138046-43-2
138046-43-2
Chemical Structure
YM-750
- No. CAS: 138046-43-2
- Formula:C31H36N2O
- Molecular Weight:452.63
IUPAC Name: 1-((9H-fluoren-2-yl)methyl)-1-cycloheptyl-3-mesitylurea
InChIKey: FMLJREWZCZHGGW-UHFFFAOYSA-N
SMILES: O=C(NC1=C(C)C=C(C)C=C1C)N(C2CCCCCC2)CC3=CC(CC4=C5C=CC=C4)=C5C=C3
Biological Activity: YM-750 is a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor (IC50=0.18 μM). ACAT catalyzes the formation of cholesteryl esters from cholesterol and long-chain fatty-acyl-coenzyme A[1][2].
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YM-750 | 99.95% | YM-750 is a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor (IC50=0.18 μM). ACAT catalyzes the formation of cholesteryl esters from cholesterol and long-chain fatty-acyl-coenzyme A. | ||||||||||||||||||||
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YM-750 (Standard) | YM-750 (Standard) is the analytical standard of YM-750 (HY-107396). This product is intended for research and analytical applications. YM-750 is a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor (IC50=0.18 μM). ACAT catalyzes the formation of cholesteryl esters from cholesterol and long-chain fatty-acyl-coenzyme A. | |||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.53
HY-B2048RPencycuron (Standard) -
Similarity Score 0.52
HY-101627YM17E -
Similarity Score 0.52
HY-19140YM-17E hydrochloride -
Similarity Score 0.50
HY-B2048SPencycuron-d5 -
Similarity Score 0.50
HY-12697NGB 2904 -
Similarity Score 0.49
HY-12697ANGB 2904 hydrochloride -
Similarity Score 0.48
HY-19370FPS-ZM1 -
Similarity Score 0.48
HY-119102BPU-11 -
Similarity Score 0.47
HY-W013514R2-Acetamidofluorene (Standard) -
Explore the MedChemAI to find more analogs
References
- [1]. Nagata Y, et al. N-[2-[N'-pentyl-(6,6-dimethyl-2,4-heptadiynyl)amino]ethyl]- (2-methyl-1-naphthylthio)acetamide (FY-087). A new acyl coenzyme a:cholesterol acyltransferase (ACAT) inhibitor of diet-induced atherosclerosis formation in mice. Biochem Pharmacol. 1995;49(5):643-651. [Content Brief]
- [2]. Chang C, et al. Human acyl-CoA:cholesterol acyltransferase (ACAT) and its potential as a target for pharmaceutical intervention against atherosclerosis. Acta Biochim Biophys Sin (Shanghai). 2006;38(3):151-156. [Content Brief]
