90 Results for "

ACER2

" in MedChemExpress (MCE) Product Catalog:
Products (90)

90 Results for "ACER2" in MCE Product Catalog:

39
Emodin
Emodin
0 Images
39 Publications Verification
Cat. No.: HY-14393
CAS No.: 518-82-1
Purity:  99.25%
Synonyms: Frangula emodin
Category:  

Polygonaceae Plants Endogenous metabolite Quinones Human Gut Microbiota Metabolites Microorganisms Rheum palmatum L. Anthraquinones Phenols Polyphenols Disease Research Fields Cancer

Target:  

SARS-CoV Casein Kinase Autophagy 11β-HSD

Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction . Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects [2]. Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice .
39
Emodin (Standard)
Emodin (Standard)
0 Images
39 Publications Verification
Cat. No.: HY-14393R
CAS No.: 518-82-1
Synonyms: Frangula emodin (Standard)
Category:  

Quinones Rheum palmatum L. Polygonaceae Phenols Plants Disease Research Fields Cancer

Target:  

Reference Standards SARS-CoV Casein Kinase Autophagy 11β-HSD

Emodin (Standard) is the analytical standard of Emodin. This product is intended for research and analytical applications. Emodin (Frangula emodin), an anthraquinone derivative, is an anti-SARS-CoV compound. Emodin blocks the SARS coronavirus spike protein and angiotensin-converting enzyme 2 (ACE2) interaction . Emodin inhibits casein kinase-2 (CK2). Anti-inflammatory and anticancer effects [2]. Emodin is a potent selective 11β-HSD1 inhibitor with the IC50 of 186 and 86 nM for human and mouse 11β-HSD1, respectively. Emodin ameliorates metabolic disorder in diet-induced obese mice .
26
Ursodeoxycholic acid
Ursodeoxycholic acid
0 Images
26 Cited Publications
Cat. No.: HY-13771
CAS No.: 128-13-2
Purity:  99.94%
Synonyms: Ursodeoxycholate; Ursodiol; UDCA
Category:  

Human Gut Microbiota Metabolites Other disease Disease markers Endogenous metabolite Disease Research Fields Cancer Steroids

Target:  

G protein-coupled Bile Acid Receptor 1 FXR Angiotensin-converting Enzyme (ACE) Endogenous Metabolite

Ursodeoxycholic acid (Ursodeoxycholate) is a secondary bile acid issued from the transformation of (cheno)deoxycholic acid by intestinal bacteria, acting as a key regulator of the intestinal barrier integrity and essential for lipid metabolism. Ursodeoxycholic acid acts as signaling molecule, exerting its effects by interacting with bile acid activated receptors, including G-protein coupled bile acid receptor 5 (TGR5, GPCR19) and the farnesoid X receptor (FXR). Ursodeoxycholic acid can be used for the research of a variety of hepatic and gastrointestinal diseases. Ursodeoxycholic acid also reduces ACE2 expression and is beneficial for reducing SARS-CoV-2 infection. Orally active [2] .
25
MLN-4760
MLN-4760
0 Images
25 Cited Publications
Cat. No.: HY-19414
CAS No.: 305335-31-3
Target:  

Angiotensin-converting Enzyme (ACE)

Research Areas:  

Cardiovascular Disease

MLN-4760 is a potent and selective human ACE2 inhibitor (IC50, 0.44 nM), with excellent selectivity (>5000-fold) versus related enzymes including human testicular ACE (IC50, >100 μM) and bovine carboxypeptidase A (CPDA; IC50, 27 μM).
19
Methylprednisolone
Methylprednisolone
0 Images
19 Cited Publications
Cat. No.: HY-B0260
CAS No.: 83-43-2
Synonyms: U 7532
Target:  

Glucocorticoid Receptor Autophagy SARS-CoV Bacterial

Research Areas:  

Cardiovascular Disease Infection Neurological Disease Metabolic Disease Inflammation/Immunology Cancer

Methylprednisolone (U 7532) is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels .
19
Methylprednisolone (Standard)
Methylprednisolone (Standard)
0 Images
19 Cited Publications
Cat. No.: HY-B0260R
CAS No.: 83-43-2
Synonyms: U 7532 (Standard)
Target:  

Reference Standards Glucocorticoid Receptor Autophagy SARS-CoV Bacterial

Research Areas:  

Infection Inflammation/Immunology Endocrinology Cancer

Methylprednisolone (Standard) is the analytical standard of Methylprednisolone. This product is intended for research and analytical applications. Methylprednisolone is a synthetic corticosteroid with anti-inflammatory and immunomodulating properties. Methylprednisolone improve severe or critical COVID-19 by activating ACE2 and reducing IL-6 levels .
11
Diminazene aceturate
Diminazene aceturate
0 Images
11 Cited Publications
Cat. No.: HY-12404
CAS No.: 908-54-3
Purity:  99.16%
Synonyms: Diminazene diaceturate
Target:  

Parasite Angiotensin-converting Enzyme (ACE)

Research Areas:  

