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Results for "

Endophytic fungus

" in MedChemExpress (MCE) Product Catalog:

By Targets:	Antibiotic (6) Apoptosis (3) Bacterial (10) Calcium Channel (1) COX (1) Drug Derivative (2) Endogenous Metabolite (20) ERK (1) Fluorescent Dye (3) Fungal (14) HIV (1) Influenza Virus (1) Insecticide (1) Isotope-Labeled Compounds (1) JNK (1) NF-κB (1) NO Synthase (1) p38 MAPK (1) Parasite (4) Prolyl Endopeptidase (PREP) (1) Reactive Oxygen Species (ROS) (1) Reference Standards (3) Reverse Transcriptase (1) Toll-like Receptor (TLR) (1) Tyrosinase (2)
By Research Areas:	Cancer (7) Infection (32) Inflammation/Immunology (3) Neurological Disease (5)

By Targets:

Antibiotic (6)

Apoptosis (3)

Bacterial (10)

Calcium Channel (1)

COX (1)

Drug Derivative (2)

Endogenous Metabolite (20)

ERK (1)

Fluorescent Dye (3)

Fungal (14)

HIV (1)

Influenza Virus (1)

Insecticide (1)

Isotope-Labeled Compounds (1)

JNK (1)

NF-κB (1)

NO Synthase (1)

p38 MAPK (1)

Parasite (4)

Prolyl Endopeptidase (PREP) (1)

Reactive Oxygen Species (ROS) (1)

Reference Standards (3)

Reverse Transcriptase (1)

Toll-like Receptor (TLR) (1)

Tyrosinase (2)

By Research Areas:

Cancer (7)

Infection (32)

Inflammation/Immunology (3)

Neurological Disease (5)

Inhibitors & Agonists

Fluorescent Dyes

Peptides

Natural
Products

Isotope-Labeled Compounds

Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-D0027

7-Amino-4-methylcoumarin Coumarin 120; AMC	Fluorescent Dye Antibiotic Fungal	Infection
7-Amino-4-methylcoumarin belongs to the coumarin class, can be isolated from the endophytic fungus Xylaria sp. and has a broad spectrum of antibacterial activity. 7-Amino-4-methylcoumarin is also commonly used as an important laser dye that emits in the blue region, capable of analyzing glycoprotein monosaccharides and N-linked oligosaccharides, and is also utilized in tissue pathology analysis, enzyme activity measurement, and copper ion detection. The excitation wavelength and emission wavelength are 351 nm and 430 nm, respectively.

HY-B1086

Afalanine N-Acetyl-DL-phenylalanine	Endogenous Metabolite	Neurological Disease
Afalanine (N-Acetyl-DL-phenylalanine) is an endogenous metabolite of an endophytic fungus with antidepressant activity. Afalanine can be used in combination with antibiotics to prevent renal damage.

HY-75564

Cyclo(Ala-Gly)	Endogenous Metabolite	Cancer
Cyclo(Ala-Gly), a metabolite of a mangrove endophytic fungus, Penicillium thomi, exhibits cytotoxicity against A549, HepG2 and HT29 cells. The IC₅₀ values range from 9.5 to 18.1 μM .

HY-N7023

7-Prenyloxycoumarin 7-O-Prenylumbelliferone	Fungal	Infection
7-Prenyloxycoumarin (7-O-Prenylumbelliferone) is a secondary metabolite from the endophytic fungus of Annulohypoxylon ilanense .

HY-N6294

Monocerin	Bacterial Fungal	Infection
Monocerin is an isocoumarin derivative. Monocerin is isolated from Microdochium bolleyi, an endophytic fungus from Fagonia cretica. Monocerin shows good antifungal, antibacterial, and antialgal activities against Microbotryum violaceum, Escherichia coli, Bacillus megaterium, and Chlorella fusca .

HY-W751002

Orthosporin (+)-Orthosporin	Endogenous Metabolite Bacterial HIV Reverse Transcriptase	Infection
Orthosporin ((+)-Orthosporin), a phytotoxic isocoumarin compound, is a microbial secondary metabolite. Orthosporin can be isolated from the endophytic fungus Lasiodiplodia tbeobromae. Orthosporin has potent antibacterial activity against B. subtilis, E. coli and P. aeruginosa. Orthosporin also has antioxidant activity against DPPH radical and antiviral activities with inhibition of HIV-1 reverse transcriptase activity .

HY-N12179

Brevianamide M	Bacterial	Others
Brevianamide M (compound 4) is a metabolite of Aspergillus versicolor. This is an endophytic fungus isolated from the marine brown alga Sargassum. Brevianamide M has antimicrobial activity against Escherichia coli and Staphylococcus aureus .

HY-W971442

Moniliphenone	Endogenous Metabolite NF-κB	Inflammation/Immunology
Moniliphenone (Compounds 5) is a secondary metabolite. Moniliphenone can be isolated from the endophytic fungus Penicillium chrysogenum. Moniliphenone has an anti-inflammatory activity and significantly inhibits TNF-α-stimulated NF-κB activation .

HY-N8406

Monomethylsulochrin	Bacterial Antibiotic	Infection
Monomethylsulochrin is a potent antibacterial metabolite from endophytic fungus Aspergillus fumigatus, isolated from Albizia lucidior leaves (fabaceae). Monomethylsulochrin exhibits anti-Staphylococcus aureus activity with minimum inhibitory concentration (MIC) of 31.25 μg/mL .

