2 Results for "

CUMS mice

" in MedChemExpress (MCE) Product Catalog:
Products (2)

2 Results for "CUMS mice" in MCE Product Catalog:

Cat. No.: HY-165471
CAS No.: 5875-50-3
Synonyms: Phosphopantothenic acid; 4'-Phosphopantothenate
D-4'-Phosphopantothenate (Phosphopantothenic acid; 4'-Phosphopantothenate) serves as a precursor for coenzyme A synthesis and is a key metabolite in the biosynthetic pathway of pantothenic acid and coenzyme A. The expression level of D-4'-Phosphopantothenate is downregulated in macrophages exposed to graphene nanosheets or the CD36 ligand sulfo-N-succinimidyl oleate. D-4'-Phosphopantothenate is positively correlated with the sucrose preference index in mice subjected to chronic unpredictable mild stress (CUMS), and its expression can be upregulated by the aqueous extract of Cistanche tubulosa. D-4'-Phosphopantothenate can be used in studies related to depression comorbid with sexual dysfunction .
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Cat. No.: HY-184011
SERT-IN-4 is a brain-penetrant and orally active SERT inhibitor and ERβ agonist with human SERT IC50 of 16.92 nM and human ERβ EC50 of 3.66 nM. SERT-IN-4 inhibits SERT-mediated substrate transport, increases hippocampal serotonin levels, modulates p-CREB and BDNF expression.SERT-IN-4 reduces immobility in CUMS mice, improves social interaction and reduces inactivity in CSDS mice.SERT-IN-4 can be used for the research of major depressive disorder .
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