentration: mg/mL.
1. Take μL DMSO stock solution;
2. Add μL .
μL , mix evenly;
3. Then add μL Tween 80, mix evenly;
4. Then add μL
Please ensure that the stock solution in the first step is dissolved to a clear state, and add co-solvents in sequence. You can use ultrasonic heating (ultrasonic cleaner, recommended frequency 20-40 kHz), vortexing, etc. to assist dissolution.
Purity & Documentation
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Data Sheet (265 KB)
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SDS (393 KB)
- English - EN (393 KB)
- Français - FR (393 KB)
- Deutsch - DE (393 KB)
- Norwegian - NO (393 KB)
- Español - ES (393 KB)
- Swedish - SV (393 KB)
- Italian - IT (393 KB)
- Korean - KR (393 KB)
- Portuguese - PT (393 KB)
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Handling Instructions (2659 KB)
References
Complete Stock Solution Preparation Table
Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months (protect from light, stored under nitrogen). When stored at -80°C, please use it within 6 months.
| Optional Solvent | Concentration Solvent Mass | 1 mg | 5 mg | 10 mg | 25 mg |
|---|---|---|---|---|---|
| DMSO | 1 mM | 3.6575 mL | 18.2876 mL | 36.5751 mL | 91.4378 mL |
| 5 mM | 0.7315 mL | 3.6575 mL | 7.3150 mL | 18.2876 mL | |
| 10 mM | 0.3658 mL | 1.8288 mL | 3.6575 mL | 9.1438 mL | |
| 15 mM | 0.2438 mL | 1.2192 mL | 2.4383 mL | 6.0959 mL | |
| 20 mM | 0.1829 mL | 0.9144 mL | 1.8288 mL | 4.5719 mL | |
| 25 mM | 0.1463 mL | 0.7315 mL | 1.4630 mL | 3.6575 mL | |
| 30 mM | 0.1219 mL | 0.6096 mL | 1.2192 mL | 3.0479 mL | |
| 40 mM | 0.0914 mL | 0.4572 mL | 0.9144 mL | 2.2859 mL | |
| 50 mM | 0.0732 mL | 0.3658 mL | 0.7315 mL | 1.8288 mL | |
| 60 mM | 0.0610 mL | 0.3048 mL | 0.6096 mL | 1.5240 mL | |
| 80 mM | 0.0457 mL | 0.2286 mL | 0.4572 mL | 1.1430 mL | |
| 100 mM | 0.0366 mL | 0.1829 mL | 0.3658 mL | 0.9144 mL |
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