HY-N10299

Guignardone J	Endogenous Metabolite	Infection
Guignardone J is the secondary metabolite isolated from endophytic fungus Phyllosticta capitalensis .

HY-N7307

Pachybasin	Bacterial	Infection
Pachybasin is a major metabolite from culture broth of endophytic coelomyceteous AFKR-18 fungus. Pachybasin showes antimicrobial activities against E. coli, B. subtilis, M. luteus, S. cerevisiae, C. albicans, A. niger, and A. flavus, with MIC values of 64.0 μg/mL, and against S. aureus and F. oxysporum with MIC values of 32.0 and 16.0 μg/mL respectively .

HY-N10301

Guignardone L	Toll-like Receptor (TLR)	Infection
Guignardone L is a metabolite isolated from the endophytic fungus Guignardia mangiferae with toll-like receptor 3 regulating activity .

HY-N8864

Isosativenediol	Others	Others
Isosativenediol is a sesquiterpene compound. Isosativenediol can be purified from Cochliobolus sativus, an endophytic fungus isolated from the desert plant Artemisia Desertorum .

HY-N10285

Phaeosphaone D	Tyrosinase	Infection
Phaeosphaone D is a thiodiketopiperazine alkaloid compound isolated from Phaeosphaeria fuckelii, an endophytic fungus. Phaeosphaone D displays mushroom tyrosinase inhibitory activity with an IC₅₀ value of 33.2 μM .

HY-158721

Penicinoline Marinamide	Endogenous Metabolite Parasite	Infection Cancer
Penicinoline (Marinamide) (Compound 1), a pyrrolyl 4-quinolinone alkaloid, is a microbial secondary metabolite. Penicinoline can be isolated from endophytic fungus Penicillium sp. Penicinoline has antimalarial activity against Chloroquine (HY-17589A) sensitive strain (pf3d7) and against Chloroquine resistant strain (pfDd2) of plasmodium falciparum. Penicinoline also has strong insecticidal activity against Aphis gossypii and selective anticancer effect with significant cytotoxicity for 95-D and HepG2 cells .

HY-N10300

Guignardone K	Fungal	Infection
Guignardone K is a meroterpene compound isolated from solid cultures of the endophytic fungus Guignardia sp.. Guignardone K has antifungal activity .

HY-N10263

Palmarumycin C3	Parasite	Infection
Palmarumycin C3 is a spirobisnaphthalene compound isolated from cultures of the endophytic fungus Berkleasmium sp. Dzf12 after treatment with 1-hexadecene. Palmarumycin C3 exhibits stronger antimicrobial and antioxidant activities .

HY-W164451

N-(2-hydroxy-2-phenylethyl)acetamide	Fungal	Infection
N-(2-hydroxy-2-phenylethyl)acetamide is isolated from the solid rice cultures of the endophytic fungus Diaporthe eucalyptorum KY-9. N-(2-hydroxy-2-phenylethyl)acetamide exhibits antifungal activities against Alternaria solani .

HY-N12197

Terretonin A	Others	Others
Terretonin A is a meroterpenoid that can be isolated from the endophytic fungus Aspergillus terreus .

HY-119328

Pestalotin	Endogenous Metabolite	Others
Pestalotin, a fungal lactone, is a secondary metabolite of endophytic fungus Pestalotiopsis microspore .

HY-125298

Cycloaspeptide A	Parasite	Infection
Cycloaspeptide A, isolated from the endophytic fungus Penicillium janczewskii, has antiparasitic activity .

HY-N10427

5,6-Epoxyergosterol	Others	Others
5,6-Epoxyergosterol is a natural product that can be isolated from endophytic fungus Phyllosticta capitalensis .

HY-N10256

Varioxepine A	Endogenous Metabolite	Infection
Varioxepine A is a 3H-oxepine-containing alkaloid with a new oxa-cage found in the marine algal-derived endophytic fungus Paecilomyces variotii. Varioxepine A inhibits plant pathogenic fungus Fusarium graminearum .

HY-N10262

Piliformic acid	Endogenous Metabolite	Others
Piliformic acid is a fungal metabolite found in the endophytic fungus Xylariasp sp.(No. 2508) from mangrove trees from the coast of the South China Sea .

HY-N13291

6-O-Methylreticulol	Fungal	Others
6-O-Methylreticulol (compound 1a) is an isocoumarin isolated from an endophytic fungus on the mangrove plant Avicennia marina in the Pearl River Estuary in southern China .

HY-N12195

Cytochalasin R	Fungal	Infection
Cytochalasin R (compound 17) is a cytochalasin analogue that can be isolated from the endophytic fungus Phomopsis sp. xz-18. Cytochalasin R shows potential antifungal activity .

HY-N16401

Aspergillumarin B	Bacterial Drug Derivative	Infection
Aspergillumarin B (Compound 2) is a derivative of dihydroisocoumarin. Aspergillumarin B can be isolated from the endophytic fungus Aspergillus sp.. Aspergillumarin B has a weak antibacterial activity against Staphylococcus aureus and Bacillus subtilis .

HY-N8498

GKK1032B	Apoptosis	Cancer
GKK1032B is an alkaloid compound that can be found in endophytic fungus Penicillium sp. GKK1032B can induce the apoptosis of human osteosarcoma MG63 cells through caspase pathway activation .

