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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
67 Results for "
AMP-Activated
" in MedChemExpress (MCE) Product Catalog:
Products (67)
67 Results for "AMP-Activated" in MCE Product Catalog:
47
47 Publications Verification
Referencia número: HY-50662
No. CAS: 844499-71-4
Target:
Áreas de investigación:
A-769662 is a AMP-activated protein kinase (AMPK) activator. A-769662 inhibits the function of the 26S proteasome by an AMPK-independent mechanism and leads to cell cycle arrest. A-769662 directly stimulates partially purified rat liver AMPK (EC50 = 0.8 μM) and inhibits fatty acid synthesis in primary rat hepatocytes (IC50 = 3.2 μM). A-769662 can alleviate the symptoms of metabolic diseases such as type 2 diabetes .
37
37 Cited Publications
Referencia número: HY-19805
No. CAS: 52029-86-4
Áreas de investigación:
STO-609 is a selective and cell-permeable inhibitor of the Ca 2+/calmodulin-dependent protein kinase kinase (CaM-KK), with Ki values of 80 and 15 ng/mL for recombinant CaM-KKα and CaM-KKβ, respectively. STO-609 inhibits AMP-activated protein kinase kinase (AMPKK) activity in HeLa cell lysates with an IC50 ~0.02 g/ml.
11
Áreas de investigación:
Phenformin (Phenethylbiguanide) is an orally active biguanide hypoglycemic agent. Phenformin inhibits mitochondrial respiratory chain complex I, leading to an increased AMP/ATP ratio, activation of AMPK, and subsequent inhibition of the mTOR pathway, thereby suppressing cell proliferation, inducing apoptosis and autophagy. Phenformin inhibits cancer stem cells (CSCs) and possesses potent antitumor potential .
6
6 Cited Publications
Target:
Áreas de investigación:
EX229, a Benzimidazole derivative, is a potent and allosteric activator of AMP-activated protein kinase (AMPK), with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1 and α1β2γ1 in biolayer interferometry, respectively.
3
Áreas de investigación:
Miglitol (BAY-m1099) is an orally active antidiabetic compound that inhibits the breakdown of glycoconjugates into glucose. Miglitol inhibits glycoside hydrolase enzymes called α-glucosidases. Miglitol inhibits oxidative stress-induced apoptosis and mitochondrial ROS over-production in endothelial cells by enhancement of AMP-activated protein kinase. Dietary supplementation with Miglitol from pre-onset stage in OLETF rats delays the onset and development of diabetes and preserves the insulin secretory function of pancreatic islets .
3
3 Cited Publications
Target:
Áreas de investigación:
MK-3903 is a potent and selective AMP-activated protein kinase (AMPK) activator with an EC50 of 8 nM.
3
3 Cited Publications
Target:
Áreas de investigación:
Ampkinone is an indirect AMP-activated protein kinase (AMPK) activator.
3
3 Cited Publications
Referencia número: HY-P0136
No. CAS: 125911-68-4
Target:
Áreas de investigación:
2
2 Cited Publications
Target:
Áreas de investigación:
COH-SR4 is an AMPK activator. COH-SR4 shows potent anti-proliferative activities against leukemia, melanoma, breast and lung cancers. COH-SR4 inhibits adipocyte differentiation via AMPK activation. COH-SR4 can be used for the research of obesity and related metabolic disorders .
2
2 Cited Publications
Referencia número: HY-P76141
Pureza: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PRKAG1; 5'-AMP-Activated Protein Kinase, Gamma-1 Subunit; Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 1; AMPK Subunit Gamma-1; 5'-AMP-Activated Protein Kinase Subunit Gamma-1; AMPK Gamma-1 Chain; Protein Kinase, AMP-Activated, Gamma 1 Non-Cat
Species:
Source:
2
2 Cited Publications
Referencia número: HY-P76143
Pureza: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PRKAG1; 5'-AMP-Activated Protein Kinase, Gamma-1 Subunit; Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 1; AMPK Subunit Gamma-1; 5'-AMP-Activated Protein Kinase Subunit Gamma-1; AMPK Gamma-1 Chain; Protein Kinase, AMP-Activated, Gamma 1 Non-Cat
Species:
Source:
2
2 Cited Publications
Referencia número: HY-P80541
Synonyms: PRKAA2; AMPK; AMPK2; 5'-AMP-Activated protein kinase catalytic subunit alpha-2; AMPK subunit alpha-2; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase
1
1
1 Cited Publications
Referencia número: HY-W338584
No. CAS: 232281-44-6
1
1
1 Cited Publications
Áreas de investigación:
Neurological Disease Metabolic Disease Inflammation/Immunology
RSVA405 is a potent, orally active activator of AMPK, with an EC50 of 1 μM. RSVA405 facilitates CaMKKβ-dependent activation of AMPK, inhibits mTOR, and promotes autophagy to increase Aβ degradation. RSVA405 has anti-inflammatory effects through the inhibition of STAT3 function. RSVA405 can also be used for the research of obesity .
1
1 Cited Publications
Referencia número: HY-P76142
Pureza: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: PRKAG1; 5'-AMP-Activated Protein Kinase, Gamma-1 Subunit; Protein Kinase AMP-Activated Non-Catalytic Subunit Gamma 1; AMPK Subunit Gamma-1; 5'-AMP-Activated Protein Kinase Subunit Gamma-1; AMPK Gamma-1 Chain; Protein Kinase, AMP-Activated, Gamma 1 Non-Cat
Species:
Source:
1
1 Cited Publications
Referencia número: HY-P80452
Synonyms: AMPK, AMPK2, PRKAA2, 5'-AMP-Activated protein kinase catalytic subunit alpha-2, AMPK subunit alpha-2, Acetyl-CoA carboxylase kinase, Hydroxymethylglutaryl-CoA reductase kinase, ACACA kinase, HMGCR kinase
1
1 Cited Publications
Referencia número: HY-P80791
Synonyms: PRKAA2; AMPK; AMPK2; 5'-AMP-Activated protein kinase catalytic subunit alpha-2; AMPK subunit alpha-2; Acetyl-CoA carboxylase kinase; ACACA kinase; Hydroxymethylglutaryl-CoA reductase kinase; HMGCR kinase
Referencia número: HY-N2055
No. CAS: 19895-95-5
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
