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Arachidonoyl

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Akt (1) Amino Acid Derivatives (1) Apoptosis (2) Biochemical Assay Reagents (15) Calcium Channel (1) Cannabinoid Receptor (8) DGK (1) DNA/RNA Synthesis (1) Dopamine Receptor (1) Drug Derivative (1) Endogenous Metabolite (24) FAAH (4) Ferroptosis (1) Fluorescent Dye (1) Fungal (1) GABA Receptor (1) GPR55 (1) Isotope-Labeled Compounds (13) Lipocalin Family (1) Liposome (4) LPL Receptor (2) MAGL (1) p38 MAPK (1) Phospholipase (1) PKC (2) Potassium Channel (1) PPAR (1) Reactive Oxygen Species (ROS) (2) Tau Protein (1) TRP Channel (7)
By Research Areas:	Cancer (4) Cardiovascular Disease (6) Endocrinology (1) Infection (2) Inflammation/Immunology (4) Metabolic Disease (30) Neurological Disease (11)
Oligonucleotides:	Phospholipids (10)

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Isotope-Labeled Compounds

Oligonucleotides

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-10863

Anandamide 2 Publications Verification AEA; Arachidonoyl ethanolamide	Cannabinoid Receptor PPAR TRP Channel GPR55 Fungal Tau Protein Endogenous Metabolite	Infection Neurological Disease Metabolic Disease Inflammation/Immunology
Anandamide is an endocannabinoid. Anandamide modulates both neuronal and immune functions through two protein-coupled cannabinoid receptors (CB1 and CB2). Anandamide can activate numerous other receptors like PPARS, TRPV1, and GPR18/GPR55. Anandamide also has potential anti-fungal and anti-inflammatory activities. Anandamide can be used for the research of Alzheimer’s disease (AD) and ulcerative colitis .

HY-177475

LysoPC(20:4) 1-Arachidonoyl-sn-glycero-3-phosphocholine	Endogenous Metabolite	Metabolic Disease Cancer
LysoPC 20:4 (20:4) (1-Arachidonoyl-sn-glycero-3-phosphocholine) is a serum metabolite. LysoPC 20:4 (20:4) decreases in tumor-bearing mice, but the reduction is not significant. LysoPC (20:4) can be used in cancer and obesity-related research .

HY-131897

*1-Stearoyl-2-arachidonoyl-sn-glycerol* 1 Publications Verification	PKC TRP Channel Endogenous Metabolite	Neurological Disease
1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) containing polyunsaturated fatty acids. 1-Stearoyl-2-arachidonoyl-sn-glycerol can activate PKC. 1-Stearoyl-2-arachidonoyl-sn-glycerol also can augment nonselective cation channel (NSCC) activity .

HY-110292

A-425619	TRP Channel Calcium Channel	Inflammation/Immunology
A-425619 is an orally active and selective transient receptor potential type V1 (TRPV1) antagonist. A-425619 blocks Capsaicin (HY-10448)- and N-arachidonoyl-dopamine (NADA)-induced Ca ²⁺ influx in dorsal root ganglia and trigeminal ganglia. A-425619 relieves pathophysiological pain associated with inflammation and tissue injury in rats. A-425619 can be used for the study of pain related to inflammation and tissue injury .

HY-126356

*1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine*	Liposome	Cardiovascular Disease
1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine is a major phospholipid in low-density lipoprotein and belongs to the group of 1-acyl phosphatidylcholines. 1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine does not induce morphological changes in washed human platelets. 1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine can be used for the research of atherosclerosis and thrombotic diseases .

HY-110072S

Anandamide-d4 AEA-d₄; Arachidonoyl ethanolamide-d₄	Isotope-Labeled Compounds	Others
Anandamide-d₄ (AEA-d₄) is the deuterium labeled Anandamide.

HY-112747

Soy PE LPI; PE (soy)	Phospholipase	Infection
Soy PE (LPI) is the most abundant phospholipid in prokaryotes and the second most abundant found in the membrane of mammalian, plant, and yeast cells, comprising approximately 25% of total mammalian phospholipids. In the brain, phosphatidylethanolamine comprises almost half of the total phospholipids. It is synthesized mainly through the cytidine diphosphate-ethanolamine and phosphatidylserine decarboxylation pathways, which occur in the endoplasmic reticulum (ER) and mitochondrial membranes, respectively. It is a precursor in the synthesis of phosphatidylcholine and arachidonoyl ethanolamide and is a source of ethanolamine used in various cellular functions. In E.coli, phosphatidylethanolamine deficiency prevents proper assembly of lactose permease, suggesting a role as a lipid chaperone. It is a cofactor in the propagation of prions in vitro and can convert recombinant mammalian proteins into infectious molecules even in the absence of RNA. This product contains phosphatidylethanolamine molecular species with variable fatty acyl chain lengths at the sn-1 and sn-2 positions .

HY-148979

*1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphorylethanolamine* SAPE	Biochemical Assay Reagents	Others
1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphorylethanolamine (SAPE) is a naturally-occurring phospholipid that can be found in inner mitochondrial membrane (MITO) .

