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Results for "

BEL-7402

" in MedChemExpress (MCE) Product Catalog:

By Targets:	5-HT Receptor (2) ADAMTS (1) Adrenergic Receptor (2) Akt (5) Apoptosis (6) Arf Family GTPase (2) Autophagy (2) Bcl-2 Family (2) Biochemical Assay Reagents (1) Caspase (3) Cyclin G-associated Kinase (GAK) (1) Dopamine Receptor (2) Drug Derivative (3) ERK (1) HDAC (2) Histone Demethylase (2) Microtubule/Tubulin (1) MMP (2) mTOR (2) NEKs (1) NF-κB (1) PARP (1) Phosphodiesterase (PDE) (1) PI3K (3) Reactive Oxygen Species (ROS) (3) Reference Standards (2) SOD (1) TGF-beta/Smad (2) TNF Receptor (1)
By Research Areas:	Cancer (30) Endocrinology (2) Inflammation/Immunology (2) Neurological Disease (2)

By Targets:

5-HT Receptor (2)

ADAMTS (1)

Adrenergic Receptor (2)

Akt (5)

Apoptosis (6)

Arf Family GTPase (2)

Autophagy (2)

Bcl-2 Family (2)

Biochemical Assay Reagents (1)

Caspase (3)

Cyclin G-associated Kinase (GAK) (1)

Dopamine Receptor (2)

Drug Derivative (3)

ERK (1)

HDAC (2)

Histone Demethylase (2)

Microtubule/Tubulin (1)

MMP (2)

mTOR (2)

NEKs (1)

NF-κB (1)

PARP (1)

Phosphodiesterase (PDE) (1)

PI3K (3)

Reactive Oxygen Species (ROS) (3)

Reference Standards (2)

SOD (1)

TGF-beta/Smad (2)

TNF Receptor (1)

By Research Areas:

Cancer (30)

Endocrinology (2)

Inflammation/Immunology (2)

Neurological Disease (2)

Inhibitors & Agonists

Biochemical Assay Reagents

Natural
Products

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-W250111

Carboxymethyl chitosan	Biochemical Assay Reagents Apoptosis Reactive Oxygen Species (ROS) Bcl-2 Family Caspase	Cancer
Carboxymethyl chitosan is a derivative of chitosan. Carboxymethyl chitosan inhibits Apoptosis and ROS. Carboxymethyl chitosan increases the expression of Bcl-2 and reduces the expression of Bax, cytochrome c and caspase-3. Carboxymethyl chitosan inhibits the migration of various cells. Carboxymethyl chitosan exerts antitumor effects on Lewis tumors and hepatocarcinoma .

HY-N6018

β-Eudesmol 1 Publications Verification	Caspase TNF Receptor SOD Reactive Oxygen Species (ROS)	Inflammation/Immunology Cancer
β-Eudesmol has anticancer and anti-inflammatory activities. Beta-Eudesmol can induce apoptosis. β-Eudesmol is a neostigmine antagonist. β-Eudesmol can antagonize neostigmine-induced neuromuscular failure. β-Eudesmoll can be used in the study of sepsis diseases. β-Eudesmol is a sesquiterpene-like compound that can be extracted from the rhizome of Atractylodes lancea .

HY-14543

Sertindole 3 Publications Verification Lu 23-174	5-HT Receptor Dopamine Receptor Adrenergic Receptor Autophagy	Neurological Disease Cancer
Sertindole (Lu 23-174) is an orally active 5-HT_2A, 5-HT_2C, dopamine D₂, and αl-adrenergic receptors antagonist. Sertindole shows antipsychotic activity and anti-proliferative activity to multiple cancer cells .

HY-15485

Zardaverine 1 Publications Verification	Phosphodiesterase (PDE) Apoptosis	Inflammation/Immunology Cancer
Zardaverine is an orally active and selective PDE3/4 inhibitor (IC₅₀)=0.58 uM/0.17 uM) with potent bronchodilator activity. Zardaverine also selectively inhibits the proliferation of HCC cells and induces apoptosis and cycle arrest (G0/G1 phase). Zardaverine has good antitumor potential and is effective in both bronchial relaxation and reduction of inflammation in asthma .

