7 Results for "

EphA2 receptor antagonist

" in MedChemExpress (MCE) Product Catalog:
Products (7)

7 Results for "EphA2 receptor antagonist" in MCE Product Catalog:

Cat. No.: HY-P3717
CAS No.: 3031514-44-7
Target:  

Ephrin Receptor

Research Areas:  

Cancer

Targefrin is a potent EphA2-targeting agent, acts as an antagonist. Targefrin binds EphA2-LBD with 21 nM dissociation constant and an IC50 value of 10.8 nM. Targefrin induces cellular receptor internalization and degradation in several pancreatic cancer cell lines .
loading...
    loading...
Cat. No.: HY-133178
CAS No.: 131086-98-1
Purity:  99.72%
Synonyms: 3,4,8,9-Tetrahydroxy urolithin
Urolithin D (3,4,8,9-Tetrahydroxy urolithin) is a colonic metabolite of Ellagitannins and a competitive, reversible, and selective antagonist of the EphA receptor. Urolithin D inhibits EphA2-ephrin-A1 binding with an IC50 of 0.9 μM. Urolithin D is also a potent antioxidant that scavenges free radicals and repairs oxidized DNA damage. Additionally, Urolithin D suppresses triglyceride accumulation and promotes fatty acid oxidation by activating the AMPK signaling pathway. Urolithin D can be used for research on tumors, metabolic, and inflammatory diseases .
loading...
    loading...
Cat. No.: HY-169849
CAS No.: 1428095-28-6
Target:  

Ephrin Receptor

Research Areas:  

Others

EphA2 antagonist 1 (4b) is a bile acid conjugate and an ephrin type-A receptor 2 (EPHA2) inhibitor .
loading...
    loading...
Cat. No.: HY-W078239
CAS No.: 313701-92-7
Target:  

Ephrin Receptor

Research Areas:  

Cancer

EPHA4 antagonist-1 (Compound 2) is an EphA4 receptor antagonist. EPHA4 antagonist-1 is also an EphA2 receptor antagonist. EPHA4 antagonist-1 inhibits ephrin-A5 AP binding to EphA4 Fc receptor, with an IC50 of 10 μM .
loading...
    loading...
Cat. No.: HY-171175
CAS No.: 2085767-98-0
Target:  

Ephrin Receptor

Research Areas:  

Cancer

UniPR500, a UniPR129 derivative, is a competitive EphA2 receptor antagonist with a Ki of 0.78 μM. UniPR500 dose-dependently reduces binding of biotinylated ephrin-A1 to EphA2 with an IC50 value of 1.1 μM .
loading...
    loading...
Cat. No.: HY-157020
Target:  

Ephrin Receptor

Research Areas:  

Cancer

UniPR1449 is an antagonist of EphA2 receptor, with th KD of 3.8±2.4 μM, that plays an important role in cancer .
loading...
    loading...
Cat. No.: HY-133178R
CAS No.: 131086-98-1
Synonyms: 3,4,8,9-Tetrahydroxy urolithin (Standard)
Urolithin D (Standard) (3,4,8,9-Tetrahydroxy urolithin (Standard)) is the analytical standard of Urolithin D (HY-133178). This product is intended for research and analytical applications. Urolithin D (3,4,8,9-Tetrahydroxy urolithin) is a colonic metabolite of Ellagitannins and a competitive, reversible, and selective antagonist of the EphA receptor. Urolithin D inhibits EphA2-ephrin-A1 binding with an IC50 of 0.9 μM. Urolithin D is also a potent antioxidant that scavenges free radicals and repairs oxidized DNA damage. Additionally, Urolithin D suppresses triglyceride accumulation and promotes fatty acid oxidation by activating the AMPK signaling pathway. Urolithin D can be used for research on tumors, metabolic, and inflammatory diseases .
loading...
    loading...