HY-131678

Palmitoyl serotonin PA-5HT	FAAH	Neurological Disease
Palmitoyl serotonin is a hybrid molecule patterned after arachidonoyl serotonin, antagonist of FAAH. Palmitoyl serotonin inhibits L-3,4-dihydroxyphenylalanine (HY-N0304) induced abnormal involuntary movements. Palmitoyl serotonin has the potential for the research of parkinson's disease (PD) .

HY-115701

1-Stearoyl-2-15(S)-Hpete-Sn-Glycero-3-Pe 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-phosphoethanolamine; 15(S)-HpETE-SAPE; 15(S)-hydroperoxyeicostetraenoic acid-SAPE	Ferroptosis	Inflammation/Immunology
1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-Pe is a phospholipid that contains stearic acid (HY-B2219) at the sn-1 position and 15(S)-HpETE at the sn-2 position. It is produced via oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-Pe (SAPE) by 15-lipoxygenase (15-LO). 1-Stearoyl-2-15(S)-HpETE-sn-glycero-3-Pe (0.6 and 0.9 μM) increases ferroptotic cell death in wild-type and Acsl4 knockout Pfa1 mouse embryonic fibroblasts (MEFs) treated with the GPX4 inhibitor RSL3.

HY-157629

*1-Palmitoyl-2-arachidonoyl-sn-glycero-3-PE* PAPE; 1-Palmitoyl-2-Arachidonoyl PE	Reactive Oxygen Species (ROS)	Others
1-Palmitoyl-2-arachidonoyl-sn-glycero-3-PE (PAPE), a compound isolated from egg yolk with antioxidant activity related to the unsaturated fatty acid content, was extracted, purified, and analyzed by various techniques.

HY-120957

*AMC Arachidonoyl* Amide** AMC-AA; 7-Amino-4-methyl coumarin-arachidonamide	Endogenous Metabolite	Metabolic Disease
AMC arachidonoyl amide (AMC-AA) is one of several fatty acid amides which can be used to measure fatty acid amide hydrolase (FAAH) activity.1 FAAH is a relatively unselective enzyme in that it accepts a variety of amide head groups other than the ethanolamine of its nominal endogenous substrate anandamide.2 Exposure of AMC-AA to FAAH activity results in the release of the fluorescent aminomethyl coumarin that absorbs at 360 nm and emits at 465 nm. This allows the fast and convenient measurement of FAAH activity using a simple cuvette or microplate fluorometer.

HY-117141

*N-Arachidonoyl-3-hydroxy-γ-aminobutyric acid* AGABA	Amino Acid Derivatives	Others
N-Arachidonoyl-3-hydroxy-γ-aminobutyric acid is an arachidonoyl amino acid .

HY-141636

1-PalMitoyl-2-arachidoyllecithin 1-Palmitoyl-2-Arachidonoyl-sn-glycero-3-phosphocholine; PAPC; PC(16:0/20:4)	Endogenous Metabolite Biochemical Assay Reagents	Cardiovascular Disease
1-Palmitoyl-2-arachidonoyl-sn-glycero-3-PC (PAPC) is a phospholipid containing palmitic acid (16:0) and arachidonic acid (20:4) at the sn-1 and sn-2 positions, respectively, that is found in biological membranes. PAPC is oxidized in vivo, and its oxidation products are involved in chronic inflammation and vascular disease. PAPC has been used to study signaling of oxidized phospholipids. Levels of PAPC are decreased in isolated human multiple myeloma cells.

HY-157697

*1-1(Z)-Octadecenyl-2-arachidonoyl-sn-glycero-3-PE* 18:0p/20:4-PE; C18(Plasm)-20:4-PE; PE(P-18:0/20:4)	Endogenous Metabolite	Metabolic Disease
1-1(Z)-Octadecenyl-2-arachidonoyl-sn-glycero-3-PE (18:0p/20:4-PE; C18(Plasm)-20:4-PE) is a plasmalogen that contains 1(Z)-octadecenoic acid and arachidonic acid (HY-109590) at the sn-1 and sn-2 positions, respectively.

HY-120962

*N-Arachidonoyl* Taurine**	TRP Channel	Metabolic Disease
N-Arachidonoyl Taurine is an activator of the transient receptor potential vanilloid TRPV1 and TRPV4, with EC₅₀s value of 28 μM and 21 μM, respectively .

HY-108455

N-Palmitoyl dopamine PALDA	Dopamine Receptor TRP Channel	Neurological Disease
N-Palmitoyl dopamine (PALDA) is a endogenous, long-chain, linear fatty acid dopamide, which is inactive on TRPV1. N-Palmitoyl dopamine displays 'entourage' effects on endovanilloids N-arachidonoyl-dopamine (NADA) and anandamide .

HY-125139

omega-3 Arachidonic acid ethyl ester, in ethanol, 98% ω-3 Arachidonic acid ethyl ester, in ethanol, 98%; (all-Z)-8,11,14,17-Eicosatetraenoic acid ethyl ester, in ethanol, 98%	Biochemical Assay Reagents	Cardiovascular Disease Others
omega-3 Arachidonic acid ethyl ester, in ethanol, 98% is a rare polyunsaturated fatty acid found in very small amounts in dietary sources. Omega-3 fatty acids are known to be essential for the growth and development of infants, and they protect against heart disease, blood clots, high blood pressure, and inflammatory and autoimmune diseases. In human platelet membranes, omega-3 arachidonic acid inhibits arachidonyl-CoA synthetase with a Ki of 14 μM. It also inhibits arachidonoyl-CoA synthetase in calf brain extract with an IC50 of approximately 5 μM. Omega-3 ethyl arachidonate is the more lipophilic form of the free acid.

