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Results for "

Acyltransferase Inhibitor

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Acyltransferase (125) Angiotensin Receptor (1) Apoptosis (5) Bacterial (4) BCRP (3) Calcium Channel (1) Casein Kinase (1) DNA/RNA Synthesis (1) Drug Intermediate (1) Drug Isomer (1) Endogenous Metabolite (6) Environmental Pollutants (1) ERK (4) Ferroptosis (1) Fungal (1) GlyT (3) HCV (1) Hedgehog (5) Isotope-Labeled Compounds (7) mTOR (1) NF-κB (2) OAT (3) Parasite (2) Phytohormone (1) PKC (3) Platelet-activating Factor Receptor (PAFR) (1) Porcupine (2) Reference Standards (14) Ribosomal S6 Kinase (RSK) (1) STAT (1) Wnt (3)
By Research Areas:	Cancer (26) Cardiovascular Disease (21) Endocrinology (1) Infection (32) Inflammation/Immunology (16) Metabolic Disease (72) Neurological Disease (7)
Oligonucleotides:	Antisense Oligonucleotides (2)

147

Inhibitors & Agonists

Fluorescent Dyes

Biochemical Assay Reagents

Natural
Products

Isotope-Labeled Compounds

Oligonucleotides

GMP Molecules

Targets Recommended: Acyltransferase PNPLA3

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10038

A 922500 Maximum Cited Publications 30 Publications Verification DGAT-1 Inhibitor 4a	Acyltransferase	Metabolic Disease
A 922500 (DGAT-1 Inhibitor 4a) is a potent, selective, and orally bioavailable *diacylglycerol acyltransferase* 1 (DGAT-1)** inhibitor with IC₅₀s of 9 and 22 nM against human and mouse DGAT-1, respectively.

HY-108341A

PF-06424439 methanesulfonate 20+ Cited Publications	Acyltransferase	Metabolic Disease
PF-06424439 methanesulfonate is an oral, potent and selective imidazopyridine *diacylglycerol acyltransferase* 2 (DGAT2)** inhibitor with an IC₅₀ of 14 nM . PF-06424439 methanesulfonate is slowly reversible, time-dependent inhibitor, which inhibits DGAT2 in a noncompetitive mode with respect to the acyl-CoA substrate .

HY-N6719

Fumonisin B1 Maximum Cited Publications 9 Publications Verification	Acyltransferase	Infection
Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of *sphingosine N-acyltransferase* (ceramide synthase)** and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin .

HY-108341

PF-06424439 20+ Cited Publications	Acyltransferase	Metabolic Disease
PF-06424439 is an oral, potent and selective imidazopyridine *diacylglycerol acyltransferase* 2 (DGAT2)** inhibitor with an IC₅₀ of 14 nM . PF-06424439 is slowly reversible, time-dependent inhibitor, which inhibits DGAT2 in a noncompetitive mode with respect to the acyl-CoA substrate .

HY-100400A

K-604 dihydrochloride 5+ Cited Publications	Acyltransferase	Cardiovascular Disease
K-604 dihydrochloride is a potent and selective acyl-CoA:cholesterol acyltransferase 1 (ACAT-1) inhibitor with an IC₅₀ of 0.45±0.06 μM.

HY-113054

DL-Glyceraldehyde 3-phosphate	Acyltransferase Bacterial Endogenous Metabolite	Infection Metabolic Disease
DL-Glyceraldehyde 3-phosphate is an intermediate in several metabolic pathways, including glycolysis and gluconeogenesis. DL-Glyceraldehyde 3-phosphate is a potent inhibitor of the growth of *E. coli. DL-Glyceraldehyde 3-phosphate is a competitive inhibitor* of the *acyltransferase* .

HY-13009

PF-04620110 5+ Cited Publications	Acyltransferase	Metabolic Disease
PF-04620110 is a potent, selective and orally bioavailable *diglyceride acyltransferase-1 (DGAT-1)* inhibitor with an IC₅₀ of 19 nM .

HY-112489

FSG67 2 Publications Verification	Acyltransferase	Metabolic Disease
FSG67 is a *glycerol 3-phosphate acyltransferase* (GPAT)** inhibitor with an IC₅₀ of 24 μM .

HY-N4193

Glabrol 3 Publications Verification	Acyltransferase	Cardiovascular Disease
Glabrol (Compound 1), One isoprenyl flavonoid was isolated from ethanol extract of licorice roots, is a potent and non-competitive Acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor with an IC₅₀ value of 24.6 μM for rat liver microsomal ACAT activity .