HY-N8511

Acremine I	Fungal	Infection
Acremine I is a fungi inhibitor and also a metabolite of the endophytic fungus Acremonium byssoides. Acremine I can effectively inhibit Plasmopara viticola. Acremine I can be used for research on plant diseases, such as grape downy mildew .

HY-N10288

Eucalyptacid A	Fungal Endogenous Metabolite	Infection
Eucalyptacid A, an antifungal metabolite, exhibits antifungal activities against Alternaria solani, with MIC values from 6.25 to 50 μM .

HY-N15655

Ravenelin	Bacterial	Infection
Ravenelin is a xanthone that can be isolated from the endophytic fungus Exserohilum rostratum. Ravenelin exhibits antiprotozoal and antibacterial activity. Ravenelin is active against gram-positive bacterial strains. Ravenelin can be studied for hit-to-lead development, especially for Chagas Disease .

HY-126649

Bacillosporin C	Antibiotic	Infection
Bacillosporin C is an oxaphenalenone dimer originally isolated from T. bacillosporus. Bacillosporin C, an anhydride, is formed from the lactone bacillosporin D in the mangrove endophytic fungus SBE-14. Similar oxaphenalenone dimers have antibiotic activity and inhibit acetylcholinesterase.

HY-N10286

Chetoseminudin B	Tyrosinase	Others
Chetoseminudin B possesses mushroom tyrosinase inhibitory activity with IC₅₀ of 31.7 μM .

HY-N16442

Pyrrocidine B	Endogenous Metabolite Prolyl Endopeptidase (PREP)	Cancer
Pyrrocidine B (Compound 6), an alkaloid, is a microbial secondary metabolite. Pyrrocidine B can be isolated from the endophytic fungus Neonectria ramulariae Wollenw KS-246. Pyrrocidine B has significant cytotoxicity against leukemia cells (IC₅₀ of 4.6  μM for HL60 cells) with a weak Prolyl oligopeptidase (POP) inhibitory activity .

HY-N15498

Gibepyrone D	Insecticide	Infection
Gibepyrone D is an α-pyrone compound found in Gibberella fujikuroi and the endophytic fungus Fusarium oxysporum 162. Gibepyrone D exhibits significant lethal activity against nematodes with an LC₅₀ value of 134 μg/mL (72 h) against the J2 larvae of Meloidogyne incognita. Gibepyrone D is promising for research of nematicides .

HY-N16457

5,6-Dihydro-6-hydroxypenicillic acid	Endogenous Metabolite Influenza Virus	Infection
5,6-Dihydro-6-hydroxypenicillic acid (Compound 6) is a microbial secondary metabolite. 5,6-Dihydro-6-hydroxypenicillic acid can be isolated from the endophytic fungus Talaromyces sp. CPCC 400783 of Reynoutria japonica Houtt. 5,6-Dihydro-6-hydroxypenicillic acid has antiviral activity against influenza A virus with an IC₅₀ of 65.45 μM .

HY-N11528

Eugenitol 7-Noreugenitin	Others	Infection
Eugenitol (Compound 3) is an antifungal metabolite isolated and purified from Diaporthe eucalyptorum. Eugenitol has inhibitory effect on four plant pathogenic fungi (Alternaria solani, Botrytis cinerea, Fusarium solani and Gibberella saubinettii) .

HY-W162983

3,4-Diphenyl-5H-furan-2-one	COX	Neurological Disease Inflammation/Immunology
3,4-Diphenyl-5H-furan-2-one is a natural compound isolated from the endophytic fungus Aspergillus flavipes AIL8 derived from the mangrove plant Acanthus ilicifolius. 3,4-Diphenyl-5H-furan-2-one is a derivative of 2,3-diphenyltetrahydrofuran (DPTF), which is a COX-2 inhibitor. 3,4-Diphenyl-5H-furan-2-one can be used as a lead compound for inflammation and pain .

HY-D0027R

7-Amino-4-methylcoumarin (Standard) Coumarin 120 (Standard); AMC (Standard)	Fluorescent Dye Antibiotic Fungal Reference Standards	Infection
7-Amino-4-methylcoumarin (Standard) is the analytical standard of 7-Amino-4-methylcoumarin. This product is intended for research and analytical applications. 7-Amino-4-methylcoumarin belongs to the coumarin class, can be isolated from the endophytic fungus Xylaria sp. and has a broad spectrum of antibacterial activity. 7-Amino-4-methylcoumarin is also commonly used as an important laser dye that emits in the blue region, capable of analyzing glycoprotein monosaccharides and N-linked oligosaccharides, and is also utilized in tissue pathology analysis, enzyme activity measurement, and copper ion detection. The excitation wavelength and emission wavelength are 351 nm and 430 nm, respectively. [4]

HY-N15306

Boerelasin E	Apoptosis	Cancer
Boerelasin E is the first cytochalasan possessing a cis-configured Δ21(22) double bond that can be isolated from endophytic fungus Boeremia exigua. Boerelasin E exhibits antiproliferative activity against MCF-7 cells (IC₅₀=20.52 μM) more potent than cisplatin (HY-17394). Boerelasin E inhibits the complete cell division of MCF-7 cells by arresting them in the G2/M phase and inducing apoptosis^[1].

