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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
35 Results for "
Cap-dependent endonuclease
" in MedChemExpress (MCE) Product Catalog:
Products (35)
35 Results for "Cap-dependent endonuclease" in MCE Product Catalog:
52
52 Cited Publications
Synonyms: Baloxavir acid; S-033447
Target:
Baloxavir (Baloxavir acid), derived from the proagent Baloxavir marboxil, is a first-in-class, potent and selective cap-dependent endonuclease (CEN) inhibitor within the polymerase PA subunit of influenza A and B viruses. Baloxavir inhibits viral RNA transcription and replication and has potently antiviral activity .
13
13 Cited Publications
Synonyms: S-033188; RG 6152
Target:
Baloxavir marboxil (S-033188) is a selective inhibitor of influenza cap-dependent endonuclease. Baloxavir marboxil, a potent antiviral agent, shows activity against influenza A and B virus .
Synonyms: TG-1000
Research Areas:
Pixavir marboxilo (TG-1000) is an orally active prodrug of TG-0527 and an analog of Baloxavir marboxil (HY-109025). Pixavir marboxilo undergoes conversion to its active metabolite and inhibits the cap‑dependent endonuclease of Influenza Virus, reduces pulmonary viral titers, and suppresses the proliferation of influenza A, influenza B, H7N9 avian influenza, and neuraminidase‑resistant strains. Pixavir marboxilo can be used in influenza-related research .
Cat. No.: HY-143744
CAS No.: 2364589-86-4
Synonyms: GP681; Cap-dependent endonuclease-IN-3
Target:
Research Areas:
Suraxavir marboxil (GP681; Cap-dependent endonuclease-IN-3) is a PA subunit cap-dependent endonuclease inhibitor with antiviral activity. Suraxavir marboxil inhibits PA subunit cap-dependent endonuclease activity and inhibits influenza A and/or influenza B viral replication. Suraxavir marboxil can be used alone or in combination with other anti-influenzal agents for the prevention of influenza A and/or influenza B viral infectious diseases. Suraxavir marboxil can be used for the research of influenza A and/or influenza B viral infectious diseases .
Cat. No.: HY-177555
CAS No.: 2417851-90-0
Target:
Research Areas:
AV5116 is a cap-dependent endonuclease inhibitor (CENI) that binds to the active site of the cap-dependent endonuclease (CEN) located in the N-terminal domain of the polymerase acidic. AV5116 exhibits potent inhibitory activity against influenza viruses (influenza A, B, and C viruses). AV5116 can be used for the study of influenza virus infections .
Cat. No.: HY-109025R
CAS No.: 1985606-14-1
Synonyms: S-033188 (Standard); RG 6152 (Standard)
Target:
Research Areas:
Baloxavir marboxil (Standard) is the analytical standard of Baloxavir marboxil. This product is intended for research and analytical applications. Baloxavir marboxil (S-033188) is a selective inhibitor of influenza cap-dependent endonuclease. Baloxavir marboxil, a potent antiviral agent, shows activity against influenza A and B virus .
Cat. No.: HY-143769
CAS No.: 2581298-44-2
Synonyms: Cap-dependent endonuclease-IN-15
Target:
Research Areas:
Sebaloxavir marboxil (Cap-dependent endonuclease-IN-15) (Compound c-1) is a potent inhibitor of cap-dependent endonuclease (CEN). Sebaloxavir marboxil inhibits the replication of influenza virus. Sebaloxavir marboxil has the potential for the research of viral infections caused by influenza viruses .
Cat. No.: HY-164927
CAS No.: 2417851-93-3
Target:
Research Areas:
AV5124, a prodrug of AV5116, is an orally active influenza virus cap-dependent endonuclease (CEN) endonuclease inhibitor .
Cat. No.: HY-143776
CAS No.: 2641942-32-5
Target:
Research Areas:
Cap-dependent endonuclease-IN-22 is a potent cap-dependent endonuclease (CEN) inhibitor .