Infection Inflammation/Immunology

Diminazene aceturate (Diminazene diaceturate) is an anti-trypanosome agent for livestock. The main biochemical mechanism of the trypanocidal actions of Diminazene aceturate is by binding to trypanosomal kinetoplast DNA (kDNA) in a non-intercalative manner through specific interaction with sites rich in adenine-thymine base pairs. Diminazene aceturate is also an angiotensin-converting enzyme 2 (ACE2) activator and has strong and potent anti-inflammatory properties [2] .
6
(Z)-Guggulsterone
(Z)-Guggulsterone
0 Images
6 Cited Publications
Cat. No.: HY-110066
CAS No.: 39025-23-5
Purity:  99.30%
Category:  

Commiphora myrrha (Nees) Engl. Plants Burseraceae Disease Research Fields Cancer Steroids

Target:  

Apoptosis VEGFR Akt Angiotensin-converting Enzyme (ACE) SARS-CoV FXR

(Z)-Guggulsterone, a constituent of Indian Ayurvedic medicinal plant Commiphora mukul, inhibits the growth of human prostate cancer cells by causing apoptosis. (Z)-Guggulsterone inhibits angiogenesis by suppressing the VEGF–VEGF-R2–Akt signaling axis . (Z)-Guggulsterone is also a potent FXR antagonist. (Z)-Guggulsterone reduces ACE2 expression and SARS-CoV-2 infection [2].
3
Punicalin
Punicalin
0 Images
3 Cited Publications
Cat. No.: HY-N0639
CAS No.: 65995-64-4
Category:  

Punica granatum L. Phenols Polyphenols Punicaceae Plants Disease Research Fields Inflammation/Immunology

Target:  

HBV Pyroptosis Carbonic Anhydrase

Punicalin is a species that can be isolated from the leaves of Punica granatum. Punicalin is an active molecule against hepatitis b virus (HBV). Punicalin can induce pyroptosis. Punicalin is a Carbonic anhydrase inhibitor. Punicalin blocks the binding of S-glycoprotein and ACE2 receptors. Pnuicalin has anti-inflammatory, antioxidant and antiviral activity [2] .
3
DX600
DX600
0 Images
3 Cited Publications
Cat. No.: HY-P2222
CAS No.: 478188-26-0
Target:  

Angiotensin-converting Enzyme (ACE)

Research Areas:  

Cardiovascular Disease

DX600 is a selective ACE2 specific inhibitor (KD: 1.3 nM), and does not cross-react with ACE. DX600 exacerbates diabetes-induced cardiovascular dysfunction and the increase in cardiac and renal NOX activity [2] .
3
DX600 TFA
DX600 TFA
0 Images
3 Cited Publications
Cat. No.: HY-P2222A
Target:  

Angiotensin-converting Enzyme (ACE)

Research Areas:  

Cardiovascular Disease Metabolic Disease

DX600 TFA is a selective ACE2 specific inhibitor (KD: 1.3 nM), and does not cross-react with ACE. DX600 TFA exacerbates diabetes-induced cardiovascular dysfunction and the increase in cardiac and renal NOX activity [2] .
2
BMS-265246
BMS-265246
0 Images
2 Cited Publications
Cat. No.: HY-15275
CAS No.: 582315-72-8
Purity:  99.59%
Target:  

CDK Angiotensin-converting Enzyme (ACE)

Research Areas:  

Infection Cardiovascular Disease Cancer

BMS-265246 is a potent and selective cyclin-dependent kinase CDK1 and CDK2 inhibitor, with IC50 values of 6 and 9 nM, respectively. BMS-265246 inhibits CHI3L1 (chitinase 3-like-1) stimulation of ACE2 (angiotensin converting enzyme 2) and SPP (viral spike protein priming proteases). BMS-265246 can be used for ovarian cancer and COVID-19 research [2] .
2
Mca-Ala-Pro-Lys(Dnp)-OH
Mca-Ala-Pro-Lys(Dnp)-OH
0 Images
2 Cited Publications
Cat. No.: HY-P2536
CAS No.: 305336-82-7
Target:  

Angiotensin-converting Enzyme (ACE)

Research Areas:  

Others

Mca-Ala-Pro-Lys(Dnp)-OH, a specific ACE2 quenched fluorogenic substrate, can be used to detect ACE2 activity, such as urinary, heart and lung [2].
2
Resorcinolnaphthalein
Resorcinolnaphthalein
0 Images
2 Cited Publications
Cat. No.: HY-122445
CAS No.: 41307-63-5
Purity:  99.87%
Target:  

Angiotensin-converting Enzyme (ACE)

Research Areas:  

Cardiovascular Disease Inflammation/Immunology

Resorcinolnaphthalein is a specific angiotensin-converting enzyme 2 (ACE2) enhancer and activates ACE2 activity with an EC50 value of 19.5 μM. Resorcinolnaphthalein can be used for the investigation of hypertension and renal fibrosis .
1
Benzoylaconine
Benzoylaconine
0 Images
1 Cited Publications
Cat. No.: HY-N0217
CAS No.: 466-24-0
Synonyms: Benzoylaconitine; Isaconitine; Pikraconitin
Category:  