HY-N19681

3-(2,6-Dihydroxyphenyl)-4-hydroxy-6-methylisobenzofuran-1(3H)-one	Endogenous Metabolite	Neurological Disease
3-(2,6-Dihydroxyphenyl)-4-hydroxy-6-methylisobenzofuran-1(3H)-one is a polyketide compound found in the mangrove endophytic fungus Phomopsis sp. xy21. 3-(2,6-Dihydroxyphenyl)-4-hydroxy-6-methylisobenzofuran-1(3H)-one shows neuroprotective activity against Corticosterone (HY-B1618)-induced injury in neuronal cells .

HY-N9553

Alternarian acid	Endogenous Metabolite	Others
Alternarian acid is a polyketide compound found in the endophytic fungus Alternaria alternata MT-47, an endophytic fungus isolated from the medicinal plant of Huperzia serrata. Alternarian acid shows little inhibitory activity against thrombin-activated platelets, acetylcholinesterase, or butyrylcholinesterase .

HY-N12193

Cytochalasin N	Others	Others
Cytochalasin N is a cytorelaxin derived from endophytic fungus Phomopsis sp.CIB-109 .

HY-N19796

Diaporol I	Drug Derivative	Others
Diaporol I is a pimarane-type sesquiterpene that can be isolated from the mangrove-derived endophytic fungus Diaporthe sp.

HY-130052

Rosellichalasin	Bacterial	Infection
Rosellichalasin is an antibacterial agent isolated from the endophytic fungus Aspergillus flavipes Y-62. Rosellichalasin exhibits antibacterial activity .

HY-N13021

2-(2-Hydroxy-5-methoxyphenoxy)-acrylic acid	Endogenous Metabolite	Others
2-(2-Hydroxy-5-methoxyphenoxy)-acrylic acid is a metabolite, which can be isolated from endophytic fungus Phoma macrostoma inhabiting the inner tissue of medicinal plant Glycyrrhiza glabra Linn .

HY-B1086R

Afalanine (Standard) N-Acetyl-DL-phenylalanine (Standard)	Endogenous Metabolite Reference Standards	Neurological Disease
Afalanine (Standard) is the analytical standard of Afalanine. This product is intended for research and analytical applications. Afalanine (N-Acetyl-DL-phenylalanine) is an endogenous metabolite of an endophytic fungus with antidepressant activity. Afalanine can be used in combination with antibiotics to prevent renal damage.

HY-N19754

Cladospirone B	Parasite	Infection
Cladospirone B is a secondary metabolite of the endophytic fungus Lasiodiplodia theobromae. Cladospirone B exhibits trypanocidal activity, with a MIC of 17.8 µM against Trypanosoma brucei. Cladospirone B can be used in the research of African human trypanosomiasis (sleeping sickness) .

HY-N16428

Neoaspergillic acid NSC 356436	Endogenous Metabolite Fungal Bacterial	Infection Cancer
Neoaspergillic acid (NSC 356436) (Compound 2) is a microbial secondary metabolite. Neoaspergillic acid can be isolated from the endophytic fungus Aspergillus sp. SPH2. Neoaspergillic acid has potent antifungal activity against Alternaria alternata, Botrytis cinerea and Fusarium oxysporum. Neoaspergillic acid appears during the exponential phase of fungal growth. Neoaspergillic acid also antitumor and antibacterial effects .

HY-75564R

Cyclo(Ala-Gly) (Standard)	Reference Standards Endogenous Metabolite	Cancer
Cyclo(Ala-Gly) (Standard) is the analytical standard of Cyclo(Ala-Gly). This product is intended for research and analytical applications. Cyclo(Ala-Gly), a metabolite of a mangrove endophytic fungus, Penicillium thomi, exhibits cytotoxicity against A549, HepG2 and HT29 cells. The IC50 values range from 9.5 to 18.1 μM[1].

Cat. No.	Product Name	Type

HY-D0027

7-Amino-4-methylcoumarin

Coumarin 120; AMC

Fluorescent Dyes

7-Amino-4-methylcoumarin belongs to the coumarin class, can be isolated from the endophytic fungus Xylaria sp. and has a broad spectrum of antibacterial activity. 7-Amino-4-methylcoumarin is also commonly used as an important laser dye that emits in the blue region, capable of analyzing glycoprotein monosaccharides and N-linked oligosaccharides, and is also utilized in tissue pathology analysis, enzyme activity measurement, and copper ion detection. The excitation wavelength and emission wavelength are 351 nm and 430 nm, respectively.

HY-D0027R

7-Amino-4-methylcoumarin (Standard)

Coumarin 120 (Standard); AMC (Standard)

Fluorescent Dyes

7-Amino-4-methylcoumarin (Standard) is the analytical standard of 7-Amino-4-methylcoumarin. This product is intended for research and analytical applications. 7-Amino-4-methylcoumarin belongs to the coumarin class, can be isolated from the endophytic fungus Xylaria sp. and has a broad spectrum of antibacterial activity. 7-Amino-4-methylcoumarin is also commonly used as an important laser dye that emits in the blue region, capable of analyzing glycoprotein monosaccharides and N-linked oligosaccharides, and is also utilized in tissue pathology analysis, enzyme activity measurement, and copper ion detection. The excitation wavelength and emission wavelength are 351 nm and 430 nm, respectively. [4]

Cat. No.	Product Name	Target	Research Area

HY-75564

Cyclo(Ala-Gly)	Endogenous Metabolite	Cancer
Cyclo(Ala-Gly), a metabolite of a mangrove endophytic fungus, Penicillium thomi, exhibits cytotoxicity against A549, HepG2 and HT29 cells. The IC₅₀ values range from 9.5 to 18.1 μM .