HY-N8633

*1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphoinositol*	Endogenous Metabolite	Others
1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphoinositol is an endogenous metabolite that is a cell membrane component .

HY-157698

*1-1(Z)-Octadecenyl-2-arachidonoyl-sn-glycero-3-PC* C18(plasm)-20:4-PC; 18:0p/20:4-PC; PC(P-18:0/20:4)	Endogenous Metabolite	Metabolic Disease
1-1(Z)-Octadecenyl-2-arachidonoyl-sn-glycero-3-PC is a plasmalogen that contains 1(Z)-octadecenoic acid and arachidonic acid (HY-109590) at the sn-1 and sn-2 positions, respectively. It scavenges singlet oxygen in a cell-free assay.

HY-120963

N-Oleoyl Taurine	Endogenous Metabolite	Metabolic Disease
Several different arachidonoyl amino acids, including N-arachidonoyl dopamine and N-arachidonoyl serine, have been isolated and characterized from bovine brain.1 During mass spectral lipidomics analysis of rat brain, a series of fatty acyl amides of a third amino acid, taurine, were discovered.2 This novel class of compounds is present in kidney and activates members of the transient receptor potential (TRP) family of calcium channels.3 N-Oleoyl taurine is an amino-acyl endocannabinoid isolated from rat brain that may activate TRPV1 and TRPV4.

HY-134545

*N-Arachidonoyl-L-alanine* 2 Publications Verification NALA	Reactive Oxygen Species (ROS)	Cancer
N-Arachidonoyl-L-alanine is an endocannabinoid analog with anti-cancer effects. N- Arachidonoyl-L-alanine kills HNSCC cells through 5-LO-mediated ROS productio .

HY-134173

Arachidonoyl ethanolamide phosphate	Cannabinoid Receptor Apoptosis	Neurological Disease
Arachidonoyl ethanolamide phosphate, an endocannabinoid, is an endogenous ligand for cannabinoid receptors in the central nervous system (CB1 subtype) and peripheral immune cells (CB2 subtype) .

HY-W127380

Arachidonoyl thio-PC	Biochemical Assay Reagents	Others
Arachidonoyl Thio-PC is a substrate of many phospholipase A2 (PLA2), including sPLA2, cPLA2 and iPLA2. Cleavage of sn-2 fatty acids by PLA2 results in the production of free thiols, which react with chromogenic reagents such as DTNB (Ellman's reagent) and DTP, allowing quantification of PLA2 activity. Isozyme-specific cPLA2 activity can be measured by depleting or inhibiting sPLA2 and iPLA2 activity in the assay.

HY-120965

N-Palmitoyl Taurine	Endogenous Metabolite	Metabolic Disease
Several different arachidonoyl amino acids, including N-arachidonoyl dopamine (NADA) and N-arachidonoyl serine (ARA-S), have been isolated and characterized from bovine brain.1 During mass spectral lipidomic analysis of rat brain, a series of fatty acyl amides of a third amino acid, taurine, is discovered. N-Palmitoyl taurine is a prominent amino-acyl endocannabinoid isolated from rat brain during lipidomics profiling. Its function is currently under investigation.

HY-126031A

(S)-KT109	Endogenous Metabolite	Others
(S)-KT109 is an inhibitor of diacylglycerol lipase β (DAGLβ) with low inhibitory activity (IC50 = 39.81 nM). (S)-KT109 has relatively low inhibitory activity against DAGLα-mediated hydrolysis of 1-stearoyl-2-arachidonoyl-sn-glycerol (IC50 = 794.3 nM). (S)-KT109 also has relatively low inhibitory activity against α/β-amidase domain-containing 6 (ABHD6) (IC50 = 630.9 nM) .

HY-134428

Arachidonoyl coenzyme A lithium	Endogenous Metabolite	Metabolic Disease
Arachidonoyl coenzyme A lithium is an unsaturated fatty acyl coenzyme A, formed by the condensation of the thiol group of coenzyme A with the carboxyl group of arachidonic acid .

HY-145486

*1-Arachidonoyl-sn-glycerol 3-phosphate ammonium* 20:4 Lyso PA	Liposome	Neurological Disease
1-Arachidonoyl-sn-glycerol 3-phosphate ammonium (20:4 Lyso PA) is a phospholipid and an LPA derived from arachidonic acid. The concentration of 1-Arachidonoyl-sn-glycerol 3-phosphate ammonium in plasma is significantly correlated with the age of onset of cocaine use and the duration of abstinence. 1-Arachidonoyl-sn-glycerol 3-phosphate ammonium can be used in the research of biomarkers for cocaine use disorder (CUD) .

HY-139931S

*1-Stearoyl-2-Arachidonoyl-d8-sn-glycero-3-PC*	Isotope-Labeled Compounds	Others
1-Stearoyl-2-Arachidonoyl-d₈-sn-glycero-3-PC is the deuterium labeled 1-Stearoyl-2-Arachidonoyl-sn-glycero-3-PC .

