APAF1

By Targets:	Apoptosis (10) Bcl-2 Family (3) Caspase (10) CDK (1) Cholinesterase (ChE) (1) DNA/RNA Synthesis (1) Environmental Pollutants (1) Fatty Acid Synthase (FASN) (2) Fungal (2) MDM-2/p53 (1) Microtubule/Tubulin (1) Mitochondrial Metabolism (2) MMP (1) NF-κB (1) Parasite (1) PARP (2) Reactive Oxygen Species (ROS) (1) Reference Standards (3) Small Interfering RNA (siRNA) (3)
By Research Areas:	Cancer (11) Infection (2) Inflammation/Immunology (4)
Oligonucleotides:	Rat Pre-designed siRNA Sets (1) Mouse Pre-designed siRNA Sets (1) Human Pre-designed siRNA Sets (1) siRNAs (3)

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-126741

Azadirachtin 2 Publications Verification	Environmental Pollutants Parasite Caspase NF-κB Apoptosis Bcl-2 Family	Infection Inflammation/Immunology Cancer
Azadirachtin is an oral active triterpenoid compound with anticancer, antimalarial, anti-inflammatory, and insecticidal activities. Azadirachtin induces cell apoptosis through the mitochondrial pathway (by inhibiting Bcl-2/Bax ratio or activating *Apaf-1* and caspase-3) or through death receptors (by inhibiting TNFR activation). Additionally, Azadirachtin exerts its anti-inflammatory effects by inhibiting NF-кB signaling pathway activation, and it exhibits insecticidal activity by inducing apoptosis in insect cells ^[1] .

HY-100472

ZYZ-488	Caspase	Cancer
ZYZ-488 is a competitive apoptotic protease activating factor-1 (Apaf-1) inhibitor. ZYZ-488 inhibits the activation of binding protein procaspase-9 and procaspase-3 ^[1].

HY-119979

Cardanol monoene Cardanol C15:1	Apoptosis Reactive Oxygen Species (ROS) Mitochondrial Metabolism MMP CDK Caspase Bcl-2 Family PARP MDM-2/p53 Cholinesterase (ChE)	Infection Inflammation/Immunology Cancer
Cardanol monoene (Cardanol C15:1) is a phenolic compound which can be found in cashew nut shell liquid. Cardanol monoene can inhibit cancer cells proliferation, migration, cause S phase arrest, induce apoptosis, ROS production and mitochondrial depolarization. Cardanol monoene downregulates MMP-2, MMP-9, *cyclinA1* expression, regulates CDK2, p53, Bax, cytochrome c, cleaved caspase-3, cleaved PARP, *Apaf-1* expression and Bax/Bcl-2 ratio. Cardanol monoene shows weak DPPH radical scavenging activity and AChE inhibition activity. Cardanol monoene is lethal to Artemia salina nauplii. Cardanol monoene. Cardanol monoene can be used for the research of cancer, infection and inflamation ^[1] .

HY-18633

MDK83190	Apoptosis	Cancer
MDK83190 is a potent apoptosis activator, induces Apaf-1 oligomerization, increases procaspase-9 processing and subsequent caspase-3 activation in a cyto c-dependent Manner ^[1].

HY-Y0598

trans-Chalcone 2 Publications Verification Benzylideneacetophenone	Fatty Acid Synthase (FASN) Apoptosis Fungal	Inflammation/Immunology Cancer
trans-Chalcone, isolated from Aronia melanocarpa skin, is a biphenolic core structure of flavonoids precursor. trans-Chalcone is a potent fatty acid synthase (FAS) and α-amylase inhibitor. trans-Chalcone causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7. trans-Chalcone has antifungal and anticancer activity ^[1] .

HY-125018

QM31 SVT016426	Caspase	Cancer
QM31 (SVT016426), a cytoprotective agent, is a selective inhibitor of *Apaf-1. QM31 inhibits the formation of the apoptosome (IC₅₀=7.9μM), the caspase activation complex composed by Apaf-1*, cytochrome c, dATP and caspase-9. QM31 exerts mitochondrioprotective functions and interferes with the intra-S-phase DNA damage checkpoint ^[1] .

HY-103349

PETCM 1 Publications Verification	Caspase Apoptosis	Cancer
PETCM is an activator of caspase-3 and acts as an cytochrome c (cyto c)-dependent manner. PETCM promotes Apaf-1 oligomerization and induces cell apoptosis in HeLa cells ^[1] .