HY-N6896

Isoviolanthin 1 Publications Verification	TGF-beta/Smad PI3K Akt mTOR MMP Histone Demethylase	Endocrinology Cancer
Isoviolanthin is a flavonoid glycoside. Isoviolanthin can be extracted from Dendrobium officinale. Isoviolanthin has a strong affinity for binding to KDM6B, CHAC2, ESCO2, and IPO4. Isoviolanthin decreases MMP-2 and MMP-9. Isoviolanthin inhibits TGF-β/Smad and PI3K/Akt/mTOR signaling pathways. Isoviolanthin increases Fhl3 expression. Isoviolanthin has cytoprotective effects. Isoviolanthin has anticancer activity against hepatocellular carcinoma .

HY-N11928

Changnanic acid	Others	Cancer
Changnanic acid (schisandrin) is a triterpene compound with potential anti-tumor effects. Changnanic acid exhibits moderate cytotoxic activity against human tumor cell lines Bel-7402, MCF-7 and HL-60, with IC₅₀s of 100 μM, 100 μM and 50.51 μM respectively .

HY-146302

14-3-3η Protein inhibitor 1 2 Publications Verification	Apoptosis	Cancer
14-3-3η Protein inhibitor 1 (Compound C11) is a 14-3-3η protein inhibitor with a K_D of 35 µM. 14-3-3η Protein inhibitor 1 shows inhibitory activities against several typical human liver cancer cell lines. 14-3-3η Protein inhibitor 1 induces cell apoptosis and G1-S cell cycle arrest with good metabolic stability .

HY-172394

ZSNI-21	HDAC ADAMTS Apoptosis Bcl-2 Family Cyclin G-associated Kinase (GAK)	Cancer
ZSNI-21 is a ADAM17/HDAC2 inhibitor with ADAM17 IC₅₀ 0.939 μM and HDAC2 IC₅₀ 0.844 μM. ZSNI-21 regulates the expression of apoptosis-related proteins (Bax, Bcl-2) and Cyclin D1, and induces apoptosis.. ZSNI-21 can be used for the research of hepatocellular carcinoma, breast cancer, and non-small cell lung cancer .

HY-N7980

Rubipodanone A	NF-κB	Cancer
Rubipodanone A, a naphthohydroquinone dimer, shows cytotoxicity against A549, BEL-7402, HeLa, HepG2, SGC-7901 and U251 cells. Rubipodanone A also shows obvious activating effect at 20 and 40 μM for NF-κB .

HY-177269

CHNQD-01269	Arf Family GTPase	Cancer
CHNQD-01269, a brefeldin A-cinnamate derivative, is an Arf1 inhibitor. CHNQD-01269 exhibits potent cytotoxic activity against HepG2 and BEL-7402 cells, with IC₅₀ values of 0.29 and 0.84 μM, respectively. CHNQD-01269 is indicated for hepatocellular carcinoma (HCC) research .

HY-155695

HDAC-IN-61	HDAC	Cancer
HDAC-IN-61 (compound 12k) is a potent and orally active HDAC inhibitor. HDAC-IN-61 has anticancer active with an IC₅₀ value of 30 nM for Bel-7402 cell. HDAC-IN-61 can be used in research of cancer .

HY-151461

CHNQD-01255	Arf Family GTPase	Cancer
CHNQD-01255 is an orally active Arf-GEFs inhibitor with potent anti-hepatocellular carcinoma (HCC) efficacy .

HY-N7623

Ursonic acid methyl ester	Drug Derivative	Cancer
Ursonic acid methyl ester is an esterified derivative of Ursolic acid (HY-N0140). Ursonic acid methyl ester shows growth inhibitory activity against four tumor cell lines, HL-60, BGC, Bel-7402 and Hela with ED₅₀ values of >100 µg/ml .

HY-146467

Anticancer agent 62	Drug Derivative	Cancer
Anticancer agent 62 (compound 4c) is a potent anticancer agent. Anticancer agent 62 shows antiproliferative activity in HepG2, Bel-7402 and MCF-7 cancer cells, with IC₅₀ values of 0.019, 0.060 and 0.016 μM, respectively. Anticancer agent 62 shows effective tumor growth inhibition .

HY-146466

Anticancer agent 61	Others	Cancer
Anticancer agent 61 (compound 3v) is an orally active and potent anticancer agent. Anticancer agent 61 shows antiproliferative activity in HepG2, Bel-7402 and MCF-7 cancer cells, with IC₅₀ values of 1.12, 1.97 and 1.08 μM, respectively. Anticancer agent 61 shows effective tumor growth inhibition .