HY-W127407

*Glycerophospho-N-arachidonoyl* ethanolamine**	Biochemical Assay Reagents	Others
Glycerophospho-N-Arachidonoyl Ethanolamine is a N-acylated ethanolamines (NAEs). Most NAEs are naturally occurring lipids with diverse biological activities. Different types of NAE can be derived from glycerophosphate-linked precursors through the activity of glycerophosphodiesterase 1 (GDE1). Glycerophosphate-N-Arachidonoyl Ethanolamine is the precursor of Anandamide (AEA), also known as Anandamide. AEA is an endocannabinoid neurotransmitter that binds to central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. It inhibits the specific binding of [3H]-HU-243 to synaptosomal membranes with a Ki value of 52 nM compared to 46 nM for δ9-THC.

HY-103507

N-Arachidonyl-GABA	GABA Receptor	Neurological Disease
N-Arachidonoyl-GABA is one member of a new class of lipoamino acids related to anandamide identified in bovine brain. N-Arachidonoyl-GABA displays analgesic activity .

HY-139182

MAGL-IN-3	Endogenous Metabolite	Metabolic Disease
CAY10762 is an inhibitor of monoacylglycerol lipase (MAGL; IC₅₀=34.1 nM). It reduces hydrogen peroxide-induced lactate dehydrogenase (LDH) release from Neuro2a cells when used at a concentration of 1 μM. CAY10762 (10 mg/kg) increases levels of 2-arachidonoyl glycerol in mouse brain.

HY-120964

N-Stearoyl Taurine	Endogenous Metabolite	Metabolic Disease
Several different arachidonoyl amino acids, including N-arachidonoyl dopamine (NADA) and N-arachidonoyl serine (ARA-S), have been isolated and characterized from bovine brain.1 During mass spectral lipidomic analysis of rat brain, a series of fatty acyl amides of a third amino acid, taurine, is discovered.2 This novel class of compounds is present in kidney and activates members of the transient receptor potential (TRP) family of calcium channels.3 N-Stearoyl taurine is a prominent amino-acyl endocannabinoid isolated from rat brain during lipidomics profiling.

HY-126720

N-Lignoceroyl Taurine	Endogenous Metabolite	Metabolic Disease
N-Lignoceroyl Taurine is an arachidonoyl amino acid and taurine conjugate with a fatty acid that can be isolated from bovine brain. N-Lignoceroyl Taurine is one of several novel taurine-conjugated fatty acids discovered during mass spectrometry lipidomic analysis of the brain and spinal cord of wild-type and fatty acid amide hydrolase (FAAH) knockout mice. N-Lignoceroyl Taurine levels were 23-26-fold higher in FAAH ^-/- mice compared to wild-type mice, suggesting that FAAH utilizes N-Lignoceroyl Taurine as a substrate. However, in vitro experiments with purified FAAH showed that N-Lignoceroyl Taurine was hydrolyzed 2,000-fold slower in FAAH compared to oleoylethanolamide. N-Acyl Taurines with polyunsaturated acyl chains can activate members of the transient receptor potential (TRP) calcium channel family, including TRPV1 and TRPV4.

HY-171906A

*1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA sodium* 1-Arachidonoyl-sn-glycerol 3-phosphate sodium; 1-Arachidonoyl LPA sodium; LPA (20:4) sodium	LPL Receptor	Cancer
1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA (sodium) (1-Arachidonoyl-sn-glycerol 3-phosphate (sodium)) is a phospholipid with arachifonic acid at the sn-1 position. 1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA (sodium) binds to the LPA₂/EDG4 receptor (EC₅₀ of 10 nM). 1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA (sodium) can be found in rat brain as 37% of the arachidoinic acid-containing lysophosphatidic acid species. 1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA (sodium) is the precursor to 1-arachidonoyl glycerol. 1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA (sodium) can prevent TNF-α and IL-6 secretion in wild type LPS-stimulated dendritic cells. 1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA (sodium) reduces differentiation of HT-29 colon carcinoma cells into goblet cells when sodium butyrate is present .

HY-146945S

Arachidonoyl LPA-d5	Isotope-Labeled Compounds	Others
Arachidonoyl LPA-d₅ is deuterium labeled Arachidonoyl LPA.

HY-158784

Arachidonoyl m-nitroaniline	FAAH	Others
Arachidonoyl m-Nitroaniline (AmNA) is one of several nitroaniline fatty acid amides which can be used to measure fatty acid amide hydrolase (FAAH) activity. Arachidonoyl m-Nitroaniline is a FAAH substrate .

HY-120960

*N-Arachidonoyl-L-serine* ARA-S	Akt p38 MAPK Apoptosis Potassium Channel	Cardiovascular Disease Neurological Disease
N-Arachidonoyl-L-serine (ARA-S) is an endocannabinoid. N-Arachidonoyl-L-serine induces phosphorylation of Akt and MAPK in endothelial cells. N-Arachidonoyl-L-serine also induces endothelium-dependent vasodilation in isolated rat mesenteric and abdominal aortas. N-Arachidonoyl-L-serine exhibits neuroprotective effects after traumatic brain injury by reducing apoptosis. N-Arachidonoyl-L-serine promotes the opening of KV7.1/KCNE1 channels in mammalian cells and shortens the action potential duration in cardiomyocytes. N-Arachidonoyl-L-serine may be used in research on cardiovascular and cerebrovascular diseases and neurological disorders .