HY-15497

AZD7687 1 Publications Verification	Acyltransferase	Metabolic Disease
AZD7687 is a potent, selective, reversible and orally active *diacylglycerol acyltransferase* 1 (DGAT1)** inhibitor with an IC₅₀ of 80 nM for human DGAT1. AZD7687 can be used for type 2 diabetes mellitus and obesity research .

HY-117832

Pyripyropene A 1 Publications Verification	Acyltransferase	Infection Cardiovascular Disease Inflammation/Immunology
Pyripyropene A is an orally active, potent and selective *sterol O-acyltransferase* 2 (SOAT2)/acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2)** inhibitor, with an IC₅₀ of 0.07 µM. Pyripyropene A attenuates hypercholesterolemia and atherosclerosis in vivo .

HY-107572

PD 128042 CI 976	Acyltransferase	Metabolic Disease
PD 128042 (CI 976) is a potent, orally active, and selective inhibitor of ACAT (acyl coenzyme A:cholesterol acyltransferase) with an IC₅₀s of 73 nM. PD 128042 is also a potent LPAT (lysophospholipid acyltransferase) inhibitor. PD 128042 inhibits Golgi-associated LPAT activity (IC₅₀=15 μM). PD 128042 inhibits multiple membrane trafficking steps, including ones found in the endocytic and secretory pathway .

HY-100399

Nevanimibe 3 Publications Verification PD-132301; ATR-101	Acyltransferase Apoptosis	Cancer
Nevanimibe (PD-132301) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC₅₀ of 9 nM. Nevanimibe inhibits ACAT2 with an EC₅₀ of 368 nM. Nevanimibe induces cell apoptosis and has the potential for adrenocortical cancer .

HY-100399A

Nevanimibe hydrochloride 3 Publications Verification PD-132301 hydrochloride; ATR101 hydrochloride	Acyltransferase Apoptosis	Cancer
Nevanimibe hydrochloride (PD-132301 hydrochloride) is an orally active and selective acyl-coenzyme A:cholesterol O-acyltransferase 1 (ACAT1) inhibitor with an EC₅₀ of 9 nM. Nevanimibe hydrochloride inhibits ACAT2 with an EC₅₀ of 368 nM. Nevanimibe hydrochloride induces cell apoptosis and has the potential for adrenocortical cancer .

HY-12425

DGAT1-IN-1 2 Publications Verification	Acyltransferase	Metabolic Disease
DGAT1-IN-1 is a diacylglycerol O-acyltransferase 1 (DGAT1) inhibitor with a human IC₅₀ of <10 nM and a mouse IC₅₀ of <50 nM. DGAT1-IN-1 is applicable to the research of obesity-related diseases, type 2 diabetes and diabetes-related diseases .

HY-105445

CP-113818 2 Publications Verification	Acyltransferase	Neurological Disease
CP-113818 is a potent cholesterol acyltransferase (ACAT) inhibitor. CP-113818 can be used for the research of Alzheimer's disease .

HY-153628

GPAT-IN-1	Acyltransferase	Metabolic Disease
GPAT-IN-1 is a glycerol-3-phosphate acyltransferase (GPAT) inhibitor with an IC₅₀ value of 8.9 μM. GPAT-IN-1 can be used for the research of obesity .

HY-101857

TP-020 MGAT2-IN-1	Acyltransferase	Metabolic Disease
TP-020 (MGAT2-IN-1), a chemical probe, is an orally active inhibitor of monoacylglycerol acyltransferase (MGAT2) with IC₅₀ of 7.8 and 2.4 nM for human and mouse MGAT2, respectively.

HY-16437

RP-64477	Acyltransferase	Cardiovascular Disease
RP-64477 is a potent inhibitor of the cholesterol esterifying enzyme Acyl-coenzyme A:cholesterol O-acyltransferase (ACAT).

HY-121254

GERI-BP002-A	Environmental Pollutants Acyltransferase	Cancer
GERI-BP002-A is an inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT) produced by Aspergillus fumigatus F93, which can be used in cancer research .

HY-N10788

Pomonic acid	Acyltransferase	Inflammation/Immunology
Pomonic acid is an acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor. Pomonic acid reduces the esterification of free cholesterol to cholesteryl esters and the accumulation of intracellular cholesteryl esters. Pomonic acid can be used in the research of atherosclerosis .

HY-169499

(R)-2-(3-(2-Ethoxyphenoxy)piperidin-1-yl)pyrimidine-5-carboxylic Acid	Acyltransferase	Metabolic Disease
(R)-2-(3-(2-Ethoxyphenoxy)piperidin-1-yl)pyrimidine-5-carboxylic Acid is an intermediate in the synthesis of the diacylglycerol acyltransferase 2 (DGAT-2) inhibitor Ervogastat.