HY-144253

AKT-IN-11	Akt ERK	Cancer
AKT-IN-11 is one of the most effective antibacterial agents against human hepatoma BEL-7402 cell line with an IC₅₀ value of 1.15μM.

HY-N12128

Ophiopogonin R	Others	Cancer
Ophiopogonin R (compound 3) is a steroid saponin. Ophiopogonin R was isolated and purified from natural ophiopogonin. Ophiopogonin R was not cytotoxic to five human tumor cell lines (HepG2, HLE, BEL7402, BEL7403 and Hela) .

HY-N12253

(19R)-13-Deoxy-19-hydroxyenmein	Others	Cancer
(19R)-13-Deoxy-19-hydroxyenmein is the parent compound of enmein-type diterpenoid analogs. (19R)-13-Deoxy-19-hydroxyenmein has anti-proliferative activities with IC₅₀ values of 0.41, 0.85, 0.43, 1.89 μM against human cancer cell lines K562, MGC-803, CaEs-17, and Bel-7402, respectively .

HY-150046

Nek2-IN-6	NEKs	Cancer
Nek2-IN-6 (Compound 28e) is a potent never in mitosis (NIMA) related kinase 2 (Nek2) inhibitor .

HY-N7535

Chlorovaltrate K	Others	Cancer
Chlorovaltrate K is a chlorinated valepotriate with anticancer effects. Chlorovaltrate K shows moderate cytotoxicity against A549, PC-3M, HCT-8 and Bel 7402 cell lines with IC₅₀ values of 2.32-8.26 μM .

HY-146465

Anticancer agent 60	Microtubule/Tubulin	Cancer
Anticancer agent 60 (compound 3h) has antiproliferative activity against human HepG2 cells (IC₅₀ = 4.13 μM) and presents antitumor efficacy in a human HepG2 xenograft mouse model .

HY-144254

PI3Kδ-IN-10	PI3K Akt Apoptosis	Cancer
PI3Kδ-IN-10 is a highly potent and orally active PI3Kδ inhibitor with IC₅₀ of 2 nM. PI3Kδ-IN-10 robustly suppresses the downstream AKT pathway to induce subsequent apoptosis in hepatocellular carcinoma models .

HY-N6896R

Isoviolanthin (Standard)	Reference Standards TGF-beta/Smad PI3K Akt mTOR MMP Histone Demethylase	Endocrinology Cancer
Isoviolanthin (Standard) is the analytical standard of Isoviolanthin (HY-N6896). This product is intended for research and analytical applications. Isoviolanthin is a flavonoid glycoside. Isoviolanthin can be extracted from Dendrobium officinale. Isoviolanthin has a strong affinity for binding to KDM6B, CHAC2, ESCO2, and IPO4. Isoviolanthin decreases MMP-2 and MMP-9. Isoviolanthin inhibits TGF-β/Smad and PI3K/Akt/mTOR signaling pathways. Isoviolanthin increases Fhl3 expression. Isoviolanthin has cytoprotective effects. Isoviolanthin has anticancer activity against hepatocellular carcinoma .

HY-N13081

3-Oxo-cinobufagin	Others	Cancer
3-Oxo-cinobufagin (compound 8) is a potential anticancer compound that can be isolated from the broth of M. spinosus by high-performance liquid chromatography. Compared to other isolated compounds, the hydroxyl group at the C-5 position of 3-Oxo-cinobufagin is further oxidized or isomerized, significantly reducing its cytotoxic activity against most cell lines (except HEL), while increasing its activity against the BEL cell line. The IC50 values of 3-Oxo-cinobufagin's cytotoxicity against cancer cells are: 71.3 μM (HepG2), 90.2 μM (SMMC-7221), 0.11 μM (BEL-7402), 72.5 μM (K562), 5.3 μM (HL-60), and 12 nM (HEL) .

HY-177268

CHNQD-01426	Apoptosis Reactive Oxygen Species (ROS) PARP Caspase Akt	Cancer
CHNQD-01426 (Compound 4a) is an anticancer agent. CHNQD-01426 has cytotoxic activities against cancer cells. CHNQD-01426 significantly inhibits hepatocellular carcinoma cells proliferation via arresting S and G2/M phase cell cycle and induces apoptosis by inducing ROS production and elevating apoptosis-related proteins expression. CHNQD-01426 potently inhibits tumor growth in HepG2 xenograft mice model .

