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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
19 Results for "
Alanine transaminase
" in MedChemExpress (MCE) Product Catalog:
Products (19)
19 Results for "Alanine transaminase" in MCE Product Catalog:
2
Target:
Research Areas:
Bifendate (DDB), extracted from Schisandrae chinensis, is an orally active anti-HBV agent against chronic hepatitis B. Bifendate inhibits ATG5-dependent autophagy and attenuates oleic acid-induced lipid accumulation with anti-oxidant properties in vitro. Bifendate can decrease alanine transaminase (ALT) level in mice. Bifendate attenuates hepatic steatosis in cholesterol/bile salt- and high-fat diet-induced hypercholesterolemia in mice. Bifendate potently increases the activity of cytochrome proteins (CYPs) and reverse P-gp-mediated multi-drug resistance (MDR) .
Cat. No.: HY-N7697B
CAS No.: 115350-24-8
Target:
Target:
Cat. No.: HY-P3170
CAS No.: 61461-61-8
Target:
Research Areas:
β-alanine-pyruvate transaminase is an enzyme. Dihydrouracil and dihydrothymine, as nitrogen sources, increase the activity of β-alanine-pyruvate transaminase in cultured B. cepacia cells. The activity of β-alanine-pyruvate transaminase can be measured by tracking the release of L-α-alanine during the reaction .
Cat. No.: HY-W018791R
CAS No.: 73536-69-3
Synonyms: DDB (Standard)
Research Areas:
Bifendate (DDB), extracted from Schisandrae chinensis, is an orally active anti-HBV agent against chronic hepatitis B. Bifendate inhibits ATG5-dependent autophagy and attenuates oleic acid-induced lipid accumulation with anti-oxidant properties in vitro. Bifendate can decrease alanine transaminase (ALT) level in mice. Bifendate attenuates hepatic steatosis in cholesterol/bile salt- and high-fat diet-induced hypercholesterolemia in mice. Bifendate potently increases the activity of cytochrome proteins (CYPs) and reverse P-gp-mediated multi-drug resistance (MDR) .
Cat. No.: HY-173293
CAS No.: 2570985-89-4
Target:
Research Areas:
ASK1-IN-8 (Compound 35) is an orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 value of 1.8 nM . In an experimental mouse model of liver injury induced by Acetaminophen (HY-66005), ASK1-IN-8 can significantly reduce the plasma alanine transaminase (ALT) level, protecting the liver . ASK1-IN-8 can be used in research related to liver diseases .
Cat. No.: HY-184701
Research Areas:
α-Glucosidase-IN-119 is an α-glucosidase inhibitor with an IC50 of 3.32 μM and oral effectiveness. α-Glucosidase-IN-119 acts as an antihyperglycemic agent, reduces blood glucose levels, restores normal levels of alkaline phosphatase, aspartate transaminase, alanine transaminase, urea, blood urea nitrogen, and total protein, and exhibits antioxidant activity. α-Glucosidase-IN-119 can be used for the research of type 2 diabetes mellitus .
Cat. No.: HY-W076861
CAS No.: 5678-45-5
Target:
Research Areas:
3-Amino-3-(4-methoxyphenyl)propanoic acid is a β-amino acid. 3-Amino-3-(4-methoxyphenyl)propanoic acid can be stereoselectively synthesized using alanine as an amino donor and 3-(4-methoxyphenyl)3-oxopropanoic acid as an amino acceptor with a β-amino acid transaminase. 3-Amino-3-(4-methoxyphenyl)propanoic acid can be enantiomerically enriched from a racemic mixture using pyruvic acid as an amino acceptor with a β-amino acid transaminase. 3-Amino-3-(4-methoxyphenyl)propanoic acid can be used for research of bacterial and fungal infections .
Cat. No.: HY-P702494
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: GPT; Glutamate Pyruvate transaminase 1; Glutamic--Pyruvic transaminase; Glutamic--Pyruvic transaminase 1; ALT1; Alanine Aminotransferase 1; GPT1; Alanine Aminotransferase; SGPT; Alanine transaminase; ALT; AAT1; Glutamic-Pyruvate transaminase (Alanine Amin
Species:
Human
Source:
E. coli
Cat. No.: HY-P75158
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GPT; Glutamate Pyruvate transaminase 1; Glutamic--Pyruvic transaminase; Glutamic--Pyruvic transaminase 1; ALT1; Alanine Aminotransferase 1; GPT1; Alanine Aminotransferase; SGPT; Alanine transaminase; ALT; AAT1; Glutamic-Pyruvate transaminase (Alanine Amin
Species:
Rat
Source:
Sf9 insect cells
Cat. No.: HY-P75797
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: GPT2; Glutamic Pyruvate transaminase (Alanine Aminotransferase) 2; Glutamic--Pyruvic transaminase 2; Glutamate Pyruvate transaminase 1; ALT2; Glutamic--Pyruvic transaminase 1; Alanine Aminotransferase 2; Glutamic--Alanine transaminase 1; Glutamate Pyruvat
Species:
Rat
Source:
Sf9 insect cells
Cat. No.: HY-W083125
CAS No.: 86711-45-7
Research Areas:
Asp-02 is an orally active AMPK activator. Asp-02 reduces non-fasting blood glucose levels, improves body weight, and normalizes elevated serum levels of aspartate transaminase (SGOT), alanine transaminase (SGPT), alkaline phosphatase (ALP), urea and creatinine. Asp-02 can be used in the research of type 2 diabetes .
