101975-10-4
101975-10-4
Chemical Structure
Zardaverine
- CAS No.: 101975-10-4
- Formula:C12H10F2N2O3
- Molecular Weight:268.22
IUPAC Name: 6-(4-(difluoromethoxy)-3-methoxyphenyl)pyridazin-3(2H)-one
InChIKey: HJMQDJPMQIHLPB-UHFFFAOYSA-N
SMILES: O=C1C=CC(C2=CC=C(OC(F)F)C(OC)=C2)=NN1
Biological Activity: Zardaverine is an orally active and selective PDE3/4 inhibitor (IC50)=0.58 uM/0.17 uM) with potent bronchodilator activity. Zardaverine also selectively inhibits the proliferation of HCC cells and induces apoptosis and cycle arrest (G0/G1 phase). Zardaverine has good antitumor potential and is effective in both bronchial relaxation and reduction of inflammation in asthma[1][2][3].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Zardaverine | 98.59% | Zardaverine is an orally active and selective PDE3/4 inhibitor (IC50)=0.58 uM/0.17 uM) with potent bronchodilator activity. Zardaverine also selectively inhibits the proliferation of HCC cells and induces apoptosis and cycle arrest (G0/G1 phase). Zardaverine has good antitumor potential and is effective in both bronchial relaxation and reduction of inflammation in asthma. | ||||||||||||||||||||
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References
- [1]. Sun L, et al. Phosphodiesterase 3/4 inhibitor zardaverine exhibits potent and selective antitumor activity against hepatocellular carcinoma both in vitro and in vivo independently of phosphodiesterase inhibition. PLoS One. 2014 Mar 5;9(3):e90627. [Content Brief]
- [2]. Kips JC, et al. The effect of zardaverine, an inhibitor of phosphodiesterase isoenzymes III and IV, on endotoxin-induced airway changes in rats. Clin Exp Allergy. 1993 Jun;23(6):518-23. [Content Brief]
- [3]. Schudt C, et al. Zardaverine: a cyclic AMP specific PDE III/IV inhibitor. Agents Actions Suppl. 1991;34:379-402. [Content Brief]