HY-RS00801

APAF1 Human Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
APAF1 Human Pre-designed siRNA Set A contains three designed siRNAs for APAF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

APAF1 Human Pre-designed siRNA Set A APAF1 Human Pre-designed siRNA Set A

HY-RS17757

Apaf1 Mouse Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Apaf1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Apaf1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

Apaf1 Mouse Pre-designed siRNA Set A Apaf1 Mouse Pre-designed siRNA Set A

HY-RS24224

Apaf1 Rat Pre-designed siRNA Set A	Small Interfering RNA (siRNA)	Others
Apaf1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Apaf1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

Apaf1 Rat Pre-designed siRNA Set A Apaf1 Rat Pre-designed siRNA Set A

HY-171447

LPT99	Caspase Apoptosis	Others
LPT-99 is an antagonist of apoptotic protease activating factor 1 (APAF-1). LPT-99 suppresses the activation of procaspase-9. LPT99 suppresses Cisplatin (HY-17394)-induced apoptosis. LPT99 can effectively mitigate cisplatin-induced hearing loss in rats. ^[1]

HY-116692

Apoptosis inducer 34	Apoptosis Caspase Mitochondrial Metabolism PARP DNA/RNA Synthesis
Apoptosis inducer 34 (Compound 4) is a small molecule compound that induces apoptosis by directly activating the intrinsic apoptotic pathway. Apoptosis inducer 34 promotes *Apaf-1* oligomerization to form mature apoptosomes, thereby activating caspase-9 and caspase-3. It significantly activates the apoptotic pathway in Jurkat cells by enhancing the cytochrome c-dependent apoptotic signaling pathway, inducing PARP cleavage and chromosomal DNA fragmentation. Furthermore, Apoptosis inducer 34 exhibits low toxicity to normal cells, demonstrating potential for selective targeting of cancer cells. Apoptosis inducer 34 is a promising candidate for studying cancer related to apoptotic pathways ^[1].

HY-103349R

PETCM (Standard)	Reference Standards Caspase Apoptosis	Cancer
PETCM (Standard) is the analytical standard of PETCM (HY-103349). This product is intended for research and analytical applications. PETCM is an activator of caspase-3 and acts as an cytochrome c (cyto c)-dependent manner. PETCM promotes Apaf-1 oligomerization and induces cell apoptosis in HeLa cells ^[1] .

HY-100472R

ZYZ-488 (Standard)	Caspase Reference Standards	Cancer
ZYZ-488 (Standard) is the analytical standard of ZYZ-488 (HY-100472). This product is intended for research and analytical applications. ZYZ-488 is a competitive apoptotic protease activating factor-1 (Apaf-1) inhibitor. ZYZ-488 inhibits the activation of binding protein procaspase-9 and procaspase-3 ^[1].

HY-136893

SP-6-27	Microtubule/Tubulin Apoptosis Caspase Bcl-2 Family	Cancer
SP-6-27 is a tubulin depolymerizing agent that binds to the colchicine site of β-tubulin. SP-6-27 induces G₂/M cell cycle arrest in ovarian cancer cells. SP-6-27 enhances intrinsic apoptosis in ovarian cancer cells through upregulation of Bax, *Apaf-1, caspase-6, caspase-9, and caspase-3*. SP-6-27 reduces ovarian cancer cell migration. SP-6-27 inhibits capillary tube formation by human umbilical vein endothelial cells. SP-6-27 shows minimum cytotoxicity to normal ovarian epithelia. SP-6-27 shows enhanced cytotoxicity in chemo-sensitive/resistant ovarian cancer cells when combined with Cisplatin (HY-17394). SP-6-27 can be used for the research of ovarian cancer ^[1].