Cat. No.: HY-143762
CAS No.: 2460686-97-7
Target:
Research Areas:
Cap-dependent endonuclease-IN-12 (EXP-35) is a potent Cap-dependent endonuclease inhibitor with low cytotoxicity. Cap-dependent endonuclease-IN-12 shows inhibitory activity against H1N1 .
Cat. No.: HY-143770
CAS No.: 2643370-92-5
Target:
Research Areas:
Cap-dependent endonuclease-IN-16 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-16 is a pyridone polycyclic derivative. Cap-dependent endonuclease-IN-16 has the potential for the research of influenza (extracted from patent CN112778330A, compound 15A) .
Cat. No.: HY-143749
CAS No.: 2489248-15-7
Target:
Research Areas:
Cap-dependent endonuclease-IN-6 (compound 13) is a cap-dependent endonuclease (CEN) inhibitor. Cap-dependent endonuclease-IN-6 shows inhibition against influenza virus (EC50=38.21 nM) .
Cat. No.: HY-143768
CAS No.: 2740486-73-9
Target:
Research Areas:
Cap-dependent endonuclease-IN-14 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-14 inhibits the replication of influenza virus. Cap-dependent endonuclease-IN-14 has the potential for the research of viral infections caused by influenza viruses (extracted from patent CN113620948A, compound 1-c) .
Cat. No.: HY-144065
CAS No.: 2567929-06-8
Target:
Research Areas:
Cap-dependent endonuclease-IN-19 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-19 is a spirocyclic pyridone derivative. Cap-dependent endonuclease-IN-19 has strong inhibitory effect on RNA polymerase activity of A virus (extracted from patent CN111410661A, compound 1) .
Cat. No.: HY-143771
CAS No.: 2649362-71-8
Target:
Research Areas:
Cap-dependent endonuclease-IN-17 is a cap-dependent endonuclease (CEN) inhibitor. Cap-dependent endonuclease-IN-17 shows antiviral activity against influenza virus A/Hanfang/359/95 (H3N2) with IC50 of 1.29 μM (CN112898346A; DSC701) .
Cat. No.: HY-143775
CAS No.: 2656435-01-5
Target:
Research Areas:
Cap-dependent endonuclease-IN-20 is a cap-dependent endonuclease (CEN) inhibitor. Cap-dependent endonuclease-IN-20 shows antiviral activity against influenza virus A/Hanfang/359/95 (H3N2) with IC50 of 4.82 μM (CN112940009A; DSC801) .
Cat. No.: HY-143781
CAS No.: 1370238-26-8
Target:
Research Areas:
Cap-dependent endonuclease-IN-26 is a cap-dependent endonuclease (CEN) inhibitor with an IC50 of 286 nM. Cap-dependent endonuclease-IN-26 shows antiviral activity against many influenza A and B strains .
Cat. No.: HY-144068
CAS No.: 2415788-71-3
Target:
Research Areas:
Cap-dependent endonuclease-IN-25 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-25 is a macrocyclic pyridotriazine derivative. Cap-dependent endonuclease-IN-25 has the potential for the research of viral infections caused by viruses belonging to the Orthomyxoviridae family (extracted from patent WO2020075080A1, compound 4) .
Cat. No.: HY-143766
CAS No.: 2703046-60-8
Target:
Research Areas:
Cap-dependent endonuclease-IN-13 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-13 has the potential for the research of influenza virus infection (only influenza A) (extracted from patent WO2021180147A1, compound I-1) .
Cat. No.: HY-144066
CAS No.: 2741952-35-0
Target:
Research Areas:
Cap-dependent endonuclease-IN-21 is a potent inhibitor of cap-dependent endonuclease (CEN). Cap-dependent endonuclease-IN-21 inhibits the replication of influenza virus. ap-dependent endonuclease-IN-21 has the potential for the research of influenza virus infection (influenza A) (extracted from patent WO2021233302A1, compound 8B or 8A) .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
