2570985-89-4
Chemical Structure
ASK1-IN-8
- CAS No.: 2570985-89-4
- Formula:C26H32N8O2
- Molecular Weight:488.58
InChIKey: PFWQYMLTRDLYDO-UHFFFAOYSA-N
SMILES: CNC(C1CCN(C2=CC=C(N3C(N(C4=NC(C5=NN=CN5C(C)C)=CC=C4)CC3)=O)C=C2)CC1)=O
Biological Activity: ASK1-IN-8 (Compound 35) is an orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 value of 1.8 nM[1]. In an experimental mouse model of liver injury induced by Acetaminophen (HY-66005), ASK1-IN-8 can significantly reduce the plasma alanine transaminase (ALT) level, protecting the liver[1]. ASK1-IN-8 can be used in research related to liver diseases[1].
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ASK1-IN-8 | ASK1-IN-8 (Compound 35) is an orally active inhibitor of apoptosis signal-regulating kinase 1 (ASK1) with an IC50 value of 1.8 nM. In an experimental mouse model of liver injury induced by Acetaminophen (HY-66005), ASK1-IN-8 can significantly reduce the plasma alanine transaminase (ALT) level, protecting the liver. ASK1-IN-8 can be used in research related to liver diseases. | |||||||||||||||||||||
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Keywords
