1. Metabolic Enzyme/Protease
  2. Angiotensin-converting Enzyme (ACE)
  3. Resorcinolnaphthalein

Resorcinolnaphthalein 

Cat. No.: HY-122445 Purity: 98.83%
Handling Instructions

Resorcinolnaphthalein is a specific angiotensin-converting enzyme 2 (ACE2) enhancer and activates ACE2 activity with an EC50 value of 19.5 μM. Resorcinolnaphthalein can be used for the investigation of hypertension and renal fibrosis.

For research use only. We do not sell to patients.

Resorcinolnaphthalein Chemical Structure

Resorcinolnaphthalein Chemical Structure

CAS No. : 41307-63-5

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO USD 55 In-stock
Estimated Time of Arrival: December 31
Solid + Solvent
10 mM * 1 mL
ready for reconstitution
USD 55 In-stock
Estimated Time of Arrival: December 31
Solid
10 mg USD 50 In-stock
Estimated Time of Arrival: December 31
25 mg USD 80 In-stock
Estimated Time of Arrival: December 31
50 mg USD 120 In-stock
Estimated Time of Arrival: December 31
100 mg USD 200 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Customer Review

Based on 1 publication(s) in Google Scholar

Top Publications Citing Use of Products
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Description

Resorcinolnaphthalein is a specific angiotensin-converting enzyme 2 (ACE2) enhancer and activates ACE2 activity with an EC50 value of 19.5 μM. Resorcinolnaphthalein can be used for the investigation of hypertension and renal fibrosis[1].

IC50 & Target

EC50: 19.5 μM (ACE2)[1]

In Vitro

Resorcinolnaphthalein (100 μM) and XNT enhances ACE2 activity in a dose-dependent manner with EC50 values of 19.5 μM and 20.1 μM, respectively[1].
ACE2 is an effective enzyme in attenuating fibrosis and structural remodeling. Enhancement of ACE2 activity has beneficial effects on the cardiovascular system and protects against hypertension induced pathophysiology[1].

MCE has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

382.36

Formula

C₂₄H₁₄O₅

CAS No.
SMILES

O=C1C2=CC=CC3=C2C(C4(C5=C(OC6=C4C=CC(O)=C6)C=C(O)C=C5)O1)=CC=C3

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 125 mg/mL (326.92 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.6153 mL 13.0767 mL 26.1534 mL
5 mM 0.5231 mL 2.6153 mL 5.2307 mL
10 mM 0.2615 mL 1.3077 mL 2.6153 mL
*Please refer to the solubility information to select the appropriate solvent.
In Vivo:
  • 1.

    Add each solvent one by one:  10% DMSO    40% PEG300    5% Tween-80    45% saline

    Solubility: 2.08 mg/mL (5.44 mM); Suspended solution; Need ultrasonic

  • 2.

    Add each solvent one by one:  10% DMSO    90% (20% SBE-β-CD in saline)

    Solubility: 2.08 mg/mL (5.44 mM); Suspended solution; Need ultrasonic

  • 3.

    Add each solvent one by one:  10% DMSO    90% corn oil

    Solubility: ≥ 2.08 mg/mL (5.44 mM); Clear solution

*All of the co-solvents are provided by MCE.
References

Purity: 98.83%

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Keywords:

ResorcinolnaphthaleinAngiotensin-converting Enzyme (ACE)ACE2hypertensionrenalfibrosisreversalmyocardialperivascularInhibitorinhibitorinhibit

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Product Name:
Resorcinolnaphthalein
Cat. No.:
HY-122445
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