Cat. No.	Product Name	Category	Target	Chemical Structure

HY-75564

Cyclo(Ala-Gly)	Natural Products Microorganisms Classification of Application Fields Endogenous metabolite Disease Research Fields Source Classification Cancer	Endogenous Metabolite
Cyclo(Ala-Gly), a metabolite of a mangrove endophytic fungus, Penicillium thomi, exhibits cytotoxicity against A549, HepG2 and HT29 cells. The IC₅₀ values range from 9.5 to 18.1 μM .

HY-N7023

7-Prenyloxycoumarin 7-O-Prenylumbelliferone	Infection Classification of Application Fields Coumarins Phenylpropanoids Plants Umbelliferae Kleinia odora (Forssk.) DC. Disease Research Fields Source Classification	Fungal
7-Prenyloxycoumarin (7-O-Prenylumbelliferone) is a secondary metabolite from the endophytic fungus of Annulohypoxylon ilanense .

HY-N6294

Monocerin	Infection Monophenols Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Phenols Disease Research Fields Source Classification	Bacterial Fungal
Monocerin is an isocoumarin derivative. Monocerin is isolated from Microdochium bolleyi, an endophytic fungus from Fagonia cretica. Monocerin shows good antifungal, antibacterial, and antialgal activities against Microbotryum violaceum, Escherichia coli, Bacillus megaterium, and Chlorella fusca .

HY-W751002

Orthosporin (+)-Orthosporin	Structural Classification Microorganisms Coumarins Phenylpropanoids Source Classification	Endogenous Metabolite Bacterial HIV Reverse Transcriptase
Orthosporin ((+)-Orthosporin), a phytotoxic isocoumarin compound, is a microbial secondary metabolite. Orthosporin can be isolated from the endophytic fungus Lasiodiplodia tbeobromae. Orthosporin has potent antibacterial activity against B. subtilis, E. coli and P. aeruginosa. Orthosporin also has antioxidant activity against DPPH radical and antiviral activities with inhibition of HIV-1 reverse transcriptase activity .

HY-N12179

Brevianamide M	Alkaloids Human Gut Microbiota Metabolites Microorganisms Other Alkaloids Endogenous metabolite Source Classification	Bacterial
Brevianamide M (compound 4) is a metabolite of Aspergillus versicolor. This is an endophytic fungus isolated from the marine brown alga Sargassum. Brevianamide M has antimicrobial activity against Escherichia coli and Staphylococcus aureus .

HY-W971442

Moniliphenone	Microorganisms Phenols Polyphenols Source Classification	Endogenous Metabolite NF-κB
Moniliphenone (Compounds 5) is a secondary metabolite. Moniliphenone can be isolated from the endophytic fungus Penicillium chrysogenum. Moniliphenone has an anti-inflammatory activity and significantly inhibits TNF-α-stimulated NF-κB activation .

HY-N8406

Monomethylsulochrin	Microorganisms Phenols Source Classification	Bacterial Antibiotic
Monomethylsulochrin is a potent antibacterial metabolite from endophytic fungus Aspergillus fumigatus, isolated from Albizia lucidior leaves (fabaceae). Monomethylsulochrin exhibits anti-Staphylococcus aureus activity with minimum inhibitory concentration (MIC) of 31.25 μg/mL .

HY-N10299

Guignardone J	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Endogenous Metabolite
Guignardone J is the secondary metabolite isolated from endophytic fungus Phyllosticta capitalensis .

HY-N7307

Pachybasin	Infection Quinones Monophenols Microorganisms Classification of Application Fields Anthraquinones Phenols Disease Research Fields Source Classification	Bacterial
Pachybasin is a major metabolite from culture broth of endophytic coelomyceteous AFKR-18 fungus. Pachybasin showes antimicrobial activities against E. coli, B. subtilis, M. luteus, S. cerevisiae, C. albicans, A. niger, and A. flavus, with MIC values of 64.0 μg/mL, and against S. aureus and F. oxysporum with MIC values of 32.0 and 16.0 μg/mL respectively .

HY-N10301

Guignardone L	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Toll-like Receptor (TLR)
Guignardone L is a metabolite isolated from the endophytic fungus Guignardia mangiferae with toll-like receptor 3 regulating activity .

HY-N8864

Isosativenediol	Terpenoids Sesquiterpenes Millettia erythrocalyx Gagnep. Plants Compositae Source Classification	Others
Isosativenediol is a sesquiterpene compound. Isosativenediol can be purified from Cochliobolus sativus, an endophytic fungus isolated from the desert plant Artemisia Desertorum .

HY-N10285

Phaeosphaone D	Infection Alkaloids Microorganisms Classification of Application Fields Disease Research Fields Indole Alkaloids Source Classification	Tyrosinase
Phaeosphaone D is a thiodiketopiperazine alkaloid compound isolated from Phaeosphaeria fuckelii, an endophytic fungus. Phaeosphaone D displays mushroom tyrosinase inhibitory activity with an IC₅₀ value of 33.2 μM .