HY-Y0598R

trans-Chalcone (Standard)	Fatty Acid Synthase (FASN) Reference Standards Apoptosis Fungal	Inflammation/Immunology Cancer
trans-Chalcone (Standard) is the analytical standard of trans-Chalcone (HY-Y0598). This product is intended for research and analytical applications. trans-Chalcone, isolated from Aronia melanocarpa skin, is a biphenolic core structure of flavonoids precursor. trans-Chalcone is a potent fatty acid synthase (FAS) and α-amylase inhibitor. trans-Chalcone causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7. trans-Chalcone has antifungal and anticancer activity ^[1] .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-126741

Azadirachtin 2 Publications Verification	Triterpenes Structural Classification Classification of Application Fields Terpenoids Other Diseases Azadirachta indica A. Juss. Plants Meliaceae Disease Research Fields Biological Pesticide Research Source Classification Agricultural Research	Environmental Pollutants Parasite Caspase NF-κB Apoptosis Bcl-2 Family
Azadirachtin is an oral active triterpenoid compound with anticancer, antimalarial, anti-inflammatory, and insecticidal activities. Azadirachtin induces cell apoptosis through the mitochondrial pathway (by inhibiting Bcl-2/Bax ratio or activating *Apaf-1* and caspase-3) or through death receptors (by inhibiting TNFR activation). Additionally, Azadirachtin exerts its anti-inflammatory effects by inhibiting NF-кB signaling pathway activation, and it exhibits insecticidal activity by inducing apoptosis in insect cells ^[1] .

HY-119979

Cardanol monoene Cardanol C15:1	Monophenols Classification of Application Fields Phenols Plants Anacardium occidentaleL. Disease Research Fields Anacardiaceae Source Classification Cancer	Apoptosis Reactive Oxygen Species (ROS) Mitochondrial Metabolism MMP CDK Caspase Bcl-2 Family PARP MDM-2/p53 Cholinesterase (ChE)
Cardanol monoene (Cardanol C15:1) is a phenolic compound which can be found in cashew nut shell liquid. Cardanol monoene can inhibit cancer cells proliferation, migration, cause S phase arrest, induce apoptosis, ROS production and mitochondrial depolarization. Cardanol monoene downregulates MMP-2, MMP-9, *cyclinA1* expression, regulates CDK2, p53, Bax, cytochrome c, cleaved caspase-3, cleaved PARP, *Apaf-1* expression and Bax/Bcl-2 ratio. Cardanol monoene shows weak DPPH radical scavenging activity and AChE inhibition activity. Cardanol monoene is lethal to Artemia salina nauplii. Cardanol monoene. Cardanol monoene can be used for the research of cancer, infection and inflamation ^[1] .

HY-Y0598

trans-Chalcone 2 Publications Verification Benzylideneacetophenone	Structural Classification Flavonoids Aronia melanocarpa Rosaceae Plants	Fatty Acid Synthase (FASN) Apoptosis Fungal
trans-Chalcone, isolated from Aronia melanocarpa skin, is a biphenolic core structure of flavonoids precursor. trans-Chalcone is a potent fatty acid synthase (FAS) and α-amylase inhibitor. trans-Chalcone causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7. trans-Chalcone has antifungal and anticancer activity ^[1] .

HY-Y0598R

trans-Chalcone (Standard)	Structural Classification Flavonoids Aronia melanocarpa Rosaceae Plants	Fatty Acid Synthase (FASN) Reference Standards Apoptosis Fungal
trans-Chalcone (Standard) is the analytical standard of trans-Chalcone (HY-Y0598). This product is intended for research and analytical applications. trans-Chalcone, isolated from Aronia melanocarpa skin, is a biphenolic core structure of flavonoids precursor. trans-Chalcone is a potent fatty acid synthase (FAS) and α-amylase inhibitor. trans-Chalcone causes cellcycle arrest and induces apoptosis in the breastcancer cell line MCF-7. trans-Chalcone has antifungal and anticancer activity ^[1] .

Species:	Human (2) Mouse (1)
Tag:	SUMO (1) His (3)
Source:	P. pastoris (1) E. coli (2)

Cat. No.	Compare	Product Name	Species	Source	Image

HY-P700502

	APAF1 Protein, Human (P. pastoris, His) APAF 1; APAF-1; APAF_HUMAN; APAF1; Apoptotic peptidase activating factor 1; Apoptotic protease activating factor 1; Apoptotic protease activating factor; Apoptotic protease-activating factor 1; CED 4; CED4; KIAA0413	Human	P. pastoris
	APAF1 protein is a key apoptotic component that coordinates cytochrome c-dependent caspase-9 precursor activation and initiates caspase-3 activation and apoptosis. APAF1 forms an apoptotic loop with cytochrome c and dATP, interacts with caspase-9 precursor, and releases mature caspase-9. APAF1 Protein, Human (P. pastoris, His) is the recombinant human-derived APAF1 protein, expressed by P. pastoris , with N-6*His labeled tag.