HY-107396

YM-750	Acyltransferase	Cardiovascular Disease
YM-750 is a potent acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor (IC₅₀=0.18 μM). ACAT catalyzes the formation of cholesteryl esters from cholesterol and long-chain fatty-acyl-coenzyme A .

HY-N3806

Enniatin B	Acyltransferase ERK	Infection Cardiovascular Disease Cancer
Enniatin B is a Fusarium mycotoxin. Enniatin B inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ of 113 μM in an enzyme assay using rat liver microsomes . Enniatins B decreases the activation of ERK (p44/p42) .

HY-161906

SD-066-4	Acyltransferase	Cancer
SD-066-4 is an orally active *acyltransferase* inhibitor. SD-066-4 can be used in cancer research .

HY-19286

Eflucimibe F 12511	Acyltransferase	Cancer
Eflucimibe (F 12511) is a new acyl-coenzyme *A cholesterol O-acyltransferase* (ACAT)** inhibitor. Eflucimibe can be used in the research of atherosclerosis .

HY-N10224

Terpendole C	Acyltransferase	Metabolic Disease
Terpendole C, produced by Albophoma yamanashiensis, shows potent inhibitory activity against acyl-CoA: cholesterol acyltransferase (ACAT) .

HY-108339

PF-06471553 1 Publications Verification	Acyltransferase	Metabolic Disease
PF-06471553 is a potent, selective and orally available *monoacylglycerol acyltransferase* 3 (MGAT3)** inhibitor, with an IC₅₀ of 92 nM.

HY-125319

Amidepsine A	Acyltransferase	Metabolic Disease
Amidepsine A is a fungal metabolite isolated from the culture broth of Humicola sp. FO-2942 that inhibits Diacylglycerol acyltransferases (DGAT) activity .

HY-15197

ABT-046	Acyltransferase	Metabolic Disease
ABT-046 is a potent, selective, and orally active acyl CoA:diacylglycerol acyltransferase 1 (DGAT-1) inhibitor with IC₅₀s of both 8 nM against human and mouse DGAT-1 .

HY-169813

Yakuchinone B	Acyltransferase	Cardiovascular Disease
Yakuchinone B is an Acyl-CoA: cholesterol O-acyltransferase (ACAT) inhibitor with hypocholesterolemic activity, which is found in the seeds of Zingiberaceae. Yakuchinone B inhibits rat hepatic ACAT with an IC₅₀ value of 20.6 μM. Yakuchinone B is promising for research of hypercholesterolemia and atherosclerosis .

HY-W014674

2,6-Dichlorophenylacetic acid	Acyltransferase	Cancer
2,6-Dichlorophenylacetic acid is an inhibitor of isopenicillin N synthase (IPNS) and **acyl-CoA: 6-APA acyltransferase**. 2,6-Dichlorophenylacetic acid is also part of a group of phenylacetate derivatives that have cytostatic activity against tumour cells .

HY-N16614

Ent-Calquiquelignan E	Acyltransferase	Metabolic Disease
Ent-Calquiquelignan E (Compound 8) is a flavonoid lignan compound. Ent-Calquiquelignan E can selectively inhibit *diacylglycerol acyltransferase* 1 (DGAT1) with an IC₅₀** of 71.5 μM. Ent-Calquiquelignan E can be used for the research of metabolic diseas .

HY-112851

*Diacylglycerol acyltransferase* inhibitor-1**	Acyltransferase	Metabolic Disease
Diacylglycerol acyltransferase inhibitor-1 is a diacylglycerol acyltransferase (DGAT1) inhibitor.

HY-N6702

Enniatin A	Acyltransferase	Infection Cardiovascular Disease
Enniatin A is a Fusarium mycotoxin. Enniatin A inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ of 22 μM in an enzyme assay using rat liver microsomes .

HY-161175

IMP-1575	Hedgehog	Cancer
IMP-1575 is the most potent Hedgehog acyltransferase (HHAT) inhibitor, with an IC₅₀ of 0.75 μM for inhibition of purified HHAT. IMP-1575 can be used for the research of cancer .

HY-129344

CL 277082	Acyltransferase	Metabolic Disease
CL 277082 is a potent and selective acyl CoA:cholesterol acyltransferase (ACAT) inhibitor in microsomes. CL 277082 inhibits ACAT with IC₅₀ values of 0.14 μM for intestinal mucosal microsomes, 0.74 μM for liver, and 1.18 μM for rat adrenal. CL 277082 is a ACAT-catalyzed cholesterol esterification and cholesterol absorption inhibitor .