HY-158721

Penicinoline Marinamide	Structural Classification Alkaloids Microorganisms Indole Alkaloids Source Classification	Endogenous Metabolite Parasite
Penicinoline (Marinamide) (Compound 1), a pyrrolyl 4-quinolinone alkaloid, is a microbial secondary metabolite. Penicinoline can be isolated from endophytic fungus Penicillium sp. Penicinoline has antimalarial activity against Chloroquine (HY-17589A) sensitive strain (pf3d7) and against Chloroquine resistant strain (pfDd2) of plasmodium falciparum. Penicinoline also has strong insecticidal activity against Aphis gossypii and selective anticancer effect with significant cytotoxicity for 95-D and HepG2 cells .

HY-N10300

Guignardone K	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Fungal
Guignardone K is a meroterpene compound isolated from solid cultures of the endophytic fungus Guignardia sp.. Guignardone K has antifungal activity .

HY-N10263

Palmarumycin C3	Infection Microorganisms Classification of Application Fields Phenols Polyphenols Disease Research Fields Source Classification	Parasite
Palmarumycin C3 is a spirobisnaphthalene compound isolated from cultures of the endophytic fungus Berkleasmium sp. Dzf12 after treatment with 1-hexadecene. Palmarumycin C3 exhibits stronger antimicrobial and antioxidant activities .

HY-W164451

N-(2-hydroxy-2-phenylethyl)acetamide	Infection Natural Products Microorganisms Classification of Application Fields Disease Research Fields Source Classification	Fungal
N-(2-hydroxy-2-phenylethyl)acetamide is isolated from the solid rice cultures of the endophytic fungus Diaporthe eucalyptorum KY-9. N-(2-hydroxy-2-phenylethyl)acetamide exhibits antifungal activities against Alternaria solani .

HY-N12197

Terretonin A	Other Monoterpenes Human Gut Microbiota Metabolites Microorganisms Terpenoids Endogenous metabolite Source Classification	Others
Terretonin A is a meroterpenoid that can be isolated from the endophytic fungus Aspergillus terreus .

HY-119328

Pestalotin	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Disease Research Fields Source Classification	Endogenous Metabolite
Pestalotin, a fungal lactone, is a secondary metabolite of endophytic fungus Pestalotiopsis microspore .

HY-125298

Cycloaspeptide A	Infection Alkaloids Microorganisms Classification of Application Fields Disease Research Fields Source Classification	Parasite
Cycloaspeptide A, isolated from the endophytic fungus Penicillium janczewskii, has antiparasitic activity .

HY-N10427

5,6-Epoxyergosterol	Classification of Application Fields Other Diseases Hamamelidaceae Plants Loropetalum chinense (R. Br.) Oliver Disease Research Fields Steroids Source Classification	Others
5,6-Epoxyergosterol is a natural product that can be isolated from endophytic fungus Phyllosticta capitalensis .

HY-N10256

Varioxepine A	Infection Alkaloids Microorganisms Classification of Application Fields Disease Research Fields Source Classification	Endogenous Metabolite
Varioxepine A is a 3H-oxepine-containing alkaloid with a new oxa-cage found in the marine algal-derived endophytic fungus Paecilomyces variotii. Varioxepine A inhibits plant pathogenic fungus Fusarium graminearum .

HY-N10262

Piliformic acid	Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Other Diseases Disease Research Fields Source Classification	Endogenous Metabolite
Piliformic acid is a fungal metabolite found in the endophytic fungus Xylariasp sp.(No. 2508) from mangrove trees from the coast of the South China Sea .

HY-N13291

6-O-Methylreticulol	Microorganisms Coumarins Phenylpropanoids Source Classification	Fungal
6-O-Methylreticulol (compound 1a) is an isocoumarin isolated from an endophytic fungus on the mangrove plant Avicennia marina in the Pearl River Estuary in southern China .

HY-N12195

Cytochalasin R	Structural Classification Alkaloids Microorganisms Pyrrole Alkaloids Source Classification	Fungal
Cytochalasin R (compound 17) is a cytochalasin analogue that can be isolated from the endophytic fungus Phomopsis sp. xz-18. Cytochalasin R shows potential antifungal activity .

HY-N16401

Aspergillumarin B	Natural Products Microorganisms Source Classification	Bacterial Drug Derivative
Aspergillumarin B (Compound 2) is a derivative of dihydroisocoumarin. Aspergillumarin B can be isolated from the endophytic fungus Aspergillus sp.. Aspergillumarin B has a weak antibacterial activity against Staphylococcus aureus and Bacillus subtilis .

HY-N8498

GKK1032B	Alkaloids Microorganisms Pyrrole Alkaloids Classification of Application Fields Disease Research Fields Cancer Source Classification	Apoptosis
GKK1032B is an alkaloid compound that can be found in endophytic fungus Penicillium sp. GKK1032B can induce the apoptosis of human osteosarcoma MG63 cells through caspase pathway activation .

HY-N8511

Acremine I	Natural Products Microorganisms Source Classification	Fungal
Acremine I is a fungi inhibitor and also a metabolite of the endophytic fungus Acremonium byssoides. Acremine I can effectively inhibit Plasmopara viticola. Acremine I can be used for research on plant diseases, such as grape downy mildew .

HY-N10288

Eucalyptacid A	Infection Microorganisms Classification of Application Fields Ketones, Aldehydes, Acids Disease Research Fields Source Classification	Fungal Endogenous Metabolite
Eucalyptacid A, an antifungal metabolite, exhibits antifungal activities against Alternaria solani, with MIC values from 6.25 to 50 μM .