HY-158801

Arachidonoyl-L-carnitine chloride C20:4 Carnitine chloride; L-Arachidonoylcarnitine chloride; L-Carnitine Arachidonoyl ester chloride	Endogenous Metabolite	Metabolic Disease
Arachidonoyl-L-carnitine (C20:4 Carnitine) chloride is an arachidonic acid-L-carnitine complex .

HY-165157

*1-1(Z)-Hexadecenyl-2-arachidonoyl-sn-glycero-3-PC* 16:0p/20:4-PC; PC(P-16:0/20:4); C16(plasm)-20:4-PC	Biochemical Assay Reagents	Others
1-1(Z)-Hexadecenyl-2-arachidonoyl-sn-glycero-3-PC is a biochemical reagent.

HY-152898A

Arachidonoyl CoA triammonium	Biochemical Assay Reagents	Others
Arachidonoyl CoA triammonium is used as a substrate in the synthesis of Arachidonoyl amino acids. Arachidonoyl CoA triammonium directly interacts with FadR to inhibit binding at its DNA targets .

HY-111293

Arachidonamide Arachidonoyl amine; Arachidonic acid amide	FAAH	Metabolic Disease
Arachidonamide is substrate of anandamide amidohydrolase .

HY-134224

Arachidonoyl 2'-fluoroethylamide	Cannabinoid Receptor	Endocrinology
Arachidonoyl 2'-fluoroethylamide is an anandamide analog. Arachidonoyl 2'-fluoroethylamide has the potential for the research of intraocular hypertension .

HY-171906

*1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA* 1-Arachidonoyl-sn-glycerol 3-phosphate; 1-Arachidonoyl LPA; LPA (20:4)	LPL Receptor	Inflammation/Immunology
1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA is a phospholipid containing arachidonic acid at the sn-1 position. It is a precursor to 1-arachidonoyl glycerol (1-Monoarachidin; HY-130567) . 1-Arachidonoyl-2-hydroxy-sn-glycero-3-PA binds to the LPA2/EDG4 receptor with an EC50 value of approximately 10 nM . It prevents TNF-α and IL-6 secretion in wild-type but not Lpa2-/- dendritic cells stimulated by LPS . It also decreases differentiation of HT-29 human colon carcinoma cells to goblet cells in the presence of sodium butyrate .

HY-120962S

*N-Arachidonoyl* Taurine-d4**	Isotope-Labeled Compounds	Others
N-Arachidonoyl Taurine-d₄ is the deuterium labeled N-Arachidonoyl Taurine .

HY-W742940

*O-Arachidonoyl* glycidol-d5**	Isotope-Labeled Compounds Cannabinoid Receptor	Metabolic Disease
O-Arachidonoyl glycidol-d₅ is the deuterium labeled O-Arachidonoyl glycidol (HY-131995). O-Arachidonoyl glycidol (compound 1) is a 2-arachidonoylglycerol (2-AG) analog. O-Arachidonoyl glycidol inhibits cytosolic 2-oleoylglycerol (2-OG) hydrolysis with an IC₅₀ value of 4.5 μM. O-Arachidonoyl glycidol blocks 2-OG hydrolysis in membrane fractions and anandamide hydrolysis with IC₅₀s of 19, 12 μM, respectively .

HY-139394

Arachidonoyl-1-thio-glycerol	Lipocalin Family	Metabolic Disease
Arachidonoyl-1-thio-glycerol (Compound 5) is an nonretinoid ligand lipid that can interact with cellular retinol binding protein 2 (CRBP2) .

HY-121476

Arachidonoyl Serinol	MAGL	Neurological Disease
Arachidonoyl Serinol, an endogenous cannabimimetic metabolite, is an inhibitor of monoacylglycerol lipase (MAGL). Arachidonoyl Serinol inhibits the hydrolysis of [ ³H]2-oleoylglycerol and [ ³H]anandamide with IC₅₀s of ～70 μM .

HY-131995

*O-Arachidonoyl* glycidol**	Cannabinoid Receptor	Metabolic Disease
O-Arachidonoyl glycidol (compound 1) is a 2-arachidonoylglycerol (2-AG) analog. O-Arachidonoyl glycidol inhibits cytosolic 2-oleoylglycerol (2-OG) hydrolysis with an IC₅₀ value of 4.5 µM. O-Arachidonoyl glycidol blocks 2-OG hydrolysis in membrane fractions and anandamide hydrolysis with IC₅₀s of 19, 12 µM, respectively .

HY-134019

Arachidonoyl p-nitroaniline	Others	Others
Arachidonoyl p-nitroaniline is a substrate for the hydrolysis of p-nitroaniline by FAAH in Dictyostelium discoideum with long-chain unsaturated fatty acids. Arachidonoyl p-nitroaniline can be used in enzyme kinetic studies. Examples include determining the hydrolysis rate of Arachidonoyl p-nitroaniline and analyzing the fatty acid amide hydrolase activity of recombinant His-FAAH purified from Dictyostelium to characterize the binding and catalytic specificity of mammalian FAAH enzymes .

