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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
45 Results for "
Chagas
" in MedChemExpress (MCE) Product Catalog:
Products (45)
45 Results for "Chagas" in MCE Product Catalog:
3
3 Cited Publications
Cat. No.: HY-B1548
CAS No.: 22994-85-0
Synonyms: Benznidazol; Ro 07-1051; Ro 71051
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Benznidazole (Ro 07-1051) is an antiparasitic medication, with an IC50 of 20.35 μM for Colombian T. cruzi strains, and has been used in the treatment of Chagas disease .
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Cardiovascular Disease Neurological Disease Plants Solanaceae Extract Infection Alkaloids Capsicum annuum L. Other Alkaloids Disease Research Fields Inflammation/Immunology
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Cat. No.: HY-N7151
CAS No.: 108354-13-8
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Cat. No.: HY-168894
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Ferroptosis JAK STAT p38 MAPK AMPK GSK-3 Apoptosis HSP TNF Receptor
Research Areas:
Cardiovascular Disease Neurological Disease Metabolic Disease Cancer
CT-1 is a secreted protein belonging to the IL-6 cytokine family. Overexpression of CT-1 enhances cell proliferation, migration and angiogenesis via the ADMA/DDAH pathway. CT-1 inhibits the growth of triple-negative breast cancer cells by simultaneously inducing Ferroptosis in N2-type tumor-associated neutrophils and cancer cells. CT-1 activates the Jak/STAT-3, p42/p44 MAPK and AMPK pathways, and inhibits GSK-3β activity through phosphorylation to induce cardiomyocyte hypertrophy. CT-1 enhances the viability of cardiomyocytes and neurons, reduces cell Apoptosis, induces the expression of heat shock proteins (HSP) and BNP, and inhibits TNF levels. CT-1 exerts anti-tumor activity in mouse models of triple-negative breast cancer. CT-1 improves cognitive impairment in mice. CT-1 is applicable to the research of ischemic heart disease, triple-negative breast cancer, myocardial hypertrophy, Parkinson's disease, hypertensive heart disease, myocardial infarction, acute Chagas cardiomyopathy, high-fat diet-induced cognitive impairment and diabetes-related cognitive impairment .
Cat. No.: HY-N11173A
CAS No.: 618-67-7
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Dendranthema morifolium (Ramat.) Tzvel. Coumarins Leguminosae Extract Phenylpropanoids Plants
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Cat. No.: HY-175741
CAS No.: 3094992-69-2
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IID432 is a potent, orally active, and covalent inhibitor of Trypanosoma cruzi topoisomerase II. IID432 shows an EC50 of 8 nM against T. cruzi intracellular amastigotes, exhibits excellent oral bioavailability (52% in rats), favorable ADME properties, and no S1P pathway modulation. IID432 achieves relapse-free cure in a chronic T. cruzi infection mouse model, can be used for the study of Chagas disease .
Cat. No.: HY-153238
CAS No.: 2152662-92-3
AN15368 is an orally active trypanocidal agent and a prodrug of AN14667. AN15368 selectively targets CPSF3-mediated mRNA maturation in intracellular amastigotes of Trypanosoma cruzi, reducing the mRNA levels of the parasite. As a prodrug, AN15368 can be cleaved into its active carboxylate form by CBP of Trypanosoma cruzi. AN15368 completely clears long-term naturally acquired Trypanosoma cruzi infections in non-human primates. AN15368 can be used in the research of Chagas disease .
T.cruzi-IN-1 is a potent Trypanosoma cruzi inhibitor with an IC50 of 8 nM. T.cruzi-IN-1, a 4-trifluoromethyl substituted analog, has the potential for both the acute and chronic stages of Chagas disease .
Cat. No.: HY-118338
CAS No.: 1076088-50-0
WRR-483 is an analog of K11777, an inhibitor of cruzain, used to inhibit the proliferation of Trypanosoma cruzi in cell culture. WRR-483 can eradicate parasitic infection in an acute Chagas disease mouse model. WRR-483 is an irreversible cysteine protease inhibitor that shows pH-dependent high affinity and potent trypanocidal activity against cruzain and T. cruzi infection, and is expected to inhibit Chagas disease.
Cat. No.: HY-B1548R
CAS No.: 22994-85-0
Synonyms: Benznidazol (Standard); Ro 07-1051 (Standard); Ro 71051 (Standard)
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Benznidazole (Standard) is the analytical standard of Benznidazole. This product is intended for research and analytical applications. Benznidazole (Ro 07-1051) is an antiparasitic medication, with an IC50 of 20.35 μM for Colombian T. cruzi strains, and has been used in the treatment of Chagas disease .
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Cat. No.: HY-175305
CAS No.: 3052352-22-1
DMU759 is a Lysyl-tRNA synthetase 1 (KRS1) inhibitor. DMU759 has potent anti-kinetoplastid activity against Trypanosoma cruzi , Trypanosoma brucei and Leishmania donovani. DMU759 significantly reduces parasitemia in acute Chagas disease mice model. DMU759 can be used for parasitic infection like Chagas disease research .
Cat. No.: HY-114763
CAS No.: 327042-42-2
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LP8 is a Pyridinyl-type CYP51 inhibitor and can be used for study of chagas disease and American trypanosomiasis .
Cat. No.: HY-117129
CAS No.: 33450-08-7
Synonyms: MK-0436
MK 436 (MK-0436) is a metabolite with anti-trypanosomal activity that can be isolated from dog urine, particularly effective against Trypanosoma cruzi, the pathogen responsible for Chagas disease in South America .
Cat. No.: HY-173461
CAS No.: 2959033-89-5
Anti-Trypanosoma cruzi agent-7 (compound 1) is a potent Trypanosoma cruzi inhibitor with an EC50 of 1.26 µM. Anti-Trypanosoma cruzi agent-7 can be used in the study of Chagas disease .
Cat. No.: HY-129228
CAS No.: 77448-64-7
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Lychnophora pseudovillosissima Semir & Leitão Terpenoids Sesquiterpenes Plants Compositae Extract
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
