Scientific Reviews
Product Guides
Blogs
Topics
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
166 Results for "
GlcNAc
" in MedChemExpress (MCE) Product Catalog:
Products (166)
166 Results for "GlcNAc" in MCE Product Catalog:
174
174 Publications Verification
Cat. No.: HY-A0098
CAS No.: 11089-65-9
54
48
48 Cited Publications
Target:
Research Areas:
OSMI-1 is a cell-permeable O-GlcNAc transferase (OGT) inhibitor with an IC50 value of 2.7 μM. OSMI-1 inhibits protein O-linked N-acetylglucosamine (O-GlcNAcylation) in several mammalian cell lines without qualitatively altering cell surface N- or O-linked glycans .
31
31 Cited Publications
Target:
Research Areas:
OSMI-4 is a low nanomolar O-GlcNAc transferase (OGT) inhibitor, with an EC50 of 3 μM in cells.
8
8 Cited Publications
Synonyms: UDP-α-D-N-Acetylglucosamine disodium
Target:
Research Areas:
UDP-GlcNAc Disodium Salt (UDP-α-D-N-Acetylglucosamine Disodium Salt) is a donor substrate of O-GlcNAc transferase (OGT).
3
3 Cited Publications
Synonyms: CMP-Neu5Ac sodium salt
Target:
1
1 Cited Publications
Cat. No.: HY-163121
CAS No.: 1096144-06-7
Research Areas:
PST3.1a is an orally active and brain-penetrant N-acetylglucosamine glycosyltransferase (MGAT5) inhibitor with a human IC50 of 2 µM. PST3.1a inhibits TGFβR and FAK signaling pathway activity. PST3.1a alters β1,6-GlcNAc N-glycans and microtubule/microfilament integrity, increases OLIG2 expression, and inhibits proliferation, migration, invasiveness, and clonogenic capacities of glioblastoma initiating cells. PST3.1a reduces invasive and proliferative capacity of glioblastoma initiating cells in orthotopic graft models, increases overall survival of orthotopic graft model mice. PST3.1a blunts MGAT5 overexpression, decreases renal fibrosis via collagen 1, collagen 4, and galectin 3 downregulation in a rat chronic kidney disease model. PST3.1a can be used for the research of glioblastoma multiforme and chronic kidney disease .
1
1 Cited Publications
Cat. No.: HY-P703650
Purity: ≥ 90%, as determined by reducing SDS-PAGE.
Synonyms: OGT; MGC22921; O-Linked N-Acetylglucosamine (GlcNAc) Transferase; FLJ23071; UDP-N-Acetylglucosamine--Peptide N-Acetylglucosaminyltransferase 110 KDa Subunit; CDNA FLJ61388, Highly Similar To UDP-N-Acetylglucosamine--PeptideN-Acetylglucosaminyltransferase
Target:
Cat. No.: HY-175222
CAS No.: 41137-10-4
Research Areas:
GlcNAc-MurNAc, a disaccharide, is a TLR4 agonist with a Kd of 383 μM for murine TLR4. GlcNAc-MurNAc directly binds to TLR4 and activates its downstream NF-κB and IRF pathways. GlcNAc-MurNAc improves Dextran sulfate sodium salt (DSS) (HY-116282C)-induced colitis in mice through a TLR4-dependent mechanism. GlcNAc-MurNAc can be used for the study of inflammatory bowel disease .
Target:
Category:
Human Gut Microbiota Metabolites Natural Products Metabolic Disease Endogenous metabolite Disease Research Fields
Target:
Cat. No.: HY-E70032
CAS No.: 1609980-80-4
Target:
Research Areas:
N-Acetylhexosamine kinase (NahK) is an anomeric kinase acting on a glucose-type substrate. N-Acetylhexosamine kinase catalyzes the phosphorylation of GlcNAc or GalNAc at the anomeric C1 position with ATP to form N-acetylhexosamine 1-phosphate (GlcNAc-1P/GalNAc-1P) .
Cat. No.: HY-W585865
CAS No.: 112710-84-6
Synonyms: UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine Tris
Target:
Cat. No.: HY-N8515C
Synonyms: UDP-3-O-(3-hydroxytetradecanoyl)-N-acetylglucosamine disodium
Target:
Synonyms: 3-O-Methyl-GlcNAc
Target:
Research Areas:
3-O-Methyl-N-acetyl-D-glucosamine is a potent inhibitor of N-acetylglucosamine kinase. 3-O-Methyl-N-acetyl-D-glucosamine potently inhibits glucose phosphorylation by N-acetylglucosamine kinase whereas glucokinase is not at all affected by this hexosamine .
Cat. No.: HY-164390
CAS No.: 64364-50-7
Synonyms: Neu5Acα2-6Galβ1-4GlcNAc
Target:
6′SLN is a cancer-related extracellular vesicle (EVs) surface glycan that serves as a key form of protein glycosylation in EVs. 6′SLN is also a sialic acid derivative that can interact with hemagglutinins (HAs) from human and avian influenza virus strains, making it useful for research into anti-influenza drugs .
Cat. No.: HY-P5375
CAS No.: 954381-93-2
-
-
Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
