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Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!2025-02-06
13 Results for "
Group IIA phospholipase A2
" in MedChemExpress (MCE) Product Catalog:
Products (13)
13 Results for "Group IIA phospholipase A2" in MCE Product Catalog:
10
10 Publications Verification
Synonyms: LY315920
Target:
Research Areas:
Varespladib (LY315920) is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 9 nM. Varespladib exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC50s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively .
10
10 Publications Verification
Synonyms: LY315920 sodium
Target:
Research Areas:
Varespladib sodium (LY315920 sodium) is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 9 nM. Varespladib sodium exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC50s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively .
3
3 Cited Publications
Cat. No.: HY-P74628
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PLA2G2A; Non-Pancreatic Secretory phospholipase A2; Prev. PLA2B; phospholipase A2; Prev. PLA2L; RASF-A; Phosphatidylcholine 2-Acylhydrolase 2A; PLA2S; phospholipase A2, Membrane Associated; PLAS1; Group IIA phospholipase A2; SPLA2; GIIC SPLA2; MOM1; Phosp
Species:
Mouse
Source:
P. pastoris
Target:
Research Areas:
LY-311727 is a potent secretory non-pancreatic phospholipase A2 (sPLA2) inhibitor (IC50 <1 μM for group IIA sPLA2). sPLA2 is an important proinflammatory enzyme .
Cat. No.: HY-P10053
CAS No.: 236394-37-9
Target:
Research Areas:
Cat. No.: HY-13402S
CAS No.: 1360701-64-9
Synonyms: LY315920-d7
Cat. No.: HY-13402AR
CAS No.: 172733-42-5
Synonyms: LY315920 sodium (Standard)
Target:
Research Areas:
Varespladib (sodium) (Standard) is the analytical standard of Varespladib (sodium). This product is intended for research and analytical applications. Varespladib sodium (LY315920 sodium) is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 9 nM. Varespladib sodium exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC50s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively .
Cat. No.: HY-13402R
CAS No.: 172732-68-2
Synonyms: LY315920 (Standard)
Target:
Research Areas:
Varespladib (Standard) is the analytical standard of Varespladib. This product is intended for research and analytical applications. Varespladib (LY315920) is a potent and selective group IIA, secretory phospholipase A2 (sPLA2) inhibitor with an IC50 of 9 nM. Varespladib exhibits the significant inhibitory effect on sPLA2 activity in serum from various species including rat, rabbit, guinea pig and human with IC50s of 8.1 nM, 5.0 nM, 3.2 nM and 6.2 nM, respectively .
Cat. No.: HY-P75977
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PLA2G2A; Non-Pancreatic Secretory phospholipase A2; Prev. PLA2B; phospholipase A2; Prev. PLA2L; RASF-A; Phosphatidylcholine 2-Acylhydrolase 2A; PLA2S; phospholipase A2, Membrane Associated; PLAS1; Group IIA phospholipase A2; SPLA2; GIIC SPLA2; MOM1; Phosp
Species:
Human
Source:
HEK293
Cat. No.: HY-P75977Y
Purity: ≥ 95%, as determined by reducing SDS-PAGE.
Synonyms: PLA2G2A; Non-Pancreatic Secretory phospholipase A2; Prev. PLA2B; phospholipase A2; Prev. PLA2L; RASF-A; Phosphatidylcholine 2-Acylhydrolase 2A; PLA2S; phospholipase A2, Membrane Associated; PLAS1; Group IIA phospholipase A2; SPLA2; GIIC SPLA2; MOM1; Phosp
Species:
Human
Source:
HEK293
Cat. No.: HY-158792
CAS No.: 1899930-93-8
GK241 (compound 31a-c) is a 2-oxoamide-based compound that has inhibitory activity against human and mouse group IIA secretory phospholipase A2 (GIIA sPLA2) (IC50 of 143 nM and 68 nM, respectively), and its inhibitory mechanism was studied by molecular dynamics simulation.
Cat. No.: HY-184012
CAS No.: 3134928-97-2
Target:
Research Areas:
BAY-163 is a tertiary urea derivative and inactive negative control probe for BAY-439 (HY-178123). BAY-163 does not inhibit phospholipase A2 group V (PLA2-G5) activity in immune cells. BAY-163 can be used for research on endometriosis .
Cat. No.: HY-116192
CAS No.: 150379-37-6
Research Areas:
CGP-43182 is a secretory phospholipase A2 group II (sPLA2) inhibitor with an IC50 of 2.8 μM. CGP-43182 binds to the active site of the enzyme, blocks IL1β-stimulated gene expression and NFκB activation, and inhibits the production of prostaglandin and nitric oxide (NO). CGP-43182 exhibits anti-inflammatory activity in multiple inflammatory models and can be used for studies on adjuvant arthritis, carrageenan-induced edema, pertussis pleurisy, and glomerular inflammatory responses .
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Protocols
Targeted therapy! The Capetin Prize winning "Click Chemistry" can be used like this!Targeted therapy! The Nobel Prize winning "Click Chemistry" can be used like this!A suitable model is crucial in drug screening experiments. Organs can mimic the three-dimensional functional structure of internal organs, have similar spatial organization to corresponding organs, maintain some key characteristics, and reproduce some physiological functions. They are widely used for modeling and personalized drug screening physiological functions.2025-02-06
