139987-54-5
Chemical Structure
OSI-7904L
Synonym(s): GW1843; 1843U89; OSI-7904
- CAS No.: 139987-54-5
- Formula:C27H24N4O6
- Molecular Weight:500.50
IUPAC Name: (S)-2-(5-(((3-methyl-1-oxo-1,4-dihydrobenzo[f]quinazolin-9-yl)methyl)amino)-1-oxoisoindolin-2-yl)pentanedioic acid
InChIKey: BRVFNEZMTRVUGW-QFIPXVFZSA-N
SMILES: O=C1C2=C3C(C=CC(CNC4=CC=C(C(N(C5)[C@H](C(O)=O)CCC(O)=O)=O)C5=C4)=C3)=CC=C2NC(C)=N1
Biological Activity: OSI-7904L (GW1843; 1843U89; OSI-7904) is a thymidylate synthase (TS) inhibitor with a Ki of 90 pM. OSI-7904L blocks de novo synthesis of thymidine nucleotides, DNA synthesis and induces cell death. OSI-7904L inhibits the growth of human cells, induces tumor regression, and achieves durable antitumor effects in mouse xenograft models. OSI-7904L can be used in research related to colon adenocarcinoma[1][2].
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OSI-7904L | OSI-7904L (GW1843; 1843U89; OSI-7904) is a thymidylate synthase (TS) inhibitor with a Ki of 90 pM. OSI-7904L blocks de novo synthesis of thymidine nucleotides, DNA synthesis and induces cell death. OSI-7904L inhibits the growth of human cells, induces tumor regression, and achieves durable antitumor effects in mouse xenograft models. OSI-7904L can be used in research related to colon adenocarcinoma. | |||||||||||||||||||||
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References
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[1]. Desjardins J, et al. Pharmacokinetics, safety, and efficacy of a liposome encapsulated thymidylate synthase inhibitor, OSI-7904L [(S)-2-[5-[(1,2-dihydro-3-methyl-1-oxobenzo[f]quinazolin-9-yl)methyl]amino-1-oxo-2-isoindolynl]-glutaric acid] in mice. J Pharmacol Exp Ther. 2004 Jun;309(3):894-902.
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[2]. Duch DS, et al. Biochemical and cellular pharmacology of 1843U89, a novel benzoquinazoline inhibitor of thymidylate synthase. Cancer Res. 1993 Feb 15;53(4):810-8.
[Content Brief]