HY-14543R

Sertindole (Standard) Lu 23-174 (Standard)	5-HT Receptor Dopamine Receptor Adrenergic Receptor Autophagy Reference Standards	Neurological Disease Cancer
Sertindole (Standard) is the analytical standard of Sertindole. This product is intended for research and analytical applications. Sertindole (Lu 23-174) is an orally active 5-HT2A, 5-HT2C, dopamine D2, and αl-adrenergic receptors antagonist. Sertindole shows antipsychotic activity and anti-proliferative activity to multiple cancer cells .

HY-N18292

Qinanone G	Drug Derivative	Cancer
Qinanone G is a 2-(2-phenylethyl)chromone (HY-N8220) derivative found in the high quality Chinese agarwood 'Qi-Nan' from Aquilaria sinensis (Lour.) Glig. Qinanone G shows no inhibitory activity against AChE and cancer cells .

HY-N18174

Glaucogenin E	Others	Others
Glaucogenin E is a C₂₁ steroid sapogenin found in rhizomes of Cynanchum stauntonii (Decne.) Schltr. ex Levl. Glaucogenin E shows no cytotoxic activity against human cancer cells .

HY-N18229

Hirundoside A	Others	Cancer
Hirundoside A is a steroidal glycoside found in the roots of Cynanchum stauntonii .

HY-N17995

GypenosideZ-3	Others	Cancer
GypenosideZ-3 is a dammarane triterpene glycoside found in the roots of Machilus yaoshansis .

HY-N18228

Stauntoside Ⅱ	Others	Cancer
Stauntoside Ⅱ is a 14,15-secopregnane-type C21 steroidal glycoside found in the roots of Cynanchum stauntonii. Stauntoside Ⅱ does not exhibit cytotoxic activity against human colon, hepatoma, gastric, lung, and ovarian cancer cells .

Carboxymethyl chitosan	Biochemical Assay Reagents
Carboxymethyl chitosan is a derivative of chitosan. Carboxymethyl chitosan inhibits Apoptosis and ROS. Carboxymethyl chitosan increases the expression of Bcl-2 and reduces the expression of Bax, cytochrome c and caspase-3. Carboxymethyl chitosan inhibits the migration of various cells. Carboxymethyl chitosan exerts antitumor effects on Lewis tumors and hepatocarcinoma .

β-Eudesmol 1 Publications Verification	Structural Classification other families Classification of Application Fields Terpenoids Sesquiterpenes Metabolic Disease Plants Disease Research Fields Source Classification	Caspase TNF Receptor SOD Reactive Oxygen Species (ROS)
β-Eudesmol has anticancer and anti-inflammatory activities. Beta-Eudesmol can induce apoptosis. β-Eudesmol is a neostigmine antagonist. β-Eudesmol can antagonize neostigmine-induced neuromuscular failure. β-Eudesmoll can be used in the study of sepsis diseases. β-Eudesmol is a sesquiterpene-like compound that can be extracted from the rhizome of Atractylodes lancea .

Isoviolanthin 1 Publications Verification	Flavonoids other families Classification of Application Fields Flavones Phenols Polyphenols Plants Disease Research Fields Source Classification Cancer	TGF-beta/Smad PI3K Akt mTOR MMP Histone Demethylase
Isoviolanthin is a flavonoid glycoside. Isoviolanthin can be extracted from Dendrobium officinale. Isoviolanthin has a strong affinity for binding to KDM6B, CHAC2, ESCO2, and IPO4. Isoviolanthin decreases MMP-2 and MMP-9. Isoviolanthin inhibits TGF-β/Smad and PI3K/Akt/mTOR signaling pathways. Isoviolanthin increases Fhl3 expression. Isoviolanthin has cytoprotective effects. Isoviolanthin has anticancer activity against hepatocellular carcinoma .

Changnanic acid	Kadsura heteroclita (Roxb.) Craib Ketones, Aldehydes, Acids Plants Schisandraceae Source Classification	Others
Changnanic acid (schisandrin) is a triterpene compound with potential anti-tumor effects. Changnanic acid exhibits moderate cytotoxic activity against human tumor cell lines Bel-7402, MCF-7 and HL-60, with IC₅₀s of 100 μM, 100 μM and 50.51 μM respectively .