HY-23199

H2-003	Acyltransferase	Metabolic Disease
H2-003 is a diacylglycerol acyltransferase DGAT2 inhibitor with an IC₅₀ value of 7.4 μM against human targets. H2-003 reduces triacylglycerol biosynthesis and inhibits lipid droplet formation. H2-003 can be used in studies related to hepatic steatosis and insulin resistance .

HY-101627

YM17E	Acyltransferase	Metabolic Disease
YM17E is an inhibitor of acyl CoA:cholesterol acyltransferase (ACAT), with IC₅₀ of 44 nM in rabbit liver microsomes in vitro.

HY-16281

Lecimibide DuP 128	Acyltransferase	Metabolic Disease
Lecimibide (DuP 128) is a potent and specific acyl-CoA:cholesterol acyltransferase (ACAT) inhibitor for antihyperlipidemia research .

HY-U00430

MGAT2-IN-2	Acyltransferase	Metabolic Disease
MGAT2-IN-2 is a potent and selective acyl CoA:monoacylglycerol acyltransferase 2 (MGAT2) inhibitor with an IC₅₀ of 3.4 nM.

HY-145624

Obeversen ION-769357	Acyltransferase	Metabolic Disease
Obeversen is an antisense oligonucleotide that inhibits the synthesis of *diacylglycerol acyltransferase* 2 (DGAT-2)**. Obeversen can be used in the research of nonalcoholic fatty liver disease .

HY-12936

DDD100097	DNA/RNA Synthesis Parasite	Infection
DDD100097 is a potent acyltransferase (TbNMT) inhibitor with an IC₅₀ value of 2 nM. DDD100097 can significantly improve blood-brain barrier permeability. DDD100097 can be used in the study of African trypanosomiasis .

HY-169085

LRAT-IN-1	Acyltransferase	Metabolic Disease
LRAT-IN-1 (compound 1) is a retinol acyltransferase (LRAT) inhibitor (IC₅₀=21.1 μM). LRAT-IN-1 provides anti-aging effects by inhibiting the esterification of retinol to form retinol esters, increasing the available retinol in the skin. Research on LRAT-IN-1 as an anti-aging ingredient in cosmetics .

HY-162854

*Diacylglycerol acyltransferase* inhibitor-2**	Acyltransferase	Metabolic Disease
Diacylglycerol acyltransferase inhibitor-2 (Example 8) is an inhibitor of Diacylglycerol Acyl Transferase 2 (DGAT2) with an IC₅₀ value of 3.7 nM .

HY-121762

NTE-122 dihydrochloride	Acyltransferase	Cardiovascular Disease
NTE-122 (dihydrochloride) is an inhibitor of acyl-CoA:cholesterol *acyltransferase* (ACAT), with the IC₅₀ in liver and aorta of cholesterol-fed rabbits of 7.6nM, 4.4nM and 9.6 nM, respectively, that plays an important role in atherosclerosis .

HY-121407

Lateritin	Acyltransferase	Infection Cancer
Lateritin is a potent inhibitor of **acyl-CoA:cholesterol acyltransferase (ACAT*), isolated from the mycelial cake of Gibberella lateritium* IFO 7188 . Lateritin also inhibits the growth of a mini-panel of human cancer cell lines, gram-positive bacteria, and Candida albicans .

HY-N14614

Pyripyropene B	Acyltransferase	Metabolic Disease
Pyripyropene B is a powerful acyl-CoA: cholesterol acyltransferase 2 (ACAT2) inhibitor found in the fungus Aspergillus fumigatus FO 1289. Pyripyropene B inhibits acyl-CoA: cholesterol acyltransferase with an IC₅₀ of 117 nM .

HY-N14648

Purpactin B	Acyltransferase	Metabolic Disease
Purpactin B is a cholesterol acyltransferase (ACAT) inhibitor .

HY-N14649

Purpactin C	Acyltransferase	Metabolic Disease
Purpactin C is a cholesterol acyltransferase (ACAT) inhibitor .

Cat. No.	Product Name	Type

HY-13912G

IWP-2 1 Publications Verification	Fluorescent Dyes
IWP-2 (GMP) is >IWP-2 (HY-13912) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. IWP-2 is an inhibitor of Wnt processing and secretion with an IC₅₀ of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and blocks Wnt ligand palmitoylation .