HY-N15655

Ravenelin	Structural Classification Microorganisms Xanthones Phenols Source Classification	Bacterial
Ravenelin is a xanthone that can be isolated from the endophytic fungus Exserohilum rostratum. Ravenelin exhibits antiprotozoal and antibacterial activity. Ravenelin is active against gram-positive bacterial strains. Ravenelin can be studied for hit-to-lead development, especially for Chagas Disease .

HY-N10286

Chetoseminudin B	Alkaloids Microorganisms Classification of Application Fields Other Diseases Disease Research Fields Indole Alkaloids Source Classification	Tyrosinase
Chetoseminudin B possesses mushroom tyrosinase inhibitory activity with IC₅₀ of 31.7 μM .

HY-N16442

Pyrrocidine B	Alkaloids Microorganisms Pyridine Alkaloids Source Classification	Endogenous Metabolite Prolyl Endopeptidase (PREP)
Pyrrocidine B (Compound 6), an alkaloid, is a microbial secondary metabolite. Pyrrocidine B can be isolated from the endophytic fungus Neonectria ramulariae Wollenw KS-246. Pyrrocidine B has significant cytotoxicity against leukemia cells (IC₅₀ of 4.6  μM for HL60 cells) with a weak Prolyl oligopeptidase (POP) inhibitory activity .

HY-N15498

Gibepyrone D	Microorganisms Ketones, Aldehydes, Acids Source Classification	Insecticide
Gibepyrone D is an α-pyrone compound found in Gibberella fujikuroi and the endophytic fungus Fusarium oxysporum 162. Gibepyrone D exhibits significant lethal activity against nematodes with an LC₅₀ value of 134 μg/mL (72 h) against the J2 larvae of Meloidogyne incognita. Gibepyrone D is promising for research of nematicides .

HY-N16457

5,6-Dihydro-6-hydroxypenicillic acid	Structural Classification Natural Products Microorganisms Source Classification	Endogenous Metabolite Influenza Virus
5,6-Dihydro-6-hydroxypenicillic acid (Compound 6) is a microbial secondary metabolite. 5,6-Dihydro-6-hydroxypenicillic acid can be isolated from the endophytic fungus Talaromyces sp. CPCC 400783 of Reynoutria japonica Houtt. 5,6-Dihydro-6-hydroxypenicillic acid has antiviral activity against influenza A virus with an IC₅₀ of 65.45 μM .

HY-N11528

Eugenitol 7-Noreugenitin	Natural Products Microorganisms Source Classification	Others
Eugenitol (Compound 3) is an antifungal metabolite isolated and purified from Diaporthe eucalyptorum. Eugenitol has inhibitory effect on four plant pathogenic fungi (Alternaria solani, Botrytis cinerea, Fusarium solani and Gibberella saubinettii) .

HY-W162983

3,4-Diphenyl-5H-furan-2-one	Callicarpa cathayana Hung T. Chang Natural Products Acanthaceae Plants Source Classification	COX
3,4-Diphenyl-5H-furan-2-one is a natural compound isolated from the endophytic fungus Aspergillus flavipes AIL8 derived from the mangrove plant Acanthus ilicifolius. 3,4-Diphenyl-5H-furan-2-one is a derivative of 2,3-diphenyltetrahydrofuran (DPTF), which is a COX-2 inhibitor. 3,4-Diphenyl-5H-furan-2-one can be used as a lead compound for inflammation and pain .

HY-N15306

Boerelasin E	Microorganisms Ketones, Aldehydes, Acids Phenols Source Classification	Apoptosis
Boerelasin E is the first cytochalasan possessing a cis-configured Δ21(22) double bond that can be isolated from endophytic fungus Boeremia exigua. Boerelasin E exhibits antiproliferative activity against MCF-7 cells (IC₅₀=20.52 μM) more potent than cisplatin (HY-17394). Boerelasin E inhibits the complete cell division of MCF-7 cells by arresting them in the G2/M phase and inducing apoptosis^[1].

HY-N19681

3-(2,6-Dihydroxyphenyl)-4-hydroxy-6-methylisobenzofuran-1(3H)-one	Structural Classification Microorganisms Phenols Polyphenols Source Classification	Endogenous Metabolite
3-(2,6-Dihydroxyphenyl)-4-hydroxy-6-methylisobenzofuran-1(3H)-one is a polyketide compound found in the mangrove endophytic fungus Phomopsis sp. xy21. 3-(2,6-Dihydroxyphenyl)-4-hydroxy-6-methylisobenzofuran-1(3H)-one shows neuroprotective activity against Corticosterone (HY-B1618)-induced injury in neuronal cells .

HY-N9553

Alternarian acid	Structural Classification Monophenols Microorganisms Phenols Source Classification	Endogenous Metabolite
Alternarian acid is a polyketide compound found in the endophytic fungus Alternaria alternata MT-47, an endophytic fungus isolated from the medicinal plant of Huperzia serrata. Alternarian acid shows little inhibitory activity against thrombin-activated platelets, acetylcholinesterase, or butyrylcholinesterase .

HY-N12193

Cytochalasin N	Natural Products Microorganisms Source Classification	Others
Cytochalasin N is a cytorelaxin derived from endophytic fungus Phomopsis sp.CIB-109 .

HY-N19796

Diaporol I	Structural Classification Microorganisms Terpenoids Sesquiterpenes Source Classification	Drug Derivative
Diaporol I is a pimarane-type sesquiterpene that can be isolated from the mangrove-derived endophytic fungus Diaporthe sp.

