2. Metabolic Enzyme/Protease
  3. Acyltransferase
  4. PD 128042

PD 128042 (CI 976) is a potent, orally active, and selective inhibitor of ACAT (acyl coenzyme A:cholesterol acyltransferase) with an IC50s of 73 nM. PD 128042 is also a potent LPAT (lysophospholipid acyltransferase) inhibitor. PD 128042 inhibits Golgi-associated LPAT activity (IC50=15 μM). PD 128042 inhibits multiple membrane trafficking steps, including ones found in the endocytic and secretory pathway.

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PD 128042 Chemical Structure

PD 128042 Chemical Structure

CAS No. : 114289-47-3

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Solid + Solvent
10 mM * 1 mL in DMSO
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 USD 138 In-stock
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10 mM * 1 mL in DMSO USD 138 In-stock
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Based on 1 publication(s) in Google Scholar

PD 128042 Related Antibodies

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ACAT1 ACAT2 MGAT2 ACAT

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Description

PD 128042 (CI 976) is a potent, orally active, and selective inhibitor of ACAT (acyl coenzyme A:cholesterol acyltransferase) with an IC50s of 73 nM. PD 128042 is also a potent LPAT (lysophospholipid acyltransferase) inhibitor. PD 128042 inhibits Golgi-associated LPAT activity (IC50=15 μM). PD 128042 inhibits multiple membrane trafficking steps, including ones found in the endocytic and secretory pathway[1][2][3].

In Vivo

PD 128042 (CI 976) (10-30 mg/kg; gavage, in the chronic cholesterol-fed rat model) decreases non-high density lipoprotein (HDL)-cholesterol and increases HDL-cholesterol in rats with pre-established dyslipidemia[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.
Molecular Weight

393.56

Formula

C23H39NO4
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCCCCCCCCCC(C)(C)C(NC1=C(C=C(OC)C=C1OC)OC)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (254.09 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.5409 mL 12.7045 mL 25.4091 mL
5 mM 0.5082 mL 2.5409 mL 5.0818 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
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Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

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Volume (start)

V1

=
Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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mg/kg

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g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.5409 mL 12.7045 mL 25.4091 mL 63.5227 mL
5 mM 0.5082 mL 2.5409 mL 5.0818 mL 12.7045 mL
10 mM 0.2541 mL 1.2705 mL 2.5409 mL 6.3523 mL
15 mM 0.1694 mL 0.8470 mL 1.6939 mL 4.2348 mL
20 mM 0.1270 mL 0.6352 mL 1.2705 mL 3.1761 mL
25 mM 0.1016 mL 0.5082 mL 1.0164 mL 2.5409 mL
30 mM 0.0847 mL 0.4235 mL 0.8470 mL 2.1174 mL
40 mM 0.0635 mL 0.3176 mL 0.6352 mL 1.5881 mL
50 mM 0.0508 mL 0.2541 mL 0.5082 mL 1.2705 mL
60 mM 0.0423 mL 0.2117 mL 0.4235 mL 1.0587 mL
80 mM 0.0318 mL 0.1588 mL 0.3176 mL 0.7940 mL
100 mM 0.0254 mL 0.1270 mL 0.2541 mL 0.6352 mL
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PD 128042 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PD 128042114289-47-3CI 976PD128042PD-128042CI976CI-976AcyltransferaseDiacylglycerol acyltransferaseDiglyceride acyltransferaseacyl-CoA:cholesterol acyltransferasemono- acylglycerol acyltransferasesecretory endocytic membrane trafficking pathwayLPAToralACATtransferaseInhibitorinhibitorinhibit

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