Cat. No.: HY-E71045
Research Areas:
D-Amino Acid Transaminase, Bacillus subtilis (EC 2.6.1.21) A pyridoxal phosphatase that acts on a variety of D-amino acids, with D-alanine and D-2-aminobutyric acid being the best amino acid donors.
Cat. No.: HY-E71806
Target:
Research Areas:
4-Aminobutyrate-pyruvate transaminase (EC 2.6.1.96) is a transferase that can catalyze multiple reactions, including reaction 1: convert 4-aminobutanoate and pyruvate into succinate semialdehyde and L-alanine; reaction 2: convert 4-aminobutanoate and glyoxylate into succinate semialdehyde and glycine.
Cat. No.: HY-E71112
Target:
Research Areas:
(S)-3-Amino-2-methylpropionate transaminase (EC 2.6.1.22) acts on β-alanine and other ω-amino acids having carbon chains between 2 and 5. The two enantiomers of the 2-methyl-3-oxopropanoate formed by the enzyme interconvert by enolization.
Cat. No.: HY-177972
Research Areas:
Zotadirsen is the core component of the AOC drug Delpacibart zotadirsen (AOC1044) (HY-177564), consisting of a phosphorodiamidate morpholino oligonucleotide (PMO) targeting exon 44 of the dystrophin gene and an SMCC linker (HY-42360). Upon conjugation with the anti-TfR1 antibody Delpacibart (HY-P990051), Zotadirsen exerts splicing regulatory activity and mediates exon skipping. Zotadirsen can be used in studies related to AOC synthesis .
Cat. No.: HY-189393
CAS No.: 3089177-97-6
Target:
Research Areas:
RTY-406 is an orally active ABCB4/MDR3 and ABCB11/BSEP positive modulator. RTY-406 increases ABCB4/MDR3 and ABCB11/BSEP protein levels and functional output, elevates biliary phospholipid levels, enhances bile acid efflux, increases bile flow and micelle formation, reduces hepatic bile acids, and promotes cholesterol-to-bile-acid conversion. RTY-406 does not induce hepatocellular injury, maintains normal serum alanine transaminase and aspartate aminotransferase levels, and shows a favorable safety profile in cynomolgus monkeys. RTY-406 can be used for the research of primary sclerosing cholangitis and cholestasis .
Cat. No.: HY-L064
1,827 compounds
Glutamine is an important metabolic fuel that helps rapidly proliferating cells meet the increased demand for ATP, biosynthetic precursors, and reducing agents. Glutamine Metabolism pathway involves the initial deamination of glutamine by glutaminase(GLS), yielding glutamate and ammonia. Glutamate is converted to the TCA cycle intermediate α-ketoglutarate (α-KG) by either glutamate dehydrogenase (GDH) or by the alanine or aspartate transaminases (TAs), to produce both ATP and anabolic carbons for the synthesis of amino acids, nucleotides and lipids. During periods of hypoxia or mitochondrial dysfunction, α-KG can be converted to citrate in a reductive carboxylation reaction catalyzed by IDH2. The newly formed citrate exits the mitochondria where it is used to synthesize fatty acids and amino acids and produce the reducing agent, NADPH.
Cancer cells display an altered metabolic circuitry that is directly regulated by oncogenic mutations and loss of tumor suppressors. Mounting evidence indicates that altered glutamine metabolism in cancer cells has critical roles in supporting macromolecule biosynthesis, regulating signaling pathways, and maintaining redox homeostasis, all of which contribute to cancer cell proliferation and survival. Thus, intervention in glutamine metabolic processes could provide novel approaches to improve cancer treatment.
MCE owns a unique collection of 1,827 compounds targeting the mainly proteins and enzymes involved in glutamine metabolism pathway. Glutamine Metabolism compound library is a useful tool for intervention in glutamine metabolic processes.
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