Cat. No.	Product Name	Type

HY-148979

*1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphorylethanolamine* SAPE	Biochemical Assay Reagents
1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphorylethanolamine (SAPE) is a naturally-occurring phospholipid that can be found in inner mitochondrial membrane (MITO) .

HY-125139

omega-3 Arachidonic acid ethyl ester, in ethanol, 98%

ω-3 Arachidonic acid ethyl ester, in ethanol, 98%; (all-Z)-8,11,14,17-Eicosatetraenoic acid ethyl ester, in ethanol, 98%

Biochemical Assay Reagents

omega-3 Arachidonic acid ethyl ester, in ethanol, 98% is a rare polyunsaturated fatty acid found in very small amounts in dietary sources. Omega-3 fatty acids are known to be essential for the growth and development of infants, and they protect against heart disease, blood clots, high blood pressure, and inflammatory and autoimmune diseases. In human platelet membranes, omega-3 arachidonic acid inhibits arachidonyl-CoA synthetase with a Ki of 14 μM. It also inhibits arachidonoyl-CoA synthetase in calf brain extract with an IC50 of approximately 5 μM. Omega-3 ethyl arachidonate is the more lipophilic form of the free acid.

HY-W127380

Arachidonoyl thio-PC

Biochemical Assay Reagents

Arachidonoyl Thio-PC is a substrate of many phospholipase A2 (PLA2), including sPLA2, cPLA2 and iPLA2. Cleavage of sn-2 fatty acids by PLA2 results in the production of free thiols, which react with chromogenic reagents such as DTNB (Ellman's reagent) and DTP, allowing quantification of PLA2 activity. Isozyme-specific cPLA2 activity can be measured by depleting or inhibiting sPLA2 and iPLA2 activity in the assay.

HY-134428

Arachidonoyl coenzyme A lithium	Biochemical Assay Reagents
Arachidonoyl coenzyme A lithium is an unsaturated fatty acyl coenzyme A, formed by the condensation of the thiol group of coenzyme A with the carboxyl group of arachidonic acid .

HY-W127407

Glycerophospho-N-arachidonoyl ethanolamine

Biochemical Assay Reagents

Glycerophospho-N-Arachidonoyl Ethanolamine is a N-acylated ethanolamines (NAEs). Most NAEs are naturally occurring lipids with diverse biological activities. Different types of NAE can be derived from glycerophosphate-linked precursors through the activity of glycerophosphodiesterase 1 (GDE1). Glycerophosphate-N-Arachidonoyl Ethanolamine is the precursor of Anandamide (AEA), also known as Anandamide. AEA is an endocannabinoid neurotransmitter that binds to central cannabinoid (CB1) and peripheral cannabinoid (CB2) receptors. It inhibits the specific binding of [3H]-HU-243 to synaptosomal membranes with a Ki value of 52 nM compared to 46 nM for δ9-THC.

HY-157651

*1-Stearoyl-2-arachidonoyl-sn-glycero-3-phospho-1'-myo-inositol-3',4'-bisphosphate ammonium*	Biochemical Assay Reagents
1-Stearoyl-2-arachidonoyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4'-bisphosphate) ammonium regulates the activity of the actin network associated with endocytic structures .

HY-157652

18:0-20:4 PI(3,4,5)P3 1-Stearoyl-2-Arachidonoyl-sn-glycero-3-phospho-1′-myo-inositol-3′,4′,5′-trisphosphate ammonium	Biochemical Assay Reagents
18:0-20:4 PI(3,4,5)P3 (1-Stearoyl-2-arachidonoyl-sn-glycero-3-phospho-(1′-myo-inositol-3′,4′,5′-trisphosphate) (ammonium)) is a kind of biochemical reagent.

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-10863

Anandamide 2 Publications Verification AEA; Arachidonoyl ethanolamide	Classification of Application Fields Ketones, Aldehydes, Acids Endogenous metabolite Inflammation/Immunology Disease Research Fields Source Classification	Cannabinoid Receptor PPAR TRP Channel GPR55 Fungal Tau Protein Endogenous Metabolite
Anandamide is an endocannabinoid. Anandamide modulates both neuronal and immune functions through two protein-coupled cannabinoid receptors (CB1 and CB2). Anandamide can activate numerous other receptors like PPARS, TRPV1, and GPR18/GPR55. Anandamide also has potential anti-fungal and anti-inflammatory activities. Anandamide can be used for the research of Alzheimer’s disease (AD) and ulcerative colitis .

HY-131897

*1-Stearoyl-2-arachidonoyl-sn-glycerol* 1 Publications Verification	Structural Classification Neurological Disease Classification of Application Fields Endogenous metabolite Disease Research Fields Lipid Source Classification	PKC TRP Channel Endogenous Metabolite
1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) containing polyunsaturated fatty acids. 1-Stearoyl-2-arachidonoyl-sn-glycerol can activate PKC. 1-Stearoyl-2-arachidonoyl-sn-glycerol also can augment nonselective cation channel (NSCC) activity .

