3031514-44-7
Chemical Structure
Targefrin
- CAS No.: 3031514-44-7
- Formula:C85H116F3N19O15
- Molecular Weight:1700.94
InChIKey: UUKDZYHYHXLKTO-LMEGGTDHSA-N
SMILES: C[C@H](NC([C@@H](NC([C@@H](NC(CN1CCNCC1)=O)CC2=CC=C(N)C=C2)=O)CC(C)C)=O)C(N[C@H](C(N3CCC[C@H]3C(N[C@@H](CC(O)=O)C(N[C@H](C(N[C@@H](C4CCCCC4)C(N(CCC5)[C@@H]5C(N[C@@H](CC6=CC=CC=C6)C(N[C@@H](CCCNC(N)=N)C(N7CCC[C@H]7C(N)=O)=O)=O)=O)=O)=O)C)=O)=O)=O)CC8=CC=C(C=C8)C9=CC=CC=C9C(F)(F)F)=O
Biological Activity: Targefrin is a potent EphA2-targeting agent, acts as an antagonist. Targefrin binds EphA2-LBD with 21 nM dissociation constant and an IC50 value of 10.8 nM. Targefrin induces cellular receptor internalization and degradation in several pancreatic cancer cell lines[1].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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Targefrin | 99.80% | Targefrin is a potent EphA2-targeting agent, acts as an antagonist. Targefrin binds EphA2-LBD with 21 nM dissociation constant and an IC50 value of 10.8 nM. Targefrin induces cellular receptor internalization and degradation in several pancreatic cancer cell lines. | ||||||||||||||||||||
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