HDAC-IN-61
HDAC-IN-61 (compound 12k) is a potent and orally active HDAC inhibitor. HDAC-IN-61 has anticancer active with an IC50 value of 30 nM for Bel-7402 cell. HDAC-IN-61 can be used in research of cancer.
For research use only. We do not sell to patients.
- Formula: C28H27N3O5
- Molecular Weight:485.53
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Storage:
Please store the product under the recommended conditions in the Certificate of Analysis.
Biological Activity
|
Cell Line
|
Type | Value | Description | References |
|---|---|---|---|---|
| AML12 | IC50 |
3.69 μM
Compound: 12k
|
Cytotoxicity against AML12 cells incubated for 72 hrs measured by MTT assay
Cytotoxicity against AML12 cells incubated for 72 hrs measured by MTT assay
|
[PMID: 37498552] |
| Bel-7402 | IC50 |
0.03 μM
Compound: 12k
|
Cytotoxicity against human Bel-7402 cells incubated for 72 hrs measured by MTT assay
Cytotoxicity against human Bel-7402 cells incubated for 72 hrs measured by MTT assay
|
[PMID: 37498552] |
| HepG2 | IC50 |
0.12 μM
Compound: 12k
|
Cytotoxicity against human HepG2 cells incubated for 72 hrs measured by MTT assay
Cytotoxicity against human HepG2 cells incubated for 72 hrs measured by MTT assay
|
[PMID: 37498552] |
| Huh-7 | IC50 |
0.24 μM
Compound: 12k
|
Cytotoxicity against human Huh-7 cells incubated for 72 hrs measured by MTT assay
Cytotoxicity against human Huh-7 cells incubated for 72 hrs measured by MTT assay
|
[PMID: 37498552] |
Chemical Information
-
Molecular Weight 485.53
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Formula C28H27N3O5
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SMILES
O=C([C@@H](N1CCC(C2=CC=C(C=C2O3)OC)=C3C1)CC4=CC=CC=C4)NC5=CC=C(C=C5)C(NO)=O
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Shipping
Room temperature in continental US; may vary elsewhere.
-
Storage
Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
Calculators
Concentration (start) × Volume (start) = Concentration (final) × Volume (final)