HY-D3391

RMR-Tre

Fluorescent Dyes

RMR-Tre is a fluorescent probe targeting the mycobacterial acyltransferase Ag85. Under the catalysis of Ag85, RMR-Tre undergoes 6-position mycoloylation and anchors to the mycobacterial membrane, while achieving fluorescence activation by inhibiting the intramolecular twisted charge transfer state transition. RMR-Tre can distinguish live mycobacteria from dead ones through metabolism-driven labeling, enabling rapid, wash-free, low-background detection of viable bacteria. RMR-Tre reports the drug resistance of Mycobacterium tuberculosis via the trehalose catalytic shift activity readout associated with TreS. In addition, RMR-Tre can be combined with flow cytometry or high-content imaging techniques to visualize and quantitatively analyze the metabolic heterogeneity of Mycobacterium tuberculosis related to persistence and drug resistance. RMR-Tre is widely used in tuberculosis-related research .

Cat. No.	Product Name	Type

HY-13912G

IWP-2 1 Publications Verification	Biochemical Assay Reagents
IWP-2 (GMP) is >IWP-2 (HY-13912) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. IWP-2 is an inhibitor of Wnt processing and secretion with an IC₅₀ of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and blocks Wnt ligand palmitoylation .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-N6719

Fumonisin B1 Maximum Cited Publications 9 Publications Verification	Infection Human Gut Microbiota Metabolites Microorganisms Classification of Application Fields Antibiotics Antibacterial Disease Research Endogenous metabolite Disease Research Fields Other Antibiotics Source Classification	Acyltransferase
Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of *sphingosine N-acyltransferase* (ceramide synthase)** and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin .

HY-113054

DL-Glyceraldehyde 3-phosphate	Infection Natural Products Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Source Classification	Acyltransferase Bacterial Endogenous Metabolite
DL-Glyceraldehyde 3-phosphate is an intermediate in several metabolic pathways, including glycolysis and gluconeogenesis. DL-Glyceraldehyde 3-phosphate is a potent inhibitor of the growth of *E. coli. DL-Glyceraldehyde 3-phosphate is a competitive inhibitor* of the *acyltransferase* .

HY-N4193

Glabrol 3 Publications Verification	Cardiovascular Disease Flavonoids Classification of Application Fields Leguminosae Flavonones Phenols Polyphenols Plants Glycyrrhiza uralensis Fisch. Disease Research Fields Source Classification	Acyltransferase
Glabrol (Compound 1), One isoprenyl flavonoid was isolated from ethanol extract of licorice roots, is a potent and non-competitive Acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor with an IC₅₀ value of 24.6 μM for rat liver microsomal ACAT activity .

HY-113202

Stearoylcarnitine 1 Publications Verification	Microorganisms Ketones, Aldehydes, Acids Endogenous metabolite Source Classification	Endogenous Metabolite PKC GlyT
Stearoylcarnitine, a fatty ester lipid molecule, is an endogenous metabolite. Stearoylcarnitine can be used as PKC inhibitor. Stearoylcarnitine accumulates in β cells, leading to arrest of insulin synthesis and energy deficiency in type 2 diabetes mouse. Stearoylcarnitine inhibits lecithin cholesterol acyltransferase (LCAT) in rat and rabbits plasma. Stearoylcarnitine acts as a metabolomics biomarker for Parkinson’s disease. Stearoylcarnitine is a less potent inhibitor of GlyT2 .

HY-117832

Pyripyropene A 1 Publications Verification	Cardiovascular Disease Microorganisms Classification of Application Fields Terpenoids Sesquiterpenes Inflammation/Immunology Disease Research Fields Source Classification	Acyltransferase
Pyripyropene A is an orally active, potent and selective *sterol O-acyltransferase* 2 (SOAT2)/acyl-coenzyme A:cholesterol acyltransferase 2 (ACAT2)** inhibitor, with an IC₅₀ of 0.07 µM. Pyripyropene A attenuates hypercholesterolemia and atherosclerosis in vivo .

HY-N3807

Enniatin B1 1 Publications Verification	Infection Cardiovascular Disease Alkaloids Microorganisms Classification of Application Fields Other Alkaloids Disease Research Fields Source Classification	Acyltransferase ERK NF-κB
Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ of 73 μM in an enzyme assay using rat liver microsomes . Enniatin B1 crosss the blood-brain barrier . Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation .

HY-121254

GERI-BP002-A	Structural Classification Natural Products Microorganisms Source Classification	Environmental Pollutants Acyltransferase
GERI-BP002-A is an inhibitor of acyl-CoA:cholesterol acyltransferase (ACAT) produced by Aspergillus fumigatus F93, which can be used in cancer research .

HY-N10788

Pomonic acid	Triterpenes Structural Classification Terpenoids Verbenaceae Plants Lantana camaraLinn. Source Classification	Acyltransferase
Pomonic acid is an acyl-coenzyme A: cholesterol acyltransferase (ACAT) inhibitor. Pomonic acid reduces the esterification of free cholesterol to cholesteryl esters and the accumulation of intracellular cholesteryl esters. Pomonic acid can be used in the research of atherosclerosis .