HY-126356

*1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine*	Structural Classification Classification of Application Fields Metabolic Disease Endogenous metabolite Disease Research Fields Lipid Source Classification	Liposome
1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine is a major phospholipid in low-density lipoprotein and belongs to the group of 1-acyl phosphatidylcholines. 1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine does not induce morphological changes in washed human platelets. 1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine can be used for the research of atherosclerosis and thrombotic diseases .

HY-120960A

*N-Arachidonoyl-L-Serine sodium* ARA-S sodium	Structural Classification Lipid	Biochemical Assay Reagents
N-Arachidonoyl-L-Serine sodium is an anandamide.

Cat. No.	Product Name	Chemical Structure

HY-110072S

Anandamide-d4
Anandamide-d₄ (AEA-d₄) is the deuterium labeled Anandamide.

HY-139931S

*1-Stearoyl-2-Arachidonoyl-d8-sn-glycero-3-PC*
1-Stearoyl-2-Arachidonoyl-d₈-sn-glycero-3-PC is the deuterium labeled 1-Stearoyl-2-Arachidonoyl-sn-glycero-3-PC .

HY-146945S

Arachidonoyl LPA-d5
Arachidonoyl LPA-d₅ is deuterium labeled Arachidonoyl LPA.

HY-120962S

*N-Arachidonoyl* Taurine-d4**
N-Arachidonoyl Taurine-d₄ is the deuterium labeled N-Arachidonoyl Taurine .

HY-W742940

O-Arachidonoyl glycidol-d5

O-Arachidonoyl glycidol-d₅ is the deuterium labeled O-Arachidonoyl glycidol (HY-131995). O-Arachidonoyl glycidol (compound 1) is a 2-arachidonoylglycerol (2-AG) analog. O-Arachidonoyl glycidol inhibits cytosolic 2-oleoylglycerol (2-OG) hydrolysis with an IC₅₀ value of 4.5 μM. O-Arachidonoyl glycidol blocks 2-OG hydrolysis in membrane fractions and anandamide hydrolysis with IC₅₀s of 19, 12 μM, respectively .

HY-139969S

*1-Arachidonoyl-d5-rac-glycerol*
1-Arachidonoyl-d₅-rac-glycerol is the deuterium labeled 1-Arachidonoyl-rac-glycerol .

HY-143670S

*1-Palmitoyl-2-arachidonoyl-3-palmitoyl-sn-glycerol-d9*
1-Palmitoyl-2-arachidonoyl-3-palmitoyl-sn-glycerol-d₉ is the deuterium labeled 1-Palmitoyl-2-arachidonoyl-3-palmitoyl-sn-glycerol .

HY-131897S

*1-Stearoyl-2-Arachidonoyl-d8-sn-Glycerol*
1-Stearoyl-2-Arachidonoyl-d₈-sn-Glycerol is the deuterium labeled 1-Stearoyl-2-arachidonoyl-sn-glycerol. 1-Stearoyl-2-arachidonoyl-sn-glycerol is a diacylglycerol (DAG) containing polyunsaturated fatty acids. 1-Stearoyl-2-arachidonoyl-sn-glycerol can activate PKC. 1-Stearoyl-2-arachidonoyl-sn-glycerol also can augment nonselective cation channel (NSCC) activity .

HY-126356S

1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine-d11

1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine-d₁₁ is the deuterium labeled 1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (HY-126356). 1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine is a major phospholipid in low-density lipoprotein and belongs to the group of 1-acyl phosphatidylcholines. 1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine does not induce morphological changes in washed human platelets. 1-Stearoyl-2-arachidonoyl-sn-glycero-3-phosphocholine can be used for the research of atherosclerosis and thrombotic diseases .

HY-143671S

*1-Stearoyl-2-arachidonoyl-sn-glycero-3-PE-d11*
1-Stearoyl-2-arachidonoyl-sn-glycero-3-PE-d₁₁ is the deuterium labeled 1-Stearoyl-2-arachidonoyl-sn-glycero-3-PE .

HY-141636S

1-PalMitoyl-2-arachidoyllecithin-d9-1

1-PalMitoyl-2-arachidoyllecithin-d₉-1 (1-Palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine-d₉-1) is deuterium labeled 1-PalMitoyl-2-arachidoyllecithin. 1-Palmitoyl-2-arachidonoyl-sn-glycero-3-PC (PAPC) is a phospholipid containing palmitic acid (16:0) and arachidonic acid (20:4) at the sn-1 and sn-2 positions, respectively, that is found in biological membranes. PAPC is oxidized in vivo, and its oxidation products are involved in chronic inflammation and vascular disease. PAPC has been used to study signaling of oxidized phospholipids. Levels of PAPC are decreased in isolated human multiple myeloma cells .

HY-W747757

*N-Arachidonoyl-L-serine-d8*
N-Arachidonoyl-L-serine-d₈ is deuterium labeled N-Arachidonoyl-L-serine .

