164083-84-5
164083-84-5
Chemical Structure
LY-311727
- CAS No.: 164083-84-5
- Formula:C22H27N2O5P
- Molecular Weight:430.43
IUPAC Name: (3-((3-(2-amino-2-oxoethyl)-1-benzyl-2-ethyl-1H-indol-5-yl)oxy)propyl)phosphonic acid
InChIKey: OPWQYOUZRHDKBR-UHFFFAOYSA-N
SMILES: NC(CC1=C(CC)N(CC2=CC=CC=C2)C3=C1C=C(OCCCP(O)(O)=O)C=C3)=O
Biological Activity: LY-311727 is a potent secretory non-pancreatic phospholipase A2 (sPLA2) inhibitor (IC50 <1 μM for group IIA sPLA2). sPLA2 is an important proinflammatory enzyme[1][2].
| Cat. No. | Product Name | Purity | Description | Pricing | |||||||||||||||||||
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LY-311727 | 99.73% | LY-311727 is a potent secretory non-pancreatic phospholipase A2 (sPLA2) inhibitor (IC50 <1 μM for group IIA sPLA2). sPLA2 is an important proinflammatory enzyme. | ||||||||||||||||||||
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Structural Analogs
-
Similarity Score 0.63
HY-127119Benanserin hydrochloride -
Similarity Score 0.60
HY-13402Varespladib -
Similarity Score 0.60
HY-109573hnps-PLA-IN-1 -
Similarity Score 0.59
HY-17448Varespladib methyl -
Similarity Score 0.59
HY-13402ARVarespladib sodium (Standard) -
Similarity Score 0.54
HY-123639LM-4108 -
Similarity Score 0.54
HY-134138Indomethacin N-octyl amide -
Similarity Score 0.53
HY-114795Indomethacin heptyl ester -
Similarity Score 0.53
HY-17483Oxametacin -
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References
- [1]. R W Schevitz, et al. Structure-based design of the first potent and selective inhibitor of human non-pancreatic secretory phospholipase A2. Nat Struct Biol. 1995 Jun;2(6):458-65. [Content Brief]
- [2]. N Fox, et al. Transgenic model for the discovery of novel human secretory non-pancreatic phospholipase A2 inhibitors. Eur J Pharmacol. 1996 Jul 18;308(2):195-203. [Content Brief]