HY-N3806

Enniatin B	Infection Cardiovascular Disease Alkaloids Microorganisms Classification of Application Fields Disease Research Fields Source Classification	Acyltransferase ERK
Enniatin B is a Fusarium mycotoxin. Enniatin B inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ of 113 μM in an enzyme assay using rat liver microsomes . Enniatins B decreases the activation of ERK (p44/p42) .

HY-N10224

Terpendole C	Alkaloids Microorganisms Classification of Application Fields Metabolic Disease Disease Research Fields Indole Alkaloids Source Classification	Acyltransferase
Terpendole C, produced by Albophoma yamanashiensis, shows potent inhibitory activity against acyl-CoA: cholesterol acyltransferase (ACAT) .

HY-125319

Amidepsine A	Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Phenols Metabolic Disease Disease Research Fields Source Classification	Acyltransferase
Amidepsine A is a fungal metabolite isolated from the culture broth of Humicola sp. FO-2942 that inhibits Diacylglycerol acyltransferases (DGAT) activity .

HY-169813

Yakuchinone B	Monophenols Phenols Plants Alpinia oxyphylla Miq. Source Classification Zingiberaceae	Acyltransferase
Yakuchinone B is an Acyl-CoA: cholesterol O-acyltransferase (ACAT) inhibitor with hypocholesterolemic activity, which is found in the seeds of Zingiberaceae. Yakuchinone B inhibits rat hepatic ACAT with an IC₅₀ value of 20.6 μM. Yakuchinone B is promising for research of hypercholesterolemia and atherosclerosis .

HY-N16614

Ent-Calquiquelignan E	Structural Classification Flavonoids Flavones Akebia quinata (Houttuyn) Decaisne Terpenoids Lardizabalaceae Sesquiterpenes Plants Source Classification	Acyltransferase
Ent-Calquiquelignan E (Compound 8) is a flavonoid lignan compound. Ent-Calquiquelignan E can selectively inhibit *diacylglycerol acyltransferase* 1 (DGAT1) with an IC₅₀** of 71.5 μM. Ent-Calquiquelignan E can be used for the research of metabolic diseas .

HY-N6702

Enniatin A	Cardiovascular Disease Microorganisms Macrolide Antibiotics Classification of Application Fields Antibiotics Antibacterial Disease Research Disease Research Fields Source Classification	Acyltransferase
Enniatin A is a Fusarium mycotoxin. Enniatin A inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ of 22 μM in an enzyme assay using rat liver microsomes .

HY-N9530

1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone	Cardiovascular Disease Alkaloids Classification of Application Fields Evodia rutaecarpa (Juss.) Benth. Rutaceae Metabolic Disease Quinoline Alkaloids Plants Disease Research Fields Source Classification	Acyltransferase Angiotensin Receptor Bacterial
1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone, a quinolone alkaloid, is a diacylglycerol acyltransferase inhibitor and angiotensin II receptor blocker, with IC₅₀s of 20.1 μM and 34.1 μM, respectively. 1-Methyl-2-[(4Z,7Z)-4,7-tridecadienyl]-4(1H)-quinolone shows potent anti-Helicobacter pylori activity with the MIC of 10 μg/mL .

HY-N14614

Pyripyropene B	Natural Products Microorganisms Ketones, Aldehydes, Acids Source Classification	Acyltransferase
Pyripyropene B is a powerful acyl-CoA: cholesterol acyltransferase 2 (ACAT2) inhibitor found in the fungus Aspergillus fumigatus FO 1289. Pyripyropene B inhibits acyl-CoA: cholesterol acyltransferase with an IC₅₀ of 117 nM .

HY-N14648

Purpactin B	Microorganisms Ketones, Aldehydes, Acids Source Classification	Acyltransferase
Purpactin B is a cholesterol acyltransferase (ACAT) inhibitor .

HY-N14649

Purpactin C	Natural Products Microorganisms Source Classification	Acyltransferase
Purpactin C is a cholesterol acyltransferase (ACAT) inhibitor .

HY-N14573

Glisoprenin B	Natural Products Microorganisms Source Classification	Acyltransferase
Glisoprenin B is a *cholesterol acyltransferase* (ACAT)** inhibitor .

HY-N14793

Amidepsin B	Microorganisms Ketones, Aldehydes, Acids Source Classification	Acyltransferase
Amidepsin B is a diacylglycerol acyltransferase (DGAT) inhibitor .