HY-145473S

1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE-d11

1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE-d₁₁ (15(S)-HETE-SAPE-d₁₁) is deuterium labeled 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE. 1-Stearoyl-2-15(S)-HETE-sn-glycero-3-PE is a phospholipid that contains stearic acid (HY-B2219) at the sn-1 position and 15(S)-HETE at the sn-2 position. It is formed in human peripheral monocytes activated by the calcium ionophore A23187 (HY-N6687) by direct oxidation of 1-stearoyl-2-arachidonoyl-sn-glycero-3-PE (SAPE) by 15-LO. Phosphoethanolamine (PE) HETEs (PE-HETEs), including 1-stearoyl-2-15(S)-HETE-sn-glycero-3-PE, are the main source of esterified HETE in ionophore-activated monocytes .

Cat. No.	Product Name		Classification

HY-157629

*1-Palmitoyl-2-arachidonoyl-sn-glycero-3-PE* PAPE; 1-Palmitoyl-2-Arachidonoyl PE		Phospholipids
1-Palmitoyl-2-arachidonoyl-sn-glycero-3-PE (PAPE), a compound isolated from egg yolk with antioxidant activity related to the unsaturated fatty acid content, was extracted, purified, and analyzed by various techniques.

HY-141636

1-PalMitoyl-2-arachidoyllecithin 1-Palmitoyl-2-Arachidonoyl-sn-glycero-3-phosphocholine; PAPC; PC(16:0/20:4)		Phospholipids
1-Palmitoyl-2-arachidonoyl-sn-glycero-3-PC (PAPC) is a phospholipid containing palmitic acid (16:0) and arachidonic acid (20:4) at the sn-1 and sn-2 positions, respectively, that is found in biological membranes. PAPC is oxidized in vivo, and its oxidation products are involved in chronic inflammation and vascular disease. PAPC has been used to study signaling of oxidized phospholipids. Levels of PAPC are decreased in isolated human multiple myeloma cells.

HY-157697

*1-1(Z)-Octadecenyl-2-arachidonoyl-sn-glycero-3-PE* 18:0p/20:4-PE; C18(Plasm)-20:4-PE; PE(P-18:0/20:4)		Phospholipids
1-1(Z)-Octadecenyl-2-arachidonoyl-sn-glycero-3-PE (18:0p/20:4-PE; C18(Plasm)-20:4-PE) is a plasmalogen that contains 1(Z)-octadecenoic acid and arachidonic acid (HY-109590) at the sn-1 and sn-2 positions, respectively.

HY-157698

*1-1(Z)-Octadecenyl-2-arachidonoyl-sn-glycero-3-PC* C18(plasm)-20:4-PC; 18:0p/20:4-PC; PC(P-18:0/20:4)		Phospholipids
1-1(Z)-Octadecenyl-2-arachidonoyl-sn-glycero-3-PC is a plasmalogen that contains 1(Z)-octadecenoic acid and arachidonic acid (HY-109590) at the sn-1 and sn-2 positions, respectively. It scavenges singlet oxygen in a cell-free assay.

HY-145486

*1-Arachidonoyl-sn-glycerol 3-phosphate ammonium* 20:4 Lyso PA		Phospholipids
1-Arachidonoyl-sn-glycerol 3-phosphate ammonium (20:4 Lyso PA) is a phospholipid and an LPA derived from arachidonic acid. The concentration of 1-Arachidonoyl-sn-glycerol 3-phosphate ammonium in plasma is significantly correlated with the age of onset of cocaine use and the duration of abstinence. 1-Arachidonoyl-sn-glycerol 3-phosphate ammonium can be used in the research of biomarkers for cocaine use disorder (CUD) .

HY-134225

*1-O-Hexadecyl-2-arachidonoyl-sn-glycero-3-PC* 16:0e/20:4-GPC		Phospholipids
1-O-Hexadecyl-2-arachidonoyl-sn-glycero-3-PC (16:0e/20:4-GPC) is an alkylether-glycerophosphocholine (GPC) .

HY-157651

*1-Stearoyl-2-arachidonoyl-sn-glycero-3-phospho-1'-myo-inositol-3',4'-bisphosphate ammonium*		Phospholipids
1-Stearoyl-2-arachidonoyl-sn-glycero-3-phospho-(1'-myo-inositol-3',4'-bisphosphate) ammonium regulates the activity of the actin network associated with endocytic structures .

HY-157652

18:0-20:4 PI(3,4,5)P3 1-Stearoyl-2-Arachidonoyl-sn-glycero-3-phospho-1′-myo-inositol-3′,4′,5′-trisphosphate ammonium		Phospholipids
18:0-20:4 PI(3,4,5)P3 (1-Stearoyl-2-arachidonoyl-sn-glycero-3-phospho-(1′-myo-inositol-3′,4′,5′-trisphosphate) (ammonium)) is a kind of biochemical reagent.

HY-W587499

*2-Arachidonoyl-sn-glycero-3-phosphocholine*		Phospholipids
2-Arachidonoyl-sn-glycero-3-phosphocholine is a phospholipid molecule that is a major component of the plasma membrane. It is a phospholipid molecule that is involved in the regulation of membrane fluidity, signal transduction, cell-cell communication, and mediator of inflammation.

HY-W753636

16:0-20:4 PG sodium 1-Palmitoyl-2-Arachidonoyl-sn-glycero-3-phospho-(1'-rac-glycerol) sodium		Phospholipids
16:0-20:4 PG (sodium)is a phosphatidylglycerol.

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