1219739-36-2
1219739-36-2
Chemical Structure
EX229
- CAS 番号: 1219739-36-2
- Formula:C24H18ClN3O3
- Molecular Weight:431.87
IUPAC Name: 5-((5-chloro-6-(1-methyl-1H-indol-5-yl)-1H-benzo[d]imidazol-2-yl)oxy)-2-methylbenzoic acid
InChIKey: FHWSAZXFPUMKFL-UHFFFAOYSA-N
SMILES: O=C(O)C1=CC(OC2=NC3=CC(Cl)=C(C4=CC5=C(N(C)C=C5)C=C4)C=C3N2)=CC=C1C
Biological Activity: EX229, a Benzimidazole derivative, is a potent and allosteric activator of AMP-activated protein kinase (AMPK), with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1 and α1β2γ1 in biolayer interferometry, respectively.
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EX229 | 99.44% | EX229, a Benzimidazole derivative, is a potent and allosteric activator of AMP-activated protein kinase (AMPK), with Kds of 0.06 μM, 0.06 μM and 0.51 μM for α1β1γ1, α2β1γ1 and α1β2γ1 in biolayer interferometry, respectively. | ||||||||||||||||||||
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Keywords