Alkaloids Other Alkaloids Ranunculaceae Other Diseases  Aconitum carmichaeli Debx. Plants Disease Research Fields

Target:  

Angiotensin-converting Enzyme (ACE) Reactive Oxygen Species (ROS) Toll-like Receptor (TLR) NF-κB COX NO Synthase p38 MAPK P-glycoprotein

Benzoylaconine (Benzoylaconitine) is an orally active monoester alkaloid found in the traditional Chinese medicine Aconitum carmichaelii. Benzoylaconine is an ACE2 agonist (EC50: 1.5 μM) with antihypertensive and anti-heart failure effects. Benzoylaconine inhibits TLR-induced MAPK and NF-κB pathways to exert anti-inflammatory effects. Benzoylaconine upregulates the protein levels of P-gp, MRP2, and has anti-tumor effects [2] .
1
Ginkgolic acid C17:1
Ginkgolic acid C17:1
0 Images
1 Cited Publications
Cat. No.: HY-N2116
CAS No.: 111047-30-4
Category:  

Monophenols Ginkgoaceae Ketones, Aldehydes, Acids Phenols Plants Disease Research Fields Ginkgo biloba Cancer

Target:  

PTEN Fatty Acid Synthase (FASN) STAT Apoptosis SARS-CoV

Ginkgolic acid C17:1 is a fatty acid synthase (FAS) inhibitor with an IC50 of 10.5 µM. Ginkgolic acid C17:1 shows anti-tumor activity by inhibiting the phosphorylation of STAT3 and inducing apoptosis. Ginkgolic acid C17:1 can block the interaction between S-RBD and ACE2, and has anti-SARS-CoV-2-S pseudovirus activity. Ginkgolic acid C17:1 inhibits the biofilm formation of enterohemorrhagic Escherichia coli and Staphylococcus aureus [2] .
1
Pyrrothiogatain
Pyrrothiogatain
0 Images
1 Cited Publications
Cat. No.: HY-138113
CAS No.: 477888-48-5
Purity:  98.61%
Target:  

DNA/RNA Synthesis Interleukin Related TNF Receptor Angiotensin-converting Enzyme (ACE) SARS-CoV

Research Areas:  

Infection Inflammation/Immunology Cancer

Pyrrothiogatain is a transcription factor GATA3 inhibitor with an IC50 of 54.7 μM. Pyrrothiogatain inhibits the DNA-binding activity of GATA3 and inhibits the T helper 2 (Th2) cell differentiation and expression of Th2 cytokines. Pyrrothiogatain shows anti-infection effect by inhibiting ACE2 expression. Pyrrothiogatain can be used for the researches of inflammation, immunology, infection and cancer, such as colon cancer and SARS-CoV-2 infection [2] .
1
JG26
JG26
0 Images
1 Cited Publications
Cat. No.: HY-120852
CAS No.: 1464910-32-4
Purity:  98.14%
Target:  

Angiotensin-converting Enzyme (ACE) MMP EGFR ERK SARS-CoV

Research Areas:  

Infection Cardiovascular Disease Cancer

JG26 is an ADAM inhibitor with IC50 values of 12 nM, 1.9 nM, and 150 nM for ADAM8, ADAM17, and ADAM10, respectively. JG26 inhibits MMP-12 with an IC50 value of 9.4 nM. JG26 inhibits AngII (HY-13948)-induced EGFR transactivation and ERK activation. JG26 increases the expression of ACE2, inhibits the cleavage of CD23, reduces the infection of SARS-CoV-2. JG26 inhibits colorectal cancer metastasis. JG26 can be used for research on Hodgkin lymphoma and vascular diseases [2] .
1
BML-111
BML-111
0 Images
1 Cited Publications
Cat. No.: HY-100450
CAS No.: 78606-80-1
Purity:  ≥98.0%
Target:  

Angiotensin-converting Enzyme (ACE)

Research Areas:  

Cardiovascular Disease Inflammation/Immunology Cancer

BML-111, a lipoxin A4 analog, is a lipoxin A4 receptor agonist. BML-111 represses the activity of angiotensin converting enzyme (ACE) and increases the activity of angiotensinconverting enzyme 2 (ACE2). BML-111 has antiangiogenic, antitumor and anti-inflammatory properties [2].
1
Anti-Spike-RBD mAb
Anti-Spike-RBD mAb
0 Images
1 Cited Publications
Cat. No.: HY-P9801
Synonyms: SARS-CoV-2 (2019-nCoV) Spike RBD Antibody

Target:  

SARS-CoV

Research Areas:  

Infection

Anti-Spike-RBD mAb is a CHO cell derived human monoclonal IgG1 antibody. Blocking the interaction of Spike protein and ACE2. Anti-Spike-RBD mAb is a potential therapeutic approach for SARS-CoV-2 treatment .
Assay Types