500214-53-9
500214-53-9
Chemical Structure
Topovale
Synonym(s): ARC 111
- CAS. Nr.: 500214-53-9
- Formula:C23H23N3O5
- Molecular Weight:421.45
IUPAC Name: 12-(2-(dimethylamino)ethyl)-2,3-dimethoxy-[1,3]dioxolo[4',5':4,5]benzo[1,2-h]benzo[c][1,6]naphthyridin-13(12H)-one
InChIKey: UVXCXZBZPFCAAJ-UHFFFAOYSA-N
SMILES: COC1=C(C=C(C2=C1)C(N(C3=C2C=NC4=C3C=C5OCOC5=C4)CCN(C)C)=O)OC
Biological Activity: Topovale (ARC 111) is a topoisomerase I inhbitor. Topovale is an antitumor agent, and shows low nM cytotoxicity against a panel of cancer cells. Topovale induces reversible topoisomerase I (TOP1) cleavage complexes in tumor cells[1].
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Topovale | 99.94% | Topovale (ARC 111) is a topoisomerase I inhbitor. Topovale is an antitumor agent, and shows low nM cytotoxicity against a panel of cancer cells. Topovale induces reversible topoisomerase I (TOP1) cleavage complexes in tumor cells. | ||||||||||||||||||||
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References
Keywords