Rubipodanone A	Quinones Classification of Application Fields Rubia podantha Rubiaceae Plants Naphthalene Quinones Disease Research Fields Source Classification Cancer	NF-κB
Rubipodanone A, a naphthohydroquinone dimer, shows cytotoxicity against A549, BEL-7402, HeLa, HepG2, SGC-7901 and U251 cells. Rubipodanone A also shows obvious activating effect at 20 and 40 μM for NF-κB .

Ophiopogonin R	Ophiopogon japonicus (L. f.) Ker-Gawl. Structural Classification Liliaceae Plants Steroids Source Classification	Others
Ophiopogonin R (compound 3) is a steroid saponin. Ophiopogonin R was isolated and purified from natural ophiopogonin. Ophiopogonin R was not cytotoxic to five human tumor cell lines (HepG2, HLE, BEL7402, BEL7403 and Hela) .

(19R)-13-Deoxy-19-hydroxyenmein	Terpenoids Labiatae Erythrina sacleuxii Hua Diterpenoids Plants Source Classification	Others
(19R)-13-Deoxy-19-hydroxyenmein is the parent compound of enmein-type diterpenoid analogs. (19R)-13-Deoxy-19-hydroxyenmein has anti-proliferative activities with IC₅₀ values of 0.41, 0.85, 0.43, 1.89 μM against human cancer cell lines K562, MGC-803, CaEs-17, and Bel-7402, respectively .

Chlorovaltrate K	Valeriana jatamansi Jones Iridoids Terpenoids Plants Valerianaceae Source Classification	Others
Chlorovaltrate K is a chlorinated valepotriate with anticancer effects. Chlorovaltrate K shows moderate cytotoxicity against A549, PC-3M, HCT-8 and Bel 7402 cell lines with IC₅₀ values of 2.32-8.26 μM .

Isoviolanthin (Standard)	Structural Classification Flavonoids other families Flavones Phenols Polyphenols Plants Source Classification	Reference Standards TGF-beta/Smad PI3K Akt mTOR MMP Histone Demethylase
Isoviolanthin (Standard) is the analytical standard of Isoviolanthin (HY-N6896). This product is intended for research and analytical applications. Isoviolanthin is a flavonoid glycoside. Isoviolanthin can be extracted from Dendrobium officinale. Isoviolanthin has a strong affinity for binding to KDM6B, CHAC2, ESCO2, and IPO4. Isoviolanthin decreases MMP-2 and MMP-9. Isoviolanthin inhibits TGF-β/Smad and PI3K/Akt/mTOR signaling pathways. Isoviolanthin increases Fhl3 expression. Isoviolanthin has cytoprotective effects. Isoviolanthin has anticancer activity against hepatocellular carcinoma .

3-Oxo-cinobufagin	Microorganisms Steroids Source Classification	Others
3-Oxo-cinobufagin (compound 8) is a potential anticancer compound that can be isolated from the broth of M. spinosus by high-performance liquid chromatography. Compared to other isolated compounds, the hydroxyl group at the C-5 position of 3-Oxo-cinobufagin is further oxidized or isomerized, significantly reducing its cytotoxic activity against most cell lines (except HEL), while increasing its activity against the BEL cell line. The IC50 values of 3-Oxo-cinobufagin's cytotoxicity against cancer cells are: 71.3 μM (HepG2), 90.2 μM (SMMC-7221), 0.11 μM (BEL-7402), 72.5 μM (K562), 5.3 μM (HL-60), and 12 nM (HEL) .

Qinanone G	Structural Classification Thymelaeaceae Phenols Plants Aquilaria sinensis (Lour.) Spreng. Source Classification	Drug Derivative
Qinanone G is a 2-(2-phenylethyl)chromone (HY-N8220) derivative found in the high quality Chinese agarwood 'Qi-Nan' from Aquilaria sinensis (Lour.) Glig. Qinanone G shows no inhibitory activity against AChE and cancer cells .

Glaucogenin E	Apocynaceae Structural Classification Natural Products Plants Vincetoxicum stauntonii (Decne.) C. Y. Wu et D. Z. Li Source Classification	Others
Glaucogenin E is a C₂₁ steroid sapogenin found in rhizomes of Cynanchum stauntonii (Decne.) Schltr. ex Levl. Glaucogenin E shows no cytotoxic activity against human cancer cells .

Hirundoside A	Apocynaceae Structural Classification Plants Vincetoxicum stauntonii (Decne.) C. Y. Wu et D. Z. Li Steroids Source Classification	Others
Hirundoside A is a steroidal glycoside found in the roots of Cynanchum stauntonii .

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