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HCT-8 colon

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By Targets:	Antibiotic (2) Apoptosis (1) Bacterial (1) c-Myc (1) DNA/RNA Synthesis (1) EGFR (1) Fungal (1) HDAC (1) MDM-2/p53 (1) Thymidylate Synthase (1) Topoisomerase (1) Wnt (1) β-catenin (1)
By Research Areas:	Cancer (11) Infection (2)

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Cat. No.	Product Name	Target	Research Areas	Chemical Structure

HY-118942

Topovale ARC 111	Topoisomerase	Cancer
Topovale (ARC 111) is a topoisomerase I inhbitor. Topovale is an antitumor agent, and shows low nM cytotoxicity against a panel of cancer cells. Topovale induces reversible topoisomerase I (TOP1) cleavage complexes in tumor cells .

HY-113700

PD 116779	Antibiotic	Cancer
PD 116779 is an Antibiotic with anticancer activity. PD 116779 demonstrates moderate cytotoxicity against L1210 lymphocytic leukemia and HCT-8 human colon adenocarcinoma cell lines with IC₅₀ values of 3.55x10 ^-7 and 4.08x10 ^-7 M, respectively .

HY-113578

PD 116152	Antibiotic Bacterial	Infection Cancer
PD 116152 is a phenazine Antibiotic with antimicrobial and antitumor activity. PD 116152 possesses cytotoxic activity against L1210 lymphocytic leukemia and human colon adenocarcinoma (HCT-8) cells with IC₅₀ values of 5.2 x 10 ^-7 M and 7.1 x 10 ^-7 M, respectively. PD 116152 is promising for research of P388 lymphocytic leukemia .

HY-10823

OSI-7904L GW1843; 1843U89; OSI-7904	Thymidylate Synthase DNA/RNA Synthesis	Cancer
OSI-7904L (GW1843; 1843U89; OSI-7904) is a thymidylate synthase (TS) inhibitor with a K_i of 90 pM. OSI-7904L blocks de novo synthesis of thymidine nucleotides, DNA synthesis and induces cell death. OSI-7904L inhibits the growth of human cells, induces tumor regression, and achieves durable antitumor effects in mouse xenograft models. OSI-7904L can be used in research related to colon adenocarcinoma .

HY-181541

HIT211504993	HDAC Apoptosis Wnt β-catenin MDM-2/p53 c-Myc	Cancer
HIT211504993 is a selective histone deacetylase 6 (HDAC6) inhibitor with an IC₅₀ of 0.070 μM. HIT211504993 suppresses cancer cell proliferation, cause G1 phase cell cycle arrest and induces apoptosis. HIT211504993 inhibits Myc-driven tumorigenesis via nucleocytoplasmic acetylation, p53 modulation, and Wnt/β-catenin signaling modulation. HIT211504993 inhibits tumor growth in a colon cancer xenograft mouse model. HIT211504993 can be used for the research of colon cancer .

HY-N17995

GypenosideZ-3	Others	Cancer
GypenosideZ-3 is a dammarane triterpene glycoside found in the roots of Machilus yaoshansis .

HY-N18229

Hirundoside A	Others	Cancer
Hirundoside A is a steroidal glycoside found in the roots of Cynanchum stauntonii .

HY-N8255

Puupehenone	Fungal	Infection Cancer
Puupehenone is a cytotoxic and antifungal agent present in various marine sponge species. Puupehenone exerts cytotoxic activity against leukemia, lung cancer, colon cancer and breast cancer cells, and inhibits the growth of *Candida albicans*. Puupehenone can be used in research related to cancers such as leukemia, lung cancer, colon cancer and breast cancer .

HY-N18086

Bruceanic acid D	Others	Cancer
Bruceanic acid D is a quassinoid compound and cytotoxic agent that can be isolated from the xylem powder of Brucea antidysenterica. Bruceanic acid D specifically inhibits P-388 lymphocytic leukemia cells but shows no activity against human lung cancer cells and human colon cancer cells. Bruceanic acid D can be used in studies related to P-388 lymphocytic leukemia .

HY-N18228

Stauntoside Ⅱ	Others	Cancer
Stauntoside Ⅱ is a 14,15-secopregnane-type C21 steroidal glycoside found in the roots of Cynanchum stauntonii. Stauntoside Ⅱ does not exhibit cytotoxic activity against human colon, hepatoma, gastric, lung, and ovarian cancer cells .