HY-N14794

Amidepsin C	Microorganisms Ketones, Aldehydes, Acids Source Classification	Acyltransferase
Amidepsin C is a diacylglycerol acyltransferase (DGAT) inhibitor .

HY-N14581

Roselipin 1A	Natural Products Microorganisms Source Classification	Acyltransferase
Roselipin 1A inhibits *diacylglycerol acyltransferases* (DGAT)** of rat hepatic microcosm .

HY-N14580

Roselipin 2A	Natural Products Microorganisms Source Classification	Acyltransferase
Roselipin 2A inhibits *diacylglycerol acyltransferases* (DGAT)** of rat hepatic microcosm .

HY-N14525

Glisoprenin A	Natural Products Microorganisms Source Classification	Acyltransferase
Glisoprenin A is a *cholesterol acyltransferase* (ACAT)** inhibitor, and it can inhibit the formation of Appressorium on the hydrophobic surface of Magnaporthegrisea .

HY-N14578

Roselipin 2B	Natural Products Microorganisms Source Classification	Acyltransferase
Roselipin 2B inhibits *diacylglycerol acyltransferases* (DGAT)** of rat hepatic microcosm .

HY-N14584

Roselipin 1B	Natural Products Microorganisms Source Classification	Acyltransferase
Roselipin 1B inhibits *diacylglycerol acyltransferases* (DGAT)** of rat hepatic microcosm .

HY-N14813

Glisoprenin D	Natural Products Microorganisms Source Classification	Acyltransferase
Glisoprenin D is a cholesterol acyltransferase (ACAT) inhibitor, and it can inhibit the formation of Appressorium on the hydrophobic surface of Magnaporthegrisea .

HY-N14574

Glisoprenin C	Structural Classification Natural Products Microorganisms Source Classification	Acyltransferase
Glisoprenin C is a *cholesterol acyltransferase* (ACAT)** inhibitor, and it can inhibit the formation of Appressorium on the hydrophobic surface of Magnaporthegrisea .

HY-N14816

Glisoprenin E	Natural Products Microorganisms Source Classification	Acyltransferase
Glisoprenin E is a cholesterol acyltransferase (ACAT) inhibitor, and it can inhibit the formation of Appressorium on the hydrophobic surface of Magnaporthegrisea .

HY-N9552

Purpactin A	Natural Products Microorganisms Source Classification	Acyltransferase
Purpactin A is a cholesterol acyltransferase (ACAT) inhibitor found in Pen. Purpurogenum FO-6 .

HY-N10234

Phenylpyropene A	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Acyltransferase
Phenylpyropene A, a fungal metabolite, is a potent acyl-CoA: cholesterol acyltransferase (ACAT) inhibitor with an IC₅₀ of 0.8 μM .

HY-N14968

Enniatin F	Natural Products Microorganisms Source Classification	Parasite Fungal
Enniatin F has insecticidal and antifungal activity. Enniatin F also can inhibit acyl-CoA, cholesterol acyltransferase (ACAT) .

HY-N15411

Helminthosporol	Terpenoids Sesquiterpenes Millettia erythrocalyx Gagnep. Plants Compositae Source Classification	Acyltransferase Phytohormone
Helminthosporol is a natural plant growth-regulator that can promote the growth of rice and lettuce seedlings. Helminthosporol can also inhibit the activity of acyl-CoA: cholesterol acyltransferase (ACAT) in rat liver microsomes and the synthesis of cholesterol esters in macrophages .

HY-N14715

Gypsetin	Natural Products Microorganisms Source Classification	Acyltransferase
Gypsetin can inhibit acylcoenzyme A, cholesterol acyltransferase (ACAT) activity, inhibit rat liver microbody ACAT with an IC₅₀ of 18 μM, and its action is competitive with oleoyl-COA substrate, K_i value is 5.5 μM. Gypsetin also inhibits Oleic acid from forming cholesterol esters with an IC₅₀ of 0.65 μM .

HY-129340

AS-183	Natural Products Microorganisms Source Classification	Acyltransferase
AS-183 is an inhibitor of cholesterol acyltransferase (ACAT) (IC₅₀=0.94 µM). AS-183 also inhibits the formation of cholesterol esters in HepG2, CaCo2 and THP-1 cells with IC₅₀ values of 18.1, 25.5 and 34.5 µM, respectively. AS-183 can be used in the study of atherosclerosis and hypercholesterolemia .

Cat. No.	Product Name	Chemical Structure

HY-N6723S

Fumonisin B2-13C34
Fumonisin B2- ¹³C₃₄ is the ¹³C labeled Fumonisin B2 (HY-N6723) . Fumonisin B2, a mycotoxin produced by Fusarium moniliforme in various grains, is a potent inhibitor of *sphingosine N-acyltransferase* (ceramide synthase)** and disrupts de novo sphingolipid biosynthesis .