HY-P790108

	NLRP3 Protein, Human (His) Angiotensin/vasopressin receptor AII/AVP-like; Caterpiller protein 1.1; Cold-induced autoinflammatory syndrome 1 protein; Cryopyrin; PYRIN-containing APAF1-like protein 1; NLRP3; NALP3; PYPAF1; CIAS1	Human	E. coli
	The NLRP3 protein acts as a sensor in the NLRP3 inflammasome, which is activated in response to membrane defects. It forms a complex with CASP1 and PYCARD/ASC, promotes the release of IL1B, IL18 and GSDMD, and induces pyroptosis. NLRP3 Protein, Human (His) is the recombinant human-derived NLRP3, expressed by E. coli, with C-6*His labeled tag.

HY-P71598

	NLRP3 Protein, Mouse (His-SUMO) 1 Publications Verification Nlrp3; Cias1; Mmig1; Nalp3; Pypaf1; NACHT; LRR and PYD domains-containing protein 3; Cold autoinflammatory syndrome 1 protein homolog; Cryopyrin; Mast cell maturation-associated-inducible protein 1; PYRIN-containing APAF1-like protein 1	Mouse	E. coli
	The NLRP3 protein acts as a sensor in the NLRP3 inflammasome, which is activated in response to membrane defects caused by pathogens or damage signals. It assembles the inflammasome complex, including NLRP3, CASP1, and PYCARD/ASC. NLRP3 Protein, Mouse (His-SUMO) is the recombinant mouse-derived NLRP3 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.

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Host:	Mouse (2) Rabbit (2)
Reactivity:	Human (4) Rat (1) Mouse (2)
Application:	IHC-P (2) ICC/IF (4) IP (1) WB (2) FC (2) ELISA (3)
Isotype:	IgG (2) IgG2b (2)
Conjugation:	Non-conjugated (4)
Clonality:	Monoclonal (3) Recombinant (1)
Modification:	Unmodified (3)

Cat. No.	Compare	Product Name	Application	Reactivity	Image

HY-P83806

	APAF1 Antibody (YA3503) CED4; APAF-1	ICC/IF, FC, ELISA	Human
	APAF1 Antibody (YA3503) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to APAF1.

HY-P83806A

	APAF1 Antibody (YA3503)(PBS only) CED4; APAF-1	ICC/IF, FC, ELISA	Human
	APAF1 Antibody (YA3503) is a Mouse-derived and non-conjugated IgG2b monoclonal antibody, targeting to APAF1.

HY-P81736

	APAF1 Antibody (YA1481) APAF; APAF-1; APAF1; apoptotic peptidase activating factor 1; apoptotic protease activating factor 1; Apoptotic protease-activating factor 1; CED4; DKFZp781B1145; KIAA0413	WB, IHC-P, ICC/IF	Human, Mouse
	APAF1 Antibody (YA1481) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to APAF1.

HY-P86650

	NLRP3 Antibody (YA6342) NLRP3; C1orf7; CIAS1; NALP3; PYPAF1; NACHT, LRR and PYD domains-containing protein 3; Angiotensin/vasopressin receptor AII/AVP-like; Caterpiller protein 1.1CLR1.1; Cold autoinflammatory syndrome 1 protein; Cryopyrin; PYRIN-containing APAF1-like protein 1	WB, IHC-P, ICC/IF, IP, ELISA	Human, Mouse, Rat
	NLRP3 Antibody (YA6342) is a Rabbit-derived and non-conjugated IgG monoclonal antibody, targeting to NLRP3.

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Cat. No.	Product Name		Classification

HY-RS00801

APAF1 Human Pre-designed siRNA Set A		siRNAs Human Pre-designed siRNA Sets
APAF1 Human Pre-designed siRNA Set A contains three designed siRNAs for APAF1 gene (Human), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS17757

Apaf1 Mouse Pre-designed siRNA Set A		siRNAs Mouse Pre-designed siRNA Sets
Apaf1 Mouse Pre-designed siRNA Set A contains three designed siRNAs for Apaf1 gene (Mouse), as well as a negative control, a positive control, and a FAM-labeled negative control.

HY-RS24224

Apaf1 Rat Pre-designed siRNA Set A		siRNAs Rat Pre-designed siRNA Sets
Apaf1 Rat Pre-designed siRNA Set A contains three designed siRNAs for Apaf1 gene (Rat), as well as a negative control, a positive control, and a FAM-labeled negative control.

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