HY-P991980

H2Mab-139 H2Mab-141, H2Mab-19	EGFR	Cancer
H2Mab-139 (H2Mab-141;H2Mab-19) is an anti-HER2 monoclonal antibody. H2Mab-139 specifically binds to HER2 on various cancer cells. H₂Mab-139 can detect HER2 overexpression in colorectal cancer via flow cytometry and immunohistochemical analysis. H₂Mab-139 exhibits anti-tumor activity in mouse oral cancer and breast cancer xenografts. H2Mab-139 is applicable to research related to multiple cancers including colon cancer, oral cancer, and breast cancer .

Cat. No.	Product Name	Target	Research Area	Image

HY-P991980

H2Mab-139 H2Mab-141, H2Mab-19	EGFR	Cancer
H2Mab-139 (H2Mab-141;H2Mab-19) is an anti-HER2 monoclonal antibody. H2Mab-139 specifically binds to HER2 on various cancer cells. H₂Mab-139 can detect HER2 overexpression in colorectal cancer via flow cytometry and immunohistochemical analysis. H₂Mab-139 exhibits anti-tumor activity in mouse oral cancer and breast cancer xenografts. H2Mab-139 is applicable to research related to multiple cancers including colon cancer, oral cancer, and breast cancer .

GypenosideZ-3	Triterpenes Structural Classification Terpenoids Cucurbitaceae Plants Gynostemma pentaphyllum (Thunb.) Makino Source Classification	Others
GypenosideZ-3 is a dammarane triterpene glycoside found in the roots of Machilus yaoshansis .

Hirundoside A	Apocynaceae Structural Classification Plants Vincetoxicum stauntonii (Decne.) C. Y. Wu et D. Z. Li Steroids Source Classification	Others
Hirundoside A is a steroidal glycoside found in the roots of Cynanchum stauntonii .

Puupehenone	Structural Classification Terpenoids Sesquiterpenes Marine natural products Sponge Source Classification	Fungal
Puupehenone is a cytotoxic and antifungal agent present in various marine sponge species. Puupehenone exerts cytotoxic activity against leukemia, lung cancer, colon cancer and breast cancer cells, and inhibits the growth of *Candida albicans*. Puupehenone can be used in research related to cancers such as leukemia, lung cancer, colon cancer and breast cancer .

Bruceanic acid D	Structural Classification Microorganisms Terpenoids Diterpenoids Source Classification	Others
Bruceanic acid D is a quassinoid compound and cytotoxic agent that can be isolated from the xylem powder of Brucea antidysenterica. Bruceanic acid D specifically inhibits P-388 lymphocytic leukemia cells but shows no activity against human lung cancer cells and human colon cancer cells. Bruceanic acid D can be used in studies related to P-388 lymphocytic leukemia .

Stauntoside Ⅱ	Apocynaceae Structural Classification Plants Vincetoxicum stauntonii (Decne.) C. Y. Wu et D. Z. Li Steroids Source Classification	Others
Stauntoside Ⅱ is a 14,15-secopregnane-type C21 steroidal glycoside found in the roots of Cynanchum stauntonii. Stauntoside Ⅱ does not exhibit cytotoxic activity against human colon, hepatoma, gastric, lung, and ovarian cancer cells .

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BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature. Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred to a PVDF membrane and blocked with 5% non-fat milk in TBST for 2 hour at room temperature. The primary antibody (1/1000) and Loading control antibody (Beta Actin, HY-P80438, 1/10000) was used in 5% non-fat milk in TBST at 4°C overnight. Goat Anti-Mouse/Rabbit IgG-HRP Secondary Antibody (1/10000) was used for 1 hour at room temperature.

BODIPY 493/503 purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Feb 1;16(1):1241. [Abstract]

MedchemExpress Validation 01

MedchemExpress Validation 03

Western blot analysis of extracts from THP-1(lane 2(20μg), Jurkat (lane 3(20μg) and NIH3T3(lane 4(20μg) using FOXO1A (HY-P80132) Rabbit mAb. Proteins were transferred

MedchemExpress Validation 04

MedchemExpress Validation

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HCT-8 colon

Inhibitors & Agonists

Inhibitory Antibodies

NaturalProducts

Natural
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