HY-N6719S

Fumonisin B1-13C34
Fumonisin B1- ¹³C₃₄ is the ¹³C labeled Fumonisin B1 (HY-N6719) . Fumonisin B1 is a mycotoxin produced from Fusarium moniliforme. Fumonisin B1 is a potent inhibitor of *sphingosine N-acyltransferase* (ceramide synthase)** and disrupts de novo sphingolipid biosynthesis. Fumonisin B1 is the most abundant and toxic fumonisin .

HY-113202S

Stearoyl-L-carnitine-d3

Stearoyl-L-carnitine-d₃ is the deuterium labeled Stearoylcarnitine. Stearoylcarnitine, a fatty ester lipid molecule, is an endogenous metabolite. Stearoylcarnitine can be used as PKC inhibitor. Stearoylcarnitine accumulates in β cells, leading to arrest of insulin synthesis and energy deficiency in type 2 diabetes mouse. Stearoylcarnitine inhibits lecithin cholesterol acyltransferase (LCAT) in rat and rabbits plasma. Stearoylcarnitine acts as a metabolomics biomarker for Parkinson’s disease. Stearoylcarnitine is a less potent inhibitor of GlyT2 .

HY-113202S1

Stearoyl-L-carnitine-d9 chloride

Stearoyl-L-carnitine-d9 chloride is the deuterium labeled Stearoyl-L-carnitine chloride. Stearoyl-L-carnitine chloride, a fatty ester lipid molecule, is an endogenous metabolite. Stearoyl-L-carnitine chloride can be used as PKC inhibitor. Stearoyl-L-carnitine chloride accumulates in β cells, leading to arrest of insulin synthesis and energy deficiency in type 2 diabetes mouse. Stearoyl-L-carnitine chloride inhibits lecithin cholesterol acyltransferase (LCAT) in rat and rabbits plasma. Stearoyl-L-carnitine chloride acts as a metabolomics biomarker for Parkinson’s disease. Stearoyl-L-carnitine chloride is a less potent inhibitor of GlyT2 .

HY-N6702S

Enniatin A-13C36
Enniatin A- ¹³C₃₆ is the ¹³C-labeled Enniatin A (HY-N6702). Enniatin A is a Fusarium mycotoxin. Enniatin A inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ of 22 μM in an enzyme assay using rat liver microsomes .

HY-N3806S

Enniatin B-13C33
Enniatin B- ¹³C₃₃ is the ¹³C-labeled Enniatin B (HY-N3806). Enniatin B is a Fusarium mycotoxin. Enniatin B inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC50 of 113 μM in an enzyme assay using rat liver microsomes . Enniatins B decreases the activation of ERK (p44/p42) .

HY-N3807S

Enniatin B1-13C34

Enniatin B1- ¹³C₃₄ is the ¹³C-labeled Enniatin B1 (HY-N3807). Enniatin B1 is a Fusarium mycotoxin. Enniatin B1 inhibits acyl-CoA: cholesterol acyltransferase (ACAT) activity with an IC₅₀ of 73 μM in an enzyme assay using rat liver microsomes . Enniatin B1 crosss the blood-brain barrier . Enniatin B1 decreases the activation of ERK (p44/p42). Enniatin B1 inhibits moderately TNF-α-induced NF-κB activation .

Cat. No.	Product Name		Classification

HY-145624

Obeversen ION-769357		Antisense Oligonucleotides
Obeversen is an antisense oligonucleotide that inhibits the synthesis of *diacylglycerol acyltransferase* 2 (DGAT-2)**. Obeversen can be used in the research of nonalcoholic fatty liver disease .

HY-145624A

Obeversen sodium ION-769357 sodium		Antisense Oligonucleotides
Obeversen sodium is an antisense oligonucleotide that inhibits the synthesis of *Diacylglycerol acyltransferase* 2 (DGAT-2)**. Obeversen sodium can be used in the research of nonalcoholic fatty liver disease .

Targets Recommended: Acyltransferase PNPLA3

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-13912G

IWP-2 1 Publications Verification	Wnt	Cancer
IWP-2 (GMP) is >IWP-2 (HY-13912) produced by using GMP guidelines. GMP small molecules work appropriately as an auxiliary reagent for cell therapy manufacture. IWP-2 is an inhibitor of Wnt processing and secretion with an IC₅₀ of 27 nM. IWP-2 targets the membrane-bound O-acyltransferase porcupine (Porcn) and blocks Wnt ligand palmitoylation .

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Acyltransferase Inhibitor

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