1. Metabolic Enzyme/Protease
  2. Acyltransferase
  3. DGAT1-IN-1

DGAT1-IN-1 

Cat. No.: HY-12425 Purity: 95.14%
Handling Instructions

DGAT1-IN-1 is a potent DGAT1 inhibitor with IC50 of < 10 nM(cell lysate from Hep3B cells overexpressing human DGAT1).

For research use only. We do not sell to patients.

DGAT1-IN-1 Chemical Structure

DGAT1-IN-1 Chemical Structure

CAS No. : 1449779-49-0

Size Price Stock Quantity
10 mM * 1 mL in DMSO USD 182 In-stock
Estimated Time of Arrival: December 31
5 mg USD 150 In-stock
Estimated Time of Arrival: December 31
10 mg USD 250 In-stock
Estimated Time of Arrival: December 31
50 mg USD 750 In-stock
Estimated Time of Arrival: December 31
100 mg USD 1250 In-stock
Estimated Time of Arrival: December 31
200 mg   Get quote  
500 mg   Get quote  

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Based on 1 publication(s) in Google Scholar

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Description

DGAT1-IN-1 is a potent DGAT1 inhibitor with IC50 of < 10 nM(cell lysate from Hep3B cells overexpressing human DGAT1). IC50 value: < 10 nM Target: DGAT1 inhibitor Imidazopyridine and imidazothiazole compounds as inhibitors of diacylglycerol o-acyltransferase type 1 enzyme and their preparation By Kim, Dooseop; Bok, Juhan; Shin, Sunmi From PCT Int. Appl. (2013), WO 2013119040 A1 20130815.

Molecular Weight

551.56

Formula

C₃₀H₂₈F₃N₃O₄

CAS No.

1449779-49-0

SMILES

OC(C[[email protected]]1CC[[email protected]](C2=CC=C(C3=CN4C=C(C(NCC5=CC=C(OC(F)(F)F)C=C5)=O)N=C4C=C3)C=C2)CC1)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 20 mg/mL (36.26 mM; Need ultrasonic)

H2O : < 0.1 mg/mL (insoluble)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8130 mL 9.0652 mL 18.1304 mL
5 mM 0.3626 mL 1.8130 mL 3.6261 mL
10 mM 0.1813 mL 0.9065 mL 1.8130 mL
*Please refer to the solubility information to select the appropriate solvent.
References
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The dilution calculator equation

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This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2

Keywords:

DGAT1-IN-1AcyltransferaseDiacylglycerol acyltransferaseDiglyceride acyltransferaseacyl-CoA:cholesterol acyltransferasemono- acylglycerol acyltransferaseInhibitorinhibitorinhibit

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Product Name:
DGAT1-IN-1
Cat. No.:
HY-12425
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