HY-130052

Rosellichalasin	Structural Classification Alkaloids Microorganisms Other Alkaloids Source Classification	Bacterial
Rosellichalasin is an antibacterial agent isolated from the endophytic fungus Aspergillus flavipes Y-62. Rosellichalasin exhibits antibacterial activity .

HY-N13021

2-(2-Hydroxy-5-methoxyphenoxy)-acrylic acid	Monophenols Microorganisms Phenols Source Classification	Endogenous Metabolite
2-(2-Hydroxy-5-methoxyphenoxy)-acrylic acid is a metabolite, which can be isolated from endophytic fungus Phoma macrostoma inhabiting the inner tissue of medicinal plant Glycyrrhiza glabra Linn .

HY-N19754

Cladospirone B	Structural Classification Natural Products Microorganisms Source Classification	Parasite
Cladospirone B is a secondary metabolite of the endophytic fungus Lasiodiplodia theobromae. Cladospirone B exhibits trypanocidal activity, with a MIC of 17.8 µM against Trypanosoma brucei. Cladospirone B can be used in the research of African human trypanosomiasis (sleeping sickness) .

HY-N16428

Neoaspergillic acid NSC 356436	Natural Products Microorganisms Source Classification	Endogenous Metabolite Fungal Bacterial
Neoaspergillic acid (NSC 356436) (Compound 2) is a microbial secondary metabolite. Neoaspergillic acid can be isolated from the endophytic fungus Aspergillus sp. SPH2. Neoaspergillic acid has potent antifungal activity against Alternaria alternata, Botrytis cinerea and Fusarium oxysporum. Neoaspergillic acid appears during the exponential phase of fungal growth. Neoaspergillic acid also antitumor and antibacterial effects .

HY-75564R

Cyclo(Ala-Gly) (Standard)	Natural Products Microorganisms Endogenous metabolite Source Classification	Reference Standards Endogenous Metabolite
Cyclo(Ala-Gly) (Standard) is the analytical standard of Cyclo(Ala-Gly). This product is intended for research and analytical applications. Cyclo(Ala-Gly), a metabolite of a mangrove endophytic fungus, Penicillium thomi, exhibits cytotoxicity against A549, HepG2 and HT29 cells. The IC50 values range from 9.5 to 18.1 μM[1].

HY-118817

Evariquinone	Quinones Structural Classification Microorganisms Anthraquinones Source Classification	Reactive Oxygen Species (ROS) Calcium Channel JNK ERK p38 MAPK Apoptosis
Evariquinone is an anthraquinone compound isolated from the endophytic fungus Colletotrichum sp. JS-0367 of mulberry. Evariquinone possesses direct antioxidant activity. It inhibits excessive phosphorylation of the JNK, ERK1/2 and p38 MAPK signaling pathways by suppressing ROS and Ca ²⁺, thereby reducing neuronal apoptosis. Evariquinone can be used to study glutamate excitotoxicity-related neurological disorders (such as Alzheimer's disease, Parkinson's disease, cerebral ischemia, etc.) .

HY-N16448

Xanthoascin	Monophenols Microorganisms Phenols Source Classification	Bacterial
Xanthoascin (Compound 1) is a natural phenolic metabolite with strong anti plant pathogen activity. Xanthoascin can be extracted from the solid fermentation product of endophytic fungus Aspergillus sp. IFB-YXS isolated from Ginkgo biloba leaves. Xanthoascin has a MIC of 0.3125 µg/mL against Clavibacter michiganense subsp. Sepedonicus and moderate inhibitory activity against other pathogens (MIC = 5-20 µg/mL). Xanthoascin can disrupt the permeability of bacterial cell membranes, leading to nucleic acid leakage .

HY-182490

Chrodrimanin H	Structural Classification Microorganisms Terpenoids Diterpenoids Source Classification	Fungal Endogenous Metabolite NO Synthase
Chrodrimanin H (Compound 13) is a sesquiterpenoid compound. Chrodrimanin H is isolated from the fungus Talaromyces primulinus H21. Chrodrimanin H blocks lipopolysaccharide-induced NO production in immune cells with an IC50 of 24.71 μM .

HY-N19907

Phomopsinone A	Structural Classification Natural Products Microorganisms Source Classification	Endogenous Metabolite Fungal Antibiotic
Phomopsinone A is an Antifungal agent. Phomopsinone A is isolated from Phomopsis sp. Phomopsinone A exhibits activity against plant and crop pathogens Pyricularia oryzae, Septoria tritici and Botrytis cinerea. Phomopsinone A can be used in the research of plant/crop fungal diseases .

Cat. No.	Product Name	Chemical Structure

HY-D0027S1

7-Amino-4-methylcoumarin-d4

7-Amino-4-methylcoumarin-d₄ (Coumarin 120-d₄) is the deuterium labeled 7-Amino-4-methylcoumarin (HY-D0027). 7-Amino-4-methylcoumarin belongs to the coumarin class, can be isolated from the endophytic fungus Xylaria sp. and has a broad spectrum of antibacterial activity. 7-Amino-4-methylcoumarin is also commonly used as an important laser dye that emits in the blue region, capable of analyzing glycoprotein monosaccharides and N-linked oligosaccharides, and is also utilized in tissue pathology analysis, enzyme activity measurement, and copper ion detection. The excitation wavelength and emission wavelength are 351 nm and 430 nm, respectively .

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